{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:44:34Z","timestamp":1793054674625,"version":"4.5.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2013,12,13]],"date-time":"2013-12-13T00:00:00Z","timestamp":1386892800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2013,12,13]],"date-time":"2013-12-13T00:00:00Z","timestamp":1386892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Crit Care"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Introduction<\/jats:title>\n                        <jats:p>Knowledge of the association of hemodynamics with progression of septic acute kidney injury (AKI) is limited. However, some recent data suggest that mean arterial pressure (MAP) exceeding current guidelines (60\u201365 mmHg) may be needed to prevent AKI. We hypothesized that higher MAP during the first 24 hours in the intensive care unit (ICU), would be associated with a lower risk of progression of AKI in patients with severe sepsis.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>We identified 423 patients with severe sepsis and electronically recorded continuous hemodynamic data in the prospective observational FINNAKI study. The primary endpoint was progression of AKI within the first 5 days of ICU admission defined as new onset or worsening of AKI by the Kidney Disease: Improving Global Outcomes (KDIGO) criteria. We evaluated the association of hemodynamic variables with this endpoint. We included 53724 10-minute medians of MAP in the analysis. We analysed the ability of time-adjusted MAP to predict progression of AKI by receiver operating characteristic (ROC) analysis.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>Of 423 patients, 153 (36.2%) had progression of AKI. Patients with progression of AKI had significantly lower time-adjusted MAP, 74.4 mmHg [68.3-80.8], than those without progression, 78.6 mmHg [72.9-85.4], <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001. A cut-off value of 73 mmHg for time-adjusted MAP best predicted the progression of AKI. Chronic kidney disease, higher lactate, higher dose of furosemide, use of dobutamine and time-adjusted MAP below 73 mmHg were independent predictors of progression of AKI.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>The findings of this large prospective multicenter observational study suggest that hypotensive episodes (MAP under 73 mmHg) are associated with progression of AKI in critically ill patients with severe sepsis.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/cc13161","type":"journal-article","created":{"date-parts":[[2013,12,13]],"date-time":"2013-12-13T18:31:44Z","timestamp":1386959504000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":150,"title":["Hemodynamic variables and progression of acute kidney injury in critically ill patients with severe sepsis: data from the prospective observational FINNAKI study"],"prefix":"10.1186","volume":"17","author":[{"given":"Meri","family":"Poukkanen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Wilkman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suvi T","family":"Vaara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ville","family":"Pettil\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsi-Maija","family":"Kaukonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Maija","family":"Korhonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari","family":"Uusaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seppo","family":"Hovilehto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Outi","family":"Inkinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raili","family":"Laru-Sompa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raku","family":"Hautam\u00e4ki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Kuitunen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sari","family":"Karlsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the FINNAKI Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,12,13]]},"reference":[{"key":"2177_CR1","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1093\/ndt\/gfm610","volume":"23","author":"M Oppert","year":"2008","unstructured":"Oppert M, Engel C, Brunkhorst FM, Bogatsch H, Reinhart K, Frei U, Eckardt KU, Loeffler M, John S, German Competence Network Sepsis (Sepnet): Acute renal failure in patients with severe sepsis and septic shock\u2013a significant independent risk factor for mortality: results from the German prevalence study. Nephrol Dial Transplant. 2008, 23: 904-909.","journal-title":"Nephrol Dial Transplant"},{"key":"2177_CR2","doi-asserted-by":"publisher","first-page":"2552","DOI":"10.1097\/CCM.0b013e3181a5906f","volume":"37","author":"CV Thakar","year":"2009","unstructured":"Thakar CV, Christianson A, Freyberg R, Almenoff P, Render ML: Incidence and outcomes of acute kidney injury in intensive care units: a Veterans Administration study. Crit Care Med. 2009, 37: 2552-2558. 10.1097\/CCM.0b013e3181a5906f.","journal-title":"Crit Care Med"},{"key":"2177_CR3","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1097\/CCM.0b013e3182281f1b","volume":"39","author":"T Mandelbaum","year":"2011","unstructured":"Mandelbaum T, Scott DJ, Lee J, Mark RG, Malhotra A, Waikar SS, Howell MD, Talmor D: Outcome of critically ill patients with acute kidney injury using the acute kidney injury network criteria. Crit Care Med. 2011, 39: 2659-2664.","journal-title":"Crit Care Med"},{"key":"2177_CR4","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1007\/s00134-008-1367-2","volume":"35","author":"SM Bagshaw","year":"2009","unstructured":"Bagshaw SM, Lapinsky S, Dial S, Arabi Y, Dodek P, Wood G, Ellis P, Guzman J, Marshall J, Parrillo JE, Skrobik Y, Kumar A, Cooperative Antimicrobial Therapy of Septic Shock (CATSS) Database Research Group: Acute kidney injury in septic shock: clinical outcomes and impact of duration of hypotension prior to initiation of antimicrobial therapy. Intensive Care Med. 2009, 35: 871-881. 10.1007\/s00134-008-1367-2.","journal-title":"Intensive Care Med"},{"key":"2177_CR5","doi-asserted-by":"publisher","first-page":"S198","DOI":"10.1097\/CCM.0b013e318168ccd5","volume":"36","author":"L Wan","year":"2008","unstructured":"Wan L, Bagshaw SM, Langenberg C, Saotome T, May C, Bellomo R: Pathophysiology of septic acute kidney injury: what do we really know?. Crit Care Med. 2008, 36: S198-S203. 10.1097\/CCM.0b013e318168ccd5.","journal-title":"Crit Care Med"},{"key":"2177_CR6","doi-asserted-by":"publisher","first-page":"R47","DOI":"10.1186\/cc6863","volume":"12","author":"SM Bagshaw","year":"2008","unstructured":"Bagshaw SM, George C, Bellomo R, ANZICS Database Management C: Early acute kidney injury and sepsis: a multicentre evaluation. Crit Care. 2008, 12: R47-10.1186\/cc6863.","journal-title":"Crit Care"},{"key":"2177_CR7","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1001\/jama.294.7.813","volume":"294","author":"S Uchino","year":"2005","unstructured":"Uchino S, Kellum JA, Bellomo R, Doig GS, Morimatsu H, Morgera S, Schetz M, Tan I, Bouman C, Macedo E, Gibney N, Tolwani A, Ronco C, Beginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators: Acute renal failure in critically ill patients: a multinational, multicenter study. JAMA. 2005, 294: 813-818. 10.1001\/jama.294.7.813.","journal-title":"JAMA"},{"key":"2177_CR8","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1681\/ASN.2010050484","volume":"22","author":"A Zarjou","year":"2011","unstructured":"Zarjou A, Agarwal A: Sepsis and acute kidney injury. J Am Soc Nephrol. 2011, 22: 999-1006. 10.1681\/ASN.2010050484.","journal-title":"J Am Soc Nephrol"},{"key":"2177_CR9","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1056\/NEJMra032401","volume":"351","author":"RW Schrier","year":"2004","unstructured":"Schrier RW, Wang W: Acute renal failure and sepsis. N Engl J Med. 2004, 351: 159-169. 10.1056\/NEJMra032401.","journal-title":"N Engl J Med"},{"key":"2177_CR10","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1007\/s00134-009-1723-x","volume":"36","author":"N Lerolle","year":"2010","unstructured":"Lerolle N, Nochy D, Guerot E, Bruneval P, Fagon JY, Diehl JL, Hill G: Histopathology of septic shock induced acute kidney injury: apoptosis and leukocytic infiltration. Intensive Care Med. 2010, 36: 471-478. 10.1007\/s00134-009-1723-x.","journal-title":"Intensive Care Med"},{"key":"2177_CR11","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1097\/MCC.0b013e328358d480","volume":"18","author":"J Prowle","year":"2012","unstructured":"Prowle J, Bagshaw SM, Bellomo R: Renal blood flow, fractional excretion of sodium and acute kidney injury: time for a new paradigm?. Curr Opin Crit Care. 2012, 18: 585-592. 10.1097\/MCC.0b013e328358d480.","journal-title":"Curr Opin Crit Care"},{"key":"2177_CR12","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1097\/CCM.0b013e318246bd85","volume":"40","author":"JR Prowle","year":"2012","unstructured":"Prowle JR, Molan MP, Hornsey E, Bellomo R: Measurement of renal blood flow by phase-contrast magnetic resonance imaging during septic acute kidney injury: a pilot investigation. Crit Care Med. 2012, 40: 1768-1776. 10.1097\/CCM.0b013e318246bd85.","journal-title":"Crit Care Med"},{"key":"2177_CR13","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1007\/s00134-009-1678-y","volume":"36","author":"M Joannidis","year":"2010","unstructured":"Joannidis M, Druml W, Forni LG, Groeneveld AB, Honore P, Oudemans-van Straaten HM, Ronco C, Schetz MR, Woittiez AJ, Critical Care Nephrology Working Group of the European Society of Intensive Care Medicine: Prevention of acute kidney injury and protection of renal function in the intensive care unit. Expert opinion of the working group for Nephrology, ESICM. Intensive Care Med. 2010, 36: 392-411. 10.1007\/s00134-009-1678-y.","journal-title":"Intensive Care Med"},{"key":"2177_CR14","doi-asserted-by":"publisher","first-page":"R135","DOI":"10.1186\/cc10253","volume":"15","author":"J Badin","year":"2011","unstructured":"Badin J, Boulain T, Ehrmann S, Skarzynski M, Bretagnol A, Buret J, Benzekri-Lefevre D, Mercier E, Runge I, Garot D, Mathonnet A, Dequin PF, Perrotin D: Relation between mean arterial pressure and renal function in the early phase of shock: a prospective, explorative cohort study. Crit Care. 2011, 15: R135-10.1186\/cc10253.","journal-title":"Crit Care"},{"key":"2177_CR15","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1007\/s00134-009-1427-2","volume":"35","author":"MW Dunser","year":"2009","unstructured":"Dunser MW, Takala J, Ulmer H, Mayr VD, Luckner G, Jochberger S, Daudel F, Lepper P, Hasibeder WR, Jakob SM: Arterial blood pressure during early sepsis and outcome. Intensive Care Med. 2009, 35: 1225-1233. 10.1007\/s00134-009-1427-2.","journal-title":"Intensive Care Med"},{"key":"2177_CR16","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1007\/s00134-012-2796-5","volume":"39","author":"S Nisula","year":"2013","unstructured":"Nisula S, Kaukonen KM, Vaara ST, Korhonen AM, Poukkanen M, Karlsson S, Haapio M, Inkinen O, Parviainen I, Suojaranta-Ylinen R, Laurila JJ, Tenhunen J, Reinikainen M, Ala-Kokko T, Ruokonen E, Kuitunen A, Pettila V, FINNAKI Study G: Incidence, risk factors and 90-day mortality of patients with acute kidney injury in Finnish intensive care units: the FINNAKI study. Intensive Care Med. 2013, 39: 420-428. 10.1007\/s00134-012-2796-5.","journal-title":"Intensive Care Med"},{"key":"2177_CR17","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1378\/chest.101.6.1644","volume":"101","author":"RC Bone","year":"1992","unstructured":"Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RM, Sibbald WJ: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP\/SCCM Consensus Conference Committee. American College of Chest Physicians\/Society of Critical Care Medicine. Chest. 1992, 101: 1644-1655. 10.1378\/chest.101.6.1644.","journal-title":"Chest"},{"key":"2177_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/kisup.2012.1","volume":"2","author":"Anonymous Kidney Disease","year":"2012","unstructured":"Anonymous Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO clinical practice guideline for acute kidney injury. Kidney Inter Suppl. 2012, 2: 1-138.","journal-title":"Kidney Inter Suppl"},{"key":"2177_CR19","doi-asserted-by":"publisher","first-page":"137","DOI":"10.7326\/0003-4819-139-2-200307150-00013","volume":"139","author":"AS Levey","year":"2003","unstructured":"Levey AS, Coresh J, Balk E, Kausz AT, Levin A, Steffes MW, Hogg RJ, Perrone RD, Lau J, Eknoyan G, National Kidney Foundation: National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Ann Intern Med. 2003, 139: 137-147. 10.7326\/0003-4819-139-2-200307150-00013.","journal-title":"Ann Intern Med"},{"key":"2177_CR20","first-page":"S1","volume":"39","author":"F National Kidney","year":"2002","unstructured":"National Kidney F: K\/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis. 2002, 39: S1-S266.","journal-title":"Am J Kidney Dis"},{"key":"2177_CR21","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s00134-007-0934-2","volume":"34","author":"RP Dellinger","year":"2008","unstructured":"Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, Reinhart K, Angus DC, Brun-Buisson C, Beale R, Calandra T, Dhainaut JF, Gerlach H, Harvey M, Marini JJ, Marshall J, Ranieri M, Ramsay G, Sevransky J, Thompson BT, Townsend S, Vender JS, Zimmerman JL, Vincent JL: Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med. 2008, 34: 17-60. 10.1007\/s00134-007-0934-2.","journal-title":"Intensive Care Med"},{"key":"2177_CR22","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1056\/NEJMoa067373","volume":"358","author":"JA Russell","year":"2008","unstructured":"Russell JA, Walley KR, Singer J, Gordon AC, H\u00e9bert PC, Cooper DJ, Holmes CL, Mehta S, Granton JT, Storms MM, Cook DJ, Presneill JJ, Ayers D, VASST Investigators: Vasopressin versus norepinephrine infusion in patients with septic shock. N Engl J Med. 2008, 358: 877-887. 10.1056\/NEJMoa067373.","journal-title":"N Engl J Med"},{"key":"2177_CR23","doi-asserted-by":"publisher","first-page":"R181","DOI":"10.1186\/cc8167","volume":"13","author":"MW Dunser","year":"2009","unstructured":"Dunser MW, Ruokonen E, Pettila V, Ulmer H, Torgersen C, Schmittinger CA, Jakob S, Takala J: Association of arterial blood pressure and vasopressor load with septic shock mortality: a post hoc analysis of a multicenter trial. Crit Care. 2009, 13: R181-10.1186\/cc8167.","journal-title":"Crit Care"},{"key":"2177_CR24","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1186\/cc3024","volume":"9","author":"M Gillies","year":"2005","unstructured":"Gillies M, Bellomo R, Doolan L, Buxton B: Bench-to-bedside review: Inotropic drug therapy after adult cardiac surgery \u2013 a systematic literature review. Crit Care. 2005, 9: 266-279. 10.1186\/cc3024.","journal-title":"Crit Care"},{"key":"2177_CR25","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1097\/ALN.0b013e3181d47604","volume":"112","author":"P Ray","year":"2010","unstructured":"Ray P, Le Manach Y, Riou B, Houle TT: Statistical evaluation of a biomarker. Anesthesiology. 2010, 112: 1023-1040. 10.1097\/ALN.0b013e3181d47604.","journal-title":"Anesthesiology"},{"key":"2177_CR26","doi-asserted-by":"publisher","first-page":"R21","DOI":"10.1186\/cc12495","volume":"17","author":"TD Correa","year":"2013","unstructured":"Correa TD, Vuda M, Takala J, Djafarzadeh S, Silva E, Jakob SM: Increasing mean arterial blood pressure in sepsis: effects on fluid balance, vasopressor load and renal function. Crit Care. 2013, 17: R21-10.1186\/cc12495.","journal-title":"Crit Care"},{"key":"2177_CR27","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1007\/s00134-005-2688-z","volume":"31","author":"M Varpula","year":"2005","unstructured":"Varpula M, Tallgren M, Saukkonen K, Voipio-Pulkki LM, Pettila V: Hemodynamic variables related to outcome in septic shock. Intensive Care Med. 2005, 31: 1066-1071. 10.1007\/s00134-005-2688-z.","journal-title":"Intensive Care Med"},{"key":"2177_CR28","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1007\/s00134-010-2057-4","volume":"37","author":"B Redfors","year":"2011","unstructured":"Redfors B, Bragadottir G, Sellgren J, Sward K, Ricksten SE: Effects of norepinephrine on renal perfusion, filtration and oxygenation in vasodilatory shock and acute kidney injury. Intensive Care Med. 2011, 37: 60-67. 10.1007\/s00134-010-2057-4.","journal-title":"Intensive Care Med"},{"key":"2177_CR29","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1186\/cc1052","volume":"5","author":"R Bellomo","year":"2001","unstructured":"Bellomo R, Giantomasso DD: Noradrenaline and the kidney: friends or foes?. Crit Care. 2001, 5: 294-298. 10.1186\/cc1052.","journal-title":"Crit Care"},{"key":"2177_CR30","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.1007\/s00134-010-2045-8","volume":"36","author":"B Levy","year":"2010","unstructured":"Levy B, Collin S, Sennoun N, Ducrocq N, Kimmoun A, Asfar P, Perez P, Meziani F: Vascular hyporesponsiveness to vasopressors in septic shock: from bench to bedside. Intensive Care Med. 2010, 36: 2019-2029. 10.1007\/s00134-010-2045-8.","journal-title":"Intensive Care Med"},{"key":"2177_CR31","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1097\/00003246-199802000-00022","volume":"26","author":"K Hoogenberg","year":"1998","unstructured":"Hoogenberg K, Smit AJ, Girbes AR: Effects of low-dose dopamine on renal and systemic hemodynamics during incremental norepinephrine infusion in healthy volunteers. Crit Care Med. 1998, 26: 260-265. 10.1097\/00003246-199802000-00022.","journal-title":"Crit Care Med"},{"key":"2177_CR32","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1097\/00003246-199607000-00014","volume":"24","author":"M Richer","year":"1996","unstructured":"Richer M, Robert S, Lebel M: Renal hemodynamics during norepinephrine and low-dose dopamine infusions in man. Crit Care Med. 1996, 24: 1150-1156. 10.1097\/00003246-199607000-00014.","journal-title":"Crit Care Med"},{"key":"2177_CR33","doi-asserted-by":"publisher","first-page":"1557","DOI":"10.1007\/s00134-007-0665-4","volume":"33","author":"S Deruddre","year":"2007","unstructured":"Deruddre S, Cheisson G, Mazoit JX, Vicaut E, Benhamou D, Duranteau J: Renal arterial resistance in septic shock: effects of increasing mean arterial pressure with norepinephrine on the renal resistive index assessed with Doppler ultrasonography. Intensive Care Med. 2007, 33: 1557-1562. 10.1007\/s00134-007-0665-4.","journal-title":"Intensive Care Med"},{"key":"2177_CR34","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1097\/01.CCM.0000215834.48023.57","volume":"34","author":"V Krejci","year":"2006","unstructured":"Krejci V, Hiltebrand LB, Sigurdsson GH: Effects of epinephrine, norepinephrine, and phenylephrine on microcirculatory blood flow in the gastrointestinal tract in sepsis. Crit Care Med. 2006, 34: 1456-1463. 10.1097\/01.CCM.0000215834.48023.57.","journal-title":"Crit Care Med"},{"key":"2177_CR35","doi-asserted-by":"publisher","first-page":"R256","DOI":"10.1186\/cc10517","volume":"15","author":"J Benes","year":"2011","unstructured":"Benes J, Chvojka J, Sykora R, Radej J, Krouzecky A, Novak I, Matejovic M: Searching for mechanisms that matter in early septic acute kidney injury: an experimental study. Crit Care. 2011, 15: R256-10.1186\/cc10517.","journal-title":"Crit Care"},{"key":"2177_CR36","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1007\/s00134-013-2982-0","volume":"39","author":"G Hernandez","year":"2013","unstructured":"Hernandez G, Bruhn A, Luengo C, Regueira T, Kattan E, Fuentealba A, Florez J, Castro R, Aquevedo A, Pairumani R, McNab P, Ince C: Effects of dobutamine on systemic, regional and microcirculatory perfusion parameters in septic shock: a randomized, placebo-controlled, double-blind, crossover study. Intensive Care Med. 2013, 39: 1435-1443. 10.1007\/s00134-013-2982-0.","journal-title":"Intensive Care Med"},{"key":"2177_CR37","doi-asserted-by":"publisher","first-page":"R51","DOI":"10.1186\/cc5904","volume":"11","author":"M Heringlake","year":"2007","unstructured":"Heringlake M, Wernerus M, Grunefeld J, Klaus S, Heinze H, Bechtel M, Bahlmann L, Poeling J, Schon J: The metabolic and renal effects of adrenaline and milrinone in patients with myocardial dysfunction after coronary artery bypass grafting. Crit Care. 2007, 11: R51-10.1186\/cc5904.","journal-title":"Crit Care"},{"key":"2177_CR38","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1056\/NEJMoa1204242","volume":"367","author":"A Perner","year":"2012","unstructured":"Perner A, Haase N, Guttormsen AB, Tenhunen J, Klemenzson G, \u00c5neman A, Madsen KR, M\u00f8ller MH, Elkj\u00e6r JM, Poulsen LM, Bendtsen A, Winding R, Steensen M, Berezowicz P, S\u00f8e-Jensen P, Bestle M, Strand K, Wiis J, White JO, Thornberg KJ, Quist L, Nielsen J, Andersen LH, Holst LB, Thormar K, Kj\u00e6ldgaard A, Fabritius ML, Mondrup F, Pott FC, M\u00f8ller TP, et al: Hydroxyethyl starch 130\/0.42 versus Ringer\u2019s acetate in severe sepsis. N Engl J Med. 2012, 367: 124-134. 10.1056\/NEJMoa1204242.","journal-title":"N Engl J Med"},{"key":"2177_CR39","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1056\/NEJMoa1209759","volume":"367","author":"JA Myburgh","year":"2012","unstructured":"Myburgh JA, Finfer S, Bellomo R, Billot L, Cass A, Gattas D, Glass P, Lipman J, Liu B, McArthur C, McGuinness S, Rajbhandari D, Taylor CB, Webb SA, CHEST I, Australian and New Zealand Intensive Care Society Clinical Trials, Group: Hydroxyethyl starch or saline for fluid resuscitation in intensive care. N Engl J Med. 2012, 367: 1901-1911. 10.1056\/NEJMoa1209759.","journal-title":"N Engl J Med"}],"container-title":["Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/cc13161.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/cc13161\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/cc13161.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T10:18:41Z","timestamp":1728382721000},"score":1,"resource":{"primary":{"URL":"https:\/\/ccforum.biomedcentral.com\/articles\/10.1186\/cc13161"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,13]]},"references-count":39,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2013,12]]}},"alternative-id":["2177"],"URL":"https:\/\/doi.org\/10.1186\/cc13161","relation":{},"ISSN":["1364-8535"],"issn-type":[{"value":"1364-8535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,13]]},"assertion":[{"value":"24 May 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"R295"}}