{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:17:43Z","timestamp":1791299863453,"version":"4.1.0"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2001,5,18]],"date-time":"2001-05-18T00:00:00Z","timestamp":990144000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2001,5,18]],"date-time":"2001-05-18T00:00:00Z","timestamp":990144000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Trials"],"DOI":"10.1186\/cvm-2-3-141","type":"journal-article","created":{"date-parts":[[2002,9,26]],"date-time":"2002-09-26T12:07:27Z","timestamp":1033042047000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Genetics University of Toronto Thrombophilia Study in Women (GUTTSI): genetic and other risk factors for venous thromboembolism in women"],"prefix":"10.1186","volume":"2","author":[{"given":"Joel G","family":"Ray","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loralie J","family":"Langman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian J","family":"Vermeulen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jovan","family":"Evrovski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik L","family":"Yeo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David EC","family":"Cole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2001,5,18]]},"reference":[{"key":"60_CR1","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1001\/archinte.160.6.809","volume":"160","author":"JA Heit","year":"2000","unstructured":"Heit JA, Silverstein MD, Mohr DN, Petterson TM, O'Fallon WM, Melton LJ: Risk factors for deep vein thrombosis and pulmonary embolism: a population-based case-control study. Arch Intern Med. 2000, 160: 809-815.","journal-title":"Arch Intern Med"},{"key":"60_CR2","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1001\/archinte.158.6.585","volume":"158","author":"MD Silverstein","year":"1998","unstructured":"Silverstein MD, Heit JA, Mohr DN, Petterson TM, O'Fallon WM, Melton LJ: Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. Arch Intern Med. 1998, 158: 585-593.","journal-title":"Arch Intern Med"},{"key":"60_CR3","doi-asserted-by":"publisher","first-page":"1886","DOI":"10.1001\/archinte.159.16.1886","volume":"159","author":"PO Hansson","year":"1999","unstructured":"Hansson PO, Eriksson H, Welin L, Svardsudd K, Wilhelmsen L: Smoking and abdominal obesity: risk factors for venous thromboembolism among middle-aged men: 'the study of men born in 1913'. Arch Intern Med. 1999, 159: 1886-1890.","journal-title":"Arch Intern Med"},{"key":"60_CR4","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1146\/annurev.med.51.1.169","volume":"51","author":"C Kearon","year":"2000","unstructured":"Kearon C, Crowther M, Hirsh J: Management of patients with hereditary hypercoagulable disorders. Annu Rev Med. 2000, 51: 169-185.","journal-title":"Annu Rev Med"},{"key":"60_CR5","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1055\/s-0038-1657675","volume":"78","author":"PJ Svensson","year":"1997","unstructured":"Svensson PJ, Benoni G, Fredin H, Bjorgell O, Nilsson P, Hedlund U, Nylander G, Bergqvist D, Dahlback B: Female gender and resistance to activated protein C (FV:Q506) as potential risk factors for thrombosis after elective hip arthroplasty. Thromb Haemost. 1997, 78: 993-996.","journal-title":"Thromb Haemost"},{"key":"60_CR6","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1093\/humupd\/5.6.688","volume":"5","author":"RD Farmer","year":"1999","unstructured":"Farmer RD, Lawrenson RA, Todd JC, Williams TJ, MacRae K: Oral contraceptives and venous thromboembolic disease. Analyses of the UK General Practice Research Database and the UK Mediplus database. Hum Reprod Update. 1999, 5: 688-706.","journal-title":"Hum Reprod Update"},{"key":"60_CR7","doi-asserted-by":"publisher","first-page":"2036","DOI":"10.1016\/S0140-6736(99)06092-4","volume":"354","author":"J Rosing","year":"1999","unstructured":"Rosing J, Middeldorp S, Curvers J, Christella M, Thomassen LG, Nicolaes GA, Meijers JC, Bouma BN, Buller HR, Prins MH, Tans G: Low-dose oral contraceptives and acquired resistance to activated protein C: a randomised cross-over study. Lancet. 1999, 354: 2036-2040.","journal-title":"Lancet"},{"key":"60_CR8","doi-asserted-by":"publisher","first-page":"689","DOI":"10.7326\/0003-4819-132-9-200005020-00002","volume":"132","author":"D Grady","year":"2000","unstructured":"Grady D, Wenger NK, Herrington D, Khan S, Furberg C, Hunninghake D, Vittinghoff E, Hulley S: Postmenopausal hormone therapy increases risk for venous thromboembolic disease. Ann Intern Med. 2000, 132: 689-696.","journal-title":"Ann Intern Med"},{"key":"60_CR9","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1046\/j.1365-2125.1998.00733.x","volume":"45","author":"CR Meier","year":"1998","unstructured":"Meier CR, Jick H: Tamoxifen and risk of idiopathic venous thromboembolism. Br J Clin Pharmacol. 1998, 45: 608-611. 10.1046\/j.1365-2125.1998.00733.x.","journal-title":"Br J Clin Pharmacol"},{"key":"60_CR10","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1056\/NEJM200002103420602","volume":"342","author":"A Gerhardt","year":"2000","unstructured":"Gerhardt A, Scharf RE, Beckmann MW, Struve S, Bender HG, Pillny M, Sandmann W, Zotz RB: Prothrombin and factor V mutations in women with a history of thrombosis during pregnancy and the puerperium. N Engl J Med. 2000, 342: 374-380.","journal-title":"N Engl J Med"},{"key":"60_CR11","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1111\/j.1471-0528.2000.tb13281.x","volume":"107","author":"MD McColl","year":"2000","unstructured":"McColl MD, Ellison , Reid F, Tait RC, Walker ID, Greer IA: Prothrombin 20210 G\u2192A, MTHFR C677T mutations in women with venous thromboembolism associated with pregnancy. Br J Obstet Gynaecol. 2000, 107: 565-569.","journal-title":"Br J Obstet Gynaecol"},{"key":"60_CR12","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1093\/ije\/21.1.48","volume":"21","author":"M Thorogood","year":"1992","unstructured":"Thorogood M, Mann J, Murphy M, Vessey M: Risk factors for fatal venous thromboembolism in young women: a case-control study. Int J Epidemiol. 1992, 21: 48-52.","journal-title":"Int J Epidemiol"},{"key":"60_CR13","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1006\/mgme.1998.2714","volume":"64","author":"I Weisberg","year":"1998","unstructured":"Weisberg I, Tran P, Christensen B, Sibani S, Rozen R: A second genetic polymorphism in methylenetetrahydrofolate reductase (MTHFR) associated with decreased enzyme activity. Mol Genet Metab. 1998, 64: 169-172. 10.1006\/mgme.1998.2714.","journal-title":"Mol Genet Metab"},{"key":"60_CR14","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/0026-0495(88)90076-5","volume":"37","author":"SS Kang","year":"1988","unstructured":"Kang SS, Wong PW, Zhou JM, Sora J, Lessick M, Ruggie N, Grcevich G: Thermolabile methylenetetrahydrofolate reductase in patients with coronary artery disease. Metabolism. 1988, 37: 611-613.","journal-title":"Metabolism"},{"key":"60_CR15","doi-asserted-by":"publisher","first-page":"2626","DOI":"10.1097\/00003246-199912000-00004","volume":"27","author":"C Martin","year":"1999","unstructured":"Martin C, Viviand X, Saux P, Gouin F: Upper-extremity deep vein thrombosis after central venous catheterization via the axillary vein. Crit Care Med. 1999, 27: 2626-2629.","journal-title":"Crit Care Med"},{"key":"60_CR16","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1001\/jama.1995.03530130055028","volume":"274","author":"CJ Boushey","year":"1995","unstructured":"Boushey CJ, Beresford SA, Omenn GS, Motulsky AG: A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. JAMA. 1995, 274: 1049-1057.","journal-title":"JAMA"},{"key":"60_CR17","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1001\/archinte.160.7.961","volume":"160","author":"LJ Langman","year":"2000","unstructured":"Langman LJ, Ray JG, Evrovski J, Yeo E, Cole DE: Hyperhomocyst(e)inemia and the increased risk of venous thromboembolism: more evidence from a case-control study. Arch Intern Med. 2000, 160: 961-964.","journal-title":"Arch Intern Med"},{"key":"60_CR18","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/clinchem\/41.5.757","volume":"41","author":"J Evrovski","year":"1995","unstructured":"Evrovski J, Callaghan M, Cole DEC: Determination of homocysteine by HPLC with pulsed integrated amperometry. Clin Chem. 1995, 41: 757-758.","journal-title":"Clin Chem"},{"key":"60_CR19","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/0165-022X(92)90014-2","volume":"25","author":"DK Lahiri","year":"1992","unstructured":"Lahiri DK, Bye S, Nurnberger JI, Hodes ME, Crisp M: A non-organic and non-enzymatic extraction method gives higher yields of genomic DNA from whole-blood samples than do nine other methods tested. J Biochem Biophys Meth. 1992, 25: 193-205.","journal-title":"J Biochem Biophys Meth"},{"key":"60_CR20","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.1182\/blood.V88.10.3698.bloodjournal88103698","volume":"88","author":"SR Poort","year":"1996","unstructured":"Poort SR, Rosendaal FR, Reitsma PH, Bertina RM: A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood. 1996, 88: 3698-8703.","journal-title":"Blood"},{"key":"60_CR21","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/ng0595-111","volume":"10","author":"P Frosst","year":"1995","unstructured":"Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJ, den Heijer M, Kluijtmans LA, van den Heuvel LP, et al: A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nature Genet. 1995, 10: 111-113.","journal-title":"Nature Genet"},{"key":"60_CR22","first-page":"4S","volume":"35","author":"LJ Langman","year":"1998","unstructured":"Langman LJ, Wong BYL, Boggis C, Rubin LA, Cole DEC: The prevalence and linkage disequilibrium of three methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms varies in different ethnic groups [abstract]. J Vasc Res. 1998, 35: 4S-","journal-title":"J Vasc Res"},{"key":"60_CR23","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1006\/mgme.1999.2879","volume":"67","author":"A Wilson","year":"1999","unstructured":"Wilson A, Platt R, Wu Q, Leclerc D, Christensen B, Yang H, Gravel RA, Rozen R: A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida. Mol Genet Metab. 1999, 67: 317-323. 10.1006\/mgme.1999.2879.","journal-title":"Mol Genet Metab"},{"key":"60_CR24","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.1001\/archinte.158.19.2101","volume":"158","author":"J Ray","year":"1998","unstructured":"Ray J: A meta-analysis of hyperhomocyst(e)inemia and the risk of venous thromboembolic disease. Arch Intern Med. 1998, 158: 2101-2106.","journal-title":"Arch Intern Med"},{"key":"60_CR25","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1161\/01.CIR.93.1.7","volume":"93","author":"PF Jacques","year":"1996","unstructured":"Jacques PF, Bostom AG, Williams RR, Ellison RC, Eckfeldt JH, Rosenberg IH, Selhub J, Rozen R: Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation. 1996, 93: 7-9.","journal-title":"Circulation"},{"key":"60_CR26","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1001\/archinte.159.1.65","volume":"159","author":"KW Bloemenkamp","year":"1999","unstructured":"Bloemenkamp KW, Rosendaal FR, Buller HR, Helmerhorst FM, Colly LP, Vandenbroucke JP: Risk of venous thrombosis with use of current low-dose oral contraceptives is not explained by diagnostic suspicion and referral bias. Arch Intern Med. 1999, 159: 65-70.","journal-title":"Arch Intern Med"},{"key":"60_CR27","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1055\/s-0037-1615049","volume":"79","author":"FR Rosendaal","year":"1998","unstructured":"Rosendaal FR, Doggen CJ, Zivelin A, Arruda VR, Aiach M, Siscov-ick DS, Hillarp A, Watzke HH, Bernardi F, Cumming AM, Preston FE, Reitsma PH: Geographic distribution of the 20210 G to A prothrombin variant. Thromb Haemost. 1998, 79: 706-708.","journal-title":"Thromb Haemost"},{"key":"60_CR28","first-page":"141","volume":"46","author":"D Ducloux","year":"2000","unstructured":"Ducloux D, Motte G, Chalopin JM: Homocysteine in renal disease. Clin Lab. 2000, 46: 141-51.","journal-title":"Clin Lab"},{"key":"60_CR29","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1001\/jama.1995.03530190040032","volume":"274","author":"O Nygard","year":"1995","unstructured":"Nygard O, Vollset SE, Refsum H, Stensvold I, Tverdal A, Nordrehaug JE, Ueland M, Kvale G: Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study. JAMA. 1995, 274: 1526-1533.","journal-title":"JAMA"},{"key":"60_CR30","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1038\/sj.bjc.6690305","volume":"79","author":"I Kato","year":"1999","unstructured":"Kato I, Dnistrian AM, Schwartz M, Toniolo P, Koenig K, Shore RE, Akhmedkhanov A, Zeleniuch-Jacquotte A, Riboli E: Serum folate, homocysteine and colorectal cancer risk in women: a nested case-control study. Br J Cancer. 1999, 79: 1917-1922.","journal-title":"Br J Cancer"},{"key":"60_CR31","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/S0009-9120(00)00083-7","volume":"33","author":"JG Ray","year":"2000","unstructured":"Ray JG, Cole DE, Boss SC: An Ontario-wide study of vitamin B12, serum folate, and red cell folate levels in relation to plasma homocysteine: is a preventable public health issue on the rise?. Clin Biochem. 2000, 33: 337-343.","journal-title":"Clin Biochem"},{"key":"60_CR32","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1136\/bmj.316.7135.894","volume":"316","author":"Homocysteine Lowering Trialists' Co","year":"1998","unstructured":"Homocysteine Lowering Trialists' Collaboration : Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. Br Med J. 1998, 316: 894-898.","journal-title":"Br Med J"},{"key":"60_CR33","doi-asserted-by":"publisher","first-page":"2520","DOI":"10.1161\/01.CIR.98.23.2520","volume":"98","author":"L Brattstrom","year":"1998","unstructured":"Brattstrom L, Wilcken DE, Ohrvik J, Brudin L: Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease: the result of a meta-analysis. Circulation. 1998, 98: 2520-2526.","journal-title":"Circulation"},{"key":"60_CR34","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1161\/01.CIR.95.7.1777","volume":"95","author":"PM Ridker","year":"1997","unstructured":"Ridker PM, Hennekens CH, Selhub J, Miletich JP, Malinow MR, Stampfer MJ: Interrelation of hyperhomocyst(e)inemia, factor V Leiden, and risk of future venous thromboembolism. Circulation. 1997, 95: 1777-1782.","journal-title":"Circulation"},{"key":"60_CR35","first-page":"566","volume":"80","author":"S Eichinger","year":"1998","unstructured":"Eichinger S, Stumpflen A, Hirschl M, Bialonczyk C, Herkner K, Stain M, Schneider B, Pabinger I, Lechner K, Kyrle PA: Hyperho-mocysteinemia is a risk factor of recurrent venous thromboembolism. Thromb Haemost. 1998, 80: 566-569.","journal-title":"Thromb Haemost"},{"key":"60_CR36","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1055\/s-2000-8097","volume":"26","author":"HP Willems","year":"2000","unstructured":"Willems HP, den Heijer M, Bos GM: Homocysteine and venous thrombosis: outline of a vitamin intervention trial. Semin Thromb Hemost. 2000, 26: 297-304. 10.1055\/s-2000-8097.","journal-title":"Semin Thromb Hemost"},{"key":"60_CR37","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1055\/s-0037-1613828","volume":"83","author":"EM Eekhoff","year":"2000","unstructured":"Eekhoff EM, Rosendaal FR, Vandenbroucke JP: Minor events and the risk of deep venous thrombosis. Thromb Haemost. 2000, 83: 408-411.","journal-title":"Thromb Haemost"},{"key":"60_CR38","first-page":"S66","volume":"28(suppl 3)","author":"M Levine","year":"1998","unstructured":"Levine M, Rickles FR: Treatment of venous thromboembolism in cancer patients. Haemostasis. 1998, 28(suppl 3): S66-S70.","journal-title":"Haemostasis"},{"key":"60_CR39","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1055\/s-0037-1613857","volume":"83","author":"G Lowe","year":"2000","unstructured":"Lowe G, Woodward M, Vessey M, Rumley A, Gough P, Daly E: Thrombotic variables and risk of idiopathic venous thromboembolism in women aged 45-64 years. Relationships to hormone replacement therapy. Thromb Haemost. 2000, 83: 530-535.","journal-title":"Thromb Haemost"},{"key":"60_CR40","doi-asserted-by":"publisher","first-page":"270","DOI":"10.7326\/0003-4819-128-4-199802150-00003","volume":"128","author":"DH Ryan","year":"1998","unstructured":"Ryan DH, Crowther MA, Ginsberg JS, Francis CW: Relation of factor V Leiden genotype to risk for acute deep venous thrombosis after joint replacement surgery. Ann Intern Med. 1998, 128: 270-276.","journal-title":"Ann Intern Med"},{"key":"60_CR41","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1055\/s-0037-1615137","volume":"80","author":"C Leroyer","year":"1998","unstructured":"Leroyer C, Mercier B, Oger E, Chenu E, Abgrall JF, Ferec C, Mottier C: Prevalence of 20210 A allele of the prothrombin gene in venous thromboembolism patients. Thromb Haemost. 1998, 80: 49-51.","journal-title":"Thromb Haemost"},{"key":"60_CR42","doi-asserted-by":"publisher","first-page":"89","DOI":"10.7326\/0003-4819-129-2-199807150-00003","volume":"129","author":"M Margaglione","year":"1998","unstructured":"Margaglione M, Brancaccio V, Giuliani N, D'Andrea G, Cappucci G, Iannaccone L, Vecchione G, Grandone E, Di Minno G: Increased risk for venous thrombosis in carriers of the prothrombin G\u2192A20210 gene variant. Ann Intern Med. 1998, 129: 89-93.","journal-title":"Ann Intern Med"},{"key":"60_CR43","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1055\/s-0037-1614551","volume":"81","author":"M Alhenc-Gelas","year":"1999","unstructured":"Alhenc-Gelas M, Arnaud E, Nicaud V, Aubry ML, Fiessinger JN, Aiach M, Emmerich J: Venous thromboembolic disease and the prothrombin, methylene tetrahydrofolate reductase and factor V genes. Thromb Haemost. 1999, 81: 506-510.","journal-title":"Thromb Haemost"},{"key":"60_CR44","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1161\/01.ATV.19.3.511","volume":"19","author":"O Salomon","year":"1999","unstructured":"Salomon O, Steinberg DM, Zivelin A, Gitel S, Dardik R, Rosen-berg N, Berliner S, Inbal A, Many A, Lubetsky A, Varon D, Martinowitz U, Seligsohn U: Single and combined prothrombotic factors in patients with idiopathic venous thromboembolism: prevalence and risk assessment. Arterioscler Thromb Vasc Biol. 1999, 19: 511-518.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"60_CR45","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1055\/s-0038-1657674","volume":"78","author":"A Hillarp","year":"1997","unstructured":"Hillarp A, Zoller B, Svensson PJ, Dahlback B: The 20210 A allele of the prothrombin gene is a common risk factor among Swedish outpatients with verified deep venous thrombosis. Thromb Haemost. 1997, 78: 990-992.","journal-title":"Thromb Haemost"},{"key":"60_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0049-3848(98)00136-4","volume":"93","author":"M Cattaneo","year":"1999","unstructured":"Cattaneo M, Chantarangkul V, Taioli E, Santos JH, Tagliabue L: The G20210A mutation of the prothrombin gene in patients with previous first episodes of deep-vein thrombosis: prevalence and association with factor V G1691A, methylenetetrahydrofolate reductase C677T and plasma prothrombin levels. Thromb Res. 1999, 93: 1-8.","journal-title":"Thromb Res"},{"key":"60_CR47","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1016\/S0002-9378(98)70155-3","volume":"179","author":"E Grandone","year":"1998","unstructured":"Grandone E, Margaglione M, Colaizzo D, D'Andrea G, Cappucci G, Brancaccio V, Di Minno G: Genetic susceptibility to pregnancy-related venous thromboembolism: roles of factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations. Am J Obstet Gynecol. 1998, 179: 1324-1328.","journal-title":"Am J Obstet Gynecol"},{"key":"60_CR48","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1111\/j.1399-0004.1997.tb02548.x","volume":"52","author":"JM Garcia-Gala","year":"1997","unstructured":"Garcia-Gala JM, Alvarez V, Pinto CR, Soto I, Urgelles MF, Menendez MJ, Carracedo C, Lopez-Larrea C, Coto E: Factor V Leiden (R506Q) and risk of venous thromboembolism: a case-control study based on the Spanish population. Clin Genet. 1997, 52: 206-210.","journal-title":"Clin Genet"},{"key":"60_CR49","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S1084-8592(97)80012-4","volume":"2","author":"IT Ocal","year":"1997","unstructured":"Ocal IT, Sadeghi A, Press RD: Risk of venous thrombosis in carriers of a common mutation in the homocysteine regulatory enzyme methylenetetrahydrofolate reductase. Mol Diagn. 1997, 2: 61-68.","journal-title":"Mol Diagn"},{"key":"60_CR50","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1046\/j.1365-2141.2000.02039.x","volume":"110","author":"P de Moerloose","year":"2000","unstructured":"de Moerloose P, Reber G, Perrier A, Perneger T, Bounameaux H: Prevalence of factor V Leiden and prothrombin G20210A mutations in unselected patients with venous thromboembolism. Br J Haematol. 2000, 110: 125-129. 10.1046\/j.1365-2141.2000.02039.x.","journal-title":"Br J Haematol"},{"key":"60_CR51","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1182\/blood.V85.6.1504.bloodjournal8561504","volume":"85","author":"FR Rosendaal","year":"1995","unstructured":"Rosendaal FR, Koster T, Vandenbroucke JP, Reitsma PH: High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance). Blood. 1995, 85: 1504-1508.","journal-title":"Blood"},{"key":"60_CR52","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1046\/j.1365-2796.1997.124140000.x","volume":"241","author":"PJ Svensson","year":"1997","unstructured":"Svensson PJ, Zoller B, Mattiasson I, Dahlback B: The factor VR506Q mutation causing APC resistance is highly prevalent amongst unselected outpatients with clinically suspected deep venous thrombosis. J Intern Med. 1997, 241: 379-378.","journal-title":"J Intern Med"},{"key":"60_CR53","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S0049-3848(99)00157-7","volume":"97","author":"N Akar","year":"2000","unstructured":"Akar N, Akar E, Akcay R, Avcu F, Yalcin A, Cin S: Effect of meth-ylenetetrahydrofolate reductase 677 C-T, 1298 A-C, and 1317 T-C on factor V 1691 mutation in Turkish deep vein thrombosis patients. Thromb Res. 2000, 97: 163-167.","journal-title":"Thromb Res"},{"key":"60_CR54","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1046\/j.1365-2141.1998.00935.x","volume":"103","author":"K Brown","year":"1998","unstructured":"Brown K, Luddington R, Baglin T: Effect of the MTHFRC677T variant on risk of venous thromboembolism: interaction with factor V Leiden and prothrombin (F2G20210A) mutations. Br J Haematol. 1998, 103: 42-44. 10.1046\/j.1365-2141.1998.00935.x.","journal-title":"Br J Haematol"},{"key":"60_CR55","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1161\/01.ATV.19.7.1761","volume":"19","author":"D Gemmati","year":"1999","unstructured":"Gemmati D, Previati M, Serino ML, Moratelli S, Guerra S, Capitani S, Forini E, Ballerini G, Scapoli GL: Low folate levels and thermolabile methylenetetrahydrofolate reductase as primary determinant of mild hyperhomocystinemia in normal and thromboembolic subjects. Arterioscler Thromb Vasc Biol. 1999, 19: 1761-1767.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"60_CR56","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1097\/00001721-199903000-00007","volume":"10","author":"C Rintelen","year":"1999","unstructured":"Rintelen C, Mannhalter C, Lechner K, Eichinger S, Kyrle PA, Papagiannopoulos M, Schneider B, Pabinger I: No evidence for an increased risk of venous thrombosis in patients with factor V Leiden by the homozygous 677 C to T mutation in the methylenetetrahydrofolate-reductase gene. Blood Coagul Fibrinolysis. 1999, 10: 101-105.","journal-title":"Blood Coagul Fibrinolysis"},{"key":"60_CR57","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/S0049-3848(99)00160-7","volume":"97","author":"JS Lin","year":"2000","unstructured":"Lin JS, Shen MC, Tsai W, Lin B: The prevalence of C677T mutation in the methylenetetrahydrofolate reductase gene and its association with venous thrombophilia in Taiwanese Chinese. Thromb Res. 2000, 97: 89-94.","journal-title":"Thromb Res"},{"key":"60_CR58","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1046\/j.1365-2141.1997.1422957.x","volume":"97","author":"A Tosetto","year":"1997","unstructured":"Tosetto A, Missiaglia E, Frezzato M, Rodeghiero F: The VITA project: C677T mutation in the methylene-tetrahydrofolate reductase gene and risk of venous thromboembolism. Br J Haematol. 1997, 97: 804-806.","journal-title":"Br J Haematol"},{"key":"60_CR59","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1055\/s-0037-1615091","volume":"79","author":"M Margaglione","year":"1998","unstructured":"Margaglione M, D'Andrea G, d'Addedda M, Giuliani N, Cappucci G, Iannaccone L, Vecchione G, Grandone E, Brancaccio V, Di Minno G: The methylenetetrahydrofolate reductase TT677 genotype is associated with venous thrombosis independently of the coexistence of the FV Leiden and the prothrombin A20210 mutation. Thromb Haemost. 1998, 79: 907-911.","journal-title":"Thromb Haemost"},{"key":"60_CR60","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1055\/s-0037-1614974","volume":"79","author":"LA Kluijtmans","year":"1998","unstructured":"Kluijtmans LA, den Heijer M, Reitsma PH, Heil SG, Blom HJ, Rosendaal FR: Thermolabile methylenetetrahydrofolate reductase and factor V Leiden in the risk of deep-vein thrombosis. Thromb Haemost. 1998, 79: 254-258.","journal-title":"Thromb Haemost"}],"container-title":["Trials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/cvm-2-3-141.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/cvm-2-3-141\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/cvm-2-3-141.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T15:02:30Z","timestamp":1714057350000},"score":1,"resource":{"primary":{"URL":"https:\/\/trialsjournal.biomedcentral.com\/articles\/10.1186\/cvm-2-3-141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,5,18]]},"references-count":60,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2001,6]]}},"alternative-id":["60"],"URL":"https:\/\/doi.org\/10.1186\/cvm-2-3-141","relation":{},"ISSN":["1745-6215"],"issn-type":[{"value":"1745-6215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,5,18]]},"assertion":[{"value":"26 January 2001","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2001","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2001","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2001","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}],"article-number":"141"}}