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Hyperoncotic albumin solutions, long in clinical use, are suitable for small-volume resuscitation; however, their clinical benefits remain uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Randomized clinical trials comparing hyperoncotic albumin with a control regimen for volume expansion were sought by multiple methods, including computer searches of bibliographic databases, perusal of reference lists, and manual searching. Major findings were qualitatively summarized. In addition, a quantitative meta-analysis was performed on available survival data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In all, 25 randomized clinical trials with a total of 1,485 patients were included. In surgery, hyperoncotic albumin preserved renal function and reduced intestinal edema compared with control fluids. In trauma and sepsis, cardiac index and oxygenation were higher after administration of hydroxyethyl starch than hyperoncotic albumin. Improved treatment response and renal function, shorter hospital stay and lower costs of care were reported in patients with liver disease receiving hyperoncotic albumin. Edema and morbidity were decreased in high-risk neonates after hyperoncotic albumin administration. Disability was reduced by therapy with hyperoncotic albumin in brain injury. There was no evidence of deleterious effects attributable to hyperoncotic albumin. Survival was unaffected by hyperoncotic albumin (pooled relative risk, 0.95; 95% confidence interval 0.78 to 1.17).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In some clinical indications, randomized trial evidence has suggested certain benefits of hyperoncotic albumin such as reductions in morbidity, renal impairment and edema. However, further clinical trials are needed, particularly in surgery, trauma and sepsis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/cc6812","type":"journal-article","created":{"date-parts":[[2008,3,4]],"date-time":"2008-03-04T14:13:15Z","timestamp":1204639995000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Small-volume resuscitation with hyperoncotic albumin: a systematic review of randomized clinical trials"],"prefix":"10.1186","volume":"12","author":[{"given":"Matthias","family":"Jacob","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Chappell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Conzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahlon M","family":"Wilkes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard F","family":"Becker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Rehm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,3,4]]},"reference":[{"key":"6245_CR1","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1007\/s001010100143","volume":"50","author":"U Kreimeier","year":"2001","unstructured":"Kreimeier U, Peter K, Me\u00dfmer K: Small volume \u2013 large benefit?\n                           Anaesthesist 2001, 50: 442-449. 10.1007\/s001010100143","journal-title":"Anaesthesist"},{"key":"6245_CR2","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1097\/01.CCM.0000155986.01926.95","volume":"33","author":"D Bruegger","year":"2005","unstructured":"Bruegger D, Bauer A, Rehm M, Niklas M, Jacob M, Irlbeck M, Becker BF, Christ F: Effect of hypertonic saline dextran on acid-base balance in patients undergoing surgery of abdominal aortic aneurysm.\n                           Crit Care Med 2005, 33: 556-563. 10.1097\/01.CCM.0000155986.01926.95","journal-title":"Crit Care Med"},{"key":"6245_CR3","first-page":"785","volume":"40","author":"JT Heyl","year":"1942","unstructured":"Heyl JT, Janeway CA: The use of human albumin in military medicine. 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