{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T15:47:19Z","timestamp":1779205639889,"version":"3.51.4"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2012,9,17]],"date-time":"2012-09-17T00:00:00Z","timestamp":1347840000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2012,9,17]],"date-time":"2012-09-17T00:00:00Z","timestamp":1347840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Crit Care"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Introduction<\/jats:title>\n                        <jats:p>Studies in the critically ill that evaluate intragastric and post-pyloric delivery of nutrient have yielded conflicting data. A limitation of these studies is that the influence in the route of feeding on glucose absorption and glycaemia has not been determined.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>In 68 mechanically ventilated critically ill patients, liquid nutrient (100 ml; 1 kcal\/ml containing 3 g of 3-O-Methyl-D-glucopyranose (3-OMG), as a marker of glucose absorption), was infused into either the stomach (n = 24) or small intestine (n = 44) over six minutes. Blood glucose and serum 3-OMG concentrations were measured at regular intervals for 240 minutes and the area under the curves (AUCs) calculated for 'early' (AUC<jats:sub>60<\/jats:sub>) and 'overall' (AUC<jats:sub>240<\/jats:sub>) time periods. Data are presented as mean (95% confidence intervals).<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>Glucose absorption was initially more rapid following post-pyloric, when compared with intragastric, feeding (3-OMG AUC<jats:sub>60<\/jats:sub>: intragastric 7.3 (4.3, 10.2) vs. post-pyloric 12.5 (10.1, 14.8) mmol\/l.min; <jats:italic>P<\/jats:italic> = 0.008); however, 'overall' glucose absorption was similar (AUC<jats:sub>240<\/jats:sub>: 49.1 (34.8, 63.5) vs. 56.6 (48.9, 64.3) mmol\/l.min; <jats:italic>P<\/jats:italic> = 0.31). Post-pyloric administration of nutrients was also associated with greater increases in blood glucose concentrations in the 'early' period (AUC<jats:sub>60<\/jats:sub>: 472 (425, 519) vs. 534 (501, 569) mmol\/l.min; <jats:italic>P<\/jats:italic> = 0.03), but 'overall' glycaemia was also similar (AUC<jats:sub>240<\/jats:sub>: 1,875 (1,674, 2,075) vs. 1,898 (1,755, 2,041) mmol\/l.min; <jats:italic>P<\/jats:italic> = 0.85).<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>In the critically ill, glucose absorption was similar whether nutrient was administered via a gastric or post-pyloric catheter. These data may have implications for the perceived benefit of post-pyloric feeding on nutritional outcomes and warrant further investigation.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/cc11522","type":"journal-article","created":{"date-parts":[[2012,9,17]],"date-time":"2012-09-17T15:56:24Z","timestamp":1347897384000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Comparative effects on glucose absorption of intragastric and post-pyloric nutrient delivery in the critically ill"],"prefix":"10.1186","volume":"16","author":[{"given":"Anna E","family":"Di Bartolomeo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne J","family":"Chapman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antony","family":"V Zaknic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J","family":"Summers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen L","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nam Q","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher K","family":"Rayner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Horowitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam M","family":"Deane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,9,17]]},"reference":[{"key":"972_CR1","doi-asserted-by":"publisher","first-page":"1962","DOI":"10.1097\/00003246-199712000-00010","volume":"25","author":"AN Galanos","year":"1997","unstructured":"Galanos AN, Pieper CF, Kussin PS, Winchell MT, Fulkerson WJ, Harrell FE Jr, Teno JM, Layde P, Connors AF Jr, Phillips RS, Wenger NS: Relationship of body mass index to subsequent mortality among seriously ill hospitalized patients. 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