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At present, revealing the molecular mechanisms of osteoporosis and developing effective prevention and treatment methods are of great significance to health worldwide. LncRNA is a non-coding RNA peptide chain with more than 200 nucleotides. Researchers have identified many lncRNAs implicated in the development of diseases and lncRNA\n                      <jats:italic>H19<\/jats:italic>\n                      is an example.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A large amount of evidence supports the fact that long non-coding RNA (lncRNA) genes, such as\n                      <jats:italic>H19<\/jats:italic>\n                      , have multiple, far-reaching effects on various biological functions. It has been found that lncRNA\n                      <jats:italic>H19<\/jats:italic>\n                      has a role in the regulation of different types of cells in the body including the osteoblasts, osteocytes, and osteoclasts found in bones. Therefore, it can be postulated that lncRNA\n                      <jats:italic>H19<\/jats:italic>\n                      affects the incidence and development of osteoporosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The prospect of targeting lncRNA\n                      <jats:italic>H19<\/jats:italic>\n                      in the treatment of osteoporosis is promising because of the effects that lncRNA\n                      <jats:italic>H19<\/jats:italic>\n                      has on the process of osteogenic differentiation. In this review, we summarize the molecular pathways and mechanisms of lncRNA\n                      <jats:italic>H19<\/jats:italic>\n                      in the pathogenesis of osteoporosis and summarize the research progress of targeting\n                      <jats:italic>H19<\/jats:italic>\n                      as a treatment option. Research is emerging that explores more effective treatment possibilities for bone metabolism diseases using molecular targets.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s10020-021-00386-0","type":"journal-article","created":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T15:06:39Z","timestamp":1632841599000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Role of long non-coding RNA H19 in the development of osteoporosis"],"prefix":"10.1186","volume":"27","author":[{"given":"Senxiang","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5224-9279","authenticated-orcid":false,"given":"Da","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zimo","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,28]]},"reference":[{"key":"386_CR1","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1359\/jbmr.060819","volume":"21","author":"H Aslan","year":"2006","unstructured":"Aslan H, Ravid-Amir O, Clancy BM, Rezvankhah S, Pittman D, Pelled G, Turgeman G, Zilberman Y, Gazit Z, Hoffmann A, et al. 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