{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T04:14:47Z","timestamp":1728360887751},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2005,7,8]],"date-time":"2005-07-08T00:00:00Z","timestamp":1120780800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2005,7,8]],"date-time":"2005-07-08T00:00:00Z","timestamp":1120780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Crit Care"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Introduction<\/jats:title>\n                        <jats:p>The base deficit is a useful tool for quantifying total acid\u2013base derangement, but cannot differentiate between various aetiologies. The Stewart\u2013Fencl equations for strong ions and albumin have recently been abbreviated; we hypothesised that the abbreviated equations could be applied to the base deficit, thus partitioning this parameter into three components (the residual being the contribution from unmeasured anions).<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>The two abbreviated equations were applied retrospectively to blood gas and chemistry results in 374 samples from a cohort of 60 children with meningococcal septic shock (mean pH 7.31, mean base deficit -7.4 meq\/L). Partitioning required the simultaneous measurement of plasma sodium, chloride, albumin and blood gas analysis.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>After partitioning for the effect of chloride and albumin, the residual base deficit was closely associated with unmeasured anions derived from the full Stewart\u2013Fencl equations (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> = 0.83, <jats:italic>y<\/jats:italic> = 1.99 \u2013 0.87<jats:italic>x<\/jats:italic>, standard error of the estimate = 2.29 meq\/L). Hypoalbuminaemia was a common finding; partitioning revealed that this produced a relatively consistent alkalinising effect on the base deficit (effect +2.9 \u00b1 2.2 meq\/L (mean \u00b1 SD)). The chloride effect was variable, producing both acidification and alkalinisation in approximately equal proportions (50% and 43%, respectively); furthermore the magnitude of this effect was substantial in some patients (SD \u00b1 5.0 meq\/L).<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusion<\/jats:title>\n                        <jats:p>It is now possible to partition the base deficit at the bedside with enough accuracy to permit clinical use. This provides valuable information on the aetiology of acid\u2013base disturbance when applied to a cohort of children with meningococcal sepsis.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/cc3760","type":"journal-article","created":{"date-parts":[[2005,7,8]],"date-time":"2005-07-08T22:27:24Z","timestamp":1120861644000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Validation of a method to partition the base deficit in meningococcal sepsis: a retrospective study"],"prefix":"10.1186","volume":"9","author":[{"given":"Ellen","family":"O'Dell","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shane M","family":"Tibby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Durward","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo","family":"Aspell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian A","family":"Murdoch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2005,7,8]]},"reference":[{"key":"3705_CR1","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/S0749-0704(01)00012-4","volume":"18","author":"PM Gauthier","year":"2002","unstructured":"Gauthier PM, Szerlip HM: Metabolic acidosis in the intensive care unit. 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