{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:59:55Z","timestamp":1791280795134,"version":"4.1.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2004,5,14]],"date-time":"2004-05-14T00:00:00Z","timestamp":1084492800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2004,5,14]],"date-time":"2004-05-14T00:00:00Z","timestamp":1084492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Crit Care"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Introduction<\/jats:title>\n                        <jats:p>Sepsis and severe sepsis are asociated with high hospital mortality. Little is known about the occurrence of sepsis in general hospital populations. The goal of the present study was to reveal the epidemiology of sepsis in Norwegian hospitals over 1 year.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>Patients admitted to all Norwegian hospitals during 1999 (<jats:italic>n<\/jats:italic> = 700,107) were analyzed by searching the database of the Norwegian Patient Registry for markers of sepsis, using International Classification of Diseases (ICD)-10 codes for sepsis and severe infections. In patients with such diagnoses, demographic data, hospital outcome data and ICD-10 codes for organ dysfunction were also retrieved. Sepsis was further classified as primary or secondary, and severe (sepsis with vital organ dysfunction) or nonsevere. The age-adjusted mortality rate, and the sepsis rates for all hospital admissions and in the Norwegian population were calculated.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>A total of 6665 patients were classified as having sepsis, and of these 2121 (31.8%) had severe sepsis. The most frequent failing organ system was the circulatory system, and 1562 had septic shock. Mortality increased from 7.1% (in those with no documented organ dysfunction) to 71.8% (in those with three or more organ dysfunctions). The mean mortality was 13.5%, and the mortality of severe sepsis was 27%. The incidence of sepsis was 9.5\/1000 hospital admissions and 1.49\/1000 inhabitants in 1999.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusion<\/jats:title>\n                        <jats:p>Sepsis is not uncommon in Norwegian hospitals and is associated with high hospital mortality, which is similar to recent findings from the USA. Awareness of sepsis and its appropriate treatment is mandatory in Norway if we are to reduce mortality from sepsis by 25% in the next 5 years.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/cc2867","type":"journal-article","created":{"date-parts":[[2004,5,18]],"date-time":"2004-05-18T06:22:49Z","timestamp":1084861369000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Epidemiology of sepsis in Norway in 1999"],"prefix":"10.1186","volume":"8","author":[{"given":"Hans","family":"Flaatten","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2004,5,14]]},"reference":[{"key":"2866_CR1","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1097\/00003246-200107000-00002","volume":"29","author":"DC Angus","year":"2001","unstructured":"Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR: Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care.\n                           Crit Care Med 2001, 29: 1303-1310. 10.1097\/00003246-200107000-00002","journal-title":"Crit Care Med"},{"key":"2866_CR2","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1056\/NEJMoa022139","volume":"348","author":"GS Martin","year":"2003","unstructured":"Martin GS, Mannino DM, Eaton S, Moss M: The epidemiology of sepsis in the United States from 1979 through 2000.\n                           N Engl J Med 2003, 348: 1546-1554. 10.1056\/NEJMoa022139","journal-title":"N Engl J Med"},{"key":"2866_CR3","unstructured":"World Health Organization:The International Statistical Classification of Diseases and Related Health Problems, tenth revision [http:\/\/www.who.int\/whosis\/icd10\/]"},{"key":"2866_CR4","unstructured":"NOMESCO:NOMESCO Classification of Surgical Procedures (NCSP) [in Norwegian] [http:\/\/www.pubcare.uu.se\/nordwho\/]"},{"key":"2866_CR5","unstructured":"Statistics Norway: Mean population, sex and age distribution [in Norwegian].[http:\/\/www.ssb.no\/folkemengde\/arkiv\/tab-2000-04-11-44.html]"},{"key":"2866_CR6","volume-title":"Patient Data","author":"Sintef","year":"1999","unstructured":"Sintef:Patient Data 1999. [in Norwegian] [http:\/\/www.npr.no\/Somatikk\/index.htm]"},{"key":"2866_CR7","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1378\/chest.101.6.1644","volume":"101","author":"R Bone","year":"1992","unstructured":"Bone R, Balk R, Cerra J: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP\/SCCM Consensus Conference Committee. American College of Chest Physicians\/Society of Critical Care Medicine.\n                           Chest 1992, 101: 1644-1655.","journal-title":"Chest"},{"key":"2866_CR8","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1186\/cc2194","volume":"7","author":"J Vincent","year":"2003","unstructured":"Vincent J, Opal S, Torres A, Bonten M, Cohen J, Wunderink R: The PIRO concept: I is for infection.\n                           Critical Care 2003, 7: 252-255. 10.1186\/cc2194","journal-title":"Critical Care"},{"key":"2866_CR9","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1056\/NEJM200103083441001","volume":"344","author":"GR Bernard","year":"2001","unstructured":"Bernard GR, Vincent JL, Laterre PF, LaRosa SP, Dhainaut JF, Lopez-Rodriguez A, Steingrub JS, Garber GE, Helterbrand JD, Ely EW, Fisher CJ Jr, Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group: Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis.\n                           N Engl J Med 2001, 344: 699-709. 10.1056\/NEJM200103083441001","journal-title":"N Engl J Med"},{"key":"2866_CR10","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1093\/clinids\/19.2.246","volume":"19","author":"JB Haug","year":"1994","unstructured":"Haug JB, Harthug S, Kalager T, Digranes A, Solberg CO: Bloodstream infections at a Norwegian university hospital, 1974\u20131979 and 1988\u20131989: changing etiology, clinical features, and outcome.\n                           Clin Infect Dis 1994, 19: 246-256.","journal-title":"Clin Infect Dis"},{"key":"2866_CR11","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1007\/s00134-001-1143-z","volume":"28","author":"C Alberti","year":"2002","unstructured":"Alberti C, Brun-Buisson C, Burchardi H, Martin C, Goodman S, Artigas A, Sicignano A, Palazzo M, Moreno R, Boulme R, Lepage E, Le Gall R: Epidemiology of sepsis and infection in ICU patients from an international multicentre cohort study.\n                           Intensive Care Med 2002, 28: 108-121. 10.1007\/s00134-001-1143-z","journal-title":"Intensive Care Med"},{"key":"2866_CR12","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1001\/jama.1995.03530120060042","volume":"274","author":"C Brun-Buisson","year":"1995","unstructured":"Brun-Buisson C, Doyon F, Carlet J, Dellamonica P, Gouin F, Lepoutre A, Mercier JC, Offenstadt G, Regnier B: Incidence, risk factors, and outcome of severe sepsis and septic shock in adults. A multicenter prospective study in intensive care units. French ICU Group for Severe Sepsis.\n                           JAMA 1995, 274: 968-974. 10.1001\/jama.274.12.968","journal-title":"JAMA"},{"key":"2866_CR13","first-page":"589","volume":"30","author":"SBR Finfer","year":"2004","unstructured":"Finfer SBR, Lipman J, French C, Dobb G, Myburgh J: Adult-population incidence of severe sepsis in Australian and New Zealand intensive care units.\n                           ICM 2004, 30: 589-596.","journal-title":"ICM"},{"key":"2866_CR14","first-page":"2102","volume":"114","author":"S Hallan","year":"1994","unstructured":"Hallan S, Naustdal T: Bacteremia at a medium-sized Norwegian hospital.\n                           Tidsskr Nor Laegeforen 1994, 114: 2102-2106.","journal-title":"Tidsskr Nor Laegeforen"},{"key":"2866_CR15","first-page":"121","volume":"23","author":"S Deeks","year":"1997","unstructured":"Deeks S, Kertesz D, Ryan A, Johnson W, Ashton F: Surveillance of invasive meningococcal disease in Canada, 1995\u20131996.\n                           Can Commun Dis Rep 1997, 23: 121-125.","journal-title":"Can Commun Dis Rep"},{"key":"2866_CR16","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3109\/00365548709032375","volume":"19","author":"A Halstensen","year":"1987","unstructured":"Halstensen A, Pedersen SH, Haneberg B, Bjorvatn B, Solberg CO: Case fatality of meningococcal disease in western Norway.\n                           Scand J Infect Dis 1987, 19: 35-42.","journal-title":"Scand J Infect Dis"},{"key":"2866_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/cc1876","volume":"7","author":"E Slade","year":"2003","unstructured":"Slade E, Tamber PS, Vincent JL: The Surviving Sepsis Campaign: raising awareness to reduce mortality.\n                           Crit Care 2003, 7: 1-2. 10.1186\/cc1876","journal-title":"Crit Care"}],"container-title":["Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/cc2867.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/cc2867\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/cc2867.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T12:13:43Z","timestamp":1728303223000},"score":1,"resource":{"primary":{"URL":"https:\/\/ccforum.biomedcentral.com\/articles\/10.1186\/cc2867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5,14]]},"references-count":17,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2004,8]]}},"alternative-id":["2866"],"URL":"https:\/\/doi.org\/10.1186\/cc2867","relation":{},"ISSN":["1364-8535"],"issn-type":[{"value":"1364-8535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,5,14]]},"assertion":[{"value":"21 January 2004","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2004","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 May 2004","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"R180"}}