{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T09:51:14Z","timestamp":1793785874083,"version":"4.6.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:00:00Z","timestamp":1611792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T00:00:00Z","timestamp":1611792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Funds of China","doi-asserted-by":"crossref","award":["Grant No.81760256 and 81960256"],"award-info":[{"award-number":["Grant No.81760256 and 81960256"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Natural Science Foundation of Jiangxi, China","award":["Grant No.20192BAB215021"],"award-info":[{"award-number":["Grant No.20192BAB215021"]}]},{"name":"Natural Science Foundation of Jiangxi, China","award":["Grant No.20192BAB205038"],"award-info":[{"award-number":["Grant No.20192BAB205038"]}]},{"name":"The Youth Scientific Research Foundation of the Second Affiliated Hospital of Nanchang University","award":["2014YNQN12013"],"award-info":[{"award-number":["2014YNQN12013"]}]},{"name":"Academic and technical leaders of major disciplines Foundation","award":["20204BCJL22049"],"award-info":[{"award-number":["20204BCJL22049"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Med"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Alzheimer's disease is a neurodegenerative disease. Previous study has reported that caspase-1\/IL-1\u03b2 is closely associated with Alzheimer's disease. However, the biological role of caspase-1\/IL-1\u03b2 in Alzheimer's disease has not been fully elucidated. This study aimed to explore the mechanism of action of caspase-1\/IL-1\u03b2 in Alzheimer's disease.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Mouse\u2002hippocampal neurones were treated with A\u03b2<jats:sub>1-42<\/jats:sub> to induce Alzheimer's disease cell model. APP\/PS1 mice and A\u03b2<jats:sub>1-42<\/jats:sub>-induced hippocampal neurones were treated with AC-YVAD-CMK (caspase-1 inhibitor). Spatial learning and memory ability of mice were detected by morris water maze. Flow cytometry, TUNEL staining, Thioflavin S staining and immunohistochemistry were performed to examine apoptosis and senile plaque deposition. Enzyme linked immunosorbent assay and western blot were performed to assess the levels of protein or cytokines. Co-Immunoprecipitation was performed to verify the interaction between Stargazin and GluA1.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>AC-YVAD-CMK treatment improved spatial learning and memory ability and reduced senile plaque deposition of APP\/PS1 mice. Moreover, AC-YVAD-CMK promoted membrane transport of GluA1 in APP\/PS1 mice. In vitro, A\u03b2<jats:sub>1-42<\/jats:sub>-induced hippocampal neurones exhibited an increase in apoptosis and a decrease in the membrane transport of GluA1, which was abolished by AC-YVAD-CMK treatment. In addition, Stargazin interacted with GluA1, which was repressed by caspase-1. Caspase-1\/IL-1\u03b2 inhibited membrane transport of GluA1 by inhibiting the interaction between Stargazin and GluA1.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our data demonstrate that caspase-1\/IL-1\u03b2 represses membrane transport of GluA1 by inhibiting the interaction between Stargazin in Alzheimer's disease. Thus, caspase-1\/IL-1\u03b2 may be a target for Alzheimer's disease treatment.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s10020-021-00273-8","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T11:28:39Z","timestamp":1611833319000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Caspase-1\/IL-1\u03b2 represses membrane transport of GluA1 by inhibiting the interaction between Stargazin and GluA1 in Alzheimer\u2019s disease"],"prefix":"10.1186","volume":"27","author":[{"given":"Xunhu","family":"Gu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanjun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5694-1297","authenticated-orcid":false,"given":"Wei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,28]]},"reference":[{"key":"273_CR1","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.nbd.2005.02.008","volume":"20","author":"CG Almeida","year":"2005","unstructured":"Almeida CG, et al. 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