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We carried out a microbiological characterization of the causative pathogens. We investigated the correlation of mortality in NF with bloodstream infection and with the presence of co-morbidities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective study, we analyzed 323 patients who presented with necrotizing fasciitis at two different institutions. Bloodstream infection (BSI) was defined as a positive blood culture result. The patients were categorized as survivors and non-survivors. Eleven clinically important variables which were statistically significant by univariate analysis were selected for multivariate regression analysis and a stepwise logistic regression model was developed to determine the association between BSI and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Univariate logistic regression analysis showed that patients with hypotension, heart disease, liver disease, presence of\n                      <jats:italic>Vibrio<\/jats:italic>\n                      spp. in wound cultures, presence of fungus in wound cultures, and presence of\n                      <jats:italic>Streptococcus<\/jats:italic>\n                      group A,\n                      <jats:italic>Aeromonas<\/jats:italic>\n                      spp. or\n                      <jats:italic>Vibrio<\/jats:italic>\n                      spp. in blood cultures, had a significantly higher risk of in-hospital mortality. Our multivariate logistic regression analysis showed a higher risk of mortality in patients with pre-existing conditions like hypotension, heart disease, and liver disease. Multivariate logistic regression analysis also showed that presence of\n                      <jats:italic>Vibrio<\/jats:italic>\n                      spp in wound cultures, and presence of\n                      <jats:italic>Streptococcus<\/jats:italic>\n                      Group A in blood cultures were associated with a high risk of mortality while debridement &gt; = 3 was associated with improved survival.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Mortality in patients with necrotizing fasciitis was significantly associated with the presence of\n                      <jats:italic>Vibrio<\/jats:italic>\n                      in wound cultures and\n                      <jats:italic>Streptococcus<\/jats:italic>\n                      group A in blood cultures.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/cc10278","type":"journal-article","created":{"date-parts":[[2011,6,22]],"date-time":"2011-06-22T03:31:09Z","timestamp":1308713469000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["The microbiological profile and presence of bloodstream infection influence mortality rates in necrotizing fasciitis"],"prefix":"10.1186","volume":"15","author":[{"given":"I-Chuan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Cheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Cheng","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shian-Sen","family":"Shie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Chih","family":"Fann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Ting","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,6,21]]},"reference":[{"key":"9569_CR1","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1177\/000313480407001002","volume":"70","author":"A Tillou","year":"2004","unstructured":"Tillou A, St Hill CR, Brown C, Velmahos G: Necrotizing soft tissue infections: improved outcomes with modern care. 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