{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:58:02Z","timestamp":1791356282936,"version":"4.3.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,2,11]],"date-time":"2010-02-11T00:00:00Z","timestamp":1265846400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2010,2,11]],"date-time":"2010-02-11T00:00:00Z","timestamp":1265846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Introduction<\/jats:title>\n                        <jats:p>Most breast cancers that occur in women with germline <jats:italic>BRCA1<\/jats:italic> mutations are estrogen receptor-negative (ER-) and also typically lack expression of progesterone receptor (PR) and HER2 overexpression. We undertook a study to assess the clinical factors that predict for an estrogen receptor positive (ER+) breast cancer in <jats:italic>BRCA1<\/jats:italic> mutation carriers and to characterize the pathologic features of these tumors.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>Clinical characteristics of <jats:italic>BRCA1<\/jats:italic> carriers with 58 ER+ and 114 ER- first invasive breast cancers were compared. Pathologic features of <jats:italic>BRCA1<\/jats:italic> ER+ cancers were compared to those of <jats:italic>BRCA1<\/jats:italic> ER- cancers and to age-matched ER+ sporadic cancers.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p><jats:italic>BRCA1<\/jats:italic> carriers aged \u2265 50 at diagnosis of first invasive breast cancer were more likely to have an ER+ cancer compared to those aged &lt; 50 (57% vs 29%, <jats:italic>P<\/jats:italic> = 0.005). ER+ <jats:italic>BRCA1<\/jats:italic> cancers were less likely than ER- <jats:italic>BRCA1<\/jats:italic> cancers to have \"<jats:italic>BRCA<\/jats:italic>-associated\" features such as high mitotic activity, geographic necrosis\/fibrotic focus, and pushing margins (RR 0.06, 0.22, 0.24; <jats:italic>P<\/jats:italic> &lt; 0.001, 0.02, 0.03 respectively). When compared to sporadic ER+ cancers, ER+ <jats:italic>BRCA1<\/jats:italic> cancers were more often of invasive ductal type (RR 2.4, <jats:italic>P<\/jats:italic> = 0.03), with a high mitotic rate (RR 5.0, <jats:italic>P<\/jats:italic> = 0.006) and absent or mild lymphocytic infiltrate (RR 10.2, <jats:italic>P<\/jats:italic> = 0.04).<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p><jats:italic>BRCA1<\/jats:italic> carriers who are older at first breast cancer diagnosis are more likely to have ER+ tumors than younger <jats:italic>BRCA1<\/jats:italic> carriers. These ER+ cancers appear pathologically \"intermediate\" between ER- <jats:italic>BRCA1<\/jats:italic> cancers and ER+ sporadic breast cancers raising the possibility that either some ER+ <jats:italic>BRCA1<\/jats:italic> cancers are incidental or that there is a unique mechanism by which these cancers develop.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/bcr2478","type":"journal-article","created":{"date-parts":[[2010,2,11]],"date-time":"2010-02-11T19:14:58Z","timestamp":1265915698000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Estrogen receptor positive breast cancers in BRCA1 mutation carriers: clinical risk factors and pathologic features"],"prefix":"10.1186","volume":"12","author":[{"given":"Nadine","family":"Tung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura C","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Gelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy H","family":"Comander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bridget","family":"Gallagher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Fetten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Krag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn A","family":"Stoeckert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D","family":"Legare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Sgroi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula D","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy E","family":"Garber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart J","family":"Schnitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,2,11]]},"reference":[{"key":"2442_CR1","first-page":"471","volume":"56","author":"F Eisinger","year":"1996","unstructured":"Eisinger F, Stoppa-Lyonnet D, Longy M, Kerangueven F, Noguchi T, Bailly C, Vincent-Salomon A, Jacquemier J, Birnbaum D, Sobol H: Germ line mutation at BRCA1 affects the histoprognostic grade in hereditary breast cancer. 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