{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:28:29Z","timestamp":1791116909304,"version":"4.1.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2013,9,11]],"date-time":"2013-09-11T00:00:00Z","timestamp":1378857600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2013,9,11]],"date-time":"2013-09-11T00:00:00Z","timestamp":1378857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Crit Care"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Introduction<\/jats:title>\n                        <jats:p>IntelliVent-ASV<jats:sup>\u2122<\/jats:sup> is a full closed-loop ventilation mode that automatically adjusts ventilation and oxygenation parameters in both passive and active patients. This feasibility study compared oxygenation and ventilation settings automatically selected by IntelliVent-ASV<jats:sup>\u2122<\/jats:sup> among three predefined lung conditions (normal lung, acute respiratory distress syndrome (ARDS) and chronic obstructive pulmonary disease (COPD)) in active and passive patients. The feasibility of IntelliVent-ASV<jats:sup>\u2122<\/jats:sup> use was assessed based on the number of safety events, the need to switch to conventional mode for any medical reason, and sensor failure.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Method<\/jats:title>\n                        <jats:p>This prospective observational comparative study included 100 consecutive patients who were invasively ventilated for less than 24 hours at the time of inclusion with an expected duration of ventilation of more than 12 hours. Patients were ventilated using IntelliVent-ASV<jats:sup>\u2122<\/jats:sup> from inclusion to extubation. Settings, automatically selected by the ventilator, delivered ventilation, respiratory mechanics, and gas exchanges were recorded once a day.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>Regarding feasibility, all patients were ventilated using IntelliVent-ASV<jats:sup>\u2122<\/jats:sup> (392 days in total). No safety issues occurred and there was never a need to switch to an alternative ventilation mode. The fully automated ventilation was used for 95% of the total ventilation time. IntelliVent-ASV<jats:sup>\u2122<\/jats:sup> selected different settings according to lung condition in passive and active patients. In passive patients, tidal volume (V<jats:sub>T<\/jats:sub>), predicted body weight (PBW) was significantly different between normal lung (<jats:italic>n<\/jats:italic> = 45), ARDS (<jats:italic>n<\/jats:italic> = 16) and COPD patients (<jats:italic>n<\/jats:italic> = 19) (8.1 (7.3 to 8.9) mL\/kg; 7.5 (6.9 to 7.9) mL\/kg; 9.9 (8.3 to 11.1) mL\/kg, respectively; <jats:italic>P<\/jats:italic> 0.05). In passive ARDS patients, FiO<jats:sub>2<\/jats:sub> and positive end-expiratory pressure (PEEP) were statistically higher than passive normal lung (35 (33 to 47)% versus 30 (30 to 31)% and 11 (8 to 13) cmH<jats:sub>2<\/jats:sub>O versus 5 (5 to 6) cmH<jats:sub>2<\/jats:sub>O, respectively; <jats:italic>P<\/jats:italic>&lt; 0.05).<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>IntelliVent-ASV<jats:sup>\u2122<\/jats:sup> was safely used in unselected ventilated ICU patients with different lung conditions. Automatically selected oxygenation and ventilation settings were different according to the lung condition, especially in passive patients.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Trial Registration<\/jats:title>\n                        <jats:p>ClinicalTrials.gov: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT01489085\">NCT01489085<\/jats:ext-link><\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/cc12890","type":"journal-article","created":{"date-parts":[[2013,9,11]],"date-time":"2013-09-11T13:51:15Z","timestamp":1378907475000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Feasibility study on full closed-loop control ventilation (IntelliVent-ASV\u2122) in ICU patients with acute respiratory failure: a prospective observational comparative study"],"prefix":"10.1186","volume":"17","author":[{"given":"Jean-Michel","family":"Arnal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aude","family":"Garnero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Novonti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Demory","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Ducros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Berric","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane Yannis","family":"Donati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00eblle","family":"Corno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Jaber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Durand-Gasselin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,9,11]]},"reference":[{"key":"2972_CR1","first-page":"251","volume-title":"Proc AMIA Symp","author":"T East","year":"1999","unstructured":"East T, Heermann L, Bradshaw R, Lugo A, Sailors M, Ershler L, Wallace J, Morris A, McKinley B, Marquez A, Tonnesen A, Parmley L, Shoemaker W, Meade P, Thaut P, Hill T, Young M, Baughman J, Olterman M, Gooder V, Quinn B, Summer W, Valentine V, Carlson J, Bonnell B, deBoisblanc B, McClarity Z, Cachere J, Kovitz K, Gallagher E, Pinsky M, et al.: Efficacy of computerized decision support for mechanical ventilation. Results of a prospective multi-center randomized trial.\n                           Proc AMIA Symp 1999, 251-255."},{"key":"2972_CR2","doi-asserted-by":"publisher","first-page":"85","DOI":"10.4187\/respcare.00967","volume":"56","author":"R Chatburn","year":"2011","unstructured":"Chatburn R, Mireles-Cabodevila E: Closed-loop control of mechanical ventilation: description and classification of targeting schemes.\n                           Respir Care 2011, 56: 85-98.","journal-title":"Respir Care"},{"key":"2972_CR3","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s00134-007-0847-0","volume":"34","author":"JM Arnal","year":"2008","unstructured":"Arnal JM, Wysocki M, Nafati C, Donati SY, Granier I, Corno G, Durand-Gasselin J: Automatic selection of breathing pattern using adaptive support ventilation.\n                           Intensive Care Med 2008, 34: 75-81.","journal-title":"Intensive Care Med"},{"key":"2972_CR4","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1097\/00000542-200112000-00010","volume":"95","author":"CF Sulzer","year":"2001","unstructured":"Sulzer CF, Chiolero R, Chassot PG, Mueller XM, Revelly JP: Adaptive support ventilation for fast tracheal extubation after cardiac surgery: a randomized controlled study.\n                           Anesthesiology 2001, 95: 1339-1345.","journal-title":"Anesthesiology"},{"key":"2972_CR5","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1097\/00003246-200204000-00014","volume":"30","author":"D Tassaux","year":"2002","unstructured":"Tassaux D, Dalmas E, Gratadour P, Jolliet P: Patient-ventilator interactions during partial ventilatory support: A preliminary study comparing the effects of adaptive support ventilation with synchronized intermittent mandatory ventilation plus inspiratory pressure support.\n                           Crit Care Med 2002, 30: 801-807.","journal-title":"Crit Care Med"},{"key":"2972_CR6","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1097\/ALN.0b013e31817881fc","volume":"109","author":"P Gruber","year":"2008","unstructured":"Gruber P, Gomersall C, Leung P, Keung S, Ho K, Underwood M: Randomized controlled trial comparing adaptive-support ventilation with pressure-regulated volume-controlled ventilation with automode in weaning patients after cardiac surgery.\n                           Anesthesiology 2008, 109: 81-87.","journal-title":"Anesthesiology"},{"key":"2972_CR7","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1164\/rccm.200511-1780OC","volume":"174","author":"F Lellouche","year":"2006","unstructured":"Lellouche F, Mancebo J, Jolliet P, Roeseler J, Schortgen F, Dojat M, Cabello B, Bouadma L, Rodriguez P, Maggiore S, Reynaert M, Mersmann S, Brochard L: A multicenter, randomized trial of computer-driven protocolized weaning from mechanical ventilation.\n                           Am J Respir Crit Care Med 2006, 174: 894-900.","journal-title":"Am J Respir Crit Care Med"},{"key":"2972_CR8","doi-asserted-by":"publisher","first-page":"976","DOI":"10.4187\/respcare.00966","volume":"56","author":"CW Chen","year":"2011","unstructured":"Chen CW, Wu CP, Dai YL, Perng WC, Chian CF, Su WL, Huang YC: Effects of implementing adaptive support ventilation in a medical intensive care unit.\n                           Respir Care 2011, 56: 976-983.","journal-title":"Respir Care"},{"key":"2972_CR9","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1007\/s00134-012-2548-6","volume":"38","author":"JM Arnal","year":"2012","unstructured":"Arnal JM, Wysocki M, Novotni D, Demory D, Lopez R, Donati SY, Granier I, Corno G, Durand-Gasselin J: Safety and efficacy of a fully close loop ventilation (IntelliVent-ASV) in ICU patients: a prospective randomized cross-over study.\n                           Intensive Care Med 2012, 38: 781-787.","journal-title":"Intensive Care Med"},{"key":"2972_CR10","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1097\/ALN.0b013e3182952608","volume":"119","author":"N Clavieras","year":"2013","unstructured":"Clavieras N, Coisel Y, Jung B, Galia F, Conseil F, Belafia F, Carr J, Verzilli D, Chanques G, Jaber S: Prospective randomized cross-over study comparing Pressure Support ventilation (PSV) and a fully close loop control ventilation (IntelliVent-ASV\n                           \n                              \u00ae\n                           \n                           ) during weaning from mechanical ventilation in ICU patients.\n                           Anesthesiology 2013, 119: 631-641.","journal-title":"Anesthesiology"},{"key":"2972_CR11","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1007\/s00134-012-2799-2","volume":"39","author":"F Lellouche","year":"2013","unstructured":"Lellouche F, Bouchard PA, Laubsher T, Blackburn S, L'Her E, Wysocki M: Prospective randomized controlled study comparing conventional ventilation versus a fully close loop ventilation (IntelliVent\n                           \n                              \u00ae\n                           \n                           ) in post cardiac surgery ICU patients.\n                           Intensive Care Med 2013, 39: 463-471.","journal-title":"Intensive Care Med"},{"key":"2972_CR12","doi-asserted-by":"publisher","first-page":"R85","DOI":"10.1186\/cc11343","volume":"16","author":"P Jouvet","year":"2012","unstructured":"Jouvet P, Eddington A, Payen V, Bourdessoule A, Emeriaud G, Lopez R, Wysocki M: A pilot prospective study on closed loop controlled ventilation and oxygenation in ventilated children during the weaning phase.\n                           Crit Care 2012, 16: R85.","journal-title":"Crit Care"},{"key":"2972_CR13","first-page":"650","volume":"8","author":"BJ Devine","year":"1974","unstructured":"Devine BJ: Gentamicin therapy.\n                           Drug Intell Clin Pharm 1974, 8: 650-655.","journal-title":"Drug Intell Clin Pharm"},{"key":"2972_CR14","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1056\/NEJM199802053380602","volume":"338","author":"MB Amato","year":"1998","unstructured":"Amato MB, Barbas CS, Medeiros DM, Magaldi RB, Schettino GP, Lorenzi-Filho G, Kairalla RA, Deheinzelin D, Munoz C, Oliveira R, Takagaki TY, Carvalho CR: Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome.\n                           N Engl J Med 1998, 338: 347-354.","journal-title":"N Engl J Med"},{"key":"2972_CR15","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1164\/rccm.200505-718OC","volume":"173","author":"M Ferrer","year":"2006","unstructured":"Ferrer M, Valencia M, Josep MN, Bernadich O, Badia JR, Torres A: Early noninvasive ventilation averts extubation failure in patients at risk: a randomized trial.\n                           Am J Respir Crit Care Med 2006, 173: 164-170.","journal-title":"Am J Respir Crit Care Med"},{"key":"2972_CR16","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1164\/ajrccm.149.3.7509706","volume":"149","author":"GR Bernard","year":"1994","unstructured":"Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, Le Gall JR, Morris A, Spragg R: Report of the American-European Consensus Conference on acute respiratory distress syndrome: definitions, mechanism, relevant outcomes, and clinical trial coordination.\n                           Am J Respir Crit Care Med 1994, 149: 818-824.","journal-title":"Am J Respir Crit Care Med"},{"key":"2972_CR17","unstructured":"Global Initiative for Chronic Obstructive Lung Disease: Global strategy for diagnosis, management and prevention of COPD.[http:\/\/www.goldcopd.com\/]"},{"key":"2972_CR18","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1097\/01.anes.0000267607.25011.e8","volume":"106","author":"MJ Schultz","year":"2007","unstructured":"Schultz MJ, Haitsma JJ, Slutsky AS, Gajic O: What tidal volumes should be used in patients without acute lung injury?\n                           Anesthesiology 2007, 106: 1226-1231.","journal-title":"Anesthesiology"},{"key":"2972_CR19","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1007\/s00134-012-2728-4","volume":"39","author":"F Lellouche","year":"2013","unstructured":"Lellouche F, Lipes J: Prophylactic protective ventilation: lower tidal volumes for all critically ill patients?\n                           Intensive Care Med 2013, 39: 6-15.","journal-title":"Intensive Care Med"},{"key":"2972_CR20","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1007\/s00134-010-2025-z","volume":"37","author":"AE De Graaff","year":"2011","unstructured":"De Graaff AE, Dongelmans DA, Binnekade JM, de Jonge E: Clinicians' response to hyperoxia in ventilated patients in a Dutch ICU depends on the level of FiO2.\n                           Intensive Care Med 2011, 37: 46-51.","journal-title":"Intensive Care Med"},{"key":"2972_CR21","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.ahj.2009.05.037","volume":"158","author":"H Farquhar","year":"2009","unstructured":"Farquhar H, Weatherall M, Wijesinghe M, Perrin K, Ranchord A, Simmonds M, Beasley R: Systematic review of studies of the effect of hyperoxia on coronary blood flow.\n                           Am Heart J 2009, 158: 371-377.","journal-title":"Am Heart J"},{"key":"2972_CR22","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1136\/hrt.2008.148742","volume":"95","author":"M Wijesinghe","year":"2009","unstructured":"Wijesinghe M, Perrin K, Ranchord A, Simmonds M, Weatherall M, Beasley R: Routine use of oxygen in the treatment of myocardial infarction: systematic review.\n                           Heart 2009, 95: 198-202.","journal-title":"Heart"},{"key":"2972_CR23","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.1152\/japplphysiol.00303.2003","volume":"95","author":"TF Floyd","year":"2003","unstructured":"Floyd TF, Clark JM, Gelfand R, Detre JA, Ratcliffe S, Guvakov D, Lambertsen CJ, Eckenhoff RG: Independent cerebral vasoconstrictive effects of hyperoxia and accompanying arterial hypocapnia at 1 ATA.\n                           J Appl Physiol 2003, 95: 2453-2461.","journal-title":"J Appl Physiol"},{"key":"2972_CR24","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/s00134-004-2506-z","volume":"31","author":"JL Moran","year":"2005","unstructured":"Moran JL, Bersten AD, Solomon PJ: Meta-analysis of controlled trials of ventilator therapy in acute lung injury and acute respiratory distress syndrome: an alternative perspective.\n                           Intensive Care Med 2005, 31: 227-235.","journal-title":"Intensive Care Med"},{"key":"2972_CR25","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1164\/rccm.200710-1589OC","volume":"178","author":"D Chiumello","year":"2008","unstructured":"Chiumello D, Carlesso E, Cadringher P, Caironi P, Valenza F, Polli F, Tallarini F, Cozzi P, Cressoni M, Colombo A, Marini JJ, Gattinoni L: Lung stress and strain during mechanical ventilation for acute respiratory distress syndrome.\n                           Am J Respir Crit Care Med 2008, 178: 346-355.","journal-title":"Am J Respir Crit Care Med"},{"key":"2972_CR26","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1164\/rccm.200706-893OC","volume":"177","author":"A Esteban","year":"2008","unstructured":"Esteban A, Ferguson ND, Meade MO, Frutos-Vivar F, Apezteguia C, Brochard L, Raymondos K, Nin N, Hurtado J, Tomicic V, Gonz\u00e1lez M, Elizalde J, Nightingale P, Abroug F, Pelosi P, Arabi Y, Moreno R, Jibaja M, D'Empaire G, Sandi F, Matamis D, Monta\u00f1ez AM, Anzueto A: VENTILA Group: Evolution of mechanical ventilation in response to clinical research.\n                           Am J Respir Crit Care Med 2008, 177: 170-177.","journal-title":"Am J Respir Crit Care Med"},{"key":"2972_CR27","doi-asserted-by":"publisher","first-page":"1932","DOI":"10.1007\/s00134-011-2380-4","volume":"37","author":"J Villar","year":"2011","unstructured":"Villar J, Blanco J, A\u00f1\u00f3n JM, Santos-Bouza A, Blanch L, Ambr\u00f3s A, Gand\u00eda F, Carriedo D, Mosteiro F, Basald\u00faa S, Fern\u00e1ndez RL, Kacmarek RM: ALIEN Network: The ALIEN study: incidence and outcome of acute respiratory distress syndrome in the era of lung protective ventilation.\n                           Intensive Care Med 2011, 37: 1932-1941.","journal-title":"Intensive Care Med"},{"key":"2972_CR28","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1097\/01.CCM.0000127784.54727.56","volume":"32","author":"MP Young","year":"2004","unstructured":"Young MP, Manning HL, Wilson DL, Mette SA, Riker RR, Leiter JC, Liu SK, Bates JT, Parsons PE: Ventilation of patients with acute lung injury and acute respiratory distress syndrome: has new evidence changed clinical practice?\n                           Crit Care Med 2004, 32: 1260-1265.","journal-title":"Crit Care Med"},{"key":"2972_CR29","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1097\/CCM.0b013e31816fc3d0","volume":"36","author":"NJ Umoh","year":"2008","unstructured":"Umoh NJ, Fan E, Mendez-Tellez PA Sevransky JE, Dennison CR, Shanholtz C, Pronovost PJ, Needham DM: Patient and intensive care unit organizational factors associated with low tidal volume ventilation in acute lung injury.\n                           Crit Care Med 2008, 36: 1463-1468.","journal-title":"Crit Care Med"},{"key":"2972_CR30","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1136\/bmj.e2124","volume":"344","author":"D Needham","year":"2012","unstructured":"Needham D, Colantuoni E, Mendez-Tellez PA, Dinglas VD, Sevransky JE, Himmelfarb CR, Desai SV, Shanholtz C, Brower RG, Pronovost PJ: Lung protective ventilation and two years survival in patients with acute lung injury: prospective cohort study.\n                           BMJ 2012, 344: 44.","journal-title":"BMJ"},{"key":"2972_CR31","doi-asserted-by":"publisher","first-page":"2228","DOI":"10.1097\/01.CCM.0000181529.08630.49","volume":"33","author":"ND Ferguson","year":"2005","unstructured":"Ferguson ND, Frutos-Vivar F, Esteban A, Fern\u00e1ndez-Segoviano P, Aramburu JA, N\u00e1jera L, Stewart TE: Acute respiratory distress syndrome: underrecognition by clinicians and diagnostic accuracy of three clinical definitions.\n                           Crit Care Med 2005, 33: 2228-2234.","journal-title":"Crit Care Med"},{"key":"2972_CR32","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1007\/s00134-002-1349-8","volume":"28","author":"JC Richard","year":"2002","unstructured":"Richard JC, Brochard L, Breton L, Aboab J, Vandelet P, Tamion F, Maggiore SM, Mercat A, Bonmarchand G: Influence of respiratory rate on gas trapping during low volume ventilation of patients with acute lung injury.\n                           Intensive Care Med 2002, 28: 1078-1083.","journal-title":"Intensive Care Med"},{"key":"2972_CR33","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1097\/01.CCM.0000127266.39560.96","volume":"32","author":"GD Rubenfeld","year":"2004","unstructured":"Rubenfeld GD, Cooper C, Carter G, Thompson BT, Hudson LD: Barriers to providing lung-protective ventilation to patients with acute lung injury.\n                           Critical Care Med 2004, 32: 1289-1293.","journal-title":"Critical Care Med"},{"key":"2972_CR34","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1056\/NEJMoa032193","volume":"351","author":"National Heart, Lung, and Blood Institute ARDS Clinical Trials Network","year":"2004","unstructured":"National Heart, Lung, and Blood Institute ARDS Clinical Trials Network: Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome.\n                           N Engl J Med 2004, 351: 327-336.","journal-title":"N Engl J Med"},{"key":"2972_CR35","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.ccc.2006.12.001","volume":"23","author":"PJ Papadakos","year":"2007","unstructured":"Papadakos PJ, Lachmann B: The open lung concept of mechanical ventilation: the role of recruitment and stabilization.\n                           Crit Care Clin 2007, 23: 241-250.","journal-title":"Crit Care Clin"},{"key":"2972_CR36","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1097\/01.CCM.0000162384.71993.A3","volume":"33","author":"KJ Deans","year":"2005","unstructured":"Deans KJ, Minneci PC, Cui Z, Banks SM, Natanson C, Eichacker PQ: Mechanical ventilation in ARDS: one size does not fit all.\n                           Crit Care Med 2005, 33: 1141-1143.","journal-title":"Crit Care Med"},{"key":"2972_CR37","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1164\/rccm.200208-956OC","volume":"166","author":"PQ Eichacker","year":"2002","unstructured":"Eichacker PQ, Gerstenberger EP, Banks SM, Cui X, Natanson C: Meta-analysis of acute lung injury and acute respiratory distress syndrome trials testing low tidal volumes.\n                           Am J Respir Crit Care Med 2002, 166: 1510-1514.","journal-title":"Am J Respir Crit Care Med"},{"key":"2972_CR38","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s10877-006-9022-3","volume":"20","author":"P Talke","year":"2006","unstructured":"Talke P, Stapelfeldt C: Effect of peripheral vasoconstriction on pulse oximetry.\n                           J Clin Monit Comput 2006, 20: 305-309.","journal-title":"J Clin Monit Comput"},{"key":"2972_CR39","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S0735-6757(99)90019-0","volume":"17","author":"JE Sinex","year":"1999","unstructured":"Sinex JE: Pulse oximetry: principles and limitations.\n                           Am J Emerg Med 1999, 17: 59-67.","journal-title":"Am J Emerg Med"}],"container-title":["Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/cc12890.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/cc12890\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/cc12890.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T13:06:42Z","timestamp":1728306402000},"score":1,"resource":{"primary":{"URL":"https:\/\/ccforum.biomedcentral.com\/articles\/10.1186\/cc12890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,11]]},"references-count":39,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2013,10]]}},"alternative-id":["2972"],"URL":"https:\/\/doi.org\/10.1186\/cc12890","relation":{},"ISSN":["1364-8535"],"issn-type":[{"value":"1364-8535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,11]]},"assertion":[{"value":"15 January 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2013","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2013","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2013","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"R196"}}