{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T23:01:03Z","timestamp":1768258863255,"version":"3.49.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T00:00:00Z","timestamp":1566950400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T00:00:00Z","timestamp":1566950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2011\/05614-1 and 2013\/16269-9"],"award-info":[{"award-number":["2011\/05614-1 and 2013\/16269-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"BNDES-FUNTEC","award":["10.2.0487.1"],"award-info":[{"award-number":["10.2.0487.1"]}]},{"DOI":"10.13039\/501100004809","name":"Financiadora de Estudos e Projetos","doi-asserted-by":"publisher","award":["01.08.0622.00"],"award-info":[{"award-number":["01.08.0622.00"]}],"id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"BNDES","award":["09.2.1066.1"],"award-info":[{"award-number":["09.2.1066.1"]}]},{"name":"CNPQ","award":["401430\/2013-8 and 461785\/2014-5"],"award-info":[{"award-number":["401430\/2013-8 and 461785\/2014-5"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Med"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s10020-019-0110-5","type":"journal-article","created":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T04:17:03Z","timestamp":1566965823000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Tamoxifen and bone morphogenic protein-7 modulate fibrosis and inflammation in the peritoneal fibrosis model developed in uremic rats"],"prefix":"10.1186","volume":"25","author":[{"given":"Filipe M. O.","family":"Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elerson C.","family":"Costalonga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cleonice","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana C. O.","family":"Carreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samirah A.","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari C.","family":"Sogayar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"Fanelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3208-4435","authenticated-orcid":false,"given":"Irene L.","family":"Noronha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,8,28]]},"reference":[{"issue":"12","key":"110_CR1","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1007\/s11255-015-1116-8","volume":"47","author":"S Ada","year":"2015","unstructured":"Ada S, Ersan S, Sifil A, Unlu M, Kolatan E, Sert M, Sarioglu S, Yilmaz O, Camsari T. Effect of bevacizumab, a vascular endothelial growth factor inhibitor, on a rat model of peritoneal sclerosis. Int Urol Nephrol. 2015;47(12):2047\u201351.","journal-title":"Int Urol Nephrol"},{"issue":"1\u20133","key":"110_CR2","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1159\/000368940","volume":"39","author":"OM Akchurin","year":"2015","unstructured":"Akchurin OM, Kaskel F. Update on inflammation in chronic kidney disease. Blood Purif. 2015;39(1\u20133):84\u201392.","journal-title":"Blood Purif"},{"key":"110_CR3","first-page":"395","volume":"6","author":"PM Allaria","year":"1999","unstructured":"Allaria PM, Giangrande A, Gandini E, Pisoni IB. Continuous ambulatory peritoneal dialysis and sclerosing encapsulating peritonitis: tamoxifen as a new therapeutic agent? Nephrol. 1999;6:395\u20137.","journal-title":"Nephrol."},{"issue":"2","key":"110_CR4","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1177\/089686080002000210","volume":"20","author":"K Ates","year":"2000","unstructured":"Ates K, Ko\u00e7 R, Nergizoglu G, Ert\u00fcrk S, Keven K, Sen A, Karatan O. The longitudinal effect of a single peritonitis episode on peritoneal membrane transport in CAPD patients. Perit Dial Int. 2000;20(2):220\u20136.","journal-title":"Perit Dial Int"},{"issue":"18","key":"110_CR5","doi-asserted-by":"publisher","first-page":"6646","DOI":"10.1128\/MCB.23.18.6646-6661.2003","volume":"23","author":"H Benchabane","year":"2003","unstructured":"Benchabane H, Wrana JL. GATA- and Smad1-dependent enhancers in the Smad7 gene differentially interpret bone morphogenetic protein concentrations. Mol Cell Biol. 2003;23(18):6646\u201361.","journal-title":"Mol Cell Biol"},{"issue":"2","key":"110_CR6","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1007\/s12033-010-9287-0","volume":"46","author":"JC Bustos-Valenzuela","year":"2010","unstructured":"Bustos-Valenzuela JC, Halcsik E, Bassi EJ, Demasi MA, Granjeiro JM, Sogayar MC. Expression, purification, bioactivity, and partial characterization of a recombinant human bone morphogenetic protein-7 produced in human 293T cells. Mol Biotechnol. 2010;46(2):118\u201326.","journal-title":"Mol Biotechnol"},{"issue":"4","key":"110_CR7","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1681\/ASN.V134887","volume":"13","author":"R Chen","year":"2002","unstructured":"Chen R, Huang C, Morinelli TA, Trojanowska M, Paul RV. Blockade of the effects of TGF-beta1 on mesangial cells by overexpression of Smad7. J Am Soc Nephrol. 2002;13(4):887\u201393.","journal-title":"J Am Soc Nephrol"},{"issue":"9","key":"110_CR8","doi-asserted-by":"publisher","first-page":"e0184302","DOI":"10.1371\/journal.pone.0184302","volume":"12","author":"EC Costalonga","year":"2017","unstructured":"Costalonga EC, de Freitas LJ, Aragone DDSP, Silva FMO, Noronha IL. Anti-fibrotic effects of valproic acid in experimental peritoneal fibrosis. PLoS One. 2017;12(9):e0184302.","journal-title":"PLoS One"},{"issue":"1","key":"110_CR9","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1681\/ASN.2011010046","volume":"23","author":"H Dell\u00ea","year":"2012","unstructured":"Dell\u00ea H, Rocha JR, Cavaglieri RC, Vieira JM Jr, Malheiros DM, Noronha IL. Antifibrotic effect of tamoxifen in a model of progressive renal disease. J Am Soc Nephrol. 2012;23(1):37\u201348.","journal-title":"J Am Soc Nephrol"},{"issue":"8","key":"110_CR10","doi-asserted-by":"publisher","first-page":"2275","DOI":"10.1016\/j.ajpath.2014.04.014","volume":"184","author":"WJ Duan","year":"2014","unstructured":"Duan WJ, Yu X, Huang XR, Yu JW, Lan HY. Opposing roles for Smad2 and Smad3 in peritoneal fibrosis in vivo and in vitro. Am J Pathol. 2014;184(8):2275\u201384.","journal-title":"Am J Pathol"},{"issue":"10","key":"110_CR11","doi-asserted-by":"publisher","first-page":"2689","DOI":"10.1681\/ASN.2007010121","volume":"18","author":"H Guo","year":"2007","unstructured":"Guo H, Leung JC, Lam MF, et al. Smad7 transgene attenuates peritoneal fibrosis in uremic rats treated with peritoneal dialysis. J Am Soc Nephrol. 2007;18(10):2689\u2013703.","journal-title":"J Am Soc Nephrol"},{"key":"110_CR12","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.1177\/089686080502504S08","volume":"4","author":"CM Hoff","year":"2005","unstructured":"Hoff CM. Experimental animal models of encapsulating peritoneal sclerosis. Perit Dial Int Supp. 2005;4:S57\u201366.","journal-title":"Perit Dial Int Supp"},{"issue":"3","key":"110_CR13","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/S0002-9440(10)62297-3","volume":"166","author":"CC Hou","year":"2005","unstructured":"Hou CC, Wang W, Huang XR, Fu P, Chen TH, Sheikh-Hamad D, Lan HY. Ultrasound-microbubble-mediated gene transfer of inducible Smad7 blocks transforming growth factor-beta signaling and fibrosis in rat remnant kidney. Am J Pathol. 2005;166(3):761\u201371.","journal-title":"Am J Pathol"},{"key":"110_CR14","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.ceb.2007.02.015","volume":"19","author":"S Itoh","year":"2007","unstructured":"Itoh S, ten Dijke P. Negative regulation of TGF-b receptor\/Smad signal transduction. Curr Opin Cell Biol. 2007;19:176\u201384.","journal-title":"Curr Opin Cell Biol"},{"key":"110_CR15","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1681\/ASN.2006080901","volume":"18","author":"SM Ka","year":"2007","unstructured":"Ka SM, Huang XR, Lan HY, Tsai PY, Yang SM, Shui HA, Chen A. Smad7 gene therapy ameliorates an autoimmune crescentic glomerulonephritis in mice. J Am Soc Nephrol. 2007;18:1777\u201388.","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"110_CR16","doi-asserted-by":"publisher","first-page":"F167","DOI":"10.1152\/ajprenal.00052.2017","volume":"314","author":"T Kariya","year":"2018","unstructured":"Kariya T, Nishimura H, Mizuno M, Suzuki Y, Matsukawa Y, Sakata F, Maruyama S, Takei Y, Ito Y. TGF-\u03b21-VEGF-A pathway induces neoangiogenesis with peritoneal fibrosis in patients undergoing peritoneal dialysis. Am J Physiol Renal Physiol. 2018;314(2):F167\u201380.","journal-title":"Am J Physiol Renal Physiol"},{"issue":"11","key":"110_CR17","doi-asserted-by":"publisher","first-page":"2043","DOI":"10.1093\/ndt\/gfu240","volume":"29","author":"D Kim","year":"2014","unstructured":"Kim D, Lee AS, Jung YJ, Yang KH, Lee S, Park SK, Kim W, Kang KP. Tamoxifen ameliorates renal tubulointerstitial fibrosis by modulation of estrogen receptor \u03b1-mediated transforming growth factor-\u03b21\/Smad signaling pathway. Nephrol Dial Transplant. 2014;29(11):2043\u201353.","journal-title":"Nephrol Dial Transplant"},{"issue":"11","key":"110_CR18","doi-asserted-by":"publisher","first-page":"F1247","DOI":"10.1152\/ajprenal.00617.2014","volume":"308","author":"D Kitterer","year":"2015","unstructured":"Kitterer D, Latus J, Ulmer C, Fritz P, Biegger D, Ott G, Alscher MD, Witowski J, Kawka E, J\u00f6rres A, et al. Activation of nuclear factor of activated T cells 5 in the peritoneal membrane of uremic patients. Am J Physiol Renal Physiol. 2015;308(11):F1247\u201358.","journal-title":"Am J Physiol Renal Physiol."},{"issue":"1","key":"110_CR19","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1159\/000314544","volume":"116","author":"KN Lai","year":"2010","unstructured":"Lai KN, Leung JC. Inflammation in peritoneal dialysis. Nephron Clin Pract. 2010;116(1):11\u20138.","journal-title":"Nephron Clin Pract"},{"key":"110_CR20","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.7150\/ijbs.7.1056","volume":"7","author":"HY Lan","year":"2011","unstructured":"Lan HY. Diverse roles of TGF-\u00df\/Smads in renal fibrosis and inflammation. Int J Biol Sci. 2011;7:1056\u201367.","journal-title":"Int J Biol Sci"},{"key":"110_CR21","doi-asserted-by":"publisher","first-page":"1535","DOI":"10.1097\/01.ASN.0000067632.04658.B8","volume":"14","author":"HY Lan","year":"2003","unstructured":"Lan HY, Mu W, Tomita N, Huang XR, Li JH, Zhu HJ, Morishita R, Johnson RJ. Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model. J Am Soc Nephrol. 2003;14:1535\u201348.","journal-title":"J Am Soc Nephrol"},{"issue":"9","key":"110_CR22","doi-asserted-by":"publisher","first-page":"1682","DOI":"10.1681\/ASN.2010111197","volume":"22","author":"J Loureiro","year":"2011","unstructured":"Loureiro J, Aguilera A, Selgas R, Sandoval P, Albar-Vizca\u00edno P, P\u00e9rez-Lozano ML, Ruiz-Carpio V, Majano PL, Lamas S, Rodr\u00edguez-Pascual F, et al. Blocking TGF-\u03b21 protects the peritoneal membrane from dialysate-induced damage. J Am Soc Nephrol. 2011;22(9):1682\u201395.","journal-title":"J Am Soc Nephrol"},{"issue":"4","key":"110_CR23","doi-asserted-by":"publisher","first-page":"e61165","DOI":"10.1371\/journal.pone.0061165","volume":"8","author":"J Loureiro","year":"2013","unstructured":"Loureiro J, Sandoval P, del Peso G, G\u00f3nzalez-Mateo G, Fern\u00e1ndez-Millara V, Santamaria B, Bajo MA, S\u00e1nchez-Tomero JA, Guerra-Azcona G, et al. Tamoxifen ameliorates peritoneal membrane damage by blocking mesothelial to mesenchymal transition in peritoneal dialysis. PLoS One. 2013;8(4):e61165.","journal-title":"PLoS One"},{"issue":"4","key":"110_CR24","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1093\/ndt\/gfp618","volume":"25","author":"J Loureiro","year":"2010","unstructured":"Loureiro J, Schilte M, Aguilera A, Albar-Vizca\u00edno P, Ram\u00edrez-Huesca M, P\u00e9rez-Lozano ML, Gonz\u00e1lez-Mateo G, Aroeira LS, Selgas R, Mendoza L, et al. BMP-7 blocks mesenchymal conversion of mesothelial cells and prevents peritoneal damage induced by dialysis fluid exposure. Nephrol Dial Transplant. 2010;25(4):1098\u2013108.","journal-title":"Nephrol Dial Transplant"},{"issue":"3","key":"110_CR25","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.2353\/ajpath.2010.090459","volume":"176","author":"DD Luo","year":"2010","unstructured":"Luo DD, Phillips A, Fraser D. Bone morphogenetic protein-7 inhibits proximal tubular epithelial cell Smad3 signaling via increased SnoN expression. Am J Pathol. 2010;176(3):1139\u201347.","journal-title":"Am J Pathol"},{"issue":"10","key":"110_CR26","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1681\/ASN.V12102029","volume":"12","author":"PJ Margetts","year":"2001","unstructured":"Margetts PJ, Kolb M, Galt T, Hoff CM, Shockley TR, Gauldie J. Gene transfer of transforming growth factor-beta1 to the rat peritoneum: effects on membrane function. J Am Soc Nephrol. 2001;12(10):2029\u201339.","journal-title":"J Am Soc Nephrol"},{"issue":"46","key":"110_CR27","doi-asserted-by":"publisher","first-page":"42908","DOI":"10.1074\/jbc.M105316200","volume":"276","author":"T Matsuda","year":"2001","unstructured":"Matsuda T, Yamamoto T, Muraguchi A, Saatcioglu F. Cross-talk between transforming growth factor-\u03b2 and estrogen receptor signaling through Smad3. J Biol Chem. 2001;276(46):42908\u201314.","journal-title":"J Biol Chem"},{"issue":"1","key":"110_CR28","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1177\/089686080502500105","volume":"25","author":"S Mortier","year":"2005","unstructured":"Mortier S, Lameire NH, De Vriese AS. Animal models in peritoneal dialysis research: a need for consensus. Perit Dial Int. 2005;25(1):16\u201324.","journal-title":"Perit Dial Int"},{"issue":"6651","key":"110_CR29","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1038\/39369","volume":"389","author":"A Nakao","year":"1997","unstructured":"Nakao A, Afrakhte M, Mor\u00e9n A, Nakayama T, Christian JL, Heuchel R, Itoh S, Kawabata M, Heldin NE, Heldin CH, et al. Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling. Nature. 1997;389(6651):631\u20135.","journal-title":"Nature"},{"key":"110_CR30","doi-asserted-by":"publisher","first-page":"S83","DOI":"10.1111\/j.1523-1755.2005.09421.x","volume":"94","author":"YY Ng","year":"2005","unstructured":"Ng YY, Hou CC, Wang W, Huang XR, Lan HY. Blockade of NFkappaB activation and renal inflammation by ultrasound-mediated gene transfer of Smad7 in rat remnant kidney. Kidney Int Suppl. 2005;94:S83\u201391.","journal-title":"Kidney Int Suppl"},{"issue":"11","key":"110_CR31","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1038\/sj.ki.5002533","volume":"72","author":"J Nie","year":"2007","unstructured":"Nie J, Dou X, Hao W, Wang X, Peng W, Jia Z, Chen W, Li X, Luo N, Lan HY, et al. Smad7 gene transfer inhibits peritoneal fibrosis. Kidney Int. 2007;72(11):1336\u201344.","journal-title":"Kidney Int"},{"issue":"4","key":"110_CR32","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/ki.2009.436","volume":"77","author":"P Patel","year":"2010","unstructured":"Patel P, Sekiguchi Y, Oh KH, Patterson SE, Kolb MR, Margetts PJ. Smad3-dependent and -independent pathways are involved in peritoneal membrane injury. Kidney Int. 2010;77(4):319\u201328.","journal-title":"Kidney Int"},{"issue":"8","key":"110_CR33","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1093\/ndt\/17.8.1480","volume":"17","author":"R Pecoits-Filho","year":"2002","unstructured":"Pecoits-Filho R, Ara\u00fajo MR, Lindholm B, Stenvinkel P, Abensur H, Rom\u00e3o JE Jr, Marcondes M, De Oliveira AH, Noronha IL. Plasma and dialysate IL-6 and VEGF concentrations are associated with high peritoneal solute transport rate. Nephrol Dial Transplant. 2002;17(8):1480\u20136.","journal-title":"Nephrol Dial Transplant"},{"issue":"5","key":"110_CR34","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1093\/ndt\/gfs569","volume":"28","author":"AC Santana","year":"2013","unstructured":"Santana AC, Degaspari S, Catanozi S, Dell\u00ea H, de S\u00e1 Lima L, Silva C, Blanco P, Solez K, Scavone C, Noronha IL. Thalidomide suppresses inflammation in adenine-induced CKD with uraemia in mice. Nephrol Dial Transplant. 2013;28(5):1140\u20139.","journal-title":"Nephrol Dial Transplant"},{"key":"110_CR35","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1172\/JCI200319270","volume":"112","author":"M Sato","year":"2003","unstructured":"Sato M, Muragaki Y, Saika S, Roberts AB, Ooshima A. Targeted disruption of TGF-beta1\/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction. J Clin Invest. 2003;112:1486\u201394.","journal-title":"J Clin Invest"},{"issue":"4","key":"110_CR36","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1159\/000326953","volume":"34","author":"AW Stavenuiter","year":"2011","unstructured":"Stavenuiter AW, Schilte MN, Ter Wee PM, Beelen RH. Angiogenesis in peritoneal dialysis. Kidney Blood Press Res. 2011;34(4):245\u201352.","journal-title":"Kidney Blood Press Res"},{"issue":"4","key":"110_CR37","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/S0940-2993(11)80261-7","volume":"47","author":"H Suga","year":"1995","unstructured":"Suga H, Teraoka S, Ota K, Komemushi S, Furutani S, Yamauchi S, Margolin S. Preventive effect of pirfenidone against experimental sclerosing peritonitis in rats. Exp Toxicol Pathol. 1995;47(4):287\u201391.","journal-title":"Exp Toxicol Pathol"},{"key":"110_CR38","doi-asserted-by":"publisher","first-page":"1825","DOI":"10.2337\/db06-1226","volume":"56","author":"H Sugimoto","year":"2007","unstructured":"Sugimoto H, Grahovac G, Zeisberg M, Kalluri R. Renal fibrosis and glomerulosclerosis in a new mouse model of diabetic nephropathy and its regression by bone morphogenic protein-7 and advanced glycation end product inhibitors. Diabetes. 2007;56:1825\u201333.","journal-title":"Diabetes"},{"key":"110_CR39","doi-asserted-by":"publisher","first-page":"101","DOI":"10.7326\/0003-4819-144-2-200601170-00007","volume":"2","author":"EF van Bommel","year":"2006","unstructured":"van Bommel EF, Hendriksz TR, Huiskes AW, Zeegers AG. Tamoxifen therapy for nonmalignant retroperitoneal fibrosis. Ann Intern Med. 2006;2:101\u20136.","journal-title":"Ann Intern Med"},{"issue":"5","key":"110_CR40","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1681\/ASN.2004121070","volume":"16","author":"W Wang","year":"2005","unstructured":"Wang W, Huang XR, Li AG, Liu F, Li JH, Truong LD, Wang XJ, Lan HY. Signaling mechanism of TGF-beta1 in prevention of renal inflammation: role of Smad7. J Am Soc Nephrol. 2005;16(5):1371\u201383.","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"110_CR41","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1681\/ASN.V132470","volume":"13","author":"JD Williams","year":"2002","unstructured":"Williams JD, Craig KJ, Topley N, Von Ruhland C, Fallon M, Newman GR, Mackenzie RK, Williams GT, Peritoneal Biopsy Study Group. Morphologic changes in the peritoneal membrane of patients with renal disease. J Am Soc Nephrol. 2002;13(2):470\u20139.","journal-title":"J Am Soc Nephrol"},{"key":"110_CR42","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1177\/089686080602600302","volume":"26","author":"J Witowski","year":"2006","unstructured":"Witowski J, J\u00f6rres A. Technological advances in peritoneal dialysis research. Peritoneal cell culture: fibroblastos. Perit Dial Int. 2006;26:292\u20139.","journal-title":"Perit Dial Int"},{"issue":"2","key":"110_CR43","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.toxlet.2013.04.017","volume":"220","author":"G Yang","year":"2013","unstructured":"Yang G, Zhu Z, Wang Y, Gao A, Niu P, Tian L. Bone morphogenetic protein-7 inhibits silica-induced pulmonary fibrosis in rats. Toxicol Lett. 2013;220(2):103\u20138.","journal-title":"Toxicol Lett"},{"issue":"3","key":"110_CR44","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1159\/000183992","volume":"44","author":"T Yokozawa","year":"1986","unstructured":"Yokozawa T, Zheng PD, Oura H, Koizumi F. Animal model of adenine-induced chronic renal failure in rats. Nephron. 1986;44(3):230\u20134.","journal-title":"Nephron"},{"issue":"7","key":"110_CR45","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1093\/ndt\/gfh835","volume":"20","author":"M Zareie","year":"2005","unstructured":"Zareie M, De Vriese AS, Hekking LH, ter Wee PM, Schalkwijk CG, Driesprong BA, Schadee-Eestermans IL, Beelen RH, Lameire N, van den Born J. Immunopathological changes in a uraemic rat model for peritoneal dialysis. Nephrol Dial Transplant. 2005;20(7):1350\u201361.","journal-title":"Nephrol Dial Transplant"},{"issue":"7","key":"110_CR46","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1038\/nm888","volume":"9","author":"M Zeisberg","year":"2003","unstructured":"Zeisberg M, Hanai J, Sugimoto H, Mammoto T, Charytan D, Strutz F, Kalluri R. BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med. 2003;9(7):964\u20138.","journal-title":"Nat Med"}],"container-title":["Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s10020-019-0110-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s10020-019-0110-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s10020-019-0110-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T17:21:35Z","timestamp":1664212895000},"score":1,"resource":{"primary":{"URL":"https:\/\/molmed.biomedcentral.com\/articles\/10.1186\/s10020-019-0110-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,28]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["110"],"URL":"https:\/\/doi.org\/10.1186\/s10020-019-0110-5","relation":{},"ISSN":["1076-1551","1528-3658"],"issn-type":[{"value":"1076-1551","type":"print"},{"value":"1528-3658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,28]]},"assertion":[{"value":"1 May 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 August 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All experimental procedures were approved by the Institutional Ethical Research Board (number 460\/11).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"41"}}