{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:28:53Z","timestamp":1758400133389},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[1986,12,1]],"date-time":"1986-12-01T00:00:00Z","timestamp":533779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[1986,12,1]],"date-time":"1986-12-01T00:00:00Z","timestamp":533779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Acta Vet Scand"],"published-print":{"date-parts":[[1986,12]]},"DOI":"10.1186\/bf03548128","type":"journal-article","created":{"date-parts":[[2021,1,3]],"date-time":"2021-01-03T19:04:33Z","timestamp":1609700673000},"page":"486-496","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mitogen Stimulation of Lymphocytes in Pigs with Hereditary Vitamin C Deficiency"],"prefix":"10.1186","volume":"27","author":[{"given":"Birte","family":"Kristensen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Preben Dybdahl","family":"Thomsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birthe","family":"Palludan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inger","family":"Wegger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[1986,12,1]]},"reference":[{"key":"BF03548128_CR1","first-page":"511","volume":"56","author":"R Anderson","year":"1979","unstructured":"Anderson, R., R. Oosthuizen & E. M. S. Gatnerf.: Effects of asicorbate on leucocytes. Part V. Effects of ascorbate and calcium and sodium ascorbate on certain functions of human blood lymphocytes in vitro. S. Afr. med. J. 1979, 56, 511\u2013515.","journal-title":"Part V. Effects of ascorbate and calcium and sodium ascorbate on certain functions of human blood lymphocytes in vitro. S. Afr. med. J."},{"key":"BF03548128_CR2","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1093\/ajcn\/33.1.71","volume":"33","author":"R Anderson","year":"1980","unstructured":"Anderson, R., R. Oosthuizen, R. Maritz, A. Theron & A. J. van Rens-burg: The effects of increasing weekly doses of ascorbate on certain cellular and humoral functions in normal volunteers. Amer. J. clin. Nutr. 1980, 33, 71\u201376.","journal-title":"Amer. J. clin. Nutr."},{"key":"BF03548128_CR3","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.1093\/ajcn\/34.9.1906","volume":"34","author":"R Anderson","year":"1981","unstructured":"Anderson, R.: Ascorbate mediated stimulation of neutrophil motility and lymphocyte transformation by inhibition of the peroxidase\/ H2O2\/halide system in vitro and in vivo. Amer. J. Clin. Nutr. 1981, 34, 1906\u20131911.","journal-title":"Amer. J. Clin. Nutr."},{"key":"BF03548128_CR4","first-page":"19","volume-title":"Advances in Nutrition","author":"R Anderson","year":"1984","unstructured":"Anderson, R.: The immunostimulatory, anti-inflammatory and antiallergic properties of ascorbate. In: Advances in Nutrition. Ed. H. H. Draper, Plenum Press, New York 1984, p. 19\u201345."},{"key":"BF03548128_CR5","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S0021-9258(18)73884-2","volume":"126","author":"O A Bessey","year":"1938","unstructured":"Bessey, O. A.: A method for the determination of small quantities of ascorbic acid and dehydroascorbic acid in turbid and colored solutions in the presence of other reducing substances. J. biol. Ghem. 1938, 126, 771\u2013784.","journal-title":"J. biol. Ghem."},{"issue":"1","key":"BF03548128_CR6","first-page":"138","volume":"67","author":"L Blair","year":"1984","unstructured":"Blair, L. & K. A. Cummins: Effect of dietary ascorbic acid on blood immunoglobulin concentration in dairy calves. J. Dairy Sei. 1984, 67 Suppl. 1, 138\u2013139.","journal-title":"J. Dairy Sei."},{"key":"BF03548128_CR7","first-page":"60","volume-title":"Ascorbic Acid in Domestic Animals","author":"R G Brown","year":"1984","unstructured":"Brown, R. G.: Ascorbic acid nutrition in the domestic pig. In: Ascorbic Acid in Domestic Animals, Eds. I. Wegger, F. J. Tagwerker & J. Moustgaard, Royal Danish Agric. Soc, Copenhagen 1984, p. 60\u201367."},{"key":"BF03548128_CR8","first-page":"211","volume":"97","author":"K Christensen","year":"1982","unstructured":"Christensen, K. & H. Pedersen: Variation in chromosome number in the blue fox (Alopex lagopus) and its effect on fertility. Here-ditas 1982, 97, 211\u2013215.","journal-title":"Here-ditas"},{"key":"BF03548128_CR9","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1093\/ajcn\/33.4.839","volume":"33","author":"R C Fraser","year":"1980","unstructured":"Fraser, R. C., S. Pavlovic, C. G. Kurahara, A. Murata, N. S. Peterson, K. B. Taylor & G. A. Feigen: The effect of variations in vitamin C intake on the cellular immune response of guinea pigs. Amer. J. clin. Nutr. 1980, 33, 839\u2013847.","journal-title":"Amer. J. clin. Nutr."},{"key":"BF03548128_CR10","first-page":"1","volume":"1988","author":"M Gadient","year":"1985","unstructured":"Gadient, M. & L. Wegger: Ascorbic acid in intensive animal husbandry. Roche Information Service 1985, 1988, 1\u201330.","journal-title":"Roche Information Service"},{"key":"BF03548128_CR11","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1186\/BF03546713","volume":"24","author":"P T Jensen","year":"1983","unstructured":"Jensen, P. T., A. Basse, D. H. Nielsen & H. Larsen: Congenital ascorbic acid deficiency in pigs. Acta vet. scand. 1983, 24, 392\u2013401.","journal-title":"Acta vet. scand."},{"key":"BF03548128_CR12","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1159\/000213131","volume":"29","author":"B Kennes","year":"1983","unstructured":"Kennes, B., I. Dumont, D. Brohee, C. Hubert & P. Neve: Effect of vitamin C supplements on cell-mediated immunity in old people. Gerontology 1983, 29, 305\u2013310.","journal-title":"Gerontology"},{"key":"BF03548128_CR13","first-page":"489","volume":"40","author":"E Kolb","year":"1985","unstructured":"Kolb, E.: Neuere Erkenntnisse zur Bedeutung und zum Stoffwechsel der Askorbins\u00e4ure bei Haustieren (\u00dcbersichtsreferat). (Recent findings on metabolism of ascorbic acid in domestic animals review paper). Mh. Vet.-Med. 1985, 40, 489\u2013494.","journal-title":"(Recent findings on metabolism of ascorbic acid in domestic animals review paper). Mh. Vet.-Med."},{"key":"BF03548128_CR14","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/0165-2427(82)90036-8","volume":"3","author":"F Kristensen","year":"1982","unstructured":"Kristensen, F., B. Kristensen Se S. Lazary: The lymphocyte stimulation test in veterinary immunology. Vet. Immunol. Immuno-pathol. 1982, 3, 203\u2013277.","journal-title":"Vet. Immunol. Immuno-pathol."},{"key":"BF03548128_CR15","volume-title":"(Studies on the importance of ascorbic acid for swine. Variations in ascorbic acid concentration in plasma and tissues)","author":"C Lund","year":"1980","unstructured":"Lund, C.: Studier over askorbinsyres betydning for svin. Variationer i askorbinsyrekoncentrationen i plasma og vsev. (Studies on the importance of ascorbic acid for swine. Variations in ascorbic acid concentration in plasma and tissues). Ph. D. Thesis, Royal Vet, & Agric. Univ., Copenhagen 1980."},{"key":"BF03548128_CR16","first-page":"1940","volume":"123","author":"J P Manzella","year":"1979","unstructured":"Manzella, J. P. & N. J. Roberts: Human machrophage and lymphocyte responses by vitamin G. Int. J. Vit. Nutr. Res. 1979, Suppl, 19, virus, ascorbic acid and hyperthermia. J. Immunol. 1979, 123, 1940\u20131944.","journal-title":"Int. J. Vit. Nutr. Res. 1979, Suppl, 19, virus, ascorbic acid and hyperthermia. J. Immunol."},{"key":"BF03548128_CR17","first-page":"193","volume":"8","author":"D N McMurray","year":"1984","unstructured":"McMurray, D. N.: Cell-mediated immunity in nutritional deficiency. Prog. Food Nutr. Sei. 1984, 8, 193\u2013228.","journal-title":"Prog. Food Nutr. Sei."},{"key":"BF03548128_CR18","first-page":"179","volume-title":"Int. J. Vit. Nutr. Res.","author":"R S Panush","year":"1979","unstructured":"Panush, R. S. & J. C. Delafuente: Modulation of certain immunologic responses by vitamin C. Int. J. Vit. Nutr. Res. 1979, Suppl. 19, 179\u2013199."},{"key":"BF03548128_CR19","unstructured":"Panush, R. S., J. C. Delafuente, P. Katz & J. Johnson: Modulation of certain immunologic response by vitamin C. {III. Potentiation of in vitro and in vivo lymphocyte responses}. tiInt. J. Vit. Nutr. Res. 1982, Suppl, 23, 35\u201347."},{"key":"BF03548128_CR20","first-page":"61","volume":"53","author":"R S Panush","year":"1983","unstructured":"Panush, R. S., P. Katz, G. Powell & L. Somberg: Immunopharmacologic effects of vitamin G. IV. Perturbation of mononuclear cell cyclic nucleotides. Int. J. Vit. Nutr. Res. 1983, 53, 61\u201367.","journal-title":"IV. Perturbation of mononuclear cell cyclic nucleotides. Int. J. Vit. Nutr. Res."},{"key":"BF03548128_CR21","first-page":"248","volume":"47","author":"W Prinz","year":"1977","unstructured":"Prinz, W., R. Bortz, B. Bregin & M. Hersch: The effect of ascorbic acid supplementation on some parameters of the human immunological defense system. Int. J. Vit. Nutr. Res. 1977, 47, 248\u2013257.","journal-title":"Int. J. Vit. Nutr. Res."},{"key":"BF03548128_CR22","first-page":"245","volume-title":"Int. J. Vit. Nutr. Res.","author":"B V Siegel","year":"1977","unstructured":"Siegel, B. V. & J. L. Morton: Vitamin G, interferon and the immune response. Int. J. Vit. Nutr. Res. 1977, Suppl. 16, 245\u2013265."},{"key":"BF03548128_CR23","first-page":"68","volume-title":"Ascorbic Acid in Domestic Animals","author":"I Wegger","year":"1984","unstructured":"Wegger, I. & B. Palludan: Ascorbic acid status of swine. Genetic and developmental variations. In: Ascorbic Acid in Domestic Animals. Eds. I. Weigiger, F. J. Tagwerker & J. Moustgaard, Royal Danish Agric. Soc, Copenhagen 1984, p. 68\u201379."},{"key":"BF03548128_CR24","first-page":"1292","volume":"53","author":"J T Yen","year":"1981","unstructured":"Yen, J. T. & W. G. Pound: Effect of dietary vitamin G addition on performance, plasma vitamin G and hematic iron status in weanling pigs, J. Anim. Sei. 1981, 53, 1292\u20131296.","journal-title":"Anim. Sei."}],"container-title":["Acta Veterinaria Scandinavica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/BF03548128.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/BF03548128\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/BF03548128.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,13]],"date-time":"2021-05-13T08:17:49Z","timestamp":1620893869000},"score":1,"resource":{"primary":{"URL":"https:\/\/actavetscand.biomedcentral.com\/articles\/10.1186\/BF03548128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,12]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1986,12]]}},"alternative-id":["BF03548128"],"URL":"https:\/\/doi.org\/10.1186\/bf03548128","relation":{},"ISSN":["1751-0147"],"issn-type":[{"value":"1751-0147","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,12]]},"assertion":[{"value":"25 June 1986","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 December 1986","order":2,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}