{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:56:14Z","timestamp":1761540974737},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2010,6,14]],"date-time":"2010-06-14T00:00:00Z","timestamp":1276473600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2010,6,14]],"date-time":"2010-06-14T00:00:00Z","timestamp":1276473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Crit Care"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Introduction<\/jats:title>\n                        <jats:p>Cystatin C could be a relevant residual glomerular filtration rate marker during hemodialysis (HD), and a high cytokine plasma (p) rate is associated with an increase in mortality during sepsis. To the best of our knowledge, cytokines and cystatin C kinetics during and after HD during sepsis have never been studied. In this study, we described p cytokines and cystatin C variations during and after hemodialysis in septic-shock patients with acute kidney injury (AKI).<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>Ten patients, from two tertiary ICUs, with septic shock-related AKI, according to RIFLE class F, were studied. In this prospective observational study, blood samples were collected at the start, after 1 hour, 2 hours, and at the end of HD with a polymethymethacrylate (PMMA) hemodialyzer (D0, D1, D2, and endD), and 30, 60, 90, 120, and 180 min after HD (postD0.5, postD1, postD1.5, postD2, and postD3). We measured p interleukins (IL)-6, IL-8, IL-10, cystatin C, and albumin. Results are expressed as variations from D0 (mean \u00b1 SD).<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>During HD, p[IL-6] did not vary significantly, whereas p[IL-8] and p[IL-10] reductions by D1 were 31.8 \u00b1 21.2% and 36.3 \u00b1 26%, respectively (<jats:italic>P<\/jats:italic> &lt; 0.05 as compared with D0). At postD3, p[IL-8] and p[IL-10] returned to their initial values. p[Cystatin C] was significantly reduced from D1 to postD1, with a maximal reduction of 30 \u00b1 6.7% on D2 (<jats:italic>P<\/jats:italic> &lt; 0.05). Norepinephrine infusion rate decreased from D0 to postD3 (0.65 \u00b1 0.39 to 0.49 \u00b1 0.37 \u03bcg\/kg\/min; <jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>HD allows a transient and selective decrease in p cytokines, which are known as being correlated with mortality during septic shock. Because of a significant decrease in p cystatin C during HD, this should not be considered as an accurate marker for residual glomerular filtration rate during septic acute renal failure when receiving HD with a PMMA hemodialyzer.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/cc9064","type":"journal-article","created":{"date-parts":[[2010,6,15]],"date-time":"2010-06-15T06:15:40Z","timestamp":1276582540000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Kinetics of plasmatic cytokines and cystatin C during and after hemodialysis in septic shock-related acute renal failure"],"prefix":"10.1186","volume":"14","author":[{"given":"Nicolas","family":"Mayeur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lionel","family":"Rostaing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie B","family":"Nogier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Acil","family":"Jaafar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Cointault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nassim","family":"Kamar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean M","family":"Conil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Fourcade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Lavayssiere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,6,14]]},"reference":[{"key":"8493_CR1","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1001\/jama.294.7.813","volume":"294","author":"S Uchino","year":"2005","unstructured":"Uchino S, Kellum JA, Bellomo R, Doig GS, Morimatsu H, Morgera S, Schetz M, Tan I, Bouman C, Macedo E, Gibney N, Tolwani A, Ronco C: Acute renal failure in critically ill patients: a multinational, multicenter study.\n                           JAMA 2005, 294: 813-818. 10.1001\/jama.294.7.813","journal-title":"JAMA"},{"key":"8493_CR2","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1056\/NEJMra021333","volume":"348","author":"RS Hotchkiss","year":"2003","unstructured":"Hotchkiss RS, Karl IE: The pathophysiology and treatment of sepsis.\n                           N Engl J Med 2003, 348: 138-150. 10.1056\/NEJMra021333","journal-title":"N Engl J Med"},{"key":"8493_CR3","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1038\/nature01326","volume":"420","author":"J Cohen","year":"2002","unstructured":"Cohen J: The immunopathogenesis of sepsis.\n                           Nature 2002, 420: 885-891. 10.1038\/nature01326","journal-title":"Nature"},{"key":"8493_CR4","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1046\/j.1523-1755.2002.00509.x","volume":"62","author":"G Clermont","year":"2002","unstructured":"Clermont G, Acker CG, Angus DC, Sirio CA, Pinsky MR, Johnson JP: Renal failure in the ICU: comparison of the impact of acute renal failure and end-stage renal disease on ICU outcomes.\n                           Kidney Int 2002, 62: 986-996. 10.1046\/j.1523-1755.2002.00509.x","journal-title":"Kidney Int"},{"key":"8493_CR5","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1111\/j.1523-1755.2004.00512.x","volume":"65","author":"EM Simmons","year":"2004","unstructured":"Simmons EM, Himmelfarb J, Sezer MT, Chertow GM, Mehta RL, Paganini EP, Soroko S, Freedman S, Becker K, Spratt D, Shyr Y, Ikizler TA: Plasma cytokine levels predict mortality in patients with acute renal failure.\n                           Kidney Int 2004, 65: 1357-1365. 10.1111\/j.1523-1755.2004.00512.x","journal-title":"Kidney Int"},{"key":"8493_CR6","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1001\/archinte.167.15.1655","volume":"167","author":"JA Kellum","year":"2007","unstructured":"Kellum JA, Kong L, Fink MP, Weissfeld LA, Yealy DM, Pinsky MR, Fine J, Krichevsky A, Delude RL, Angus DC: Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study.\n                           Arch Intern Med 2007, 167: 1655-1663. 10.1001\/archinte.167.15.1655","journal-title":"Arch Intern Med"},{"key":"8493_CR7","first-page":"488","volume":"23","author":"A Oberholzer","year":"2005","unstructured":"Oberholzer A, Souza SM, Tschoeke SK, Oberholzer C, Abouhamze A, Pribble JP, Moldawer LL: Plasma cytokine measurements augment prognostic scores as indicators of outcome in patients with severe sepsis.\n                           Shock 2005, 23: 488-493.","journal-title":"Shock"},{"key":"8493_CR8","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1016\/S0140-6736(05)60606-X","volume":"351","author":"JT van Dissel","year":"1998","unstructured":"van Dissel JT, van Langevelde P, Westendorp RG, Kwappenberg K, Frolich M: Anti-inflammatory cytokine profile and mortality in febrile patients.\n                           Lancet 1998, 351: 950-953.","journal-title":"Lancet"},{"key":"8493_CR9","doi-asserted-by":"publisher","first-page":"2110","DOI":"10.1097\/01.ccm.0000281447.22966.8b","volume":"35","author":"C Schmidt","year":"2007","unstructured":"Schmidt C, Hocherl K, Schweda F, Bucher M: Proinflammatory cytokines cause down-regulation of renal chloride entry pathways during sepsis.\n                           Crit Care Med 2007, 35: 2110-2119. 10.1097\/01.ccm.0000281447.22966.8b","journal-title":"Crit Care Med"},{"key":"8493_CR10","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1056\/NEJM199102143240701","volume":"324","author":"EJ Ziegler","year":"1991","unstructured":"Ziegler EJ, Fisher CJ Jr, Sprung CL, Straube RC, Sadoff JC, Foulke GE, Wortel CH, Fink MP, Dellinger RP, Teng NN, et al.: Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin: a randomized, double-blind, placebo-controlled trial: the HA-1A Sepsis Study Group.\n                           N Engl J Med 1991, 324: 429-436. 10.1056\/NEJM199102143240701","journal-title":"N Engl J Med"},{"key":"8493_CR11","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1056\/NEJM199606273342603","volume":"334","author":"CJ Fisher Jr","year":"1996","unstructured":"Fisher CJ Jr, Agosti JM, Opal SM, Lowry SF, Balk RA, Sadoff JC, Abraham E, Schein RM, Benjamin E: Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein: the Soluble TNF Receptor Sepsis Study Group.\n                           N Engl J Med 1996, 334: 1697-1702. 10.1056\/NEJM199606273342603","journal-title":"N Engl J Med"},{"key":"8493_CR12","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1056\/NEJM199703273361311","volume":"336","author":"HS Warren","year":"1997","unstructured":"Warren HS: Strategies for the treatment of sepsis.\n                           N Engl J Med 1997, 336: 952-953. 10.1056\/NEJM199703273361311","journal-title":"N Engl J Med"},{"key":"8493_CR13","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1007\/s001340050981","volume":"25","author":"AS De Vriese","year":"1999","unstructured":"De Vriese AS, Vanholder RC, Pascual M, Lameire NH, Colardyn FA: Can inflammatory cytokines be removed efficiently by continuous renal replacement therapies?\n                           Intensive Care Med 1999, 25: 903-910. 10.1007\/s001340050981","journal-title":"Intensive Care Med"},{"key":"8493_CR14","doi-asserted-by":"publisher","first-page":"3581","DOI":"10.1097\/00003246-200011000-00001","volume":"28","author":"PM Honore","year":"2000","unstructured":"Honore PM, Jamez J, Wauthier M, Lee PA, Dugernier T, Pirenne B, Hanique G, Matson JR: Prospective evaluation of short-term, high-volume isovolemic hemofiltration on the hemodynamic course and outcome in patients with intractable circulatory failure resulting from septic shock.\n                           Crit Care Med 2000, 28: 3581-3587. 10.1097\/00003246-200011000-00001","journal-title":"Crit Care Med"},{"key":"8493_CR15","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1053\/j.ajkd.2007.05.003","volume":"50","author":"M Haase","year":"2007","unstructured":"Haase M, Bellomo R, Baldwin I, Haase-Fielitz A, Fealy N, Davenport P, Morgera S, Goehl H, Storr M, Boyce N, Neumayer HH: Hemodialysis membrane with a high-molecular-weight cutoff and cytokine levels in sepsis complicated by acute renal failure: a phase 1 randomized trial.\n                           Am J Kidney Dis 2007, 50: 296-304. 10.1053\/j.ajkd.2007.05.003","journal-title":"Am J Kidney Dis"},{"key":"8493_CR16","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/S0272-6386(96)90549-1","volume":"27","author":"M Leblanc","year":"1996","unstructured":"Leblanc M, Charbonneau R, Lalumiere G, Cartier P, Deziel C: Postdialysis urea rebound: determinants and influence on dialysis delivery in chronic hemodialysis patients.\n                           Am J Kidney Dis 1996, 27: 253-261. 10.1016\/S0272-6386(96)90549-1","journal-title":"Am J Kidney Dis"},{"issue":"Suppl 6","key":"8493_CR17","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1093\/ndt\/13.suppl_6.25","volume":"13","author":"S Alloatti","year":"1998","unstructured":"Alloatti S, Molino A, Manes M, Bosticardo GM: Urea rebound and effectively delivered dialysis dose.\n                           Nephrol Dial Transplant 1998,13(Suppl 6):25-30. 10.1093\/ndt\/13.suppl_6.25","journal-title":"Nephrol Dial Transplant"},{"key":"8493_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.clinbiochem.2004.09.025","volume":"38","author":"G Filler","year":"2005","unstructured":"Filler G, Bokenkamp A, Hofmann W, Le Bricon T, Martinez-Bru C, Grubb A: Cystatin C as a marker of GFR: history, indications, and future research.\n                           Clin Biochem 2005, 38: 1-8. 10.1016\/j.clinbiochem.2004.09.025","journal-title":"Clin Biochem"},{"key":"8493_CR19","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1097\/01.shk.0000225415.5969694.ce","volume":"26","author":"RJ Trof","year":"2006","unstructured":"Trof RJ, Di Maggio F, Leemreis J, Groeneveld AB: Biomarkers of acute renal injury and renal failure.\n                           Shock 2006, 26: 245-253. 10.1097\/01.shk.0000225415.5969694.ce","journal-title":"Shock"},{"key":"8493_CR20","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1053\/j.ajkd.2008.04.022","volume":"52","author":"A Mulay","year":"2008","unstructured":"Mulay A, Biyani M, Akbari A: Cystatin C and residual renal function in patients on peritoneal dialysis.\n                           Am J Kidney Dis 2008, 52: 194-195. author reply, 195-196 10.1053\/j.ajkd.2008.04.022","journal-title":"Am J Kidney Dis"},{"key":"8493_CR21","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1093\/ndt\/gfm027","volume":"22","author":"FJ Hoek","year":"2007","unstructured":"Hoek FJ, Korevaar JC, Dekker FW, Boeschoten EW, Krediet RT: Estimation of residual glomerular filtration rate in dialysis patients from the plasma cystatin C level.\n                           Nephrol Dial Transplant 2007, 22: 1633-1638. 10.1093\/ndt\/gfm027","journal-title":"Nephrol Dial Transplant"},{"key":"8493_CR22","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1378\/chest.101.6.1644","volume":"101","author":"RC Bone","year":"1992","unstructured":"Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RM, Sibbald WJ: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis: The ACCP\/SCCM Consensus Conference Committee: American College of Chest Physicians\/Society of Critical Care Medicine.\n                           Chest 1992, 101: 1644-1655. 10.1378\/chest.101.6.1644","journal-title":"Chest"},{"key":"8493_CR23","doi-asserted-by":"publisher","first-page":"R204","DOI":"10.1186\/cc2872","volume":"8","author":"R Bellomo","year":"2004","unstructured":"Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P: Acute renal failure: definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group.\n                           Crit Care 2004, 8: R204-R212. 10.1186\/cc2872","journal-title":"Crit Care"},{"key":"8493_CR24","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1007\/s00134-004-2398-y","volume":"30","author":"RP Dellinger","year":"2004","unstructured":"Dellinger RP, Carlet JM, Masur H, Gerlach H, Calandra T, Cohen J, Gea-Banacloche J, Keh D, Marshall JC, Parker MM, Ramsay G, Zimmerman JL, Vincent JL, Levy MM: Surviving sepsis campaign guidelines for management of severe sepsis and septic shock.\n                           Intensive Care Med 2004, 30: 536-555. 10.1007\/s00134-004-2398-y","journal-title":"Intensive Care Med"},{"key":"8493_CR25","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1164\/ajrccm.162.1.9907098","volume":"162","author":"F Schortgen","year":"2000","unstructured":"Schortgen F, Soubrier N, Delclaux C, Thuong M, Girou E, Brun-Buisson C, Lemaire F, Brochard L: Hemodynamic tolerance of intermittent hemodialysis in critically ill patients: usefulness of practice guidelines.\n                           Am J Respir Crit Care Med 2000, 162: 197-202.","journal-title":"Am J Respir Crit Care Med"},{"key":"8493_CR26","doi-asserted-by":"publisher","first-page":"257","DOI":"10.2119\/2007-00108.Nakada","volume":"14","author":"TA Nakada","year":"2008","unstructured":"Nakada TA, Oda S, Matsuda K, Sadahiro T, Nakamura M, Abe R, Hirasawa H: Continuous hemodiafiltration with PMMA Hemofilter in the treatment of patients with septic shock.\n                           Mol Med 2008, 14: 257-263. 10.2119\/2007-00108.Nakada","journal-title":"Mol Med"},{"key":"8493_CR27","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1111\/j.1523-1755.2005.67138.x","volume":"67","author":"F Galli","year":"2005","unstructured":"Galli F, Benedetti S, Floridi A, Canestrari F, Piroddi M, Buoncristiani E, Buoncristiani U: Glycoxidation and inflammatory markers in patients on treatment with PMMA-based protein-leaking dialyzers.\n                           Kidney Int 2005, 67: 750-759. 10.1111\/j.1523-1755.2005.67138.x","journal-title":"Kidney Int"},{"key":"8493_CR28","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1159\/000094779","volume":"26","author":"I Ishikawa","year":"2006","unstructured":"Ishikawa I, Chikazawa Y, Sato K, Nakagawa M, Imamura H, Hayama S, Yamaya H, Asaka M, Tomosugi N, Yokoyama H, Matsumoto K: Proteomic analysis of serum, outflow dialysate and adsorbed protein onto dialysis membranes (polysulfone and PMMA) during hemodialysis treatment using SELDI-TOF-MS.\n                           Am J Nephrol 2006, 26: 372-380. 10.1159\/000094779","journal-title":"Am J Nephrol"},{"issue":"Suppl 5","key":"8493_CR29","doi-asserted-by":"publisher","first-page":"v8","DOI":"10.1093\/ndt\/gfm293","volume":"22","author":"F Aucella","year":"2007","unstructured":"Aucella F, Vigilante M, Gesuete A, Maruccio G, Specchio A, Gesualdo L: Uraemic itching: do polymethylmethacrylate dialysis membranes play a role?\n                           Nephrol Dial Transplant 2007,22(Suppl 5):v8-v12. 10.1093\/ndt\/gfm293","journal-title":"Nephrol Dial Transplant"},{"key":"8493_CR30","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1681\/ASN.2006080821","volume":"18","author":"CA Hutchison","year":"2007","unstructured":"Hutchison CA, Cockwell P, Reid S, Chandler K, Mead GP, Harrison J, Hattersley J, Evans ND, Chappell MJ, Cook M, Goehl H, Storr M, Bradwell AR: Efficient removal of immunoglobulin free light chains by hemodialysis for multiple myeloma: in vitro and in vivo studies.\n                           J Am Soc Nephrol 2007, 18: 886-895. 10.1681\/ASN.2006080821","journal-title":"J Am Soc Nephrol"},{"key":"8493_CR31","doi-asserted-by":"publisher","first-page":"R49","DOI":"10.1186\/cc5783","volume":"11","author":"FA Bozza","year":"2007","unstructured":"Bozza FA, Salluh JI, Japiassu AM, Soares M, Assis EF, Gomes RN, Bozza MT, Castro-Faria-Neto HC, Bozza PT: Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis.\n                           Crit Care 2007, 11: R49. 10.1186\/cc5783","journal-title":"Crit Care"},{"key":"8493_CR32","first-page":"S8","volume-title":"Kidney Int Suppl","author":"C Ronco","year":"1999","unstructured":"Ronco C, Brendolan A, Bellomo R: Online monitoring in continuous renal replacement therapies.\n                           Kidney Int Suppl 1999, S8-14. 10.1046\/j.1523-1755.56.s72.11.x"},{"key":"8493_CR33","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1007\/BF01709399","volume":"16","author":"B Stein","year":"1990","unstructured":"Stein B, Pfenninger E, Grunert A, Schmitz JE, Hudde M: Influence of continuous haemofiltration on haemodynamics and central blood volume in experimental endotoxic shock.\n                           Intensive Care Med 1990, 16: 494-499. 10.1007\/BF01709399","journal-title":"Intensive Care Med"},{"key":"8493_CR34","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/BF01709839","volume":"18","author":"AF Grootendorst","year":"1992","unstructured":"Grootendorst AF, van Bommel EF, van der Hoven B, van Leengoed LA, van Osta AL: High volume hemofiltration improves right ventricular function in endotoxin-induced shock in the pig.\n                           Intensive Care Med 1992, 18: 235-240. 10.1007\/BF01709839","journal-title":"Intensive Care Med"},{"key":"8493_CR35","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1007\/s001340050330","volume":"23","author":"P Heering","year":"1997","unstructured":"Heering P, Morgera S, Schmitz FJ, Schmitz G, Willers R, Schultheiss HP, Strauer BE, Grabensee B: Cytokine removal and cardiovascular hemodynamics in septic patients with continuous venovenous hemofiltration.\n                           Intensive Care Med 1997, 23: 288-296. 10.1007\/s001340050330","journal-title":"Intensive Care Med"},{"key":"8493_CR36","first-page":"150","volume":"15","author":"K Klouche","year":"2002","unstructured":"Klouche K, Cavadore P, Portales P, Clot J, Canaud B, Beraud JJ: Continuous veno-venous hemofiltration improves hemodynamics in septic shock with acute renal failure without modifying TNFalpha and IL6 plasma concentrations.\n                           J Nephrol 2002, 15: 150-157.","journal-title":"J Nephrol"}],"container-title":["Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/cc9064.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/cc9064\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/cc9064.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T12:12:37Z","timestamp":1728303157000},"score":1,"resource":{"primary":{"URL":"https:\/\/ccforum.biomedcentral.com\/articles\/10.1186\/cc9064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,14]]},"references-count":36,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2010,6]]}},"alternative-id":["8493"],"URL":"https:\/\/doi.org\/10.1186\/cc9064","relation":{},"ISSN":["1364-8535"],"issn-type":[{"type":"electronic","value":"1364-8535"}],"subject":[],"published":{"date-parts":[[2010,6,14]]},"assertion":[{"value":"11 November 2009","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 March 2010","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2010","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2010","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"R115"}}