{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:30:34Z","timestamp":1790847034316,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2014,6,20]],"date-time":"2014-06-20T00:00:00Z","timestamp":1403222400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2014,6,20]],"date-time":"2014-06-20T00:00:00Z","timestamp":1403222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Crit Care"],"abstract":"Abstract<\/jats:title>\n \n Introduction<\/jats:title>\n Inherited variability in host immune responses influences susceptibility and outcome of Influenza A virus (IAV) infection, but these factors remain largely unknown. Components of the innate immune response may be crucial in the first days of the infection. The collectins surfactant protein (SP)-A1, -A2, and -D and mannose-binding lectin (MBL) neutralize IAV infectivity, although only SP-A2 can establish an efficient neutralization of poorly glycosylated pandemic IAV strains.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We studied the role of polymorphic variants at the genes of MBL (\n MBL2<\/jats:italic>\n ), SP-A1 (\n SFTPA1<\/jats:italic>\n ), SP-A2 (\n SFTPA2<\/jats:italic>\n ), and SP-D (\n SFTPD<\/jats:italic>\n ) in 93 patients with H1N1 pandemic 2009 (H1N1pdm) infection.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Multivariate analysis showed that two frequent\n SFTPA2<\/jats:italic>\n missense alleles (rs1965708-\n C<\/jats:italic>\n and rs1059046-\n A<\/jats:italic>\n ) and the\n SFTPA2<\/jats:italic>\n haplotype\n 1A<\/jats:italic>\n \n 0<\/jats:italic>\n <\/jats:sup>\n were associated with a need for mechanical ventilation, acute respiratory failure, and acute respiratory distress syndrome. The\n SFTPA2<\/jats:italic>\n haplotype\n 1A<\/jats:italic>\n \n 1<\/jats:italic>\n <\/jats:sup>\n was a protective variant. Kaplan-Meier analysis and Cox regression also showed that diplotypes not containing the\n 1A<\/jats:italic>\n \n 1<\/jats:italic>\n <\/jats:sup>\n haplotype were associated with a significantly shorter time to ICU admission in hospitalized patients. In addition, rs1965708-\n C<\/jats:italic>\n (\n P<\/jats:italic>\n \u2009=\u20090.0007), rs1059046-\n A<\/jats:italic>\n (\n P<\/jats:italic>\n \u2009=\u20090.0007), and haplotype\n 1A<\/jats:italic>\n \n 0<\/jats:italic>\n <\/jats:sup>\n (\n P<\/jats:italic>\n \u2009=\u20090.0004) were associated, in a dose-dependent fashion, with lower PaO\n 2<\/jats:sub>\n \/FiO\n 2<\/jats:sub>\n ratio, whereas haplotype\n 1A<\/jats:italic>\n \n 1<\/jats:italic>\n <\/jats:sup>\n was associated with a higher PaO\n 2<\/jats:sub>\n \/FiO\n 2<\/jats:sub>\n ratio (\n P<\/jats:italic>\n \u2009=\u20090.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Our data suggest an effect of genetic variants of\n SFTPA2<\/jats:italic>\n on the severity of H1N1pdm infection and could pave the way for a potential treatment with haplotype-specific (\n 1A<\/jats:italic>\n \n 1<\/jats:italic>\n <\/jats:sup>\n ) SP-A2 for future IAV pandemics.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1186\/cc13934","type":"journal-article","created":{"date-parts":[[2014,6,20]],"date-time":"2014-06-20T05:04:00Z","timestamp":1403240640000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Surfactant protein A genetic variants associate with severe respiratory insufficiency in pandemic influenza A virus infection"],"prefix":"10.1186","volume":"18","author":[{"given":"Estefan\u00eda","family":"Herrera-Ramos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"L\u00f3pez-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Juan","family":"Ru\u00edz-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan 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