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Information about cancer family history is usually available, but has rarely been used to evaluate UVs. The aim of the present study was to identify which is the best combination of clinical parameters that can predict whether a UV is deleterious, to be used for the classification of UVs.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>We developed logistic regression models with the best combination of clinical features that distinguished a positive control of <jats:italic>BRCA<\/jats:italic> pathogenic variants (115 families) from a negative control population of <jats:italic>BRCA<\/jats:italic> variants initially classified as UVs and later considered neutral (38 families).<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>The models included a combination of BRCAPRO scores, Myriad scores, number of ovarian cancers in the family, the age at diagnosis, and the number of persons with ovarian tumors and\/or breast tumors. The areas under the receiver operating characteristic curves were respectively 0.935 and 0.836 for the <jats:italic>BRCA1<\/jats:italic> and <jats:italic>BRCA2<\/jats:italic> models. For each model, the minimum receiver operating characteristic distance (respectively 90% and 78% specificity for <jats:italic>BRCA1<\/jats:italic> and <jats:italic>BRCA2<\/jats:italic>) was chosen as the cutoff value to predict which UVs are deleterious from a study population of 12 UVs, present in 59 Dutch families. The p.S1655F, p.R1699W, and p.R1699Q variants in <jats:italic>BRCA1<\/jats:italic> and the p.Y2660D, p.R2784Q, and p.R3052W variants in <jats:italic>BRCA2<\/jats:italic> are classified as deleterious according to our models. The predictions of the p.L246V variant in <jats:italic>BRCA1<\/jats:italic> and of the p.Y42C, p.E462G, p.R2888C, and p.R3052Q variants in <jats:italic>BRCA2<\/jats:italic> are in agreement with published information of them being neutral. The p.R2784W variant in <jats:italic>BRCA2<\/jats:italic> remains uncertain.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>The present study shows that these developed models are useful to classify UVs in clinical genetic practice.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/bcr2223","type":"journal-article","created":{"date-parts":[[2009,2,7]],"date-time":"2009-02-07T08:19:46Z","timestamp":1233994786000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["A method to assess the clinical significance of unclassified variants in the BRCA1 and BRCA2genes based on cancer family history"],"prefix":"10.1186","volume":"11","author":[{"given":"Encarna B","family":"G\u00f3mez Garc\u00eda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan C","family":"Oosterwijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Timmermans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christi J","family":"van Asperen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans BL","family":"Hogervorst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoline","family":"Hoogerbrugge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogier","family":"Oldenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senno","family":"Verhoef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte J","family":"Dommering","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margreet GEM","family":"Ausems","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theo AM","family":"van Os","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie H","family":"van der Hout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjolijn","family":"Ligtenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ans","family":"van den Ouweland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob B","family":"van der Luijt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juul T","family":"Wijnen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan JP","family":"Gille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J","family":"Lindsey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Devilee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinus J","family":"Blok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maaike PG","family":"Vreeswijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,2,6]]},"reference":[{"key":"2187_CR1","unstructured":"Breast Cancer Information Core. 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