{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:16:16Z","timestamp":1792084576376,"version":"4.4.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2011,11,16]],"date-time":"2011-11-16T00:00:00Z","timestamp":1321401600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2011,11,16]],"date-time":"2011-11-16T00:00:00Z","timestamp":1321401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Crit Care"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Introduction<\/jats:title>\n                        <jats:p>Although effective strategies are available for the management of chronic hypertension, less is known about treating patients with acute, severe elevations in blood pressure. Using data from the European registry for Studying the Treatment of Acute hyperTension (Euro-STAT), we sought to evaluate 'real-life' management practices and outcomes in patients who received intravenous antihypertensive therapy to treat an episode of acute hypertension.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>Euro-STAT is a European, hospital-based, observational study of consecutive adult patients treated with intravenous antihypertensive therapy while in the emergency department, perioperative unit or ICU. Enrolment took place between 1 July and 15 October 2009 in 11 hospitals in 7 European countries (Austria, Belgium, Germany, Italy, Spain, Sweden and the United Kingdom).<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>The study population was composed of 791 consecutive patients (median age 69 years, 37% women). Median arterial blood pressure before treatment was 166 mmHg systolic blood pressure (IQR 141 to 190 mmHg) and 80 mmHg diastolic blood pressure (IQR 68 to 95). Nitroglycerine was the most commonly used antihypertensive treatment overall (40% of patients), followed by urapidil (21%), clonidine (16%) and furosemide (8%). Treatment was associated with hypotension in almost 10% of patients. Overall 30-day mortality was 4%, and new or worsening end-organ damage occurred in 19% of patients.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>High blood pressure requiring intravenous therapy is currently managed with a variety of agents in Europe, with those most commonly used being nitroglycerine, urapidil and clonidine. Patients with acute hypertension have substantial concomitant morbidity and mortality, and intravenous antihypertensive treatment is associated with hypotension in almost 10% of cases.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/cc10551","type":"journal-article","created":{"date-parts":[[2011,12,7]],"date-time":"2011-12-07T21:26:37Z","timestamp":1323293197000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Characteristics, practice patterns, and outcomes in patients with acute hypertension: European registry for Studying the Treatment of Acute hyperTension (Euro-STAT)"],"prefix":"10.1186","volume":"15","author":[{"given":"Alain","family":"Vuylsteke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Vincent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Payen de La Garanderie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick A","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leigh","family":"Emery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Wyman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Rushton-Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel M","family":"Gore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Euro-STAT Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,11,16]]},"reference":[{"key":"9778_CR1","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1161\/01.HYP.0000107251.49515.c2","volume":"42","author":"AV Chobanian","year":"2003","unstructured":"Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL, Jones DW, Materson BJ, Oparil S, Wright JT, Roccella EJ, Joint National Committee on Prevention, and Treatment of High Blood Pressure. National Heart, and Blood Institute, National High Blood Pressure Education Program Coordinating Committee: JNC 7: Complete report. Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension. 2003, 42: 1206-1252. 10.1161\/01.HYP.0000107251.49515.c2.","journal-title":"Hypertension"},{"key":"9778_CR2","doi-asserted-by":"publisher","first-page":"e25","DOI":"10.1161\/CIRCULATIONAHA.107.187998","volume":"117","author":"W Rosamond","year":"2008","unstructured":"Rosamond W, Flegal K, Furie K, Go A, Greenlund K, Haase N, Hailpern SM, Ho M, Howard V, Kissela B, Kittner S, Lloyd-Jones D, McDermott M, Meigs J, Moy C, Nichol G, O'Donnell C, Roger V, Sorlie P, Steinberger J, Thom T, Wilson M, Hong Y, American Heart Association Statistics Committee and Stroke Statistics Subcommittee: Heart disease and stroke statistics-2008 update: a Report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2008, 117: e25-e146.","journal-title":"Circulation"},{"key":"9778_CR3","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1097\/00004872-200304000-00013","volume":"21","author":"CM Lawes","year":"2003","unstructured":"Lawes CM, Rodgers A, Bennett DA, Parag V, Suh I, Ueshima H, MacMahon S, Asia Pacific Cohort Studies Collaboration: Blood pressure and cardiovascular disease in the Asia Pacific region. J Hypertens. 2003, 21: 707-716.","journal-title":"J Hypertens"},{"key":"9778_CR4","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1016\/S0140-6736(02)11911-8","volume":"360","author":"S Lewington","year":"2002","unstructured":"Lewington S, Clarke R, Qizilbash N, Peto R, Collins R, Prospective Studies Collaboration: Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet. 2002, 360: 1903-1913. A published erratum appears in Lancet 2003, 361:1060","journal-title":"Lancet"},{"key":"9778_CR5","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/0140-6736(90)90878-9","volume":"335","author":"S MacMahon","year":"1990","unstructured":"MacMahon S, Peto R, Cutler J, Collins R, Sorlie P, Neaton J, Abbott R, Godwin J, Dyer A, Stamler J: Blood pressure, stroke, and coronary heart disease. Part 1, Prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias. Lancet. 1990, 335: 765-774. 10.1016\/0140-6736(90)90878-9.","journal-title":"Lancet"},{"key":"9778_CR6","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.semnephrol.2005.02.008","volume":"25","author":"M Wiederkehr","year":"2005","unstructured":"Wiederkehr M, Toto R, Fenves AZ, Ram CV: Hypertension and the kidney. Semin Nephrol. 2005, 25: 236-245. 10.1016\/j.semnephrol.2005.02.008.","journal-title":"Semin Nephrol"},{"key":"9778_CR7","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1046\/j.1525-1497.2002.20389.x","volume":"17","author":"D Cherney","year":"2002","unstructured":"Cherney D, Straus S: Management of patients with hypertensive urgencies and emergencies: a systematic review of the literature. J Gen Intern Med. 2002, 17: 937-945. 10.1046\/j.1525-1497.2002.20389.x.","journal-title":"J Gen Intern Med"},{"key":"9778_CR8","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1161\/01.HYP.27.1.144","volume":"27","author":"B Zampaglione","year":"1996","unstructured":"Zampaglione B, Pascale C, Marchisio M, Cavallo-Perin P: Hypertensive urgencies and emergencies. Prevalence and clinical presentation. Hypertension. 1996, 27: 144-147.","journal-title":"Hypertension"},{"key":"9778_CR9","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.ahj.2009.07.020","volume":"158","author":"JN Katz","year":"2009","unstructured":"Katz JN, Gore JM, Amin A, Anderson FA, Dasta JF, Ferguson JJ, Kleinschmidt K, Mayer SA, Multz AS, Peacock WF, Peterson E, Pollack C, Sung GY, Shorr A, Varon J, Wyman A, Emery LA, Granger CB, on behalf of the STAT Investigators: Practice patterns, outcomes, and end-organ dysfunction for patients with acute severe hypertension: The Studying the Treatment of Acute hyperTension (STAT) Registry. Am Heart J. 2009, 158: 599-606. 10.1016\/j.ahj.2009.07.020. e1","journal-title":"Am Heart J"},{"key":"9778_CR10","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.ahj.2010.06.032","volume":"160","author":"JM Gore","year":"2010","unstructured":"Gore JM, Peterson E, Amin A, Anderson FA, Dasta JF, Levy PD, O'Neil BJ, Sung GY, Varon J, Wyman A, Granger CB, for the STAT Investigators: Predictors of 90-day readmission among patients with acute severe hypertension: The cross-sectional observational Studying the Treatment of Acute hyperTension (STAT) study. Am Heart J. 2010, 160: 521-527. 10.1016\/j.ahj.2010.06.032. e1","journal-title":"Am Heart J"},{"key":"9778_CR11","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1097\/CRD.0b013e3181c307b7","volume":"18","author":"MA Rodriguez","year":"2010","unstructured":"Rodriguez MA, Kumar SK, De Caro M: Hypertensive crisis. Cardiol Rev. 2010, 18: 102-107. 10.1097\/CRD.0b013e3181c307b7.","journal-title":"Cardiol Rev"},{"key":"9778_CR12","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1590\/S1516-31802009000600009","volume":"127","author":"LM Souza","year":"2009","unstructured":"Souza LM, Riera R, Saconato H, Demath\u00e9 A, Atallah AN: Oral drugs for hypertensive urgencies: systematic review and meta-analysis. Sao Paulo Med J. 2009, 127: 366-372.","journal-title":"Sao Paulo Med J"},{"key":"9778_CR13","doi-asserted-by":"publisher","first-page":"24","DOI":"10.4037\/ccn2010664","volume":"30","author":"PL Smithburger","year":"2010","unstructured":"Smithburger PL, Kane-Gill SL, Nestor BL, Seybert AL: Recent advances in the treatment of hypertensive emergencies. Crit Care Nurse. 2010, 30: 24-31. 10.4037\/ccn2010664.","journal-title":"Crit Care Nurse"}],"container-title":["Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/cc10551.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/cc10551\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/cc10551.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T12:35:11Z","timestamp":1728304511000},"score":1,"resource":{"primary":{"URL":"https:\/\/ccforum.biomedcentral.com\/articles\/10.1186\/cc10551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,16]]},"references-count":13,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2011,12]]}},"alternative-id":["9778"],"URL":"https:\/\/doi.org\/10.1186\/cc10551","relation":{},"ISSN":["1364-8535"],"issn-type":[{"value":"1364-8535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,16]]},"assertion":[{"value":"29 July 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2011","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 November 2011","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 November 2011","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"R271"}}