{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T22:24:15Z","timestamp":1768256655430,"version":"3.49.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2001,4,26]],"date-time":"2001-04-26T00:00:00Z","timestamp":988243200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2001,4,26]],"date-time":"2001-04-26T00:00:00Z","timestamp":988243200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res"],"DOI":"10.1186\/bcr304","type":"journal-article","created":{"date-parts":[[2002,9,26]],"date-time":"2002-09-26T12:07:27Z","timestamp":1033042047000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Possible association of \u03b22- and \u03b23-adrenergic receptor gene polymorphisms with susceptibility to breast cancer"],"prefix":"10.1186","volume":"3","author":[{"given":"Xin-En","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Hamajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiko","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keitaro","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhiro","family":"Mizutani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroji","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuji","family":"Iwase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeto","family":"Miura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinkan","family":"Tokudome","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Tajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2001,4,26]]},"reference":[{"key":"309_CR1","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1002\/(SICI)1097-0215(19990315)80:6<827::AID-IJC6>3.0.CO;2-P","volume":"80","author":"DM Parkin","year":"1999","unstructured":"Parkin DM, Pisani P, Ferlay J: Estimates of the world incidence of 25 major cancers in 1990. Int J Cancer. 1999, 80: 827-841. 10.1002\/(SICI)1097-0215(19990315)80:6<827::AID-IJC6>3.0.CO;2-P.","journal-title":"Int J Cancer"},{"key":"309_CR2","first-page":"153","volume":"47","author":"T Kuroishi","year":"1999","unstructured":"Kuroishi T, Nishikawa Y, Tominaga S, Aoki K: Cancer mortality statistics in 33 countries (1953-1992). Gann Monogr Cancer Res. 1999, 47: 153-217.","journal-title":"Gann Monogr Cancer Res"},{"key":"309_CR3","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1002\/(SICI)1097-0215(19990129)80:3<349::AID-IJC3>3.0.CO;2-8","volume":"80","author":"K Hirose","year":"1999","unstructured":"Hirose K, Tajima K, Hamajima N, Takezaki T, Inoue M, Kuroishi T, Miura S, Tokudome S: Effect of body size on breast-cancer risk among Japanese women. Int J Cancer. 1999, 80: 349-355. 10.1002\/(SICI)1097-0215(19990129)80:3<349::AID-IJC3>3.0.CO;2-8.","journal-title":"Int J Cancer"},{"key":"309_CR4","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1002\/ijc.2910450311","volume":"45","author":"LJ Vatten","year":"1990","unstructured":"Vatten LJ, Kvinnsland S: Body mass index and risk of breast cancer. A prospective study of 23,826 Norwegian women. Int J Cancer. 1990, 45: 440-444.","journal-title":"Int J Cancer"},{"key":"309_CR5","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/S0022-2275(20)37695-1","volume":"34","author":"M Lafontan","year":"1993","unstructured":"Lafontan M, Berlan M: Fat cell adrenergic receptors and the control of white and brown fat cell function. J Lipid Res. 1993, 34: 1057-1091.","journal-title":"J Lipid Res"},{"key":"309_CR6","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1002\/med.2610130604","volume":"13","author":"JRS Arch","year":"1993","unstructured":"Arch JRS, Kaumann AJ: \u03b23 and atypical adrenoceptors. Med Res Rev. 1993, 13: 663-729.","journal-title":"Med Res Rev"},{"key":"309_CR7","doi-asserted-by":"publisher","first-page":"1118","DOI":"10.1126\/science.2570461","volume":"245","author":"LJ Emorine","year":"1989","unstructured":"Emorine LJ, Marullo SM, Briend-Sutren M, Patey G, Tate K, Delavier-Klutchko C, Strosberg D: Molecular characterization of the human \u03b23-adrenergic receptor. Science. 1989, 245: 1118-1121.","journal-title":"Science"},{"key":"309_CR8","first-page":"264","volume":"44","author":"JG Granneman","year":"1993","unstructured":"Granneman JG, Lahners KN, Chaudry A: Characterization of the human \u03b23-adrenergic receptor gene. Mol Pharmacol. 1993, 44: 264-270.","journal-title":"Mol Pharmacol"},{"key":"309_CR9","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/0014-5793(93)81377-C","volume":"324","author":"JM Lelias","year":"1993","unstructured":"Lelias JM, Kaghad M, Rodriguez M, Chalon P, Bonnin J, Dupr\u00e9 I, Delpech B, Bensaid M, LeFur G, Ferrara P, Caput D: Molecular cloning of a human \u03b23-adrenergic receptor. FEBS Lett. 1993, 324: 127-130. 10.1016\/0014-5793(93)81377-C.","journal-title":"FEBS Lett"},{"key":"309_CR10","doi-asserted-by":"publisher","first-page":"2239","DOI":"10.1172\/JCI117914","volume":"95","author":"S Enocksson","year":"1995","unstructured":"Enocksson S, Shimizu M, Lonnqvist F, Nordenstrom J, Arner P: Demonstration of an in vivo functional \u03b23-adrenoceptor in man. J Clin Invest. 1995, 95: 2239-2245.","journal-title":"J Clin Invest"},{"key":"309_CR11","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1046\/j.1365-2796.1999.00495.x","volume":"245","author":"P Arner","year":"1999","unstructured":"Arner P, Hoffstedt J: Adrenoceptor genes in human obesity. J Intern Med. 1999, 245: 667-672. 10.1046\/j.1365-2796.1999.00495.x.","journal-title":"J Intern Med"},{"key":"309_CR12","doi-asserted-by":"publisher","first-page":"3005","DOI":"10.1172\/JCI119854","volume":"100","author":"V Large","year":"1997","unstructured":"Large V, Hellstrom L, Reynisdottir S, Lonnqvist F, Eriksson P, Lannfeld L, Arner P: Human beta-2 adrenoceptor gene polymorphisms are highly frequent in obesity and associate with altered adipocyte beta-2 adrenoceptor function. J Clin Invest. 1997, 100: 3005-3013.","journal-title":"J Clin Invest"},{"key":"309_CR13","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1038\/sj.ijo.0801063","volume":"23","author":"B Kortner","year":"1999","unstructured":"Kortner B, Wolf A, Wendt D, Beisiegel U, Evans D: Lack of association between a human \u03b2-2 adrenoceptor gene polymorphism (gln27glu) and morbid obesity. Int J Obes Relat Metab Disord. 1999, 23: 1099-1100. 10.1038\/sj\/ijo\/0801063.","journal-title":"Int J Obes Relat Metab Disord"},{"key":"309_CR14","doi-asserted-by":"publisher","first-page":"1976","DOI":"10.1016\/S0140-6736(05)77192-0","volume":"353","author":"N Sakane","year":"1999","unstructured":"Sakane N, Yoshida T, Umekawa T, Kogure A, Kondo M: Beta2-adrenoceptor gene polymorphism and obesity [letter]. Lancet. 1999, 353: 1976-","journal-title":"Lancet"},{"key":"309_CR15","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/S0140-6736(99)00251-2","volume":"353","author":"A Meirhaeghe","year":"1999","unstructured":"Meirhaeghe A, Helbecque N, Cottel D, Amouyel P: Beta2-adrenoceptor gene polymorphism, body weight, and physical activity [letter]. Lancet. 1999, 353: 896-10.1016\/S0140-6736(99)00251-2.","journal-title":"Lancet"},{"key":"309_CR16","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1006\/bbrc.1995.2500","volume":"215","author":"H Kadowaki","year":"1995","unstructured":"Kadowaki H, Yasuda K, Iwamoto K, Otabe S, Shimokawa K, Silver K, Walston J, Yoshinaga H, Kosaka K, Yamada N: A mutation in the \u03b23-adrenergic receptor gene is associated with obesity and hyperinsulinemia in Japanese subjects. Biochem Biophys Res Commun. 1995, 215: 555-560. 10.1006\/bbrc.1995.2500.","journal-title":"Biochem Biophys Res Commun"},{"key":"309_CR17","first-page":"1410","volume":"39","author":"K Yoshioka","year":"1996","unstructured":"Yoshioka K, Yoshida T, Sakane N, Umekawa T, Takahashi T, Sakai Y, Kondo M: Association of Trp64Arg mutation of the beta 3-adrenergic receptor gene with NIDDM, current and maximal body mass index. Diabetologia. 1996, 39: 1410-1411.","journal-title":"Diabetologia"},{"key":"309_CR18","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.1172\/JCI119014","volume":"98","author":"J Gagnon","year":"1996","unstructured":"Gagnon J, Mauriege P, Roy S, Sjostrom D, Chagnon YC, Dionne FT, Oppert JM, Perusse L, Sjostrom L, Bouchard C: The Trp64Arg mutation of the beta 3 adrenergic receptor gene has no effect on obesity phenotypes in the Quebec Family Study and Swedish Obese Subjects cohorts. J Clin Invest. 1996, 98: 2086-2093.","journal-title":"J Clin Invest"},{"key":"309_CR19","unstructured":"SAS Institute:. SAS\/STAT User's guide, ver 6, 4th ed. Cary, NC: SAS Institute Inc;. 1990"},{"key":"309_CR20","first-page":"81","volume":"75","author":"R Sato","year":"2000","unstructured":"Sato R: The role of beta2-adrenoceptor gene polymorphism in asthma. Hokkaido J Med Sci. 2000, 75: 81-94.","journal-title":"Hokkaido J Med Sci"},{"key":"309_CR21","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1007\/BF00418352","volume":"39","author":"T Fujisawa","year":"1996","unstructured":"Fujisawa T, Ikegami H, Yamato E, Takekawa K, Nakagawa Y, Hamada Y, Oga T, Ueda H, Shintani M, Fukuda M, Ogihara T: Association of Trp64Arg mutation of the beta3-adrenergic-receptor with NIDDM and body weight gain. Diabetologia. 1996, 39: 349-352. 10.1007\/s001250050452.","journal-title":"Diabetologia"},{"key":"309_CR22","unstructured":"Stata Corp:. Stata Statistical Software, release 6. College Station, TX: Stata Corporation;. 1999"},{"key":"309_CR23","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1093\/jjco\/29.10.490","volume":"29","author":"N Hamajima","year":"1999","unstructured":"Hamajima N, Yuasa H, Matsuo K, Kurobe Y: Detection of gene-environment interaction by case-only studies. Jpn J Clin Oncol. 1999, 29: 490-493. 10.1093\/jjco\/29.10.490.","journal-title":"Jpn J Clin Oncol"},{"key":"309_CR24","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S0895-4356(96)00297-1","volume":"50","author":"M Inoue","year":"1997","unstructured":"Inoue M, Tajima K, Hirose K, Hamajima N, Takezaki T, Kuroishi T, Tominaga S: Epidemiological features of first-visit outpatients in Japan: comparison with general population and variation by sex, age, and season. J Clin Epidemiol. 1997, 50: 69-77. 10.1016\/S0895-4356(96)00297-1.","journal-title":"J Clin Epidemiol"},{"key":"309_CR25","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1007\/s001250051120","volume":"42","author":"S Ishiyama-Shigemoto","year":"1996","unstructured":"Ishiyama-Shigemoto S, Yamada K, Yuan X, Ichikawa F, Nonaka K: Association of polymorphisms in the beta2-adrenergic receptor gene with obesity, hypertriglyceridaemia, and diabetes mellitus. Diabetologia. 1996, 42: 98-101. 10.1007\/s001250051120.","journal-title":"Diabetologia"},{"key":"309_CR26","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1111\/j.1349-7006.1990.tb02637.x","volume":"81","author":"S Kyogoku","year":"1990","unstructured":"Kyogoku S, Hirohata T, Takeshita S, Hirota Y, Shigematsu T: Anthropometric indicators of breast cancer risk in Japanese women in Fukuoka. Jpn J Cancer Res. 1990, 81: 731-737.","journal-title":"Jpn J Cancer Res"},{"key":"309_CR27","first-page":"S228","volume":"55(suppl)","author":"P Arner","year":"1989","unstructured":"Arner P: Adrenergic receptor function in fat cells. Am J Clin Nutr. 1989, 55(suppl): S228-S236.","journal-title":"Am J Clin Nutr"},{"key":"309_CR28","first-page":"16","volume":"12(suppl 1)","author":"M Lafontan","year":"1997","unstructured":"Lafontan M, Barbe P, Galitzky J, Tavernier G, Langin D, Carpene C, Bousquet-Melou A, Berlan M: Adrenergic regulation of adipocyte metabolism. Hum Reprod. 1997, 12(suppl 1): 16-20.","journal-title":"Hum Reprod"}],"container-title":["Breast Cancer Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/bcr304.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/bcr304\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/bcr304.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T16:23:59Z","timestamp":1714062239000},"score":1,"resource":{"primary":{"URL":"https:\/\/breast-cancer-research.biomedcentral.com\/articles\/10.1186\/bcr304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4,26]]},"references-count":28,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2001,8]]}},"alternative-id":["309"],"URL":"https:\/\/doi.org\/10.1186\/bcr304","relation":{},"ISSN":["1465-542X"],"issn-type":[{"value":"1465-542X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,4,26]]},"assertion":[{"value":"2 January 2001","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 March 2001","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2001","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 April 2001","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"264"}}