{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T04:59:12Z","timestamp":1769835552306,"version":"3.49.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2010,7,20]],"date-time":"2010-07-20T00:00:00Z","timestamp":1279584000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2010,7,20]],"date-time":"2010-07-20T00:00:00Z","timestamp":1279584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Crit Care"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Introduction<\/jats:title>\n                        <jats:p>There are only limited data on the long-term outcome of patients receiving specialized neurocritical care. In this study we analyzed survival, long-term mortality and functional outcome after neurocritical care and determined predictors for good functional outcome.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>We retrospectively investigated 796 consecutive patients admitted to a non-surgical neurologic intensive care unit over a period of two years (2006 and 2007). Demographic and clinical parameters were analyzed. Depending on the diagnosis, we grouped patients according to their diseases (cerebral ischemia, intracranial hemorrhage (ICH), subarachnoid hemorrhage (SAH), meningitis\/encephalitis, epilepsy, Guillain-Barr\u00e9 syndrome (GBS) and myasthenia gravis (MG), neurodegenerative diseases and encephalopathy, cerebral neoplasm and intoxication). Clinical parameters, mortality and functional outcome of all treated patients were analyzed. Functional outcome (using the modified Rankin Scale, mRS) one year after discharge was assessed by a mailed questionnaire or telephone interview. Outcome was dichotomized into good (mRS \u2264 2) and poor (mRS \u2265 3). Logistic regression analyses were calculated to determine independent predictors for good functional outcome.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>Overall in-hospital mortality amounted to 22.5% of all patients, and a good long-term functional outcome was achieved in 28.4%. The parameters age, length of ventilation (LOV), admission diagnosis of ICH, GBS\/MG, and inoperable cerebral neoplasm as well as Therapeutic Intervention Scoring System (TISS)-28 on Day 1 were independently associated with functional outcome after one year.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>This investigation revealed that age, LOV and TISS-28 on Day 1 were strongly predictive for the outcome. The diagnoses of hemorrhagic stroke and cerebral neoplasm leading to neurocritical care predispose for functional dependence or death, whereas patients with GBS and MG are more likely to recover after neurocritical care.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/cc9192","type":"journal-article","created":{"date-parts":[[2010,8,4]],"date-time":"2010-08-04T23:21:38Z","timestamp":1280964098000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Predictors for good functional outcome after neurocritical care"],"prefix":"10.1186","volume":"14","author":[{"given":"Ines C","family":"Kiphuth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter D","family":"Schellinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"K\u00f6hrmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Bardutzky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannes","family":"L\u00fccking","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Kloska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Schwab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hagen B","family":"Huttner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,7,20]]},"reference":[{"key":"8600_CR1","doi-asserted-by":"publisher","first-page":"1922","DOI":"10.1097\/01.CCM.0000178184.97813.52","volume":"33","author":"CM Martin","year":"2005","unstructured":"Martin CM, Hill AD, Burns K, Chen LM: Characteristics and outcomes for critically ill patients with prolonged intensive care unit stays. Crit Care Med. 2005, 33: 1922-1927. 10.1097\/01.CCM.0000178184.97813.52. quiz 1936","journal-title":"Crit Care Med"},{"key":"8600_CR2","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1097\/01.CCM.0000146132.29042.4C","volume":"32","author":"JI Suarez","year":"2004","unstructured":"Suarez JI, Zaidat OO, Suri MF, Feen ES, Lynch G, Hickman J, Georgiadis A, Selman WR: Length of stay and mortality in neurocritically ill patients: impact of a specialized neurocritical care team. Crit Care Med. 2004, 32: 2311-2317.","journal-title":"Crit Care Med"},{"key":"8600_CR3","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.1097\/01.ccm.0000281449.07719.2b","volume":"35","author":"G Broessner","year":"2007","unstructured":"Broessner G, Helbok R, Lackner P, Mitterberger M, Beer R, Engelhardt K, Brenneis C, Pfausler B, Schmutzhard E: Survival and long-term functional outcome in 1,155 consecutive neurocritical care patients. Crit Care Med. 2007, 35: 2025-2030. 10.1097\/01.ccm.0000281449.07719.2b.","journal-title":"Crit Care Med"},{"key":"8600_CR4","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1097\/00003246-197403000-00001","volume":"2","author":"DJ Cullen","year":"1974","unstructured":"Cullen DJ, Civetta JM, Briggs BA, Ferrara LC: Therapeutic intervention scoring system: a method for quantitative comparison of patient care. Crit Care Med. 1974, 2: 57-60. 10.1097\/00003246-197403000-00001.","journal-title":"Crit Care Med"},{"key":"8600_CR5","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1161\/01.STR.0000153055.43138.2f","volume":"36","author":"JG Merino","year":"2005","unstructured":"Merino JG, Lattimore SU, Warach S: Telephone assessment of stroke outcome is reliable. Stroke. 2005, 36: 232-233. 10.1161\/01.STR.0000153055.43138.2f.","journal-title":"Stroke"},{"key":"8600_CR6","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1159\/000210548","volume":"61","author":"M Kohrmann","year":"2009","unstructured":"Kohrmann M, Huttner HB, Nowe T, Schellinger PD, Schwab S: Mechanical Ventilation in Guillain-Barre Syndrome: Does Age Influence Functional Outcome?. Eur Neurol. 2009, 61: 358-363. 10.1159\/000210548.","journal-title":"Eur Neurol"},{"key":"8600_CR7","doi-asserted-by":"publisher","first-page":"2518","DOI":"10.1161\/STROKEAHA.107.485649","volume":"38","author":"E Juttler","year":"2007","unstructured":"Juttler E, Schwab S, Schmiedek P, Unterberg A, Hennerici M, Woitzik J, Witte S, Jenetzky E, Hacke W: Decompressive Surgery for the Treatment of Malignant Infarction of the Middle Cerebral Artery (DESTINY): a randomized, controlled trial. Stroke. 2007, 38: 2518-2525. 10.1161\/STROKEAHA.107.485649.","journal-title":"Stroke"},{"key":"8600_CR8","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1161\/hs0202.102376","volume":"33","author":"S Schwarz","year":"2002","unstructured":"Schwarz S, Georgiadis D, Aschoff A, Schwab S: Effects of body position on intracranial pressure and cerebral perfusion in patients with large hemispheric stroke. Stroke. 2002, 33: 497-501. 10.1161\/hs0202.102376.","journal-title":"Stroke"},{"key":"8600_CR9","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1161\/STROKEAHA.108.526566","volume":"40","author":"S Nagel","year":"2009","unstructured":"Nagel S, Schellinger PD, Hartmann M, Juettler E, Huttner HB, Ringleb P, Schwab S, Kohrmann M: Therapy of acute basilar artery occlusion: intraarterial thrombolysis alone vs bridging therapy. Stroke. 2009, 40: 140-146. 10.1161\/STROKEAHA.108.526566.","journal-title":"Stroke"},{"key":"8600_CR10","doi-asserted-by":"publisher","first-page":"2286","DOI":"10.1007\/s00330-009-1390-x","volume":"19","author":"T Struffert","year":"2009","unstructured":"Struffert T, Kohrmann M, Engelhorn T, Nowe T, Richter G, Schellinger PD, Schwab S, Doerfler A: Penumbra Stroke System as an \"add-on\" for the treatment of large vessel occlusive disease following thrombolysis: first results. Eur Radiol. 2009, 19: 2286-2293. 10.1007\/s00330-009-1390-x.","journal-title":"Eur Radiol"},{"key":"8600_CR11","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1161\/01.STR.0000251795.02560.62","volume":"38","author":"HB Huttner","year":"2007","unstructured":"Huttner HB, Nagel S, Tognoni E, Kohrmann M, Juttler E, Orakcioglu B, Schellinger PD, Schwab S, Bardutzky J: Intracerebral hemorrhage with severe ventricular involvement: lumbar drainage for communicating hydrocephalus. Stroke. 2007, 38: 183-187. 10.1161\/01.STR.0000251795.02560.62.","journal-title":"Stroke"},{"key":"8600_CR12","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1111\/j.1468-1331.2008.02077.x","volume":"15","author":"HB Huttner","year":"2008","unstructured":"Huttner HB, Tognoni E, Bardutzky J, Hartmann M, Kohrmann M, Kanter IC, Juttler E, Schellinger PD, Schwab S: Influence of intraventricular fibrinolytic therapy with rt-PA on the long-term outcome of treated patients with spontaneous basal ganglia hemorrhage: a case-control study. Eur J Neurol. 2008, 15: 342-349. 10.1111\/j.1468-1331.2008.02077.x.","journal-title":"Eur J Neurol"},{"key":"8600_CR13","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1385\/NCC:5:3:193","volume":"5","author":"HB Huttner","year":"2006","unstructured":"Huttner HB, Schwab S, Bardutzky J: Lumbar drainage for communicating hydrocephalus after ICH with ventricular hemorrhage. Neurocrit Care. 2006, 5: 193-196. 10.1385\/NCC:5:3:193.","journal-title":"Neurocrit Care"},{"key":"8600_CR14","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1007\/s12028-007-9009-z","volume":"8","author":"KZ Guluma","year":"2008","unstructured":"Guluma KZ, Oh H, Yu SW, Meyer BC, Rapp K, Lyden PD: Effect of endovascular hypothermia on acute ischemic edema: morphometric analysis of the ICTuS trial. Neurocrit Care. 2008, 8: 42-47. 10.1007\/s12028-007-9009-z.","journal-title":"Neurocrit Care"},{"key":"8600_CR15","doi-asserted-by":"publisher","first-page":"e10","DOI":"10.1016\/j.ijcard.2006.07.086","volume":"117","author":"M Kordouni","year":"2007","unstructured":"Kordouni M, Jibrini M, Siddiqui MA: Long-term transvenous temporary pacing with active fixation bipolar lead in the management of severe autonomic dysfunction in Miller-Fisher syndrome: a case report. Int J Cardiol. 2007, 117: e10-12. 10.1016\/j.ijcard.2006.07.086.","journal-title":"Int J Cardiol"},{"key":"8600_CR16","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.jocn.2008.08.033","volume":"16","author":"S Vucic","year":"2009","unstructured":"Vucic S, Kiernan MC, Cornblath DR: Guillain-Barre syndrome: an update. J Clin Neurosci. 2009, 16: 733-741. 10.1016\/j.jocn.2008.08.033.","journal-title":"J Clin Neurosci"},{"key":"8600_CR17","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1097\/00003246-200103000-00031","volume":"29","author":"MN Diringer","year":"2001","unstructured":"Diringer MN, Edwards DF: Admission to a neurologic\/neurosurgical intensive care unit is associated with reduced mortality rate after intracerebral hemorrhage. Crit Care Med. 2001, 29: 635-640. 10.1097\/00003246-200103000-00031.","journal-title":"Crit Care Med"},{"key":"8600_CR18","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1097\/00008506-200104000-00004","volume":"13","author":"MA Mirski","year":"2001","unstructured":"Mirski MA, Chang CW, Cowan R: Impact of a neuroscience intensive care unit on neurosurgical patient outcomes and cost of care: evidence-based support for an intensivist-directed specialty ICU model of care. J Neurosurg Anesthesiol. 2001, 13: 83-92. 10.1097\/00008506-200104000-00004.","journal-title":"J Neurosurg Anesthesiol"},{"key":"8600_CR19","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/s12028-008-9051-5","volume":"9","author":"EM Bershad","year":"2008","unstructured":"Bershad EM, Feen ES, Hernandez OH, Suri MF, Suarez JI: Impact of a specialized neurointensive care team on outcomes of critically ill acute ischemic stroke patients. Neurocrit Care. 2008, 9: 287-292. 10.1007\/s12028-008-9051-5.","journal-title":"Neurocrit Care"},{"key":"8600_CR20","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.jcrc.2009.01.008","volume":"24","author":"J Fichet","year":"2009","unstructured":"Fichet J, Mercier E, Genee O, Garot D, Legras A, Dequin PF, Perrotin D: Prognosis and 1-year mortality of intensive care unit patients with severe hepatic encephalopathy. J Crit Care. 2009, 24: 364-370. 10.1016\/j.jcrc.2009.01.008.","journal-title":"J Crit Care"},{"key":"8600_CR21","doi-asserted-by":"publisher","first-page":"R55","DOI":"10.1186\/cc5915","volume":"11","author":"WH Hartl","year":"2007","unstructured":"Hartl WH, Wolf H, Schneider CP, Kuchenhoff H, Jauch KW: Acute and long-term survival in chronically critically ill surgical patients: a retrospective observational study. Crit Care. 2007, 11: R55-10.1186\/cc5915.","journal-title":"Crit Care"},{"key":"8600_CR22","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1007\/s00134-005-2744-8","volume":"31","author":"TA Williams","year":"2005","unstructured":"Williams TA, Dobb GJ, Finn JC, Webb SA: Long-term survival from intensive care: a review. Intensive Care Med. 2005, 31: 1306-1315. 10.1007\/s00134-005-2744-8.","journal-title":"Intensive Care Med"},{"key":"8600_CR23","doi-asserted-by":"publisher","first-page":"3758","DOI":"10.1002\/cncr.24413","volume":"115","author":"FM Iwamoto","year":"2009","unstructured":"Iwamoto FM, Cooper AR, Reiner AS, Nayak L, Abrey LE: Glioblastoma in the elderly: the Memorial Sloan-Kettering Cancer Center Experience (1997-2007). Cancer. 2009, 115: 3758-3766. 10.1002\/cncr.24413.","journal-title":"Cancer"},{"key":"8600_CR24","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1159\/000050777","volume":"46","author":"HC Diener","year":"2001","unstructured":"Diener HC, Haupt WF, Kloss TM, Rosenow F, Philipp T, Koeppen S, Vietorisz A: A preliminary, randomized, multicenter study comparing intravenous immunoglobulin, plasma exchange, and immune adsorption in Guillain-Barre syndrome. Eur Neurol. 2001, 46: 107-109. 10.1159\/000050777.","journal-title":"Eur Neurol"},{"key":"8600_CR25","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1001\/archneur.58.6.893","volume":"58","author":"ND Lawn","year":"2001","unstructured":"Lawn ND, Fletcher DD, Henderson RD, Wolter TD, Wijdicks EF: Anticipating mechanical ventilation in Guillain-Barre syndrome. Arch Neurol. 2001, 58: 893-898. 10.1001\/archneur.58.6.893.","journal-title":"Arch Neurol"},{"key":"8600_CR26","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s12028-008-9139-y","volume":"10","author":"JY Wu","year":"2009","unstructured":"Wu JY, Kuo PH, Fan PC, Wu HD, Shih FY, Yang PC: The role of non-invasive ventilation and factors predicting extubation outcome in myasthenic crisis. Neurocrit Care. 2009, 10: 35-42. 10.1007\/s12028-008-9139-y.","journal-title":"Neurocrit Care"},{"key":"8600_CR27","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1097\/SMJ.0b013e31815d4398","volume":"101","author":"EM Bershad","year":"2008","unstructured":"Bershad EM, Feen ES, Suarez JI: Myasthenia gravis crisis. South Med J. 2008, 101: 63-69.","journal-title":"South Med J"},{"key":"8600_CR28","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/S1474-4422(08)70215-1","volume":"7","author":"PA van Doorn","year":"2008","unstructured":"van Doorn PA, Ruts L, Jacobs BC: Clinical features, pathogenesis, and treatment of Guillain-Barre syndrome. Lancet Neurol. 2008, 7: 939-950. 10.1016\/S1474-4422(08)70215-1.","journal-title":"Lancet Neurol"},{"key":"8600_CR29","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1111\/j.1528-1167.2007.01033.x","volume":"48","author":"FJ Bottaro","year":"2007","unstructured":"Bottaro FJ, Martinez OA, Pardal MM, Bruetman JE, Reisin RC: Nonconvulsive status epilepticus in the elderly: a case-control study. Epilepsia. 2007, 48: 966-972. 10.1111\/j.1528-1167.2007.01033.x.","journal-title":"Epilepsia"},{"key":"8600_CR30","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.ijid.2005.12.004","volume":"11","author":"A Faustini","year":"2007","unstructured":"Faustini A, Arca M, Fusco D, Perucci CA: Prognostic factors and determinants of fatal outcome due to bacterial meningitis in the Lazio region of Italy, 1996-2000. Int J Infect Dis. 2007, 11: 137-144. 10.1016\/j.ijid.2005.12.004.","journal-title":"Int J Infect Dis"},{"key":"8600_CR31","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/S1059-1311(02)00324-2","volume":"12","author":"E Garzon","year":"2003","unstructured":"Garzon E, Fernandes RM, Sakamoto AC: Analysis of clinical characteristics and risk factors for mortality in human status epilepticus. Seizure. 2003, 12: 337-345. 10.1016\/S1059-1311(02)00324-2.","journal-title":"Seizure"},{"key":"8600_CR32","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1136\/jnnp.2005.080887","volume":"77","author":"AO Rossetti","year":"2006","unstructured":"Rossetti AO, Hurwitz S, Logroscino G, Bromfield EB: Prognosis of status epilepticus: role of aetiology, age, and consciousness impairment at presentation. J Neurol Neurosurg Psychiatry. 2006, 77: 611-615. 10.1136\/jnnp.2005.080887.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"8600_CR33","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1212\/WNL.0b013e3181b8b332","volume":"73","author":"JC Hemphill","year":"2009","unstructured":"Hemphill JC, Farrant M, Neill TA: Prospective validation of the ICH Score for 12-month functional outcome. Neurology. 2009, 73: 1088-1094. 10.1212\/WNL.0b013e3181b8b332.","journal-title":"Neurology"},{"key":"8600_CR34","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1097\/01.CCM.0000129022.27323.DC","volume":"32","author":"U Corbanese","year":"2004","unstructured":"Corbanese U, Possamai C, Dal Cero P: Outcome of patients who underwent mechanical ventilation following intracerebral hemorrhage: is the glass really half full?. Crit Care Med. 2004, 32: 1431-10.1097\/01.CCM.0000129022.27323.DC.","journal-title":"Crit Care Med"},{"key":"8600_CR35","doi-asserted-by":"publisher","first-page":"2651","DOI":"10.1097\/01.CCM.0000094222.57803.B4","volume":"31","author":"A Roch","year":"2003","unstructured":"Roch A, Michelet P, Jullien AC, Thirion X, Bregeon F, Papazian L, Roche P, Pellet W, Auffray JP: Long-term outcome in intensive care unit survivors after mechanical ventilation for intracerebral hemorrhage. Crit Care Med. 2003, 31: 2651-2656. 10.1097\/01.CCM.0000094222.57803.B4.","journal-title":"Crit Care Med"},{"key":"8600_CR36","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1378\/chest.129.4.954","volume":"129","author":"KB Laupland","year":"2006","unstructured":"Laupland KB, Kirkpatrick AW, Kortbeek JB, Zuege DJ: Long-term mortality outcome associated with prolonged admission to the ICU. Chest. 2006, 129: 954-959. 10.1378\/chest.129.4.954.","journal-title":"Chest"},{"key":"8600_CR37","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1161\/01.STR.0000258355.23810.c6","volume":"38","author":"JL Banks","year":"2007","unstructured":"Banks JL, Marotta CA: Outcomes validity and reliability of the modified Rankin scale: implications for stroke clinical trials: a literature review and synthesis. Stroke. 2007, 38: 1091-1096. 10.1161\/01.STR.0000258355.23810.c6.","journal-title":"Stroke"},{"key":"8600_CR38","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.1185\/030079907X210444","volume":"23","author":"KF Huybrechts","year":"2007","unstructured":"Huybrechts KF, Caro JJ: The Barthel Index and modified Rankin Scale as prognostic tools for long-term outcomes after stroke: a qualitative review of the literature. Curr Med Res Opin. 2007, 23: 1627-1636. 10.1185\/030079907X210444.","journal-title":"Curr Med Res Opin"}],"container-title":["Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/cc9192.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/cc9192\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/cc9192.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,7]],"date-time":"2024-10-07T12:17:04Z","timestamp":1728303424000},"score":1,"resource":{"primary":{"URL":"https:\/\/ccforum.biomedcentral.com\/articles\/10.1186\/cc9192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,20]]},"references-count":38,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2010,8]]}},"alternative-id":["8600"],"URL":"https:\/\/doi.org\/10.1186\/cc9192","relation":{},"ISSN":["1364-8535"],"issn-type":[{"value":"1364-8535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,20]]},"assertion":[{"value":"5 February 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2010","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2010","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2010","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"R136"}}