{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T04:23:52Z","timestamp":1728447832289},"reference-count":9,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2005,3,4]],"date-time":"2005-03-04T00:00:00Z","timestamp":1109894400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2005,3,4]],"date-time":"2005-03-04T00:00:00Z","timestamp":1109894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Introduction<\/jats:title>\n                        <jats:p><jats:italic>AIB1<\/jats:italic>, located at 20q12, is a member of the steroid hormone coactivator family. It contains a glutamine repeat (CAG\/CAA) polymorphism at its carboxyl-terminal region that may alter the transcriptional activation of the receptor and affect susceptibility to breast cancer through altered sensitivity to hormones.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>We evaluated this repeat polymorphism in the context of early-onset disease by conducting a case-control study of 432 Australian women diagnosed with breast cancer before the age of 40 years and 393 population-based control individuals who were frequency matched for age. Genotyping was performed using a scanning laser fluorescence imager.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>There were no differences in genotype frequencies between cases and control individuals, or between cases categorized by family history or by <jats:italic>BRCA1<\/jats:italic> and <jats:italic>BRCA2<\/jats:italic> germline mutation status. There was no evidence that the presence of one or two alleles of 26 glutamine repeats or fewer was associated with breast cancer (odds ratio = 1.03, 95% confidence interval = 0.73\u20131.44), or that women with alleles greater than 29 repeats were at increased risk of breast cancer. Exclusion of women who carried a <jats:italic>BRCA1<\/jats:italic> or <jats:italic>BRCA2<\/jats:italic> mutation (24 cases) and non-Caucasian women (44 cases) did not alter the risk estimates or inferences. We present raw data, including that on mutation carriers, to allow pooling with other studies.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusion<\/jats:title>\n                        <jats:p>There was no evidence that risk of breast cancer depends on <jats:italic>AIB1<\/jats:italic> CAG\/CAA polymorphism status, even if affected women carry a mutation in <jats:italic>BRCA1<\/jats:italic> or <jats:italic>BRCA2<\/jats:italic>.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/bcr1009","type":"journal-article","created":{"date-parts":[[2005,3,5]],"date-time":"2005-03-05T07:25:39Z","timestamp":1110007539000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The AIB1 glutamine repeat polymorphism is not associated with risk of breast cancer before age 40 years in Australian women"],"prefix":"10.1186","volume":"7","author":[{"given":"Karen G","family":"Montgomery","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiun-Horng","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorota M","family":"Gertig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gillian S","family":"Dite","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret R","family":"McCredie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham G","family":"Giles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa C","family":"Southey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John L","family":"Hopper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian G","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2005,3,4]]},"reference":[{"key":"1007_CR1","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1186\/bcr82","volume":"2","author":"CA Haiman","year":"2000","unstructured":"Haiman CA, Hankinson SE, Spiegelman D, Colditz GA, Willett WC, Speizer FE, Brown M, Hunter DJ: Polymorphic repeat in AIB1 does not alter breast cancer risk. Breast Cancer Res. 2000, 2: 378-385. 10.1186\/bcr82.","journal-title":"Breast Cancer Res"},{"key":"1007_CR2","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1126\/science.277.5328.965","volume":"277","author":"SL Anzick","year":"1997","unstructured":"Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM, Meltzer PS: AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science. 1997, 277: 965-968. 10.1126\/science.277.5328.965.","journal-title":"Science"},{"key":"1007_CR3","first-page":"5420","volume":"61","author":"TR Rebbeck","year":"2001","unstructured":"Rebbeck TR, Wang Y, Kantoff PW, Krithivas K, Neuhausen SL, Godwin AK, Daly MB, Narod SA, Brunet JS, Vesprini D, et al: Modification of BRCA1- and BRCA2-associated breast cancer risk by AIB1 genotype and reproductive history. Cancer Res. 2001, 61: 5420-5424.","journal-title":"Cancer Res"},{"key":"1007_CR4","first-page":"2925","volume":"4","author":"S Bautista","year":"1998","unstructured":"Bautista S, Valles H, Walker RL, Anzick S, Zeillinger R, Meltzer P, Theillet C: In breast cancer, amplification of the steroid receptor coactivator gene AIB1 is correlated with estrogen and progesterone receptor positivity. Clin Cancer Res. 1998, 4: 2925-2929.","journal-title":"Clin Cancer Res"},{"key":"1007_CR5","doi-asserted-by":"publisher","first-page":"3181","DOI":"10.1093\/nar\/22.15.3181","volume":"22","author":"NL Chamberlain","year":"1994","unstructured":"Chamberlain NL, Driver ED, Miesfeld RL: The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function. 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Int J Cancer. 2004, 108: 399-403. 10.1002\/ijc.11531.","journal-title":"Int J Cancer"},{"key":"1007_CR8","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1093\/oxfordjournals.jncimonographs.a024232","volume":"26","author":"JL Hopper","year":"1999","unstructured":"Hopper JL, Chenevix-Trench G, Jolley DJ, Dite GS, Jenkins MA, Venter DJ, McCredie MR, Giles GG: Design and analysis issues in a population-based, case-control-family study of the genetic epidemiology of breast cancer and the Co-operative Family Registry for Breast Cancer Studies (CFRBCS). J Natl Cancer Inst Monogr. 1999, 26: 95-100.","journal-title":"J Natl Cancer Inst Monogr"},{"key":"1007_CR9","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1093\/jnci\/95.6.448","volume":"95","author":"GS Dite","year":"2003","unstructured":"Dite GS, Jenkins MA, Southey MC, Hocking JS, Giles GG, McCredie MR, Venter DJ, Hopper JL: Familial risks, early-onset breast cancer, and BRCA1 and BRCA2 germline mutations. J Natl Cancer Inst. 2003, 95: 448-457.","journal-title":"J Natl Cancer Inst"}],"container-title":["Breast Cancer Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/bcr1009.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/bcr1009\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/bcr1009.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T11:00:04Z","timestamp":1728385204000},"score":1,"resource":{"primary":{"URL":"https:\/\/breast-cancer-research.biomedcentral.com\/articles\/10.1186\/bcr1009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3,4]]},"references-count":9,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2005,6]]}},"alternative-id":["1007"],"URL":"https:\/\/doi.org\/10.1186\/bcr1009","relation":{},"ISSN":["1465-542X"],"issn-type":[{"type":"electronic","value":"1465-542X"}],"subject":[],"published":{"date-parts":[[2005,3,4]]},"assertion":[{"value":"15 October 2004","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 January 2005","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2005","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2005","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"R353"}}