{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T06:33:38Z","timestamp":1776753218045,"version":"3.51.2"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T00:00:00Z","timestamp":1402358400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T00:00:00Z","timestamp":1402358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Crit Care"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It is well established that prolonged, controlled mechanical ventilation is associated with contractile dysfunction of the diaphragm due to impaired function of the mitochondrial respiratory chain as a result of aggravated oxidative and nitrosative stress. Sepsis and circulatory failure induce a similar response pattern. Callahan and Supinski now show that streptozotocin-induced insulin-dependent diabetes causes a comparable response pattern, both with respect to function and physiology - that is, reduced fiber force and, consequently, muscle contractility - but also as far as the underlying mechanisms are concerned. In other words, the authors elegantly demonstrate that the consequences of a chronic metabolic disease and that of acute critical illness may lead to the same phenotype response. It remains to be elucidated whether the underlying co-morbidity (for example, diabetes) adds to or even synergistically enhances the effect of an acute stress situation (for example, sepsis, mechanical ventilation). In addition, extending their previous work during shock states, the authors also show that administration of a preparation of the enzymatic anti-oxidant superoxide dismutase can reverse the deleterious effects of diabetes. These data are discussed in the context of the fundamental role of hyperglycemia in relation to metabolism-dependent formation of reactive oxygen species.<\/jats:p>","DOI":"10.1186\/cc13913","type":"journal-article","created":{"date-parts":[[2014,6,10]],"date-time":"2014-06-10T15:08:20Z","timestamp":1402412900000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Hyperglycemia, oxidative stress, and the diaphragm: a link between chronic co-morbidity and acute stress?"],"prefix":"10.1186","volume":"18","author":[{"given":"Sebastian","family":"Hafner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Radermacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"Frick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Dietl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Calzia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,6,10]]},"reference":[{"key":"2503_CR1","doi-asserted-by":"publisher","first-page":"R88","DOI":"10.1186\/cc13855","volume":"18","author":"LA Callahan","year":"2014","unstructured":"Callahan LA, Supinski GS: Hyperglycemia-induced diaphragm weakness is mediated by oxidative stress.\n                           Crit Care 2014, 18: R88. 10.1186\/cc13855","journal-title":"Crit Care"},{"key":"2503_CR2","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1164\/ajrccm.153.6.8665049","volume":"153","author":"W Hida","year":"1996","unstructured":"Hida W, Shindoh C, Satoh J, Sagara M, Kikuchi Y, Toyota T, Shirato K: N\n                           -acetylcysteine inhibits loss of diaphragm function in streptozotocin-treated rats.\n                           Am J Respir Crit Care Med 1996, 153: 1875-1879. 10.1164\/ajrccm.153.6.8665049","journal-title":"Am J Respir Crit Care Med"},{"key":"2503_CR3","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1186\/cc10023","volume":"15","author":"S Jaber","year":"2011","unstructured":"Jaber S, Jung B, Matecki S, Petrof BJ: Clinical review: Ventilator-induced diaphragmatic dysfunction - human studies confirm animal model findings!\n                           Crit Care 2011, 15: 206. 10.1186\/cc10023","journal-title":"Crit Care"},{"key":"2503_CR4","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1164\/rccm.201206-0982OC","volume":"186","author":"M Picard","year":"2012","unstructured":"Picard M, Jung B, Liang F, Azuelos I, Hussain S, Goldberg P, Godin R, Danialou G, Chaturvedi R, Rygiel K, Matecki S, Jaber S, Des Rosiers C, Karpati G, Ferri L, Burelle Y, Turnbull DM, Taivassalo T, Petrof BJ: Mitochondrial dysfunction and lipid accumulation in the human diaphragm during mechanical ventilation.\n                           Am J Respir Crit Care Med 2012, 186: 1140-1149. 10.1164\/rccm.201206-0982OC","journal-title":"Am J Respir Crit Care Med"},{"key":"2503_CR5","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1097\/CCM.0b013e31823c8cc9","volume":"40","author":"MB Hudson","year":"2012","unstructured":"Hudson MB, Smuder AJ, Nelson WB, Bruells CS, Levine S, Powers SK: Both high level pressure support ventilation and controlled mechanical ventilation induce diaphragm dysfunction and atrophy.\n                           Crit Care Med 2012, 40: 1254-1260. 10.1097\/CCM.0b013e31823c8cc9","journal-title":"Crit Care Med"},{"key":"2503_CR6","doi-asserted-by":"publisher","first-page":"R228","DOI":"10.1186\/cc13051","volume":"17","author":"F Saddy","year":"2013","unstructured":"Saddy F, Moraes L, Santos CL, Oliveira GP, Cruz FF, Morales MM, Capelozzi VL, Gama De Abreu M, Garcia CSNB, Pelosi P, Rocco PRM: Biphasic positive airway pressure minimizes biological impact on lung tissue in mild acute lung injury independent of etiology.\n                           Crit Care 2013, 17: R228. 10.1186\/cc13051","journal-title":"Crit Care"},{"key":"2503_CR7","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/S0891-5849(00)00454-8","volume":"30","author":"LA Callahan","year":"2001","unstructured":"Callahan LA, Stofan DA, Szweda LI, Nethery DE, Supinski GS: Free radicals alter maximal diaphragmatic mitochondrial oxygen consumption in endotoxin-induced sepsis.\n                           Free Radic Biol Med 2001, 30: 129-138. 10.1016\/S0891-5849(00)00454-8","journal-title":"Free Radic Biol Med"},{"key":"2503_CR8","doi-asserted-by":"publisher","first-page":"e333","DOI":"10.1016\/j.jss.2010.11.893","volume":"167","author":"BB Peruchi","year":"2011","unstructured":"Peruchi BB, Petronilho F, Rojas HA, Constantino L, Mina F, Vuolo F, Cardoso MR, Gon\u00e7alves CL, Rezin GT, Streck EL, Dal-Pizzol F: Skeletal muscle electron transport chain dysfunction after sepsis in rats.\n                           J Surg Res 2011, 167: e333-e338. 10.1016\/j.jss.2010.11.893","journal-title":"J Surg Res"},{"key":"2503_CR9","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1097\/CCM.0b013e318206cca9","volume":"39","author":"A Agden","year":"2011","unstructured":"Agden A, Maes K, Smuder A, Powers SK, Decramer M, Gayan-Ramirez G: N\n                           -Acetylcysteine protects the rat diaphragm from the decreased contractility associated with controlled mechanical ventilation.\n                           Crit Care Med 2011, 39: 777-782. 10.1097\/CCM.0b013e318206cca9","journal-title":"Crit Care Med"},{"key":"2503_CR10","doi-asserted-by":"publisher","first-page":"931903","DOI":"10.1155\/2010\/931903","volume":"2010","author":"M Brotto","year":"2010","unstructured":"Brotto M, Brotto L, Jin JP, Nosek TM, Romani A: Temporal adaptive changes in contractility and fatigability of diaphragm muscles from streptozotocin-diabetic rats.\n                           J Biomed Biotechnol 2010, 2010: 931903.","journal-title":"J Biomed Biotechnol"},{"key":"2503_CR11","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1186\/cc3992","volume":"10","author":"S Magder","year":"2006","unstructured":"Magder S: Reactive oxygen species: toxic molecules or spark of life?\n                           Crit Care 2006, 10: 208. 10.1186\/cc3992","journal-title":"Crit Care"},{"key":"2503_CR12","doi-asserted-by":"publisher","first-page":"112","DOI":"10.3181\/00379727-209-43885C","volume":"209","author":"JM McCord","year":"1995","unstructured":"McCord JM: Superoxide radical: controversies, contradictions, and paradoxes.\n                           Proc Soc Exp Biol Med 1995, 209: 112-117. 10.3181\/00379727-209-43885C","journal-title":"Proc Soc Exp Biol Med"},{"key":"2503_CR13","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1097\/SHK.0b013e31816a6e0f","volume":"30","author":"V Simkova","year":"2008","unstructured":"Simkova V, Baumgart K, Vogt JA, Wachter U, Weber S, Gr\u00f6ger M, Speit S, Radermacher P, Albuszies G, Barth E: The effect of SOD-1 over-expression on hepatic gluconeogenesis and whole-body glucose oxidation during resuscitated, normotensive murine septic shock.\n                           Shock 2008, 30: 578-584. 10.1097\/SHK.0b013e31816a6e0f","journal-title":"Shock"},{"key":"2503_CR14","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1097\/ALN.0000000000000125","volume":"120","author":"CS Bruells","year":"2014","unstructured":"Bruells CS, Maes K, Rossaint R, Thomas D, Cielen N, Bergs I, Bleilevens C, Weis J, Gayan-ramirez G: Sedation using propofol induces similar diaphragm dysfunction and atrophy during spontaneous breathing and mechanical ventilation in rats.\n                           Anesthesiology 2014, 120: 665-672. 10.1097\/ALN.0000000000000125","journal-title":"Anesthesiology"},{"key":"2503_CR15","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1164\/ajrccm.165.2.2108041","volume":"165","author":"S Ebihara","year":"2002","unstructured":"Ebihara S, Hussan SNA, Ganialou G, Cho WK, Gottfried SB, Petrof BJ: Mechanical ventilation protects against diaphragm injury in sepsis.\n                           Am J Respir Crit Care Med 2002, 165: 221-228. 10.1164\/ajrccm.165.2.2108041","journal-title":"Am J Respir Crit Care Med"},{"key":"2503_CR16","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s00134-002-1629-3","volume":"29","author":"XM Leverve","year":"2003","unstructured":"Leverve XM: Hyperglycemia and oxidative stress complex relationships with attractive prospects.\n                           Intensive Care Med 2003, 29: 511-514.","journal-title":"Intensive Care Med"},{"key":"2503_CR17","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1097\/CCM.0b013e31819cec17","volume":"37","author":"I Vanhorebeek","year":"2009","unstructured":"Vanhorebeek I, Ellger B, De Vos R, Boussemaere M, Debaveye Y, Van der Perre S, Rabbani N, Thornally PJ, Van den Berghe G: Tissue specific glucose toxicity induces mitochondrial damage in a burn injury model of critical illness.\n                           Crit Care Med 2009, 37: 1355-1364. 10.1097\/CCM.0b013e31819cec17","journal-title":"Crit Care Med"},{"key":"2503_CR18","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/2197-425X-2-19","volume":"2","author":"JA Vogt","year":"2014","unstructured":"Vogt JA, Wachter U, Wagner K, Calzia E, Gr\u00f6ger M, Weber S, Stahl B, Georgieff M, Asfar P, Fontaine E, Radermacher P, Leverve XM, Wagner F: Effects of glycemic control on glucose utilization and mitochondrial respiration during resuscitated murine septic shock.\n                           Intensive Care Med Exp 2014, 2: 19. 10.1186\/2197-425X-2-19","journal-title":"Intensive Care Med Exp"}],"container-title":["Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/cc13913.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/cc13913\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/cc13913.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T16:09:56Z","timestamp":1728922196000},"score":1,"resource":{"primary":{"URL":"https:\/\/ccforum.biomedcentral.com\/articles\/10.1186\/cc13913"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,10]]},"references-count":18,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,6]]}},"alternative-id":["2503"],"URL":"https:\/\/doi.org\/10.1186\/cc13913","relation":{},"ISSN":["1364-8535"],"issn-type":[{"value":"1364-8535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,10]]},"assertion":[{"value":"10 June 2014","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"149"}}