{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T06:45:19Z","timestamp":1772693119035,"version":"3.50.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T00:00:00Z","timestamp":1374451200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T00:00:00Z","timestamp":1374451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Introduction<\/jats:title>\n                        <jats:p>Mammographic density is a strong risk factor for breast cancer, but it is unknown whether density at first breast cancer diagnosis and changes during follow-up influences risk of non-simultaneous contralateral breast cancer (CBC).<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>We collected mammograms for CBC-patients (cases, N = 211) and unilateral breast cancer patients (controls, N = 211), individually matched on age and calendar period of first breast cancer diagnosis, type of adjuvant therapy and length of follow-up (mean follow-up time: 8.25 years). The odds of CBC as a function of changes of density during follow-up were investigated using conditional logistic regression, adjusting for non-dense area at diagnosis.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>Patients who experienced \u226510% absolute decrease in percent density had a 55% decreased odds of CBC (OR = 0.45 95% CI: 0.24 to 0.84) relative to patients who had little or no change in density from baseline to first follow-up mammogram (mean = 1.6 (SD = 0.6) years after diagnosis), whereas among those who experienced an absolute increase in percent density we could not detect any effect on the odds of CBC (OR = 0.83 95% CI: 0.24 to 2.87).<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusion<\/jats:title>\n                        <jats:p>Decrease of mammographic density within the first two years after first diagnosis is associated with a significantly reduced risk of CBC, this potential new risk predictor can thus contribute to decision-making in follow-up strategies and treatment.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/bcr3451","type":"journal-article","created":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T14:14:23Z","timestamp":1374502463000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Change of mammographic density predicts the risk of contralateral breast cancer - a case-control study"],"prefix":"10.1186","volume":"15","author":[{"given":"Maria EC","family":"Sandberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingmei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Hall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikael","family":"Hartman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"dos-Santos-Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keith","family":"Humphreys","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamila","family":"Czene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,7,22]]},"reference":[{"key":"3256_CR1","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1158\/1055-9965.EPI-06-0034","volume":"15","author":"VA McCormack","year":"2006","unstructured":"McCormack VA, dos Santos Silva I: Breast density and parenchymal patterns as markers of breast cancer risk: a meta-analysis. Cancer Epidemiol Biomarkers Prev. 2006, 15: 1159-1169. 10.1158\/1055-9965.EPI-06-0034.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"3256_CR2","doi-asserted-by":"publisher","first-page":"5780","DOI":"10.1002\/cncr.24638","volume":"115","author":"T Cil","year":"2009","unstructured":"Cil T, Fishell E, Hanna W, Sun P, Rawlinson E, Narod SA, McCready DR: Mammographic density and the risk of breast cancer recurrence after breast-conserving surgery. Cancer. 2009, 115: 5780-5787. 10.1002\/cncr.24638.","journal-title":"Cancer"},{"key":"3256_CR3","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1158\/1055-9965.EPI-09-1028","volume":"19","author":"SY Chiu","year":"2010","unstructured":"Chiu SY, Duffy S, Yen AM, Tabar L, Smith RA, Chen HH: Effect of baseline breast density on breast cancer incidence, stage, mortality, and screening parameters: 25-year follow-up of a Swedish mammographic screening. Cancer Epidemiol Biomarkers Prev. 2010, 19: 1219-1228. 10.1158\/1055-9965.EPI-09-1028.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"3256_CR4","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1093\/jnci\/93.1.51","volume":"93","author":"M Freedman","year":"2001","unstructured":"Freedman M, San Martin J, O'Gorman J, Eckert S, Lippman ME, Lo SC, Walls EL, Zeng J: Digitized mammography: a clinical trial of postmenopausal women randomly assigned to receive raloxifene, estrogen, or placebo. J Natl Cancer Inst. 2001, 93: 51-56. 10.1093\/jnci\/93.1.51.","journal-title":"J Natl Cancer Inst"},{"key":"3256_CR5","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1093\/jnci\/djh106","volume":"96","author":"J Cuzick","year":"2004","unstructured":"Cuzick J, Warwick J, Pinney E, Warren RM, Duffy SW: Tamoxifen and breast density in women at increased risk of breast cancer. J Natl Cancer Inst. 2004, 96: 621-628. 10.1093\/jnci\/djh106.","journal-title":"J Natl Cancer Inst"},{"key":"3256_CR6","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1093\/jnci\/djp181","volume":"101","author":"AW Kurian","year":"2009","unstructured":"Kurian AW, McClure LA, John EM, Horn-Ross PL, Ford JM, Clarke CA: Second primary breast cancer occurrence according to hormone receptor status. J Natl Cancer Inst. 2009, 101: 1058-1065. 10.1093\/jnci\/djp181.","journal-title":"J Natl Cancer Inst"},{"key":"3256_CR7","doi-asserted-by":"crossref","unstructured":"Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet. 2005, 365: 1687-1717.","DOI":"10.1016\/S0140-6736(05)66544-0"},{"key":"3256_CR8","first-page":"855","volume":"8","author":"Y Chen","year":"1999","unstructured":"Chen Y, Thompson W, Semenciw R, Mao Y: Epidemiology of contralateral breast cancer. Cancer Epidemiol Biomarkers Prev. 1999, 8: 855-861.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"3256_CR9","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1002\/1097-0142(196412)17:12<1501::AID-CNCR2820171202>3.0.CO;2-P","volume":"17","author":"GF Robbins","year":"1964","unstructured":"Robbins GF, Berg JW: Bilateral primary breast cancer: a prospective clinicopathological study. Cancer. 1964, 17: 1501-1527. 10.1002\/1097-0142(196412)17:12<1501::AID-CNCR2820171202>3.0.CO;2-P.","journal-title":"Cancer"},{"key":"3256_CR10","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1023\/A:1010665603732","volume":"67","author":"Y Chen","year":"2001","unstructured":"Chen Y, Semenciw R, Kliewer E, Shi Y, Mao Y: Incidence of second primary breast cancer among women with a first primary in Manitoba, Canada. Breast Cancer Res Treat. 2001, 67: 35-40. 10.1023\/A:1010665603732.","journal-title":"Breast Cancer Res Treat"},{"key":"3256_CR11","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/S1470-2045(05)70174-1","volume":"6","author":"M Hartman","year":"2005","unstructured":"Hartman M, Czene K, Reilly M, Bergh J, Lagiou P, Trichopoulos D, Adami HO, Hall P: Genetic implications of bilateral breast cancer: a population based cohort study. Lancet Oncol. 2005, 6: 377-382. 10.1016\/S1470-2045(05)70174-1.","journal-title":"Lancet Oncol"},{"key":"3256_CR12","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1093\/oxfordjournals.aje.a116565","volume":"136","author":"JL Bernstein","year":"1992","unstructured":"Bernstein JL, Thompson WD, Risch N, Holford TR: Risk factors predicting the incidence of second primary breast cancer among women diagnosed with a first primary breast cancer. Am J Epidemiol. 1992, 136: 925-936.","journal-title":"Am J Epidemiol"},{"key":"3256_CR13","doi-asserted-by":"publisher","first-page":"5312","DOI":"10.1200\/JCO.2009.23.1597","volume":"27","author":"CI Li","year":"2009","unstructured":"Li CI, Daling JR, Porter PL, Tang MT, Malone KE: Relationship between potentially modifiable lifestyle factors and risk of second primary contralateral breast cancer among women diagnosed with estrogen receptor-positive invasive breast cancer. J Clin Oncol. 2009, 27: 5312-5318. 10.1200\/JCO.2009.23.1597.","journal-title":"J Clin Oncol"},{"key":"3256_CR14","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1007\/s10552-010-9510-0","volume":"21","author":"JN Poynter","year":"2010","unstructured":"Poynter JN, Langholz B, Largent J, Mellemkjaer L, Bernstein L, Malone KE, Lynch CF, Borg A, Concannon P, Teraoka SN, Xue S, Diep AT, Torngren T, Begg CB, Capanu M, Haile RW, Bernstein JL: Reproductive factors and risk of contralateral breast cancer by BRCA1 and BRCA2 mutation status: results from the WECARE study. Cancer Causes Control. 2010, 21: 839-846. 10.1007\/s10552-010-9510-0.","journal-title":"Cancer Causes Control"},{"key":"3256_CR15","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1002\/em.10062","volume":"39","author":"JV Lacey Jr","year":"2002","unstructured":"Lacey JV, Devesa SS, Brinton LA: Recent trends in breast cancer incidence and mortality. Environ Mol Mutagen. 2002, 39: 82-88. 10.1002\/em.10062.","journal-title":"Environ Mol Mutagen"},{"key":"3256_CR16","doi-asserted-by":"publisher","first-page":"4210","DOI":"10.1200\/JCO.2006.10.5056","volume":"25","author":"M Hartman","year":"2007","unstructured":"Hartman M, Czene K, Reilly M, Adolfsson J, Bergh J, Adami HO, Dickman PW, Hall P: Incidence and prognosis of synchronous and metachronous bilateral breast cancer. J Clin Oncol. 2007, 25: 4210-4216. 10.1200\/JCO.2006.10.5056.","journal-title":"J Clin Oncol"},{"key":"3256_CR17","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1093\/jnci\/djk066","volume":"99","author":"K Kerlikowske","year":"2007","unstructured":"Kerlikowske K, Ichikawa L, Miglioretti DL, Buist DS, Vacek PM, Smith-Bindman R, Yankaskas B, Carney PA, Ballard-Barbash R: Longitudinal measurement of clinical mammographic breast density to improve estimation of breast cancer risk. J Natl Cancer Inst. 2007, 99: 386-395. 10.1093\/jnci\/djk066.","journal-title":"J Natl Cancer Inst"},{"key":"3256_CR18","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1097\/00008469-199912000-00006","volume":"8","author":"CH van Gils","year":"1999","unstructured":"van Gils CH, Hendriks JH, Holland R, Karssemeijer N, Otten JD, Straatman H, Verbeek AL: Changes in mammographic breast density and concomitant changes in breast cancer risk. Eur J Cancer Prev. 1999, 8: 509-515. 10.1097\/00008469-199912000-00006.","journal-title":"Eur J Cancer Prev"},{"key":"3256_CR19","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1158\/1055-9965.EPI-06-1047","volume":"16","author":"CM Vachon","year":"2007","unstructured":"Vachon CM, Pankratz VS, Scott CG, Maloney SD, Ghosh K, Brandt KR, Milanese T, Carston MJ, Sellers TA: Longitudinal trends in mammographic percent density and breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2007, 16: 921-928. 10.1158\/1055-9965.EPI-06-1047.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"3256_CR20","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1093\/jnci\/djr079","volume":"103","author":"J Cuzick","year":"2011","unstructured":"Cuzick J, Warwick J, Pinney E, Duffy SW, Cawthorn S, Howell A, Forbes JF, Warren RM: Tamoxifen-induced reduction in mammographic density and breast cancer risk reduction: a nested case-control study. J Natl Cancer Inst. 2011, 103: 744-752. 10.1093\/jnci\/djr079.","journal-title":"J Natl Cancer Inst"},{"key":"3256_CR21","volume-title":"Modern Epidemiology","author":"KJ Rothman","year":"2008","unstructured":"Rothman KJ, Lash TL, Greenland S: Modern Epidemiology. 2008, Philadelphia, PA: Lippincott Williams \u0192 Wilkins, 3","edition":"3"},{"key":"3256_CR22","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1002\/1097-0142(197609)38:3<1124::AID-CNCR2820380312>3.0.CO;2-P","volume":"38","author":"B Lundgren","year":"1976","unstructured":"Lundgren B, Jakobsson S: Single view mammography: a simple and efficent approach to breast cancer screening. Cancer. 1976, 38: 1124-1129. 10.1002\/1097-0142(197609)38:3<1124::AID-CNCR2820380312>3.0.CO;2-P.","journal-title":"Cancer"},{"key":"3256_CR23","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1002\/(SICI)1097-0215(19990505)81:3<339::AID-IJC5>3.0.CO;2-6","volume":"81","author":"C Magnusson","year":"1999","unstructured":"Magnusson C, Baron JA, Correia N, Bergstrom R, Adami HO, Persson I: Breast-cancer risk following long-term oestrogen- and oestrogen-progestin-replacement therapy. Int J Cancer. 1999, 81: 339-344. 10.1002\/(SICI)1097-0215(19990505)81:3<339::AID-IJC5>3.0.CO;2-6.","journal-title":"Int J Cancer"},{"key":"3256_CR24","doi-asserted-by":"publisher","first-page":"R114","DOI":"10.1186\/bcr3238","volume":"14","author":"J Li","year":"2012","unstructured":"Li J, Szekely L, Eriksson L, Heddson B, Sundbom A, Czene K, Hall P, Humphreys K: High-throughput mammographic-density measurement: a tool for risk prediction of breast cancer. Breast Cancer Res. 2012, 14: R114-10.1186\/bcr3238.","journal-title":"Breast Cancer Res"},{"key":"3256_CR25","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1148\/radiographics.18.6.9821201","volume":"18","author":"JW Byng","year":"1998","unstructured":"Byng JW, Yaffe MJ, Jong RA, Shumak RS, Lockwood GA, Tritchler DL, Boyd NF: Analysis of mammographic density and breast cancer risk from digitized mammograms. Radiographics. 1998, 18: 1587-1598.","journal-title":"Radiographics"},{"key":"3256_CR26","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.1093\/jnci\/87.21.1622","volume":"87","author":"C Byrne","year":"1995","unstructured":"Byrne C, Schairer C, Wolfe J, Parekh N, Salane M, Brinton LA, Hoover R, Haile R: Mammographic features and breast cancer risk: effects with time, age, and menopause status. J Natl Cancer Inst. 1995, 87: 1622-1629. 10.1093\/jnci\/87.21.1622.","journal-title":"J Natl Cancer Inst"},{"key":"3256_CR27","doi-asserted-by":"publisher","first-page":"R103","DOI":"10.1186\/bcr3044","volume":"13","author":"M Lokate","year":"2011","unstructured":"Lokate M, Peeters PH, Peelen LM, Haars G, Veldhuis WB, van Gils CH: Mammographic density and breast cancer risk: the role of the fat surrounding the fibroglandular tissue. Breast Cancer Res. 2011, 13: R103-10.1186\/bcr3044.","journal-title":"Breast Cancer Res"},{"key":"3256_CR28","first-page":"1133","volume":"7","author":"NF Boyd","year":"1998","unstructured":"Boyd NF, Lockwood GA, Byng JW, Tritchler DL, Yaffe MJ: Mammographic densities and breast cancer risk. Cancer Epidemiol Biomarkers Prev. 1998, 7: 1133-1144.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"3256_CR29","first-page":"1277","volume":"72","author":"F de Waard","year":"1984","unstructured":"de Waard F, Rombach JJ, Collette HJ, Slotboom B: Breast cancer risk associated with reproductive factors and breast parenchymal patterns. J Natl Cancer Inst. 1984, 72: 1277-1282.","journal-title":"J Natl Cancer Inst"},{"key":"3256_CR30","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1023\/A:1005792830054","volume":"43","author":"L Del Mastro","year":"1997","unstructured":"Del Mastro L, Venturini M, Sertoli MR, Rosso R: Amenorrhea induced by adjuvant chemotherapy in early breast cancer patients: prognostic role and clinical implications. Breast Cancer Res Treat. 1997, 43: 183-190. 10.1023\/A:1005792830054.","journal-title":"Breast Cancer Res Treat"},{"key":"3256_CR31","first-page":"1048","volume":"11","author":"N Boyd","year":"2002","unstructured":"Boyd N, Martin L, Stone J, Little L, Minkin S, Yaffe M: A longitudinal study of the effects of menopause on mammographic features. Cancer Epidemiol Biomarkers Prev. 2002, 11: 1048-1053.","journal-title":"Cancer Epidemiol Biomarkers Prev"}],"container-title":["Breast Cancer Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/bcr3451.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/bcr3451\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/bcr3451.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T10:53:01Z","timestamp":1728384781000},"score":1,"resource":{"primary":{"URL":"https:\/\/breast-cancer-research.biomedcentral.com\/articles\/10.1186\/bcr3451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,22]]},"references-count":31,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,8]]}},"alternative-id":["3256"],"URL":"https:\/\/doi.org\/10.1186\/bcr3451","relation":{},"ISSN":["1465-542X"],"issn-type":[{"value":"1465-542X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,22]]},"assertion":[{"value":"17 January 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 April 2013","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2013","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2013","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"R57"}}