{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:25:58Z","timestamp":1791289558173,"version":"4.3.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2007,11,6]],"date-time":"2007-11-06T00:00:00Z","timestamp":1194307200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2007,11,6]],"date-time":"2007-11-06T00:00:00Z","timestamp":1194307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Crit Care"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Introduction<\/jats:title>\n                        <jats:p>The receptor for advanced glycation end products (RAGE), a multi-ligand member of the immunoglobulin superfamily, contributes to acute and chronic disease processes, including sepsis.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>We studied the possible therapeutic role of RAGE inhibition in the cecal ligation and puncture (CLP) model of polymicrobial sepsis and a model of systemic listeriosis using mice genetically deficient in RAGE expression or mice injected with a rat anti-murine RAGE monoclonal antibody.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>The 7-day survival rates after CLP were 80% for RAGE<jats:sup>-\/-<\/jats:sup> mice (<jats:italic>n<\/jats:italic> = 15) (<jats:italic>P<\/jats:italic> &lt; 0.01 versus wild-type), 69% for RAGE<jats:sup>+\/-<\/jats:sup> mice (<jats:italic>n<\/jats:italic> = 23), and 37% for wild-type mice (<jats:italic>n<\/jats:italic> = 27). Survival benefits were evident in BALB\/c mice given anti-RAGE antibody (<jats:italic>n<\/jats:italic> = 15 per group) over serum-treated control animals (<jats:italic>P<\/jats:italic> &lt; 0.05). Moreover, delayed treatment with anti-RAGE antibody up to 24 hours after CLP resulted in a significant survival benefit compared with control mice. There was no significant increase in tissue colony counts from enteric Gram-negative or Gram-positive bacteria in animals treated with anti-RAGE antibody. RAGE<jats:sup>-\/-<\/jats:sup>, RAGE<jats:sup>+\/-<\/jats:sup>, and anti-RAGE antibody-treated animals were resistant to lethality from <jats:italic>Listeria monocytogenes<\/jats:italic> by almost two orders of magnitude compared with wild-type mice.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusion<\/jats:title>\n                        <jats:p>Further studies are warranted to determine the clinical utility of anti-RAGE antibody as a novel treatment for sepsis.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/cc6184","type":"journal-article","created":{"date-parts":[[2007,11,27]],"date-time":"2007-11-27T19:13:57Z","timestamp":1196190837000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":142,"title":["Inhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection"],"prefix":"10.1186","volume":"11","author":[{"given":"Emily C","family":"Lutterloh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M","family":"Opal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra D","family":"Pittman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"James C","family":"Keith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Yang","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian M","family":"Clancy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Milarski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E","family":"Palardy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas A","family":"Parejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noubar","family":"Kessimian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,11,6]]},"reference":[{"key":"5608_CR1","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1146\/annurev.med.56.082103.104356","volume":"56","author":"TW Rice","year":"2005","unstructured":"Rice TW, Bernard GR: Therapeutic intervention and targets for sepsis.\n                           Annu Rev Med 2005, 56: 225-248. 10.1146\/annurev.med.56.082103.104356","journal-title":"Annu Rev Med"},{"key":"5608_CR2","doi-asserted-by":"publisher","first-page":"502","DOI":"10.7326\/0003-4819-138-6-200303180-00016","volume":"138","author":"AS Cross","year":"2003","unstructured":"Cross AS, Opal SM: A new paradigm for the treatment of sepsis: is it time to consider combination therapy?\n            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August 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2007","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2007","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2007","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"R122"}}