{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:27:01Z","timestamp":1790803621012,"version":"4.1.0"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2005,1,21]],"date-time":"2005-01-21T00:00:00Z","timestamp":1106265600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2005,1,21]],"date-time":"2005-01-21T00:00:00Z","timestamp":1106265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Crit Care"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Objective<\/jats:title>\n                        <jats:p>To test the ability of a novel super high-flux (SHF) membrane with a larger pore size to clear myoglobin from serum.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Setting<\/jats:title>\n                        <jats:p>The intensive care unit of a university teaching hospital.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Subject<\/jats:title>\n                        <jats:p>A patient with serotonin syndrome complicated by severe rhabodomyolysis and oliguric acute renal failure<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Method<\/jats:title>\n                        <jats:p>Initially continuous veno-venous hemofiltration was performed at 2 l\/hour ultrafiltration (UF) with a standard polysulphone 1.4 m<jats:sup>2<\/jats:sup> membrane (cutoff point, 20 kDa), followed by continuous veno-venous hemofiltration with a SHF membrane (cutoff point, 100 kDa) at 2 l\/hour UF, then at 3 l\/hour UF and then at 4 l\/hour UF, in an attempt to clear myoglobin.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>The myoglobin concentration in the ultrafiltrate at 2 l\/hour exchange was at least five times greater with the SHF membrane than with the conventional membrane (&gt;100,000 \u03bcg\/l versus 23,003 \u03bcg\/l). The sieving coefficients with the SHF membrane at 3 l\/hour UF and 4 l\/hour UF were 72.2% and 68.8%, respectively. The amount of myoglobin removed with the conventional membrane was 1.1 g\/day compared with 4.4\u20135.1 g\/day for the SHF membrane. The SHF membrane achieved a clearance of up to 56.4 l\/day, and achieved a reduction in serum myoglobin concentration from &gt;100,000 \u03bcg\/l to 16,542 \u03bcg\/l in 48 hours.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>SHF hemofiltration achieved a much greater clearance of myoglobin than conventional hemofiltration, and it may provide a potential modality for the treatment of myoglobinuric acute renal failure.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/cc3034","type":"journal-article","created":{"date-parts":[[2005,1,21]],"date-time":"2005-01-21T13:34:26Z","timestamp":1106314466000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":100,"title":["Myoglobin clearance by super high-flux hemofiltration in a case of severe rhabdomyolysis: a case 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