{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:07:32Z","timestamp":1787504852821,"version":"build-2736575974"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2011,6,29]],"date-time":"2011-06-29T00:00:00Z","timestamp":1309305600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2011,6,29]],"date-time":"2011-06-29T00:00:00Z","timestamp":1309305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Crit Care"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The aim of the study was to evaluate the effects of high-dose fenoldopam, a selective dopamine-1 receptor, on renal function and organ perfusion during cardiopulmonary bypass (CPB) in infants with congenital heart disease (CHD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective single-center randomized double-blind controlled trial was conducted in a pediatric cardiac surgery department. We randomized infants younger than 1 year with CHD and biventricular anatomy (with exclusion of isolated ventricular and atrial septal defect) to receive blindly a continuous infusion of fenoldopam at 1 \u03bcg\/kg\/min or placebo during CPB. Perioperative urinary and plasma levels of neutrophil gelatinase-associated lipocaline (NGAL), cystatin C (CysC), and creatinine were measured to assess renal injury after CPB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We enrolled 80 patients: 40 received fenoldopam (group F) during CPB, and 40 received placebo (group P). A significant increase of urinary NGAL and CysC levels from baseline to intensive care unit (ICU) admission followed by restoration of normal values after 12 hours was observed in both groups. However, urinary NGAL and CysC values were significantly reduced at the end of surgery and 12 hours after ICU admission (uNGAL only) in group F compared with group P (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.025 and 0.039, respectively). Plasma NGAL and CysC tended to increase from baseline to ICU admission in both groups, but they were not significantly different between the two groups. No differences were observed on urinary and plasma creatinine levels and on urine output between the two groups. Acute kidney injury (AKI) incidence in the postoperative period, as indicated by pRIFLE classification (pediatric score indicating Risk, Injury, Failure, Loss of function, and End-stage kidney disease level of renal damage) was 50% in group F and 72% in group P (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.08; odds ratio (OR), 0.38; 95% confidence interval (CI), 0.14 to 1.02). A significant reduction in diuretics (furosemide) and vasodilators (phentolamine) administration was observed in group F (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.0085; OR, 0.22; 95% CI, 0.07 to 0.7).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The treatment with high-dose fenoldopam during CPB in pediatric patients undergoing cardiac surgery for CHD with biventricular anatomy significantly decreased urinary levels of NGAL and CysC and reduced the use of diuretics and vasodilators during CPB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>\n                      Clinical Trial.Gov\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT00982527\">NCT00982527<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/cc10295","type":"journal-article","created":{"date-parts":[[2011,6,30]],"date-time":"2011-06-30T02:26:07Z","timestamp":1309400767000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["High-dose fenoldopam reduces postoperative neutrophil gelatinase-associated lipocaline and cystatin C levels in pediatric cardiac surgery"],"prefix":"10.1186","volume":"15","author":[{"given":"Zaccaria","family":"Ricci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Luciano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Favia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiana","family":"Garisto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Muraca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Morelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Di Chiara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Cogo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Picardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,6,29]]},"reference":[{"key":"9573_CR1","first-page":"P50","volume":"41","author":"A Miller","year":"2009","unstructured":"Miller A, Lu CK, Wang S, Umstead TM, Freeman WM, Vrana K, Yang S, Myers JL, Phelps DS, Zahn JD, Undar A: Pediatric cardiopulmonary bypass circuits: a review of studies conducted at the Penn State Pediatric Cardiac Research Laboratories. J Extra Corpor Technol. 2009, 41: P50-P58.","journal-title":"J Extra Corpor Technol"},{"key":"9573_CR2","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1213\/ane.0b013e3181875e2e","volume":"108","author":"GS Murphy","year":"2009","unstructured":"Murphy GS, Hessel EA, Groom RC: Optimal perfusion during cardiopulmonary bypass: an evidence-based approach. Anesth Analg. 2009, 108: 1394-1417. 10.1213\/ane.0b013e3181875e2e.","journal-title":"Anesth Analg"},{"key":"9573_CR3","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1111\/j.1460-9592.2011.03532.x","volume":"21","author":"SD Chiravuri","year":"2011","unstructured":"Chiravuri SD, Riegger LQ, Christensen R, Butler RR, Malviya S, Tait AR, Voepel-Lewis T: Factors associated with acute kidney injury or failure in children undergoing cardiopulmonary bypass: a case-controlled study. Paediatr Anaesth. 2011, 21: 880-886. 10.1111\/j.1460-9592.2011.03532.x.","journal-title":"Paediatr Anaesth"},{"key":"9573_CR4","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1177\/0267659109105251","volume":"23","author":"E Sirvinskas","year":"2008","unstructured":"Sirvinskas E, Andrejaitiene J, Raliene L, Nasvytis L, Karbonskiene A, Pilvinis V, Sakalauskas J: Cardiopulmonary bypass management and acute renal failure: risk factors and prognosis. Perfusion. 2008, 23: 323-327. 10.1177\/0267659109105251.","journal-title":"Perfusion"},{"key":"9573_CR5","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1038\/ki.2009.270","volume":"76","author":"M Zappitelli","year":"2009","unstructured":"Zappitelli M, Bernier PL, Saczkowski RS, Tchervenkov CI, Gottesman R, Dancea A, Hyder A, Alkandari O: A small post-operative rise in serum creatinine predicts acute kidney injury in children undergoing cardiac surgery. Kidney Int. 2009, 76: 885-892. 10.1038\/ki.2009.270.","journal-title":"Kidney Int"},{"key":"9573_CR6","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/S0022-5223(95)70394-2","volume":"109","author":"F Fleming","year":"1995","unstructured":"Fleming F, Bohn D, Edwards H, Cox P, Geary D, McCrindle BW, Williams WG: Renal replacement therapy after repair of congenital heart disease in children: a comparison of hemofiltration and peritoneal dialysis. J Thorac Cardiovasc Surg. 1995, 109: 322-331. 10.1016\/S0022-5223(95)70394-2.","journal-title":"J Thorac Cardiovasc Surg"},{"key":"9573_CR7","doi-asserted-by":"publisher","first-page":"732","DOI":"10.2215\/CJN.03200906","volume":"2","author":"JM Symons","year":"2007","unstructured":"Symons JM, Chua AN, Somers MJ, Baum MA, Bunchman TE, Benfield MR, Brophy PD, Blowey D, Fortenberry JD, Chand D, Flores FX, Hackbarth R, Alexander SR, Mahan J, McBryde KD, Goldstein SL: Demographic characteristics of pediatric continuous renal replacement therapy: a report of the prospective pediatric continuous renal replacement therapy registry. Clin J Am Soc Nephrol. 2007, 2: 732-738. 10.2215\/CJN.03200906.","journal-title":"Clin J Am Soc Nephrol"},{"key":"9573_CR8","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1177\/0267659109105251","volume":"23","author":"E Sirvinskas","year":"2008","unstructured":"Sirvinskas E, Andrejaitiene J, Raliene L, Nasvytis L, Karbonskiene A, Pilvinis V, Sakalauskas J: Cardiopulmonary bypass management and acute renal failure: risk factors and prognosis. Perfusion. 2008, 23: 323-327. 10.1177\/0267659109105251.","journal-title":"Perfusion"},{"key":"9573_CR9","doi-asserted-by":"publisher","first-page":"2024","DOI":"10.1016\/j.jacc.2009.12.046","volume":"55","author":"M Haase","year":"2010","unstructured":"Haase M, Bellomo R, Haase-Fielitz A: Novel biomarkers, oxidative stress, and the role of labile iron toxicity in cardiopulmonary bypass-associated acute kidney injury. J Am Coll Cardiol. 2010, 55: 2024-2033. 10.1016\/j.jacc.2009.12.046.","journal-title":"J Am Coll Cardiol"},{"key":"9573_CR10","doi-asserted-by":"publisher","first-page":"2213","DOI":"10.1016\/j.athoracsur.2005.05.069","volume":"80","author":"M Ranucci","year":"2005","unstructured":"Ranucci M, Romitti F, Isgr\u00f2 G, Cotza M, Brozzi S, Boncilli A, Ditta A: Oxygen delivery during cardiopulmonary bypass and acute renal failure after coronary operations. Ann Thorac Surg. 2005, 80: 2213-2220. 10.1016\/j.athoracsur.2005.05.069.","journal-title":"Ann Thorac Surg"},{"key":"9573_CR11","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1002\/9780470754986.ch5","volume-title":"Anesthesia for Congenital Heart Disease","author":"SD Markowitz","year":"2005","unstructured":"Markowitz SD, Greeley WJ: Cardiopulmonary bypass. Anesthesia for Congenital Heart Disease. Edited by: Andropulos DB, Layer SA, Russel IA. 2005, Boston, Mass., USA: Blackwell Publishing, 64-81. 1","edition":"1"},{"key":"9573_CR12","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s00467-010-1576-0","volume":"26","author":"Z Al-Ismaili","year":"2011","unstructured":"Al-Ismaili Z, Palijan A, Zappitelli M: Biomarkers of acute kidney injury in children: discovery, evaluation, and clinical application. Pediatr Nephrol. 2011, 26: 29-40. 10.1007\/s00467-010-1576-0.","journal-title":"Pediatr Nephrol"},{"key":"9573_CR13","volume-title":"Curr Opin Crit Care","author":"S Uchino","year":"2010","unstructured":"Uchino S: Creatinine. Curr Opin Crit Care. 2010,"},{"key":"9573_CR14","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1097\/CCM.0b013e318195846e","volume":"37","author":"A Haase-Fielitz","year":"2009","unstructured":"Haase-Fielitz A, Bellomo R, Devarajan P, Story D, Matalanis G, Dragun D, Haase M: Novel and conventional serum biomarkers predicting acute kidney injury in adult cardiac surgery: a prospective cohort study. Crit Care Med. 2009, 37: 553-560. 10.1097\/CCM.0b013e318195846e.","journal-title":"Crit Care Med"},{"key":"9573_CR15","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1016\/S0140-6736(05)74811-X","volume":"365","author":"J Mishra","year":"2005","unstructured":"Mishra J, Dent C, Tarabishi R, Mitsnefes MM, Ma Q, Kelly C, Ruff SM, Zahedi K, Shao M, Bean J, Mori K, Barasch J, Devarajan P: Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet. 2005, 365: 1231-1238. 10.1016\/S0140-6736(05)74811-X.","journal-title":"Lancet"},{"key":"9573_CR16","volume-title":"Curr Opin Crit Care","author":"M Haase","year":"2010","unstructured":"Haase M, Bellomo R, Haase-Fielitz A: Neutrophil gelatinase-associated lipocalin. Curr Opin Crit Care. 2010,"},{"key":"9573_CR17","volume-title":"Curr Opin Crit Care","author":"SM Bagshaw","year":"2010","unstructured":"Bagshaw SM, Bellomo R: Cystatin C in acute kidney injury. Curr Opin Crit Care. 2010,"},{"key":"9573_CR18","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/S1053-0770(99)90086-1","volume":"13","author":"O K\u00f6ner","year":"1999","unstructured":"K\u00f6ner O, Tekin S, K\u00f6ner A, Soybir N, Seren S, Karaoglu K: Effects of phentolamine on tissue perfusion in pediatric cardiac surgery. J Cardiothorac Vasc Anesth. 1999, 13: 191-197. 10.1016\/S1053-0770(99)90086-1.","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"9573_CR19","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S0003-4975(98)01266-1","volume":"67","author":"JS Tweddell","year":"1999","unstructured":"Tweddell JS, Hoffman GM, Fedderly RT, Berger S, Thomas JP, Ghanayem NS, Kessel MW, Litwin SB: Phenoxybenzamine improves systemic oxygen delivery after the Norwood procedure. Ann Thorac Surg. 1999, 67: 161-167. 10.1016\/S0003-4975(98)01266-1.","journal-title":"Ann Thorac Surg"},{"key":"9573_CR20","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/S1053-0770(97)90163-4","volume":"11","author":"M Tu\u011frul","year":"1997","unstructured":"Tu\u011frul M, Pembeci K, Camci E, Ozkan T, Telci L: Comparison of the effects of sodium nitroprusside and isoflurane during rewarming on cardiopulmonary bypass. J Cardiothorac Vasc Anesth. 1997, 11: 712-717. 10.1016\/S1053-0770(97)90163-4.","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"9573_CR21","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.ejcts.2006.11.015","volume":"31","author":"K Kaya","year":"2007","unstructured":"Kaya K, O\u011fuz M, Akar AR, Durdu S, Aslan A, Erturk S, Ta\u015f\u00f6z R, Ozyurda U: The effect of sodium nitroprusside infusion on renal function during reperfusion period in patients undergoing coronary artery bypass grafting: a prospective randomized clinical trial. Eur J Cardiothorac Surg. 2007, 31: 290-297. 10.1016\/j.ejcts.2006.11.015.","journal-title":"Eur J Cardiothorac Surg"},{"key":"9573_CR22","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1016\/j.semnephrol.2008.05.006","volume":"28","author":"S Picca","year":"2008","unstructured":"Picca S, Ricci Z, Picardo S: Acute kidney injury in an infant after cardiopulmonary bypass. Semin Nephrol. 2008, 28: 470-476. 10.1016\/j.semnephrol.2008.05.006.","journal-title":"Semin Nephrol"},{"key":"9573_CR23","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1007\/s001340000819","volume":"27","author":"MM van der Vorst","year":"2001","unstructured":"van der Vorst MM, Ruys-Dudok van Heel I, Kist-van Holthe JE, den Hartigh J, Schoemaker RC, Cohen AF, Burggraaf J: Continuous intravenous furosemide in haemodynamically unstable children after cardiac surgery. Intensive Care Med. 2001, 27: 711-715. 10.1007\/s001340000819.","journal-title":"Intensive Care Med"},{"key":"9573_CR24","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1097\/MCC.0b013e328332f6f9","volume":"15","author":"JA Tumlin","year":"2009","unstructured":"Tumlin JA: Impaired blood flow in acute kidney injury: pathophysiology and potential efficacy of intrarenal vasodilator therapy. Curr Opin Crit Care. 2009, 15: 514-519. 10.1097\/MCC.0b013e328332f6f9.","journal-title":"Curr Opin Crit Care"},{"key":"9573_CR25","doi-asserted-by":"publisher","first-page":"3230","DOI":"10.1161\/CIRCULATIONAHA.104.509141","volume":"111","author":"T Bove","year":"2005","unstructured":"Bove T, Landoni G, Calabr\u00f2 MG, Aletti G, Marino G, Cerchierini E, Crescenzi G, Zangrillo A: Renoprotective action of fenoldopam in high-risk patients undergoing cardiac surgery: a prospective, double-blind, randomized clinical trial. Circulation. 2005, 111: 3230-3235. 10.1161\/CIRCULATIONAHA.104.509141.","journal-title":"Circulation"},{"key":"9573_CR26","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1053\/j.jvca.2007.07.015","volume":"22","author":"G Landoni","year":"2008","unstructured":"Landoni G, Biondi-Zoccai GG, Marino G, Bove T, Fochi O, Maj G, Calabr\u00f2 MG, Sheiban I, Tumlin JA, Ranucci M, Zangrillo A: Fenoldopam reduces the need for renal replacement therapy and in-hospital death in cardiovascular surgery: a meta-analysis. J Cardiothorac Vasc Anesth. 2008, 22: 27-33. 10.1053\/j.jvca.2007.07.015.","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"9573_CR27","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1097\/PCC.0b013e3181728c25","volume":"9","author":"BS Moffett","year":"2008","unstructured":"Moffett BS, Mott AR, Nelson DP, Goldstein SL, Jefferies JL: Renal effects of fenoldopam in critically ill pediatric patients: a retrospective review. Pediatr Crit Care Med. 2008, 9: 403-406. 10.1097\/PCC.0b013e3181728c25.","journal-title":"Pediatr Crit Care Med"},{"key":"9573_CR28","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1097\/01.PCC.0000194046.47306.FB","volume":"7","author":"JM Costello","year":"2006","unstructured":"Costello JM, Thiagarajan RR, Dionne RE, Allan CK, Booth KL, Burmester M, Wessel DL, Laussen PC: Initial experience with fenoldopam after cardiac surgery in neonates with an insufficient response to conventional diuretics. Pediatr Crit Care Med. 2006, 7: 28-33. 10.1097\/01.PCC.0000194046.47306.FB.","journal-title":"Pediatr Crit Care Med"},{"key":"9573_CR29","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.athoracsur.2009.09.071","volume":"89","author":"M Meco","year":"2010","unstructured":"Meco M, Cirri S: The effect of various fenoldopam doses on renal perfusion in patients undergoing cardiac surgery. Ann Thorac Surg. 2010, 89: 497-550. 10.1016\/j.athoracsur.2009.09.071.","journal-title":"Ann Thorac Surg"},{"key":"9573_CR30","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1510\/icvts.2008.185025","volume":"7","author":"Z Ricci","year":"2008","unstructured":"Ricci Z, Stazi GV, Di Chiara L, Morelli S, Vitale V, Giorni C, Ronco C, Picardo S: Fenoldopam in newborn patients undergoing cardiopulmonary bypass: controlled clinical trial. Interact Cardiovasc Thorac Surg. 2008, 7: 1049-1053. 10.1510\/icvts.2008.185025.","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"9573_CR31","first-page":"8","volume":"6","author":"GB Hammer","year":"2008","unstructured":"Hammer GB, Verghese ST, Drover DR, Yaster M, Tobin JR: Pharmacokinetics and pharmacodynamics of fenoldopam mesylate for blood pressure control in pediatric patients. BMC Anesthesiol. 2008, 6: 8-16.","journal-title":"BMC Anesthesiol"},{"key":"9573_CR32","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1038\/sj.ki.5002231","volume":"71","author":"A Akcan-Arikan","year":"2007","unstructured":"Akcan-Arikan A, Zappitelli M, Loftis LL, Washburn KK, Jefferson LS, Goldstein SL: Modified RIFLE criteria in critically ill children with acute kidney injury. Kidney Int. 2007, 71: 1028-1035. 10.1038\/sj.ki.5002231.","journal-title":"Kidney Int"},{"key":"9573_CR33","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/S0002-9149(01)01751-9","volume":"88","author":"S Shore","year":"2001","unstructured":"Shore S, Nelson D, Pearl J, Manning P, Wong H, Shanley T, Keyser T, Schwartz S: Usefulness of corticosteroid therapy in decreasing epinephrine requirements in critically ill infants with congenital heart disease. Am J Cardiol. 2001, 88: 591-594. 10.1016\/S0002-9149(01)01751-9.","journal-title":"Am J Cardiol"},{"key":"9573_CR34","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1053\/j.pcsu.2004.02.009","volume":"7","author":"KJ Jenkins","year":"2004","unstructured":"Jenkins KJ: Risk adjustment for congenital heart surgery: the RACHS-1 method. Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2004, 7: 180-184. 10.1053\/j.pcsu.2004.02.009.","journal-title":"Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu"},{"key":"9573_CR35","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1053\/j.ajkd.2009.07.020","volume":"54","author":"M Haase","year":"2009","unstructured":"Haase M, Bellomo R, Devarajan P, Schlattmann P, Haase-Fielitz A, for the NGAL Meta-analysis Investigator Group: Accuracy of neutrophil gelatinase-associated lipocalin (NGAL) in diagnosis and prognosis in acute kidney injury: a systematic review and meta-analysis. Am J Kidney Dis. 2009, 54: 1012-1024. 10.1053\/j.ajkd.2009.07.020.","journal-title":"Am J Kidney Dis"},{"key":"9573_CR36","doi-asserted-by":"publisher","first-page":"1752","DOI":"10.1016\/j.jacc.2010.11.051","volume":"57","author":"M Haase","year":"2011","unstructured":"Haase M, Devarajan P, Haase-Fielitz A, Bellomo R, Cruz DN, Wagener G, Krawczeski CD, Koyner JL, Murray P, Zappitelli M, Goldstein SL, Makris K, Ronco C, Martensson J, Martling CR, Venge P, Siew E, Ware LB, Ikizler TA, Mertens PR: The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury: a multicenter pooled analysis of prospective studies. J Am Coll Cardiol. 2011, 57: 1752-1761. 10.1016\/j.jacc.2010.11.051.","journal-title":"J Am Coll Cardiol"},{"key":"9573_CR37","first-page":"249","volume":"76","author":"M Ranucci","year":"2010","unstructured":"Ranucci M, De Benedetti D, Bianchini C, Castelvecchio S, Ballotta A, Frigiola A, Menicanti L: Effects of fenoldopam infusion in complex cardiac surgical operations: a prospective, randomized, double-blind, placebo-controlled study. Minerva Anestesiol. 2010, 76: 249-259.","journal-title":"Minerva Anestesiol"}],"container-title":["Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/cc10295.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/cc10295\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/cc10295.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T08:29:46Z","timestamp":1728289786000},"score":1,"resource":{"primary":{"URL":"https:\/\/ccforum.biomedcentral.com\/articles\/10.1186\/cc10295"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,29]]},"references-count":37,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2011,6]]}},"alternative-id":["9573"],"URL":"https:\/\/doi.org\/10.1186\/cc10295","relation":{},"ISSN":["1364-8535"],"issn-type":[{"value":"1364-8535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,29]]},"assertion":[{"value":"13 April 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 May 2011","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2011","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2011","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"R160"}}