{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:31:17Z","timestamp":1759336277911},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Crit Care"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Introduction<\/jats:title>\n                        <jats:p>Postoperative care after oesophageal tumour resection holds a high risk of respiratory complications. We therefore aimed to determine the value of systemic inflammatory markers in predicting arterial hypoxaemia as the earliest sign of developing lung injury after oesophageal tumour resection.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>In a prospective observational study, 33 consecutive patients were observed for three days (T1\u2013T3) after admission (T0) to an intensive care unit following oesophageal tumour resection. The daily highest values of the heart rate, axillary temperature, leukocyte count and PaCO<jats:sub>2<\/jats:sub> were recorded. Serum C-reactive protein and procalcitonin concentrations and the leukocyte antisedimentation rate (LAR) were determined at T1 and T2. Respiratory function was monitored 6-hourly measurement of the PaO<jats:sub>2<\/jats:sub>\/FIO<jats:sub>2<\/jats:sub> ratio, and the lowest value was recorded at T3. Patients were categorised as normoxaemic or hypoxaemic using the cutoff value of 300 mmHg for PaO<jats:sub>2<\/jats:sub>\/FIO<jats:sub>2<\/jats:sub>.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>Seventeen out of 33 patients were classified as hypoxaemic and 16 patients as normoxaemic at T3. Increases of temperature at T0 and of the procalcitonin and LAR values at T2 were predictive of hypoxaemia at T3 (<jats:italic>P<\/jats:italic> &lt; 0.05, <jats:italic>P<\/jats:italic> &lt; 0.01 and <jats:italic>P<\/jats:italic> &lt; 0.001, respectively). The area under the receiver-operating characteristic curve was 0.65 for the temperature at T0, which was significantly lower than that for the procalcitonin level at T2 (0.83; 95% confidence interval, 0.69\u20130.97; <jats:italic>P<\/jats:italic> &lt; 0.01) and that for LAR at T2 (0.89; 95% confidence interval, 0.77\u20131.00; <jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusion<\/jats:title>\n                        <jats:p>These results suggest that an elevated LAR (&gt;15%) and an elevated procalcitonin concentration (&gt;2.5 ng\/ml) measured on the second postoperative day can predict next-day arterial hypoxaemia (PaO<jats:sub>2<\/jats:sub>\/FIO<jats:sub>2<\/jats:sub> &lt; 300 mmHg) after oesophageal tumour resection.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/cc4992","type":"journal-article","created":{"date-parts":[[2006,7,21]],"date-time":"2006-07-21T20:12:41Z","timestamp":1153512761000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Serum procalcitonin level and leukocyte antisedimentation rate as early predictors of respiratory dysfunction after oesophageal tumour resection"],"prefix":"10.1186","volume":"10","author":[{"given":"Lajos","family":"Bogar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zsolt","family":"Molnar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piroska","family":"Tarsoly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Kenyeres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandor","family":"Marton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"4513_CR1","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1136\/bmj.327.7425.1192","volume":"327 (7425)","author":"P McCulloch","year":"2003","unstructured":"McCulloch P, Ward J, Tekkis PP: Mortality and morbidity in gastro-oesophageal cancer surgery: initial results of ASCOT multicentre prospective cohort study.\n                           Br Med J 2003, 327 (7425): 1192-1197.","journal-title":"Br Med J"},{"key":"4513_CR2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/dote\/11.1.43","volume":"11","author":"AM Gillinov","year":"1998","unstructured":"Gillinov AM, Heitmiller RF: Strategies to reduce pulmonary complications after transhiatal esophagectomy.\n                           Dis Esophagus 1998, 11: 43-47.","journal-title":"Dis Esophagus"},{"key":"4513_CR3","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1046\/j.1365-2346.2000.00694.x","volume":"17","author":"Z Molnar","year":"2000","unstructured":"Molnar Z, Szakmany T, Koszegi T, Tekeres M: Microalbuminuria and serum procalcitonin levels following oesophagectomy.\n                           Eur J Anaesthesiol 2000, 17: 464-465. 10.1046\/j.1365-2346.2000.00694.x","journal-title":"Eur J Anaesthesiol"},{"key":"4513_CR4","doi-asserted-by":"publisher","first-page":"2172","DOI":"10.1097\/00003246-199910000-00016","volume":"27","author":"FM Brunkhorst","year":"1999","unstructured":"Brunkhorst FM, Eberhard OK, Brunkhorst R: Discrimination of infectious and noninfectious causes of early acute respiratory distress syndrome by procalcitonin.\n                           Crit Care Med 1999, 27: 2172-2176. 10.1097\/00003246-199910000-00016","journal-title":"Crit Care Med"},{"key":"4513_CR5","first-page":"13","volume-title":"Advances in critical care testing. 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