{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T05:44:01Z","timestamp":1778564641480,"version":"3.51.4"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2006,10,4]],"date-time":"2006-10-04T00:00:00Z","timestamp":1159920000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2006,10,4]],"date-time":"2006-10-04T00:00:00Z","timestamp":1159920000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Crit Care"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Introduction<\/jats:title>\n                        <jats:p>Elevated serum levels of S100\u03b2, an astrocyte-derived protein, correlate with unfavourable neurological outcomes following cardiac surgery, neurotrauma, and resuscitation. This study evaluated whether pre-\/postoperative serum S100\u03b2 levels correlate with unfavourable clinical and radiological findings in patients undergoing elective meningioma resection.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>In 52 consecutive patients admitted for meningioma surgery, serum S100\u03b2 levels were determined upon admission and immediately, 24 hours, and 48 hours after surgery. All patients underwent complete pre- and postoperative neurological examination and mini-mental state examination. Radiological evaluation included preoperative magnetic resonance imaging (MRI) and postoperative computed tomography. Tumour volume, brain edema, and bleeding volume were calculated using BrainSCAN\u2122 software.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>Preoperative S100\u03b2 levels did not correlate with the tumour characteristics demonstrated by preoperative MRI (for example, tumour volume, edema volume, ventricular asymmetry, and\/or midline shift). Preoperative serum S100\u03b2 levels (0.065 \u00b1 0.040 \u03bcg\/l) were significantly lower than the levels measured immediately (0.138 \u00b1 0.081 \u03bcg\/l), 24 hours (0.142 \u00b1 0.084 \u03bcg\/l), and 48 hours (0.155 \u00b1 0.119 \u03bcg\/l) postoperatively (<jats:italic>p<\/jats:italic> &lt; 0.0001). Significantly greater postcraniotomy S100\u03b2 levels were observed with prolonged surgery (<jats:italic>p<\/jats:italic> = 0.039), deterioration in the mini-mental state examination (<jats:italic>p<\/jats:italic> = 0.005, 0.011, and 0.036 for pre versus immediate, 24 hours, and 48 hours postsurgery, respectively), and with postoperative brain computed tomography evidence of brain injury; bleeding was associated with higher serum S100\u03b2 levels at 24 and 48 hours after surgery (<jats:italic>p<\/jats:italic> = 0.046, 95% confidence interval [CI] -0.095 to -0.001 and <jats:italic>p<\/jats:italic> = 0.034, 95% CI -0.142 to -0.006, respectively) as was the presence of midline shift (<jats:italic>p<\/jats:italic> = 0.005, 95% CI -0.136 to -0.025 and <jats:italic>p<\/jats:italic> = 0.006, 95% CI -0.186 to -0.032, respectively). Edema was associated with higher serum S100\u03b2 levels immediately (<jats:italic>p<\/jats:italic> = 0.022, 95% CI -0.092 to -0.007) and at 48 hours after surgery (<jats:italic>p<\/jats:italic> = 0.017, 95% CI -0.142 to -0.026). The degree of elevation in S100\u03b2 levels at 24 and 48 hours after surgery also correlated with the severity of midline shift and edema.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusion<\/jats:title>\n                        <jats:p>In patients with meningioma, serum S100\u03b2 levels perform poorly as an indicator of tumour characteristics but may suggest ongoing postcraniotomy injury. Serum S100\u03b2 levels may serve as a potentially useful early marker of postcraniotomy brain damage in patients undergoing elective meningioma resection.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/cc5058","type":"journal-article","created":{"date-parts":[[2006,10,4]],"date-time":"2006-10-04T18:26:31Z","timestamp":1159986391000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Early postoperative serum S100\u03b2 levels predict ongoing brain damage after meningioma surgery: a prospective observational 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