{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:49:49Z","timestamp":1791107389092,"version":"4.1.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2010,11,23]],"date-time":"2010-11-23T00:00:00Z","timestamp":1290470400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"},{"start":{"date-parts":[[2010,11,23]],"date-time":"2010-11-23T00:00:00Z","timestamp":1290470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Crit Care"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                        <jats:title>Introduction<\/jats:title>\n                        <jats:p>A new system has been developed to assess global end-diastolic volume (GEDV), a volumetric marker of cardiac preload, and extravascular lung water (EVLW) from a transpulmonary thermodilution curve. Our goal was to compare this new system with the system currently in clinical use.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>Eleven anesthetized and mechanically ventilated pigs were instrumented with a central venous catheter and a right (PulsioCath; Pulsion, Munich, Germany) and a left (VolumeView\u2122; Edwards Lifesciences, Irvine, CA, USA) thermistor-tipped femoral arterial catheter. The right femoral catheter was used to measure GEDV and EVLW using the PiCCO<jats:sub>2<\/jats:sub>\u2122 (Pulsion) method (GEDV<jats:sub>1<\/jats:sub> and EVLW<jats:sub>1<\/jats:sub>, respectively). The left femoral catheter was used to measure the same parameters using the new VolumeView\u2122 (Edwards Lifesciences) method (GEDV<jats:sub>2<\/jats:sub> and EVLW<jats:sub>2<\/jats:sub>, respectively). Measurements were made during inotropic stimulation (dobutamine), during hypovolemia (bleeding), during hypervolemia (fluid overload), and after inducing acute lung injury (intravenous oleic acid).<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>One hundred and thirty-seven paired measurements were analyzed. GEDV<jats:sub>1<\/jats:sub> and GEDV<jats:sub>2<\/jats:sub> ranged from 701 to 1,629 ml and from 774 to 1,645 ml, respectively. GEDV<jats:sub>1<\/jats:sub> and GEDV<jats:sub>2<\/jats:sub> were closely correlated (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> = 0.79), with mean bias of -11 \u00b1 80 ml and percentage error of 14%. EVLW<jats:sub>1<\/jats:sub> and EVLW2 ranged from 507 to 2,379 ml and from 495 to 2,222 ml, respectively. EVLW<jats:sub>1<\/jats:sub> and EVLW<jats:sub>2<\/jats:sub> were closely correlated (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> = 0.97), with mean bias of -5 \u00b1 72 ml and percentage error of 15%.<\/jats:p>\n                     <\/jats:sec><jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>In animals, and over a very wide range of values, a good agreement was found between the new VolumeView\u2122 system and the PiCCO\u2122 system to assess GEDV and EVLW.<\/jats:p>\n                     <\/jats:sec>","DOI":"10.1186\/cc9332","type":"journal-article","created":{"date-parts":[[2010,11,23]],"date-time":"2010-11-23T19:14:02Z","timestamp":1290539642000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Validation of a new transpulmonary thermodilution system to assess global end-diastolic volume and extravascular lung water"],"prefix":"10.1186","volume":"14","author":[{"given":"Karim","family":"Bendjelid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Giraud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Siegenthaler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Michard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,11,23]]},"reference":[{"key":"8822_CR1","first-page":"508","volume-title":"Yearbook of Intensive Care and Emergency Medicine","author":"F Michard","year":"2003","unstructured":"Michard F, Perel A: Management of circulatory and respiratory failure using less invasive hemodynamic monitoring. 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