{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T06:26:02Z","timestamp":1789971962174,"version":"4.0.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2008,11,26]],"date-time":"2008-11-26T00:00:00Z","timestamp":1227657600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2008,11,26]],"date-time":"2008-11-26T00:00:00Z","timestamp":1227657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Introduction<\/jats:title>\n                        <jats:p>The stroma is the supportive framework of biologic tissue in the breast, consisting of various proteins such as the proteoglycans, decorin and lumican. Altered expression of decorin and lumican is associated with breast tumors. We hypothesized that genetic variation in the decorin (<jats:italic>DCN<\/jats:italic>) and lumican (<jats:italic>LUM<\/jats:italic>) genes may contribute to breast cancer.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>We investigated associations of 14 common polymorphisms in the <jats:italic>DCN<\/jats:italic> and <jats:italic>LUM<\/jats:italic> genes with 798 breast cancer cases and 843 controls from Mayo Clinic, MN, USA. One polymorphism per gene with the strongest risk association in the Mayo Clinic sample was genotyped in 4,470 breast cancer cases and 4,560 controls from East Anglia, England (Studies of Epidemiology and Risk Factors in Cancer Heredity (SEARCH)).<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>In the Mayo Clinic sample, six polymorphisms were associated with breast cancer risk (<jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub> \u2264 0.05). The association with <jats:italic>LUM<\/jats:italic> rs2268578, evaluated further in SEARCH, was positive, although the odds ratios (OR) were weaker and not statistically significant. ORs were 1.4 (95% confidence interval [CI], 1.1 to 1.8) for heterozygotes and 2.2 (95% CI, 1.1 to 4.3; <jats:italic>P<\/jats:italic><jats:sub>2 df<\/jats:sub> = 0.002) for homozygotes in the Mayo Clinic sample, and were 1.1 (95% CI, 0.9 to 1.2) for heterozygotes and 1.4 (95% CI, 1.0 to 2.1; <jats:italic>P<\/jats:italic><jats:sub>2 df<\/jats:sub> = 0.13) for homozygotes in the SEARCH sample. In combined analyses, the ORs were 1.1 (95% CI, 1.0 to 1.2) for heterozygotes and 1.6 (95% CI, 1.2 to 2.3; <jats:italic>P<\/jats:italic><jats:sub>2 df<\/jats:sub> = 0.005) for homozygotes. Positive associations for this polymorphism were observed for estrogen receptor-positive tumors in both the Mayo Clinic sample (OR for heterozygotes = 1.5, 1.1 to 1.9 and OR for homozygotes = 2.5, 1.2 to 5.3;<jats:italic>P<\/jats:italic><jats:sub>2 df<\/jats:sub> = 0.001) and the SEARCH sample (OR for heterozygotes = 1.0, 0.9 to 1.1 and OR for homozygotes = 1.6, 1.0 to 2.5; <jats:italic>P<\/jats:italic><jats:sub>2 df<\/jats:sub> = 0.10). In combined analyses, the ORs were 1.1 (95% CI, 0.9 to 1.2) for heterozygotes and 1.9 (95% CI, 1.3 to 2.8; <jats:italic>P<\/jats:italic><jats:sub>2 df<\/jats:sub> = 0.001) for homozygotes.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>Although <jats:italic>LUM<\/jats:italic> rs2268578 was associated with breast cancer in the Mayo Clinic study, particularly estrogen receptor-positive breast cancer, weaker and modest associations were observed in the SEARCH sample. These modest associations will require larger samples to adequately assess the importance of this polymorphism in breast cancer.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/bcr2201","type":"journal-article","created":{"date-parts":[[2008,11,26]],"date-time":"2008-11-26T19:14:14Z","timestamp":1227726854000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Genetic variation in stromal proteins decorin and lumican with breast cancer: investigations in two case-control studies"],"prefix":"10.1186","volume":"10","author":[{"given":"Linda E","family":"Kelemen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fergus J","family":"Couch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahana","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison M","family":"Dunning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul DP","family":"Pharoah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas F","family":"Easton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary S","family":"Fredericksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A","family":"Vierkant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V Shane","family":"Pankratz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen L","family":"Goode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David N","family":"Rider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianshu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R","family":"Cerhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine M","family":"Vachon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,11,26]]},"reference":[{"key":"2165_CR1","first-page":"1254","volume":"60","author":"MH Barcellos-Hoff","year":"2000","unstructured":"Barcellos-Hoff MH, Ravani SA: Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells. Cancer Res. 2000, 60: 1254-1260.","journal-title":"Cancer Res"},{"key":"2165_CR2","first-page":"1041","volume":"5","author":"LF Brown","year":"1999","unstructured":"Brown LF, Guidi AJ, Schnitt SJ, Water Van De L, Iruela-Arispe ML, Yeo TK, Tognazzi K, Dvorak HF: Vascular stroma formation in carcinoma in situ, invasive carcinoma, and metastatic carcinoma of the breast. Clin Cancer Res. 1999, 5: 1041-1056.","journal-title":"Clin Cancer Res"},{"key":"2165_CR3","first-page":"497","volume":"150","author":"S Peyrol","year":"1997","unstructured":"Peyrol S, Raccurt M, Gerard F, Gleyzal C, Grimaud JA, Sommer P: Lysyl oxidase gene expression in the stromal reaction to in situ and invasive ductal breast carcinoma. Am J Pathol. 1997, 150: 497-507.","journal-title":"Am J Pathol"},{"key":"2165_CR4","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1152\/physrev.1996.76.1.69","volume":"76","author":"L Ronnov-Jessen","year":"1996","unstructured":"Ronnov-Jessen L, Petersen OW, Bissell MJ: Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction. Physiol Rev. 1996, 76: 69-125.","journal-title":"Physiol Rev"},{"key":"2165_CR5","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1126\/science.280.5366.1036","volume":"280","author":"KW Kinzler","year":"1998","unstructured":"Kinzler KW, Vogelstein B: Landscaping the cancer terrain. Science. 1998, 280: 1036-1037. 10.1126\/science.280.5366.1036.","journal-title":"Science"},{"key":"2165_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0945-053X(98)90121-4","volume":"17","author":"AM Hocking","year":"1998","unstructured":"Hocking AM, Shinomura T, McQuillan DJ: Leucine-rich repeat glycoproteins of the extracellular matrix. Matrix Biol. 1998, 17: 1-19. 10.1016\/S0945-053X(98)90121-4.","journal-title":"Matrix Biol"},{"key":"2165_CR7","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1083\/jcb.136.3.729","volume":"136","author":"KG Danielson","year":"1997","unstructured":"Danielson KG, Baribault H, Holmes DF, Graham H, Kadler KE, Iozzo RV: Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility. J Cell Biol. 1997, 136: 729-743. 10.1083\/jcb.136.3.729.","journal-title":"J Cell Biol"},{"key":"2165_CR8","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1083\/jcb.141.5.1277","volume":"141","author":"S Chakravarti","year":"1998","unstructured":"Chakravarti S, Magnuson T, Lass JH, Jepsen KJ, LaMantia C, Carroll H: Lumican regulates collagen fibril assembly: skin fragility and corneal opacity in the absence of lumican. J Cell Biol. 1998, 141: 1277-1286. 10.1083\/jcb.141.5.1277.","journal-title":"J Cell Biol"},{"key":"2165_CR9","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1038\/sj.onc.1208329","volume":"24","author":"CC Reed","year":"2005","unstructured":"Reed CC, Waterhouse A, Kirby S, Kay P, Owens RT, McQuillan DJ, Iozzo RV: Decorin prevents metastatic spreading of breast cancer. Oncogene. 2005, 24: 1104-1110. 10.1038\/sj.onc.1208329.","journal-title":"Oncogene"},{"key":"2165_CR10","first-page":"207","volume":"9","author":"S Troup","year":"2003","unstructured":"Troup S, Njue C, Kliewer EV, Parisien M, Roskelley C, Chakravarti S, Roughley PJ, Murphy LC, Watson PH: Reduced expression of the small leucine-rich proteoglycans, lumican, and decorin is associated with poor outcome in node-negative invasive breast cancer. Clin Cancer Res. 2003, 9: 207-214.","journal-title":"Clin Cancer Res"},{"key":"2165_CR11","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1002\/1096-9896(200011)192:3<313::AID-PATH694>3.0.CO;2-B","volume":"192","author":"E Leygue","year":"2000","unstructured":"Leygue E, Snell L, Dotzlaw H, Troup S, Hiller-Hitchcock T, Murphy LC, Roughley PJ, Watson PH: Lumican and decorin are differentially expressed in human breast carcinoma. J Pathol. 2000, 192: 313-320. 10.1002\/1096-9896(200011)192:3<313::AID-PATH694>3.0.CO;2-B.","journal-title":"J Pathol"},{"key":"2165_CR12","doi-asserted-by":"publisher","first-page":"R129","DOI":"10.1186\/bcr622","volume":"5","author":"S Alowami","year":"2003","unstructured":"Alowami S, Troup S, Al-Haddad S, Kirkpatrick I, Watson PH: Mammographic density is related to stroma and stromal proteoglycan expression. Breast Cancer Res. 2003, 5: R129-R135. 10.1186\/bcr622.","journal-title":"Breast Cancer Res"},{"key":"2165_CR13","first-page":"2562","volume":"60","author":"F Moinfar","year":"2000","unstructured":"Moinfar F, Man YG, Arnould L, Bratthauer GL, Ratschek M, Tavassoli FA: Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis. Cancer Res. 2000, 60: 2562-2566.","journal-title":"Cancer Res"},{"key":"2165_CR14","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1093\/hmg\/10.18.1907","volume":"10","author":"K Kurose","year":"2001","unstructured":"Kurose K, Hoshaw-Woodard S, Adeyinka A, Lemeshow S, Watson PH, Eng C: Genetic model of multi-step breast carcinogenesis involving the epithelium and stroma: clues to tumour-microenvironment interactions. Hum Mol Genet. 2001, 10: 1907-1913. 10.1093\/hmg\/10.18.1907.","journal-title":"Hum Mol Genet"},{"key":"2165_CR15","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/ng1013","volume":"32","author":"K Kurose","year":"2002","unstructured":"Kurose K, Gilley K, Matsumoto S, Watson PH, Zhou XP, Eng C: Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas. Nat Genet. 2002, 32: 355-357. 10.1038\/ng1013.","journal-title":"Nat Genet"},{"key":"2165_CR16","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1038\/nature05887","volume":"447","author":"DF Easton","year":"2007","unstructured":"Easton DF, Pooley KA, Dunning AM, Pharoah PD, Thompson D, Ballinger DG, Struewing JP, Morrison J, Field H, Luben R, Wareham N, Ahmed S, Healey CS, Bowman R, SEARCH collaborators, Meyer KB, Haiman CA, Kolonel LK, Henderson BE, Le Marchand L, Brennan P, Sangrajrang S, Gaborieau V, Odefrey F, Shen CY, Wu PE, Wang HC, Eccles D, Evans DG, Peto J, et al: Genome-wide association study identifies novel breast cancer susceptibility loci. Nature. 2007, 447: 1087-1093. 10.1038\/nature05887.","journal-title":"Nature"},{"key":"2165_CR17","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/ng1981","volume":"39","author":"A Cox","year":"2007","unstructured":"Cox A, Dunning AM, Garcia-Closas M, Balasubramanian S, Reed MW, Pooley KA, Scollen S, Baynes C, Ponder BA, Chanock S, Lissowska J, Brinton L, Peplonska B, Southey MC, Hopper JL, McCredie MR, Giles GG, Fletcher O, Johnson N, dos Santos Silva I, Gibson L, Bojesen SE, Nordestgaard BG, Axelsson CK, Torres D, Hamann U, Justenhoven C, Brauch H, Chang-Claude J, Kropp S, et al: A common coding variant in CASP8 is associated with breast cancer risk. Nat Genet. 2007, 39: 352-358. 10.1038\/ng1981.","journal-title":"Nat Genet"},{"key":"2165_CR18","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1038\/nature02168","volume":"426","author":"The International HapMap Consortium","year":"2003","unstructured":"The International HapMap Consortium: The International HapMap Project. Nature. 2003, 426: 789-796. 10.1038\/nature02168.","journal-title":"Nature"},{"key":"2165_CR19","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1086\/381000","volume":"74","author":"CS Carlson","year":"2004","unstructured":"Carlson CS, Eberle MA, Rieder MJ, Yi Q, Kruglyak L, Nickerson DA: Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. Am J Hum Genet. 2004, 74: 106-120. 10.1086\/381000.","journal-title":"Am J Hum Genet"},{"key":"2165_CR20","doi-asserted-by":"publisher","first-page":"777","DOI":"10.2217\/14622416.6.7.777","volume":"6","author":"FJ Steemers","year":"2005","unstructured":"Steemers FJ, Gunderson KL: Illumina, Inc. Pharmacogenomics. 2005, 6: 777-782. 10.2217\/14622416.6.7.777.","journal-title":"Pharmacogenomics"},{"key":"2165_CR21","doi-asserted-by":"crossref","unstructured":"Oliphant A, Barker DL, Stuelpnagel JR, Chee MS: BeadArray technology: enabling an accurate, cost-effective approach to high-throughput genotyping. Biotechniques. 2002, 56-61. Suppl","DOI":"10.2144\/jun0207"},{"key":"2165_CR22","doi-asserted-by":"publisher","first-page":"583","DOI":"10.2144\/000112047","volume":"39","author":"JB Fan","year":"2005","unstructured":"Fan JB, Hu SX, Craumer WC, Barker DL: BeadArray-based solutions for enabling the promise of pharmacogenomics. Biotechniques. 2005, 39: 583-588. 10.2144\/000112047.","journal-title":"Biotechniques"},{"key":"2165_CR23","doi-asserted-by":"publisher","first-page":"e42","DOI":"10.1371\/journal.pgen.0030042","volume":"3","author":"PD Pharoah","year":"2007","unstructured":"Pharoah PD, Tyrer J, Dunning AM, Easton DF, Ponder BA: Association between common variation in 120 candidate genes and breast cancer risk. PLoS Genet. 2007, 3: e42-10.1371\/journal.pgen.0030042.","journal-title":"PLoS Genet"},{"key":"2165_CR24","unstructured":"Applied Biosystems. [http:\/\/www.appliedbiosystems.com\/]"},{"key":"2165_CR25","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1006\/geno.1995.9003","volume":"29","author":"B Devlin","year":"1995","unstructured":"Devlin B, Risch N: A comparison of linkage disequilibrium measures for fine-scale mapping. Genomics. 1995, 29: 311-322. 10.1006\/geno.1995.9003.","journal-title":"Genomics"},{"key":"2165_CR26","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","volume":"21","author":"JC Barrett","year":"2005","unstructured":"Barrett JC, Fry B, Maller J, Daly MJ: Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics (Oxford, England). 2005, 21: 263-265. 10.1093\/bioinformatics\/bth457.","journal-title":"Bioinformatics (Oxford, England)"},{"key":"2165_CR27","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1086\/338688","volume":"70","author":"DJ Schaid","year":"2002","unstructured":"Schaid DJ, Rowland CM, Tines DE, Jacobson RM, Poland GA: Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am J Hum Genet. 2002, 70: 425-434. 10.1086\/338688.","journal-title":"Am J Hum Genet"},{"key":"2165_CR28","doi-asserted-by":"publisher","first-page":"R37","DOI":"10.1186\/bcr1732","volume":"9","author":"AG Mackay","year":"2007","unstructured":"Mackay AG, Urruticoechea A, Dixon JM, Dexter T, Fenwick K, Ashworth A, Drury S, Larionov A, Young O, White S, Miller WR, Evans DB, Dowsett M: Molecular response to aromatase inhibitor treatment in primary breast cancer. Breast Cancer Res. 2007, 9: R37-10.1186\/bcr1732.","journal-title":"Breast Cancer Res"},{"key":"2165_CR29","unstructured":"Schaid DJ: Mayo Clinic Research. [http:\/\/mayoresearch.mayo.edu\/mayo\/research\/biostat\/schaid.cfm]"},{"key":"2165_CR30","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1038\/447655a","volume":"447","author":"SJ Chanock","year":"2007","unstructured":"Chanock SJ, Manolio T, Boehnke M, Boerwinkle E, Hunter DJ, Thomas G, Hirschhorn JN, Abecasis G, Altshuler D, Bailey-Wilson JE, Brooks LD, Cardon LR, Daly M, Donnelly P, Fraumeni JF, Freimer NB, Gerhard DS, Gunter C, Guttmacher AE, Guyer MS, Harris EL, Hoh J, Hoover R, Kong CA, Merikangas KR, Morton CC, Palmer LJ, Phimister EG, Rice JP, Roberts J, et al: Replicating genotype-phenotype associations. Nature. 2007, 447: 655-660. 10.1038\/447655a.","journal-title":"Nature"},{"key":"2165_CR31","unstructured":"Cancer Genetic Markers of Susceptibility. [https:\/\/caintegrator.nci.nih.gov\/cgems\/]"},{"key":"2165_CR32","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1038\/ng2075","volume":"39","author":"DJ Hunter","year":"2007","unstructured":"Hunter DJ, Kraft P, Jacobs KB, Cox DG, Yeager M, Hankinson SE, Wacholder S, Wang Z, Welch R, Hutchinson A, Wang J, Yu K, Chatterjee N, Orr N, Willett WC, Colditz GA, Ziegler RG, Berg CD, Buys SS, McCarty CA, Feigelson HS, Calle EE, Thun MJ, Hayes RB, Tucker M, Gerhard DS, Fraumeni JF, Hoover RN, Thomas G, Chanock SJ: A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet. 2007, 39: 870-874. 10.1038\/ng2075.","journal-title":"Nat Genet"},{"key":"2165_CR33","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1158\/1055-9965.EPI-08-0262","volume":"17","author":"AH Eliassen","year":"2008","unstructured":"Eliassen AH, Missmer SA, Tworoger SS, Hankinson SE: Circulating 2-hydroxy- and 16\u03b1-hydroxy estrone levels and risk of breast cancer among postmenopausal women. Cancer Epidemiol Biomarkers Prev. 2008, 17: 2029-2035. 10.1158\/1055-9965.EPI-08-0262.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2165_CR34","first-page":"959","volume":"#4066","author":"EL Goode","year":"2005","unstructured":"Goode EL, Pharoah PDP, Dunning AM, Wareham NJ, Ponder BAJ, Easton D: No evidence for population substructure within the EPIC-Norfolk cohort [abstract]. AACR Meeting Abstracts. 2005, #4066: 959-","journal-title":"AACR Meeting Abstracts"},{"key":"2165_CR35","unstructured":"Ries LAG, Krapcho M, Mariotto A, Miller BA, Feuer EJ, Clegg L, Horner MJ, Howlader N, Eisner MP, Reichman M, Edwards BK, Eds: SEER Cancer Statistics Review, 1975\u20132004. Bethesda, MD: National Cancer Institute, [http:\/\/seer.cancer.gov\/csr\/1975_2004\/]"}],"container-title":["Breast Cancer Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/bcr2201.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/bcr2201\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/bcr2201.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T10:49:01Z","timestamp":1728384541000},"score":1,"resource":{"primary":{"URL":"https:\/\/breast-cancer-research.biomedcentral.com\/articles\/10.1186\/bcr2201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,26]]},"references-count":35,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2008,12]]}},"alternative-id":["2165"],"URL":"https:\/\/doi.org\/10.1186\/bcr2201","relation":{},"ISSN":["1465-542X"],"issn-type":[{"value":"1465-542X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,26]]},"assertion":[{"value":"30 July 2008","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 November 2008","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2008","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2008","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"R98"}}