{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:42:36Z","timestamp":1791322956526,"version":"4.3.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T00:00:00Z","timestamp":1389744000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T00:00:00Z","timestamp":1389744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Crit Care"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Introduction<\/jats:title>\n                        <jats:p><jats:italic>Pseudomonas aeruginosa<\/jats:italic> frequently causes nosocomial pneumonia and is associated with poor outcome. The purpose of this study was to assess the prevalence and clinical outcome of nosocomial pneumonia caused by serotype-specific <jats:italic>P. aeruginosa<\/jats:italic> in critically ill patients under appropriate antimicrobial therapy management.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>A retrospective, non-interventional epidemiological multicenter cohort study involving 143 patients with confirmed nosocomial pneumonia caused by <jats:italic>P. aeruginosa<\/jats:italic>. Patients were analyzed for a period of 30\u00a0days from time of nosocomial pneumonia onset. Fourteen patients fulfilling the same criteria from a phase IIa studyconducted at the same time\/centers were included in the prevalence calculations but not in the clinical outcome analysis.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>The prevalence of serotypes was: O6 (29%), O11 (23%), O10 (10%), O2 (9%), and O1 (8%). Serotypes with a prevalence of less than 5% were found in 13% of patients, 8% were classified as not typeable. Across all serotypes, 19% mortality, 70% clinical resolution, 11% clinical continuation, and 5% clinical recurrence were recorded. Age and higher APACHE II (Acute Physiology and Chronic Health Evaluation II) were predictive risk factors associated with probability of death and lower clinical resolution for <jats:italic>P. aeruginosa<\/jats:italic> nosocomial pneumonia. Mortality tends to be higher with O1 (40%) and lower with O2 (0%); clinical resolution tends to be better with O2 (82%) compared to other serotypes. Persisting pneumonia with O6 and O11 was, respectively, 8% and 21%; clinical resolution with O6 and O11 was, respectively, 75% and 57%.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>In <jats:italic>P. aeruginosa<\/jats:italic> nosocomial pneumonia, the most prevalent serotypes were O6 and O11. Further studies including larger group sizes are needed to correlate clinical outcome with virulence factors of <jats:italic>P. aeruginosa<\/jats:italic> in patients with nosocomial pneumonia caused by various serotypes; and to compare O6 and O11, the two serotypes most frequently encountered in critically ill patients.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/cc13697","type":"journal-article","created":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T12:03:23Z","timestamp":1389787403000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Pseudomonas aeruginosa serotypes in nosocomial pneumonia: prevalence and clinical outcomes"],"prefix":"10.1186","volume":"18","author":[{"given":"Qin","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Eggimann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles-Edouard","family":"Luyt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Wolff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Tamm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Fran\u00e7ois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Mercier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Garbino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Fran\u00e7ois","family":"Laterre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"Gafner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P","family":"Rudolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erkan","family":"Mus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedvika","family":"Lazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Chastre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Jacques","family":"Rouby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,1,15]]},"reference":[{"key":"2855_CR1","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1378\/chest.120.6.2059","volume":"120","author":"P Eggimann","year":"2001","unstructured":"Eggimann P, Pittet D: Infection control in the ICU.\n                           Chest 2001, 120: 2059-2093. 10.1378\/chest.120.6.2059","journal-title":"Chest"},{"key":"2855_CR2","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1378\/chest.10-0166","volume":"139","author":"S Fujitani","year":"2011","unstructured":"Fujitani S, Sun HY, Yu VL, Weingarten JA: Pneumonia due to Pseudomonas aeruginosa: part I: epidemiology, clinical diagnosis, and source.\n                           Chest 2011, 139: 909-919. 10.1378\/chest.10-0166","journal-title":"Chest"},{"key":"2855_CR3","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1378\/chest.109.4.1019","volume":"109","author":"S Crouch Brewer","year":"1996","unstructured":"Crouch Brewer S, Wunderink RG, Jones CB, Leeper KV Jr: Ventilator-associated pneumonia due to Pseudomonas aeruginosa.\n                           Chest 1996, 109: 1019-1029. 10.1378\/chest.109.4.1019","journal-title":"Chest"},{"key":"2855_CR4","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/0002-9343(93)90060-3","volume":"94","author":"JY Fagon","year":"1993","unstructured":"Fagon JY, Chastre J, Hance AJ, Montravers P, Novara A, Gibert C: Nosocomial pneumonia in ventilated patients: a cohort study evaluating attributable mortality and hospital stay.\n                           Am J Med 1993, 94: 281-288. 10.1016\/0002-9343(93)90060-3","journal-title":"Am J Med"},{"key":"2855_CR5","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1164\/ajrccm\/139.4.877","volume":"139","author":"JY Fagon","year":"1989","unstructured":"Fagon JY, Chastre J, Domart Y, Trouillet JL, Pierre J, Darne C, Gibert C: Nosocomial pneumonia in patients receiving continuous mechanical ventilation. 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