{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T13:30:09Z","timestamp":1767706209875},"reference-count":6,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2004,10,27]],"date-time":"2004-10-27T00:00:00Z","timestamp":1098835200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2004,10,27]],"date-time":"2004-10-27T00:00:00Z","timestamp":1098835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Crit Care"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Differences in the composition of ventricular and lumbar cerebrospinal fluid (CSF) based on single pairs of samples have previously been described. We describe a patient that developed post-surgical recurrent meningitis monitored by daily biochemical and bacteriological CSF analysis, simultaneously withdrawn from lumbar space and ventricles. A 20-year-old Caucasian man was admitted to the ICU after a resection of a chordoma that extended from the sphenoidal sinus to the anterior face of C2. CSF was continuously leaking into the pharyngeal cavity after surgery, and three episodes of recurrent meningitis, all due to <jats:italic>Pseudomonas aeruginosa<\/jats:italic> O12, occurred. Our case showed permanent ventricular-to-lumbar CSF gradients of leukocytes, protein and glucose that were increased during the acute phase of meningitis, with the greatest amplitude being observed when bacteria were present in both ventricular and lumbar CSF. This might suggest a greater extent of meningeal inflammation in the lumbar than in the ventricular region. Our case also showed that the increase in intravenous antibiotics (cefepim from 8 to 12 g\/day and ciprofloxacine from 1.2 to 2.4 g\/day) led to an increase in concentration in plasma but not in CSF.<\/jats:p>","DOI":"10.1186\/cc2972","type":"journal-article","created":{"date-parts":[[2004,10,28]],"date-time":"2004-10-28T16:38:47Z","timestamp":1098981527000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Case report: Greater meningeal inflammation in lumbar than in ventricular region in human bacterial meningitis"],"prefix":"10.1186","volume":"8","author":[{"given":"Walid","family":"Naija","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaquim","family":"Mat\u00e9o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Raskine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Fran\u00e7ois","family":"Timsit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Claire","family":"Lukascewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"George","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Payen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Mebazaa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2004,10,27]]},"reference":[{"key":"2951_CR1","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1097\/00006123-200207000-00024","volume":"51","author":"A Lozier","year":"2002","unstructured":"Lozier A, Sciacca R, Romagnoli M, Connolly EJ: Ventriculostomy-related infections: a critical review of the literature.\n                           Neurosurgery 2002, 51: 170-181. 10.1097\/00006123-200207000-00024","journal-title":"Neurosurgery"},{"key":"2951_CR2","doi-asserted-by":"publisher","first-page":"1710","DOI":"10.1212\/WNL.51.6.1710","volume":"51","author":"J Gerber","year":"1998","unstructured":"Gerber J, Tumani H, Kolenda H, Nau R: Lumbar and ventricular CSF protein, leukocytes, and lactate in suspected bacterial CNS infections.\n                           Neurology 1998, 51: 1710-1714.","journal-title":"Neurology"},{"key":"2951_CR3","first-page":"94","volume-title":"In The Cerebrospinal Fluid","author":"H Merritt","year":"1938","unstructured":"Merritt H, Fremont-Smith F: Acute purulent meningitis. 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A prospective study in patients with external ventricular drainage.\n                           Eur Neurol 2002, 47: 224-232. 10.1159\/000057904","journal-title":"Eur Neurol"},{"key":"2951_CR5","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1128\/iai.41.1.275-279.1983","volume":"41","author":"J Ernst","year":"1983","unstructured":"Ernst J, Decazes J, Sande M: Experimental pneumococcal meningitis: role of leukocytes in pathogenesis.\n                           Infect Immun 1983, 41: 275-279.","journal-title":"Infect Immun"},{"key":"2951_CR6","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1128\/AAC.31.6.899","volume":"31","author":"M Wolff","year":"1987","unstructured":"Wolff M, Boutron L, Singlas E, Clair B, Decazes J, Regnier B: Penetration of ciprofloxacin into cerebrospinal fluid of patients with bacterial meningitis.\n                           Antimicrob Agents Chemother 1987, 31: 899-902.","journal-title":"Antimicrob Agents Chemother"}],"container-title":["Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/cc2972.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/cc2972\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/cc2972.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T12:12:52Z","timestamp":1728303172000},"score":1,"resource":{"primary":{"URL":"https:\/\/ccforum.biomedcentral.com\/articles\/10.1186\/cc2972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10,27]]},"references-count":6,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2004,12]]}},"alternative-id":["2951"],"URL":"https:\/\/doi.org\/10.1186\/cc2972","relation":{},"ISSN":["1364-8535"],"issn-type":[{"type":"electronic","value":"1364-8535"}],"subject":[],"published":{"date-parts":[[2004,10,27]]},"assertion":[{"value":"1 September 2004","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 September 2004","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 October 2004","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"R491"}}