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Semi-automatic calculation of values of perfusion parameters \u2013 blood flow (BF), blood volume (BV), mean transit time (MTT), and permeability surface (PS) \u2013 was performed. Results were compared with pathology and with Her-2\/neu and Ki-67 levels in a surgical specimen of the primary tumor.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>Examined lymph nodes were inflammatory in 8 cases and metastatic in 18. Mean values of perfusion parameters in inflammatory and metastatic nodes, respectively, were BF of 76.18 (confidence interval [CI], 31.53) and 161.60 (CI, 40.94) ml\/100 mg per minute (<jats:italic>p<\/jats:italic> &lt; 0.05), BV of 5.81 (CI, 2.50) and 9.15 (CI, 3.02) ml\/100 mg (not significant [n.s.]), MTT of 6.80 (CI, 1.55) and 5.50 (CI, 1.84) seconds (<jats:italic>p<\/jats:italic> = 0.07), and PS of 25.82 (CI, 4.62) and 25.96 (CI, 7.47) ml\/100 mg per minute (n.s.). Size of nodes, stage of breast cancer, Ki-67 and Her-2\/neu levels in breast cancer, and expression of primary tumor activity were not correlated to any perfusion parameter in metastatic nodes.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusion<\/jats:title>\n                        <jats:p>CT perfusion might be an effective tool for studying enlarged axillary lymph nodes in patients with breast cancer. It gives information on vascularization of lymph nodes, helping to understand the changes occurring when neoplastic cells implant in lymph nodes.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/bcr1738","type":"journal-article","created":{"date-parts":[[2007,7,5]],"date-time":"2007-07-05T18:12:21Z","timestamp":1183659141000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Accuracy of computed tomography perfusion in assessing metastatic involvement of enlarged axillary lymph nodes in patients with breast cancer"],"prefix":"10.1186","volume":"9","author":[{"given":"Yun","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Bellomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Gatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Ping","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,7,5]]},"reference":[{"key":"1703_CR1","first-page":"135","volume-title":"Cancer: Principles and Practice of Oncology","author":"IJ Fidler","year":"1997","unstructured":"Fidler IJ: Molecular biology of cancer: invasion and metastasis. 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