{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:53:20Z","timestamp":1791143600001,"version":"4.1.0"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2011,10,26]],"date-time":"2011-10-26T00:00:00Z","timestamp":1319587200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2011,10,26]],"date-time":"2011-10-26T00:00:00Z","timestamp":1319587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Introduction<\/jats:title>\n                        <jats:p>E-cadherin (E-cad; cadherin 1) and N-cadherin (N-cad; cadherin 2) are the most prominent members of the cadherin family of cell adhesion molecules. Although they share many structural and functional features, they are expressed in an almost mutually exclusive manner <jats:italic>in vivo<\/jats:italic>.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>To explore functional differences between the two cadherins <jats:italic>in vivo<\/jats:italic>, we recently generated a knock-in line in which N-cad is expressed from the E-cad locus. In combination with a conditional gene inactivation approach, we expressed N-cad in the absence of E-cad (referred to as Ncadk.i.) in alveolar epithelial cells of the mammary gland starting in late pregnancy.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>We found that the sole presence of N-cad induces constitutively active fibroblast growth factor (Fgf) signaling and a precocious involution resulting in massive apoptosis of alveolar cells. To block apoptosis, we conditionally deleted one allele of p53 in Ncadk.i. mice and observed a temporal rescue of alveolar morphology and function. However, an accumulation of fibrotic tissue and cysts with increasing age and lactation cycles was observed. This phenotype closely resembled fibrocystic mastopathy (FM), a common disorder in humans, which is thought to precede breast cancer. Concordantly, 55% of Ncadk.i. mice harboring a heterozygous p53 deletion developed malignant and invasive tumors.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>Our results demonstrate a possible role for N-cad in the formation of fibrosis and cysts in the mammary gland. Moreover, we show that these lesions precede the development of malignant tumors. Thus, we provide a new mouse model to investigate the molecular mechanisms of fibrocystic mastopathy and the transition from benign to malignant tumors.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/bcr3046","type":"journal-article","created":{"date-parts":[[2011,10,26]],"date-time":"2011-10-26T18:33:28Z","timestamp":1319654008000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Replacement of E-cadherin by N-cadherin in the mammary gland leads to fibrocystic changes and tumor formation"],"prefix":"10.1186","volume":"13","author":[{"given":"Ahmed M","family":"Kotb","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Hierholzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Kemler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,10,26]]},"reference":[{"key":"2853_CR1","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/0955-0674(95)80102-2","volume":"7","author":"M Takeichi","year":"1995","unstructured":"Takeichi M: Morphogenetic roles of classic cadherins. Curr Opin Cell Biol. 1995, 7: 619-627. 10.1016\/0955-0674(95)80102-2.","journal-title":"Curr Opin Cell Biol"},{"key":"2853_CR2","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1039\/b719215k","volume":"4","author":"MP Stemmler","year":"2008","unstructured":"Stemmler MP: Cadherins in development and cancer. Mol Biosyst. 2008, 4: 835-850. 10.1039\/b719215k.","journal-title":"Mol Biosyst"},{"key":"2853_CR3","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1006\/dbio.1996.8443","volume":"181","author":"GL Radice","year":"1997","unstructured":"Radice GL, Rayburn H, Matsunami H, Knudsen KA, Takeichi M, Hynes RO: Developmental defects in mouse embryos lacking N-cadherin. Dev Biol. 1997, 181: 64-78. 10.1006\/dbio.1996.8443.","journal-title":"Dev Biol"},{"key":"2853_CR4","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1002\/j.1460-2075.1989.tb03563.x","volume":"8","author":"M Ozawa","year":"1989","unstructured":"Ozawa M, Baribault H, Kemler R: The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J. 1989, 8: 1711-1717.","journal-title":"EMBO J"},{"key":"2853_CR5","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1083\/jcb.127.5.1375","volume":"127","author":"H Hoschuetzky","year":"1994","unstructured":"Hoschuetzky H, Aberle H, Kemler R: Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor. J Cell Biol. 1994, 127: 1375-1380. 10.1083\/jcb.127.5.1375.","journal-title":"J Cell Biol"},{"key":"2853_CR6","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/0896-6273(94)90027-2","volume":"13","author":"EJ Williams","year":"1994","unstructured":"Williams EJ, Furness J, Walsh FS, Doherty P: Activation of the FGF receptor underlies neurite outgrowth stimulated by L1, N-CAM, and N-cadherin. Neuron. 1994, 13: 583-594. 10.1016\/0896-6273(94)90027-2.","journal-title":"Neuron"},{"key":"2853_CR7","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1242\/dev.02722","volume":"134","author":"NG Kan","year":"2007","unstructured":"Kan NG, Stemmler MP, Junghans D, Kanzler B, de Vries WN, Dominis M, Kemler R: Gene replacement reveals a specific role for E-cadherin in the formation of a functional trophectoderm. Development. 2007, 134: 31-41. 10.1242\/dev.02722.","journal-title":"Development"},{"key":"2853_CR8","doi-asserted-by":"publisher","first-page":"2297","DOI":"10.1242\/dev.048488","volume":"137","author":"L Libusova","year":"2010","unstructured":"Libusova L, Stemmler MP, Hierholzer A, Schwarz H, Kemler R: N-cadherin can structurally substitute for E-cadherin during intestinal development but leads to polyp formation. Development. 2010, 137: 2297-2305. 10.1242\/dev.048488.","journal-title":"Development"},{"key":"2853_CR9","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/s10911-006-9026-0","volume":"11","author":"C Brisken","year":"2006","unstructured":"Brisken C, Rajaram RD: Alveolar and lactogenic differentiation. J Mammary Gland Biol Neoplasia. 2006, 11: 239-248. 10.1007\/s10911-006-9026-0.","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"2853_CR10","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s10911-005-9582-8","volume":"10","author":"MM Faraldo","year":"2005","unstructured":"Faraldo MM, Teuliere J, Deugnier MA, Taddei-De La Hosseraye I, Thiery JP, Glukhova MA: Myoepithelial cells in the control of mammary development and tumorigenesis: data from genetically modified mice. J Mammary Gland Biol Neoplasia. 2005, 10: 211-219. 10.1007\/s10911-005-9582-8.","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"2853_CR11","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0925-4773(02)00090-4","volume":"115","author":"O Boussadia","year":"2002","unstructured":"Boussadia O, Kutsch S, Hierholzer A, Delmas V, Kemler R: E-cadherin is a survival factor for the lactating mouse mammary gland. Mech Dev. 2002, 115: 53-62. 10.1016\/S0925-4773(02)00090-4.","journal-title":"Mech Dev"},{"key":"2853_CR12","doi-asserted-by":"publisher","first-page":"4323","DOI":"10.1093\/nar\/25.21.4323","volume":"25","author":"KU Wagner","year":"1997","unstructured":"Wagner KU, Wall RJ, St-Onge L, Gruss P, Wynshaw-Boris A, Garrett L, Li M, Furth PA, Hennighausen L: Cre-mediated gene deletion in the mammary gland. Nucleic Acids Res. 1997, 25: 4323-4330. 10.1093\/nar\/25.21.4323.","journal-title":"Nucleic Acids Res"},{"key":"2853_CR13","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.ccr.2006.09.013","volume":"10","author":"PWB Derksen","year":"2006","unstructured":"Derksen PWB, Liu X, Saridin F, van der Gulden H, Zevenhoven J, Evers B, van Beijnum JR, Griffioen AW, Vink J, Krimpenfort P: Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis. Cancer Cell. 2006, 10: 437-449. 10.1016\/j.ccr.2006.09.013.","journal-title":"Cancer Cell"},{"key":"2853_CR14","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1038\/ng747","volume":"29","author":"J Jonkers","year":"2001","unstructured":"Jonkers J, Meuwissen R, van der Gulden H, Peterse H, van der Valk M, Berns A: Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer. Nat Genet. 2001, 29: 418-425. 10.1038\/ng747.","journal-title":"Nat Genet"},{"key":"2853_CR15","doi-asserted-by":"publisher","first-page":"2892","DOI":"10.1210\/me.2002-0128","volume":"16","author":"K Miyoshi","year":"2002","unstructured":"Miyoshi K: Mammary Epithelial Cells Are Not Able to Undergo Pregnancy-Dependent Differentiation in the Absence of the Helix-Loop-Helix Inhibitor Id2. Molecular Endocrinology. 2002, 16: 2892-2901. 10.1210\/me.2002-0128.","journal-title":"Molecular Endocrinology"},{"key":"2853_CR16","volume-title":"Theory and practice of histological techniques","author":"JD Bancroft","year":"1990","unstructured":"Bancroft JD, Stevens A: Theory and practice of histological techniques. 1990, Edinburgh; New York: Churchill Livingstone, 3","edition":"3"},{"key":"2853_CR17","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/S0092-8674(02)01015-2","volume":"111","author":"E Batlle","year":"2002","unstructured":"Batlle E, Henderson JT, Beghtel H, van den Born MM, Sancho E, Huls G, Meeldijk J, Robertson J, van de Wetering M, Pawson T, Clevers H: Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB\/ephrinB. Cell. 2002, 111: 251-263. 10.1016\/S0092-8674(02)01015-2.","journal-title":"Cell"},{"key":"2853_CR18","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/0014-4827(84)90241-6","volume":"152","author":"D Vestweber","year":"1984","unstructured":"Vestweber D, Kemler R: Rabbit antiserum against a purified surface glycoprotein decompacts mouse preimplantation embryos and reacts with specific adult tissues. Exp Cell Res. 1984, 152: 169-178. 10.1016\/0014-4827(84)90241-6.","journal-title":"Exp Cell Res"},{"key":"2853_CR19","first-page":"685","volume":"10","author":"RC Humphreys","year":"1999","unstructured":"Humphreys RC, Hennighausen L: Signal transducer and activator of transcription 5a influences mammary epithelial cell survival and tumorigenesis. Cell Growth Differ. 1999, 10: 685-694.","journal-title":"Cell Growth Differ"},{"key":"2853_CR20","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/5007","volume":"21","author":"P Soriano","year":"1999","unstructured":"Soriano P: Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet. 1999, 21: 70-71. 10.1038\/5007.","journal-title":"Nat Genet"},{"key":"2853_CR21","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1210\/me.2005-0392","volume":"20","author":"RW Clarkson","year":"2006","unstructured":"Clarkson RW, Boland MP, Kritikou EA, Lee JM, Freeman TC, Tiffen PG, Watson CJ: The genes induced by signal transducer and activators of transcription (STAT)3 and STAT5 in mammary epithelial cells define the roles of these STATs in mammary development. Mol Endocrinol. 2006, 20: 675-685.","journal-title":"Mol Endocrinol"},{"key":"2853_CR22","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1054\/cdip.2001.0088","volume":"8","author":"MN Sheppard","year":"2002","unstructured":"Sheppard MN: The pathology of cystic fibrosis. Curr Diagnc Pathol. 2002, 8: 50-59. 10.1054\/cdip.2001.0088.","journal-title":"Curr Diagnc Pathol"},{"key":"2853_CR23","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S1092-9134(98)80019-1","volume":"2","author":"FU Garcia","year":"1998","unstructured":"Garcia FU, Galindo LM, Holsclaw DS: Breast abnormalities in patients with cystic fibrosis: previously unrecognized changes. Ann Diagn Pathol. 1998, 2: 281-285. 10.1016\/S1092-9134(98)80019-1.","journal-title":"Ann Diagn Pathol"},{"key":"2853_CR24","doi-asserted-by":"publisher","first-page":"e10446","DOI":"10.1371\/journal.pone.0010446","volume":"5","author":"G Mailhot","year":"2010","unstructured":"Mailhot G, Rabasa-Lhoret R, Moreau A, Berthiaume Y, Levy E: CFTR depletion results in changes in fatty acid composition and promotes lipogenesis in intestinal Caco 2\/15 cells. PLoS One. 2010, 5: e10446-10.1371\/journal.pone.0010446.","journal-title":"PLoS One"},{"key":"2853_CR25","doi-asserted-by":"publisher","first-page":"G1239","DOI":"10.1152\/ajpgi.00206.2009","volume":"297","author":"G Mailhot","year":"2009","unstructured":"Mailhot G, Ravid Z, Barchi S, Moreau A, Rabasa-Lhoret R, Levy E: CFTR knockdown stimulates lipid synthesis and transport in intestinal Caco-2\/15 cells. Am J Physiol Gastrointest Liver Physiol. 2009, 297: G1239-1249. 10.1152\/ajpgi.00206.2009.","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"2853_CR26","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.cytogfr.2005.01.007","volume":"16","author":"L Dailey","year":"2005","unstructured":"Dailey L, Ambrosetti D, Mansukhani A, Basilico C: Mechanisms underlying differential responses to FGF signaling. Cytokine Growth Factor Rev. 2005, 16: 233-247. 10.1016\/j.cytogfr.2005.01.007.","journal-title":"Cytokine Growth Factor Rev"},{"key":"2853_CR27","doi-asserted-by":"crossref","first-page":"5075","DOI":"10.1242\/dev.128.24.5075","volume":"128","author":"FJ Lovicu","year":"2001","unstructured":"Lovicu FJ, McAvoy JW: FGF-induced lens cell proliferation and differentiation is dependent on MAPK (ERK1\/2) signalling. Development. 2001, 128: 5075-5084.","journal-title":"Development"},{"key":"2853_CR28","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1126\/science.276.5314.955","volume":"276","author":"M Mohammadi","year":"1997","unstructured":"Mohammadi M, McMahon G, Sun L, Tang C, Hirth P, Yeh BK, Hubbard SR, Schlessinger J: Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. Science. 1997, 276: 955-960. 10.1126\/science.276.5314.955.","journal-title":"Science"},{"key":"2853_CR29","doi-asserted-by":"publisher","first-page":"17969","DOI":"10.1074\/jbc.M802917200","volume":"283","author":"Y Chen","year":"2008","unstructured":"Chen Y, Shi L, Zhang L, Li R, Liang J, Yu W, Sun L, Yang X, Wang Y, Zhang Y, Shang Y: The molecular mechanism governing the oncogenic potential of SOX2 in breast cancer. J Biol Chem. 2008, 283: 17969-17978. 10.1074\/jbc.M802917200.","journal-title":"J Biol Chem"},{"key":"2853_CR30","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1158\/1078-0432.CCR-05-1519","volume":"12","author":"H Zhang","year":"2006","unstructured":"Zhang H, Stephens LC, Kumar R: Metastasis tumor antigen family proteins during breast cancer progression and metastasis in a reliable mouse model for human breast cancer. Clin Cancer Res. 2006, 12: 1479-1486. 10.1158\/1078-0432.CCR-05-1519.","journal-title":"Clin Cancer Res"},{"key":"2853_CR31","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s10911-007-9043-7","volume":"12","author":"RR Singh","year":"2007","unstructured":"Singh RR, Kumar R: MTA family of transcriptional metaregulators in mammary gland morphogenesis and breast cancer. J Mammary Gland Biol Neoplasia. 2007, 12: 115-125. 10.1007\/s10911-007-9043-7.","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"2853_CR32","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1023\/A:1018777224808","volume":"4","author":"DJ Jerry","year":"1999","unstructured":"Jerry DJ, Pinkas J, Kuperwasser C, Dickinson ES, Naber SP: Regulation of p53 and its targets during involution of the mammary gland. J Mammary Gland Biol Neoplasia. 1999, 4: 177-181. 10.1023\/A:1018777224808.","journal-title":"J Mammary Gland Biol Neoplasia"},{"key":"2853_CR33","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.ccr.2006.09.013","volume":"10","author":"PW Derksen","year":"2006","unstructured":"Derksen PW, Liu X, Saridin F, van der Gulden H, Zevenhoven J, Evers B, van Beijnum JR, Griffioen AW, Vink J, Krimpenfort P, Peterse JL, Cardiff RD, Berns A, Jonkers J: Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis. Cancer Cell. 2006, 10: 437-449. 10.1016\/j.ccr.2006.09.013.","journal-title":"Cancer Cell"},{"key":"2853_CR34","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1006\/dbio.1995.1165","volume":"169","author":"CW Daniel","year":"1995","unstructured":"Daniel CW, Strickland P, Friedmann Y: Expression and functional role of E- and P-cadherins in mouse mammary ductal morphogenesis and growth. Dev Biol. 1995, 169: 511-519. 10.1006\/dbio.1995.1165.","journal-title":"Dev Biol"},{"key":"2853_CR35","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1038\/sj.emboj.7600605","volume":"24","author":"JA Tunggal","year":"2005","unstructured":"Tunggal JA, Helfrich I, Schmitz A, Schwarz H, Gunzel D, Fromm M, Kemler R, Krieg T, Niessen CM: E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J. 2005, 24: 1146-1156. 10.1038\/sj.emboj.7600605.","journal-title":"EMBO J"},{"key":"2853_CR36","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1002\/jcb.20469","volume":"95","author":"KA Knudsen","year":"2005","unstructured":"Knudsen KA, Sauer C, Johnson KR, Wheelock MJ: Effect of N-cadherin misexpression by the mammary epithelium in mice. J Cell Biochem. 2005, 95: 1093-1107. 10.1002\/jcb.20469.","journal-title":"J Cell Biochem"},{"key":"2853_CR37","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/0092-8674(91)90143-M","volume":"66","author":"K Vleminckx","year":"1991","unstructured":"Vleminckx K, Vakaet L, Mareel M, Fiers W, van Roy F: Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell. 1991, 66: 107-119. 10.1016\/0092-8674(91)90143-M.","journal-title":"Cell"},{"key":"2853_CR38","doi-asserted-by":"publisher","first-page":"3309","DOI":"10.1038\/sj.onc.1203650","volume":"19","author":"KC Hart","year":"2000","unstructured":"Hart KC, Robertson SC, Kanemitsu MY, Meyer AN, Tynan JA, Donoghue DJ: Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4. Oncogene. 2000, 19: 3309-3320. 10.1038\/sj.onc.1203650.","journal-title":"Oncogene"},{"key":"2853_CR39","doi-asserted-by":"publisher","first-page":"35208","DOI":"10.1074\/jbc.M608655200","volume":"281","author":"E Sanchez-Heras","year":"2006","unstructured":"Sanchez-Heras E, Howell FV, Williams G, Doherty P: The fibroblast growth factor receptor acid box is essential for interactions with N-cadherin and all of the major isoforms of neural cell adhesion molecule. J Biol Chem. 2006, 281: 35208-35216. 10.1074\/jbc.M608655200.","journal-title":"J Biol Chem"},{"key":"2853_CR40","doi-asserted-by":"publisher","first-page":"5805","DOI":"10.1038\/sj.emboj.7601455","volume":"25","author":"KD Sutherland","year":"2006","unstructured":"Sutherland KD, Vaillant F, Alexander WS, Wintermantel TM, Forrest NC, Holroyd SL, McManus EJ, Schutz G, Watson CJ, Chodosh LA, Lindeman GJ, Visvader JE: c-myc as a mediator of accelerated apoptosis and involution in mammary glands lacking Socs3. EMBO J. 2006, 25: 5805-5815. 10.1038\/sj.emboj.7601455.","journal-title":"EMBO J"},{"key":"2853_CR41","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1006\/excr.1998.4160","volume":"243","author":"H Petersen","year":"1998","unstructured":"Petersen H, Haldosen LA: EGF modulates expression of STAT5 in mammary epithelial cells. Exp Cell Res. 1998, 243: 347-358. 10.1006\/excr.1998.4160.","journal-title":"Exp Cell Res"},{"key":"2853_CR42","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1006\/dbio.2000.9961","volume":"229","author":"MI Gallego","year":"2001","unstructured":"Gallego MI, Binart N, Robinson GW, Okagaki R, Coschigano KT, Perry J, Kopchick JJ, Oka T, Kelly PA, Hennighausen L: Prolactin, growth hormone, and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects. Dev Biol. 2001, 229: 163-175. 10.1006\/dbio.2000.9961.","journal-title":"Dev Biol"},{"key":"2853_CR43","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/0002-9378(86)90421-7","volume":"154","author":"H Vorherr","year":"1986","unstructured":"Vorherr H: Fibrocystic breast disease: pathophysiology, pathomorphology, clinical picture, and management. Am J Obstet Gynecol. 1986, 154: 161-179.","journal-title":"Am J Obstet Gynecol"},{"key":"2853_CR44","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1056\/NEJMra035692","volume":"353","author":"RJ Santen","year":"2005","unstructured":"Santen RJ, Mansel R: Benign breast disorders. N Engl J Med. 2005, 353: 275-285. 10.1056\/NEJMra035692.","journal-title":"N Engl J Med"},{"key":"2853_CR45","first-page":"394","volume":"2","author":"JW Logie","year":"1942","unstructured":"Logie JW: Mastopathia Cystica and Mammary Carcinoma. Cancer Res. 1942, 2: 394-397.","journal-title":"Cancer Res"},{"key":"2853_CR46","doi-asserted-by":"publisher","first-page":"22299","DOI":"10.1074\/jbc.M109.098566","volume":"285","author":"J Berube","year":"2010","unstructured":"Berube J, Roussel L, Nattagh L, Rousseau S: Loss of cystic fibrosis transmembrane conductance regulator function enhances activation of p38 and ERK MAPKs, increasing interleukin-6 synthesis in airway epithelial cells exposed to Pseudomonas aeruginosa. J Biol Chem. 2010, 285: 22299-22307. 10.1074\/jbc.M109.098566.","journal-title":"J Biol Chem"},{"key":"2853_CR47","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1097\/MCO.0b013e32832595b7","volume":"12","author":"TS Worgall","year":"2009","unstructured":"Worgall TS: Lipid metabolism in cystic fibrosis. Curr Opin Clin Nutr Metab Care. 2009, 12: 105-109. 10.1097\/MCO.0b013e32832595b7.","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"2853_CR48","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s12282-010-0199-4","volume":"18","author":"R Nishimura","year":"2010","unstructured":"Nishimura R, Taira N, Sugata S, Takabatake D, Ohsumi S, Takashima S: Suspicious calcifications in benign breast lesions: a radio-pathologic correlation. Breast Cancer. 2010, 18: 33-6.","journal-title":"Breast Cancer"},{"key":"2853_CR49","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1741-7015-6-11","volume":"6","author":"PP Provenzano","year":"2008","unstructured":"Provenzano PP, Inman DR, Eliceiri KW, Knittel JG, Yan L, Rueden CT, White JG, Keely PJ: Collagen density promotes mammary tumor initiation and progression. BMC Med. 2008, 6: 11-10.1186\/1741-7015-6-11.","journal-title":"BMC Med"},{"key":"2853_CR50","first-page":"101","volume":"104","author":"O Alexa","year":"2000","unstructured":"Alexa O, Stolnicu S, Horvath E, Jung J: [The relationship between benign breast proliferation (fibrocystic mastopathy) and the appearance of breast carcinoma]. Rev Med Chir Soc Med Nat Iasi. 2000, 104: 101-109.","journal-title":"Rev Med Chir Soc Med Nat Iasi"},{"key":"2853_CR51","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.molmed.2007.03.002","volume":"13","author":"JJ Fuster","year":"2007","unstructured":"Fuster JJ, Sanz-Gonzalez SM, Moll UM, Andres V: Classic and novel roles of p53: prospects for anticancer therapy. Trends Mol Med. 2007, 13: 192-199. 10.1016\/j.molmed.2007.03.002.","journal-title":"Trends Mol Med"},{"key":"2853_CR52","doi-asserted-by":"publisher","first-page":"353","DOI":"10.2307\/3579468","volume":"146","author":"RL Ullrich","year":"1996","unstructured":"Ullrich RL, Bowles ND, Satterfield LC, Davis CM: Strain-dependent susceptibility to radiation-induced mammary cancer is a result of differences in epithelial cell sensitivity to transformation. Radiat Res. 1996, 146: 353-355. 10.2307\/3579468.","journal-title":"Radiat Res"},{"key":"2853_CR53","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1016\/S0002-9440(10)64853-5","volume":"157","author":"C Kuperwasser","year":"2000","unstructured":"Kuperwasser C, Hurlbut GD, Kittrell FS, Dickinson ES, Laucirica R, Medina D, Naber SP, Jerry DJ: Development of spontaneous mammary tumors in BALB\/c p53 heterozygous mice. A model for Li-Fraumeni syndrome. Am J Pathol. 2000, 157: 2151-2159. 10.1016\/S0002-9440(10)64853-5.","journal-title":"Am J Pathol"},{"key":"2853_CR54","doi-asserted-by":"publisher","first-page":"4325","DOI":"10.1242\/jcs.02552","volume":"118","author":"DC Radisky","year":"2005","unstructured":"Radisky DC: Epithelial-mesenchymal transition. J Cell Sci. 2005, 118: 4325-4326. 10.1242\/jcs.02552.","journal-title":"J Cell Sci"},{"key":"2853_CR55","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1093\/jnci\/djn032","volume":"100","author":"K Garber","year":"2008","unstructured":"Garber K: Epithelial-to-mesenchymal transition is important to metastasis, but questions remain. J Natl Cancer Inst. 2008, 100: 232-233. 10.1093\/jnci\/djn032. 239","journal-title":"J Natl Cancer Inst"},{"key":"2853_CR56","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1083\/jcb.200601018","volume":"172","author":"JM Lee","year":"2006","unstructured":"Lee JM, Dedhar S, Kalluri R, Thompson EW: The epithelial-mesenchymal transition: new insights in signaling, development, and disease. J Cell Biol. 2006, 172: 973-981. 10.1083\/jcb.200601018.","journal-title":"J Cell Biol"},{"key":"2853_CR57","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1159\/000320174","volume":"193","author":"HJ Hugo","year":"2011","unstructured":"Hugo HJ, Kokkinos MI, Blick T, Ackland ML, Thompson EW, Newgreen DF: Defining the E-cadherin repressor interactome in epithelial-mesenchymal transition: the PMC42 model as a case study. Cells Tissues Organs. 2011, 193: 23-40. 10.1159\/000320174.","journal-title":"Cells Tissues Organs"}],"container-title":["Breast Cancer Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/bcr3046.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/bcr3046\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/bcr3046.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T10:40:30Z","timestamp":1728384030000},"score":1,"resource":{"primary":{"URL":"https:\/\/breast-cancer-research.biomedcentral.com\/articles\/10.1186\/bcr3046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,26]]},"references-count":57,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2011,10]]}},"alternative-id":["2853"],"URL":"https:\/\/doi.org\/10.1186\/bcr3046","relation":{},"ISSN":["1465-542X"],"issn-type":[{"value":"1465-542X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,26]]},"assertion":[{"value":"31 May 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2011","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 October 2011","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 October 2011","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"R104"}}