{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T08:51:09Z","timestamp":1774947069593,"version":"3.50.1"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,11,26]],"date-time":"2022-11-26T00:00:00Z","timestamp":1669420800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,11,26]],"date-time":"2022-11-26T00:00:00Z","timestamp":1669420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"China Academy of Chinese Medical Sciences Innovation Funds","award":["CI2021A05033"],"award-info":[{"award-number":["CI2021A05033"]}]},{"name":"National Major Scientifc and Technological Special Project for\u201cSignifcant New Drug Develop Ment\u201d","award":["2017ZX09301059"],"award-info":[{"award-number":["2017ZX09301059"]}]},{"name":"Fundamental Research Funds for the Central public welfare research institutes","award":["ZZ13-YQ-076"],"award-info":[{"award-number":["ZZ13-YQ-076"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Med"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Analyzing disease\u2013disease relationships plays an important role for understanding etiology, disease classification, and drug repositioning. However, as cardiovascular diseases with causative links, the molecular relationship among stable angina pectoris (SAP), ischemic cardiomyopathy (ICM) and chronic heart failure (CHF) is not clear.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In this study, by integrating the multi-database data, we constructed paired disease progression modules (PDPMs) to identified relationship among SAP, ICM and CHF based on module reconstruction pairs (MRPs) of <jats:italic>K<\/jats:italic>-value calculation (a Euclidean distance optimization by integrating module topology parameters and their weights) methods. Finally, enrichment analysis, literature validation and structural variation (SV) were performed to verify the relationship between the three diseases in PDPMs.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Total 16 PDPMs were found with <jats:italic>K<\/jats:italic>\u2009&gt;\u20090.3777 among SAP, ICM and CHF, in which 6 pairs in SAP\u2013ICM, 5 pairs for both ICM\u2013CHF and SAP\u2013CHF. SAP\u2013ICM was the most closely related by having the smallest average <jats:italic>K<\/jats:italic>-value (<jats:italic>K<\/jats:italic>\u2009=\u20090.3899) while the maximum is SAP\u2013CHF (<jats:italic>K<\/jats:italic>\u2009=\u20090.4006). According to the function of the validation gene, inflammatory response were through each stage of SAP\u2013ICM\u2013CHF, while SAP\u2013ICM was uniquely involved in fibrosis, and genes were related in affecting the upstream of PI3K\u2013Akt signaling pathway. 4 of the 11 genes (FLT1, KDR, ANGPT2 and PGF) in SAP\u2013ICM\u2013CHF related to angiogenesis in HIF-1 signaling pathway. Furthermore, we identified 62.96% SVs were protein deletion in SAP\u2013ICM\u2013CHF, and 53.85% SVs were defined as protein replication in SAP\u2013ICM, while ICM\u2013CHF genes were mainly affected by protein deletion.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The PDPMs analysis approach combined with genomic structural variation provides a new avenue for determining target associations contributing to disease progression and reveals that inflammation and angiogenesis may be important links among SAP, ICM and CHF progression.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s10020-022-00569-3","type":"journal-article","created":{"date-parts":[[2022,11,27]],"date-time":"2022-11-27T01:18:52Z","timestamp":1669511932000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Modular networks and genomic variation during progression from stable angina pectoris through ischemic cardiomyopathy to chronic heart failure"],"prefix":"10.1186","volume":"28","author":[{"given":"Lin","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Nan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin-ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Fei","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Guan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying-Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanhui","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0975-9251","authenticated-orcid":false,"given":"Zhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,11,26]]},"reference":[{"issue":"10","key":"569_CR1","doi-asserted-by":"publisher","first-page":"3472","DOI":"10.3390\/ijms21103472","volume":"21","author":"A Alimadadi","year":"2020","unstructured":"Alimadadi A, Aryal S, Manandhar I, Joe B, Cheng X. Identification of upstream transcriptional regulators of ischemic cardiomyopathy using cardiac RNA-Seq meta-analysis. Int J Mol Sci. 2020;21(10):3472.","journal-title":"Int J Mol Sci"},{"issue":"2","key":"569_CR2","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1161\/CIRCULATIONAHA.118.036065","volume":"139","author":"SS Bansal","year":"2019","unstructured":"Bansal SS, Ismahil MA, Goel M, Zhou G, Rokosh G, Hamid T, Prabhu SD. Dysfunctional and proinflammatory regulatory T-lymphocytes are essential for adverse cardiac remodeling in ischemic cardiomyopathy. Circulation. 2019;139(2):206\u201321.","journal-title":"Circulation"},{"issue":"8","key":"569_CR3","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1007\/s00246-019-02203-2","volume":"40","author":"JS Bennett","year":"2019","unstructured":"Bennett JS, Bernhardt M, McBride KL, Reshmi SC, Zmuda E, Kertesz NJ, Garg V, Fitzgerald-Butt S, Kamp AN. Reclassification of variants of uncertain significance in children with inherited arrhythmia syndromes is predicted by clinical factors. Pediatr Cardiol. 2019;40(8):1679\u201387.","journal-title":"Pediatr Cardiol"},{"key":"569_CR4","unstructured":"Bhandari B, Quintanilla Rodriguez BS, Masood W. Ischemic Cardiomyopathy. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2021."},{"key":"569_CR5","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1098\/rsif.2010.0287","volume":"8","author":"CG Bowsher","year":"2011","unstructured":"Bowsher CG. Information processing by biochemical networks: a dynamic approach. J R Soc Interface. 2011;8:186\u2013200.","journal-title":"J R Soc Interface"},{"issue":"7","key":"569_CR6","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/nrg1383","volume":"5","author":"HG Brunner","year":"2004","unstructured":"Brunner HG, van Driel MA. From syndrome families to functional genomics. Nat Rev Genet. 2004;5(7):545\u201351.","journal-title":"Nat Rev Genet"},{"issue":"6396","key":"569_CR7","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1038\/359641a0","volume":"359","author":"F Cambien","year":"1992","unstructured":"Cambien F, Poirier O, Lecerf L, et al. Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction. Nature. 1992;359(6396):641\u20134.","journal-title":"Nature"},{"key":"569_CR8","doi-asserted-by":"publisher","first-page":"9834856","DOI":"10.1155\/2021\/9834856","volume":"2021","author":"J Cao","year":"2021","unstructured":"Cao J, Lei L, Wang K, et al. A Network pharmacology approach to predict the proangiogenesis mechanism of Huangqi-Honghua Herb pair after cerebral ischemia. Evid Based Complement Alternat Med. 2021;2021:9834856.","journal-title":"Evid Based Complement Alternat Med"},{"issue":"Suppl 3","key":"569_CR9","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1159\/000088478","volume":"69","author":"P Carmeliet","year":"2005","unstructured":"Carmeliet P. VEGF as a key mediator of angiogenesis in cancer. Oncology. 2005;69(Suppl 3):4\u201310.","journal-title":"Oncology"},{"key":"569_CR10","doi-asserted-by":"publisher","first-page":"e0158379","DOI":"10.1371\/journal.pone.0158379","volume":"11","author":"YY Chen","year":"2016","unstructured":"Chen YY, Yu YN, Zhang YY, Li B, Liu J, Li DF, et al. Quantitative determination of flexible pharmacological mechanisms based on topological variation in mice anti-ischemic modular networks. PLoS ONE. 2016;11:e0158379.","journal-title":"PLoS ONE"},{"key":"569_CR11","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s12017-021-08670-2","volume":"24","author":"Y Chen","year":"2021","unstructured":"Chen Y, Liu Q, Liu J, Wei P, Li B, Wang N, Liu Z, Wang Z. Revealing the modular similarities and differences among Alzheimer\u2019s disease, vascular dementia, and Parkinson\u2019s disease in genomic networks. Neuromol Med. 2021;24:125\u201338.","journal-title":"Neuromol Med"},{"key":"569_CR12","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.semcdb.2021.08.007","volume":"121","author":"M Chili\u0144ski","year":"2022","unstructured":"Chili\u0144ski M, Sengupta K, Plewczynski D. From DNA human sequence to the chromatin higher order organisation and its biological meaning: Using biomolecular interaction networks to understand the influence of structural variation on spatial genome organisation and its functional effect. Semin Cell Dev Biol. 2022;121:171\u201385.","journal-title":"Semin Cell Dev Biol"},{"key":"569_CR13","first-page":"100766","volume":"33","author":"S Chumakova","year":"2021","unstructured":"Chumakova S, Urazova O, Shipulin V, et al. Galectin 3 and non-classical monocytes of blood as myocardial remodeling factors at ischemic cardiomyopathy. Int J Cardiol Heart Vasc. 2021;33:100766.","journal-title":"Int J Cardiol Heart Vasc"},{"issue":"2","key":"569_CR14","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1007\/s11906-003-0072-3","volume":"5","author":"P Corvol","year":"2003","unstructured":"Corvol P, Lamand\u00e9 N, Cruz A, Celerier J, Gasc JM. Inhibition of angiogenesis: a new function for angiotensinogen and des(angiotensin I)angiotensinogen. Curr Hypertens Rep. 2003;5(2):149\u201354.","journal-title":"Curr Hypertens Rep"},{"issue":"12","key":"569_CR15","doi-asserted-by":"publisher","first-page":"e2000116","DOI":"10.1002\/minf.202000116","volume":"39","author":"B Dafniet","year":"2020","unstructured":"Dafniet B, Cerisier N, Audouze K, Taboureau O. Drug-target-ADR network and possible implications of structural variants in adverse events. Mol Inform. 2020;39(12):e2000116.","journal-title":"Mol Inform"},{"issue":"18","key":"569_CR16","doi-asserted-by":"publisher","first-page":"2112","DOI":"10.2174\/1381612827666210125155821","volume":"27","author":"A Daiber","year":"2021","unstructured":"Daiber A, Steven S, Euler G, Schulz R. Vascular and cardiac oxidative stress and inflammation as targets for cardioprotection. Curr Pharm Des. 2021;27(18):2112\u201330.","journal-title":"Curr Pharm Des"},{"issue":"1","key":"569_CR17","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1186\/s12872-020-01596-w","volume":"20","author":"H Dang","year":"2020","unstructured":"Dang H, Ye Y, Zhao X, Zeng Y. Identification of candidate genes in ischemic cardiomyopathy by gene expression omnibus database. BMC Cardiovasc Disord. 2020;20(1):320.","journal-title":"BMC Cardiovasc Disord"},{"key":"569_CR18","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1146\/annurev-pharmtox-010818-021154","volume":"59","author":"T De","year":"2019","unstructured":"De T, Park CS, Perera MA. Cardiovascular pharmacogenomics: does it matter if you\u2019re black or white? Annu Rev Pharmacol Toxicol. 2019;59:577\u2013603.","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"569_CR19","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1093\/bioinformatics\/btp083","volume":"25","author":"G Del Mondo","year":"2009","unstructured":"Del Mondo G, Eveillard D, Rusu I. Homogeneous decomposition of protein interaction networks: refining the description of intra-modular interactions. Bioinformatics. 2009;25:926\u201332.","journal-title":"Bioinformatics"},{"key":"569_CR20","doi-asserted-by":"publisher","first-page":"106076","DOI":"10.1016\/j.biocel.2021.106076","volume":"140","author":"JA Dundas","year":"2021","unstructured":"Dundas JA, Hassanabad AF, Zarzycki AN, Fedak PW, Deniset JF. Ischemic heart disease: cellular and molecular immune contributions of the pericardium. Int J Biochem Cell Biol. 2021;140:106076.","journal-title":"Int J Biochem Cell Biol"},{"issue":"9","key":"569_CR21","first-page":"1241","volume":"114","author":"J Erdmann","year":"2018","unstructured":"Erdmann J, Kessler T, Munoz Venegas L, Schunkert H. A decade of genome-wide association studies for coronary artery disease: the challenges ahead. Cardiovasc Res. 2018;114(9):1241\u201357.","journal-title":"Cardiovasc Res"},{"key":"569_CR22","doi-asserted-by":"publisher","first-page":"1458","DOI":"10.1161\/01.RES.68.5.1458","volume":"68","author":"MF Flanagan","year":"1991","unstructured":"Flanagan MF, Fujii AM, Colan SD, Flanagan RG, Lock JE. Myocardial angiogenesis and coronary perfusion in left ventricular pressure-overload hypertrophy in the young lamb. Evidence for inhibition with chronic protamine administration. Circ Res. 1991;68:1458\u201370.","journal-title":"Circ Res"},{"issue":"2","key":"569_CR23","first-page":"647","volume":"18","author":"NG Frangogiannis","year":"2003","unstructured":"Frangogiannis NG. The pathological basis of myocardial hibernation. Histol Histopathol. 2003;18(2):647\u201355.","journal-title":"Histol Histopathol"},{"key":"569_CR24","unstructured":"Gillen C, Goyal A. Stable Angina. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2021."},{"issue":"6","key":"569_CR25","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1093\/bfgp\/els032","volume":"11","author":"KI Goh","year":"2012","unstructured":"Goh KI, Choi IG. Exploring the human disease some: the human disease network. Briefings Funct Genomics. 2012;11(6):533\u201342.","journal-title":"Briefings Funct Genomics"},{"key":"569_CR26","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1057\/jors.1992.3","volume":"43","author":"AJ Gregory","year":"1992","unstructured":"Gregory AJ, Jackson MC. Evaluation methodologies: a system for use. J Oper Res Soc. 1992;43:19\u201328.","journal-title":"J Oper Res Soc"},{"key":"569_CR27","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.copbio.2019.11.015","volume":"63","author":"TW Grunberg","year":"2020","unstructured":"Grunberg TW, Del Vecchio D. Modular analysis and design of biological circuits. Curr Opin Biotechnol. 2020;63:41\u20137.","journal-title":"Curr Opin Biotechnol"},{"issue":"11","key":"569_CR28","doi-asserted-by":"publisher","first-page":"593233","DOI":"10.3389\/fpsyt.2020.593233","volume":"21","author":"CT Gualtieri","year":"2021","unstructured":"Gualtieri CT. Genomic variation, evolvability, and the paradox of mental illness. Front Psychiatry. 2021;21(11):593233.","journal-title":"Front Psychiatry"},{"issue":"8","key":"569_CR29","doi-asserted-by":"publisher","first-page":"e0221620","DOI":"10.1371\/journal.pone.0221620","volume":"14","author":"S He","year":"2019","unstructured":"He S, Liu YJ, Ye FY, Li RP, Dai RJ. A new grid- and modularity-based layout algorithm for complex biological networks. PLoS ONE. 2019;14(8):e0221620.","journal-title":"PLoS ONE"},{"issue":"9","key":"569_CR30","doi-asserted-by":"publisher","first-page":"1948","DOI":"10.1161\/01.ATV.0000233387.90257.9b","volume":"26","author":"J Herrmann","year":"2006","unstructured":"Herrmann J, Lerman LO, Mukhopadhyay D, Napoli C, Lerman A. Angiogenesis in atherogenesis. Arterioscler Thromb Vasc Biol. 2006;26(9):1948\u201357.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"3","key":"569_CR31","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/s41576-019-0180-9","volume":"21","author":"SS Ho","year":"2020","unstructured":"Ho SS, Urban AE, Mills RE. Structural variation in the sequencing era. Nat Rev Genet. 2020;21(3):171\u201389.","journal-title":"Nat Rev Genet"},{"issue":"3","key":"569_CR32","doi-asserted-by":"publisher","first-page":"e0227244","DOI":"10.1371\/journal.pone.0227244","volume":"15","author":"K Hu","year":"2020","unstructured":"Hu K, Xiang J, Yu YX, et al. Significance-based multi-scale method for network community detection and its application in disease-gene prediction. PLoS ONE. 2020;15(3):e0227244.","journal-title":"PLoS ONE"},{"issue":"Suppl_1","key":"569_CR33","doi-asserted-by":"publisher","first-page":"i516","DOI":"10.1093\/bioinformatics\/btaa439","volume":"36","author":"M Iida","year":"2020","unstructured":"Iida M, Iwata M, Yamanishi Y. Network-based characterization of disease\u2013disease relationships in terms of drugs and therapeutic targets. Bioinformatics. 2020;36(Suppl_1):i516\u201324.","journal-title":"Bioinformatics"},{"issue":"17","key":"569_CR34","doi-asserted-by":"publisher","first-page":"2549","DOI":"10.1016\/j.febslet.2008.06.023","volume":"582","author":"X Jiang","year":"2008","unstructured":"Jiang X, Liu B, Jiang J, Zhao H, Fan M, Zhang J, Fan Z, Jiang T. Modularity in the genetic disease-phenotype network. FEBS Lett. 2008;582(17):2549\u201354.","journal-title":"FEBS Lett"},{"key":"569_CR35","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/s41540-019-0115-2","volume":"5","author":"S Jin","year":"2019","unstructured":"Jin S, Zeng X, Fang J, Lin J, Chan SY, Erzurum SC, Cheng F. A network-based approach to uncover microRNA-mediated disease comorbidities and potential pathobiological implications. NPJ Syst Biol Appl. 2019;5:41.","journal-title":"NPJ Syst Biol Appl"},{"key":"569_CR36","first-page":"94","volume":"48","author":"S Julong","year":"2005","unstructured":"Julong S, Fucai Q. The global optimization method based on golden-section. Comput Eng Appl. 2005;48:94\u20135.","journal-title":"Comput Eng Appl"},{"issue":"14","key":"569_CR37","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1096\/fj.03-0329fje","volume":"17","author":"YJ Jung","year":"2003","unstructured":"Jung YJ, Isaacs JS, Lee S, Trepel J, Neckers L. IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB\/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis. FASEB J. 2003;17(14):2115\u20137.","journal-title":"FASEB J"},{"key":"569_CR38","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.carpath.2005.03.003","volume":"14","author":"R Karch","year":"2005","unstructured":"Karch R, Neumann F, Ullrich R, Neum\u00fcller J, Podesser BK, Neumann M, Schreiner W. The spatial pattern of coronary capillaries in patients with dilated, ischemic, or inflammatory cardiomyopathy. Cardiovasc Pathol. 2005;14:135\u201344.","journal-title":"Cardiovasc Pathol"},{"key":"569_CR39","doi-asserted-by":"publisher","first-page":"13773","DOI":"10.1073\/pnas.0503610102","volume":"102","author":"N Kashtan","year":"2005","unstructured":"Kashtan N, Alon U. Spontaneous evolution of modularity and network motifs. Proc Natl Acad Sci USA. 2005;102:13773\u20138.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"569_CR40","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3858\/emm.2012.44.1.023","volume":"44","author":"KJ Kim","year":"2012","unstructured":"Kim KJ, Cho CS, Kim WU. Role of placenta growth factor in cancer and inflammation. Exp Mol Med. 2012;44(1):10\u20139.","journal-title":"Exp Mol Med"},{"issue":"6","key":"569_CR41","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1093\/aje\/kwm129","volume":"166","author":"G Kitsios","year":"2007","unstructured":"Kitsios G, Zintzaras E. Genetic variation associated with ischemic heart failure: a HuGE review and meta-analysis. Am J Epidemiol. 2007;166(6):619\u201333.","journal-title":"Am J Epidemiol"},{"issue":"7","key":"569_CR42","first-page":"61","volume":"17","author":"F Lacquaniti","year":"2013","unstructured":"Lacquaniti F, Ivanenko YP, d\u2019Avella A, Zelik KE, Zago M. Evolutionary and developmental modules. Front Comput Neurosci. 2013;17(7):61.","journal-title":"Front Comput Neurosci"},{"issue":"9","key":"569_CR43","doi-asserted-by":"publisher","first-page":"795883","DOI":"10.3389\/fcell.2021.795883","volume":"25","author":"X Lin","year":"2021","unstructured":"Lin X. Genomic variation prediction: a summary from different views. Front Cell Dev Biol. 2021;25(9):795883.","journal-title":"Front Cell Dev Biol"},{"issue":"9","key":"569_CR44","first-page":"654","volume":"55","author":"XJ Lin","year":"2020","unstructured":"Lin XJ, Zhang D, Huang MY, Cheng H, Yu H. Evaluation of computer-aided diagnosis system for detecting dental approximal caries lesions on periapical radiographs. Zhonghua Kou Qiang Yi Xue Za Zhi. 2020;55(9):654\u201360 (Chinese).","journal-title":"Zhonghua Kou Qiang Yi Xue Za Zhi"},{"issue":"5","key":"569_CR45","doi-asserted-by":"publisher","first-page":"2268","DOI":"10.1002\/cam4.1845","volume":"8","author":"Q Liu","year":"2019","unstructured":"Liu Q, Zhang Y, Wang P, et al. Deciphering the scalene association among type-2 diabetes mellitus, prostate cancer, and chronic myeloid leukemia via enrichment analysis of disease-gene network. Cancer Med. 2019;8(5):2268\u201377.","journal-title":"Cancer Med"},{"issue":"1","key":"569_CR46","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/s41392-021-00741-x","volume":"6","author":"J Liu","year":"2021","unstructured":"Liu J, Li DD, Dong W, et al. Detection of an anti-angina therapeutic module in the effective population treated by a multi-target drug Danhong injection: a randomized trial. Signal Transduct Target Ther. 2021;6(1):329.","journal-title":"Signal Transduct Target Ther"},{"issue":"5","key":"569_CR47","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.3892\/ijmm.2015.2115","volume":"35","author":"R Matsuoka","year":"2015","unstructured":"Matsuoka R, Abe S, Tokoro F, Arai M, Noda T, Watanabe S, Horibe H, Fujimaki T, Oguri M, Kato K, Minatoguchi S, Yamada Y. Association of six genetic variants with myocardial infarction. Int J Mol Med. 2015;35(5):1451\u20139.","journal-title":"Int J Mol Med"},{"issue":"38","key":"569_CR48","doi-asserted-by":"publisher","first-page":"2949","DOI":"10.1093\/eurheartj\/eht296","volume":"34","author":"G Montalescot","year":"2013","unstructured":"Montalescot G, Sechtem U, Achenbach S, Andreotti F, Arden C, Budaj A, et al. 2013 ESC guidelines on the management of stable coronary artery disease: the Task Force on the management of stable coronary artery disease of the European Society of Cardiology. Eur Heart J. 2013;34(38):2949\u20133003.","journal-title":"Eur Heart J"},{"issue":"7","key":"569_CR49","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1007\/s11886-021-01520-4","volume":"23","author":"F Moroni","year":"2021","unstructured":"Moroni F, Gertz Z, Azzalini L. Relief of ischemia in ischemic cardiomyopathy. Curr Cardiol Rep. 2021;23(7):80.","journal-title":"Curr Cardiol Rep"},{"issue":"1","key":"569_CR50","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1186\/s13059-020-02108-x","volume":"21","author":"L Nanni","year":"2020","unstructured":"Nanni L, Ceri S, Logie C. Spatial patterns of CTCF sites define the anatomy of TADs and their boundaries. Genome Biol. 2020;21(1):197.","journal-title":"Genome Biol"},{"issue":"2","key":"569_CR51","doi-asserted-by":"publisher","first-page":"026113","DOI":"10.1103\/PhysRevE.69.026113","volume":"69","author":"MEJ Newman","year":"2004","unstructured":"Newman MEJ, Girvan M. Finding and evaluating community structure in networks. Phys Rev E. 2004;69(2):026113.","journal-title":"Phys Rev E"},{"issue":"3","key":"569_CR52","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1109\/TCBB.2018.2817624","volume":"17","author":"P Ni","year":"2020","unstructured":"Ni P, Wang J, Zhong P, Li Y, Wu FX, Pan Y. Constructing disease similarity networks based on disease module theory. IEEE\/ACM Trans Comput Biol Bioinform. 2020;17(3):906\u201315.","journal-title":"IEEE\/ACM Trans Comput Biol Bioinform"},{"issue":"3","key":"569_CR53","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1161\/CIRCRESAHA.114.300507","volume":"114","author":"T Oka","year":"2014","unstructured":"Oka T, Akazawa H, Naito AT, Komuro I. Angiogenesis and cardiac hypertrophy: maintenance of cardiac function and causative roles in heart failure. Circ Res. 2014;114(3):565\u201371.","journal-title":"Circ Res"},{"issue":"1","key":"569_CR54","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.atherosclerosis.2006.10.038","volume":"196","author":"K Pilarczyk","year":"2008","unstructured":"Pilarczyk K, Sattler KJE, Galili O, et al. Placenta growth factor expression in human atherosclerotic carotid plaques is related to plaque destabilization. Atherosclerosis. 2008;196(1):333\u201340.","journal-title":"Atherosclerosis"},{"issue":"2","key":"569_CR55","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s10456-017-9552-y","volume":"20","author":"RR Ramjiawan","year":"2017","unstructured":"Ramjiawan RR, Griffioen AW, Duda DG. Anti-angiogenesis for cancer revisited: is there a role for combinations with immunotherapy? Angiogenesis. 2017;20(2):185\u2013204.","journal-title":"Angiogenesis"},{"key":"569_CR56","doi-asserted-by":"publisher","first-page":"104080","DOI":"10.1016\/j.biosystems.2019.104080","volume":"189","author":"MMG Santos","year":"2020","unstructured":"Santos MMG, Beijo LA, Avelar FG, Petrini J. Statistical methods for identification of golden ratio. Biosystems. 2020;189:104080.","journal-title":"Biosystems"},{"issue":"12","key":"569_CR57","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1007\/s11906-018-0900-0","volume":"20","author":"R Satou","year":"2018","unstructured":"Satou R, Penrose H, Navar LG. Inflammation as a regulator of the renin-angiotensin system and blood pressure. Curr Hypertens Rep. 2018;20(12):100.","journal-title":"Curr Hypertens Rep"},{"issue":"6","key":"569_CR58","doi-asserted-by":"publisher","first-page":"e006006","DOI":"10.1161\/CIRCHEARTFAILURE.119.006006","volume":"12","author":"M Sekulic","year":"2019","unstructured":"Sekulic M, Zacharias M, Medalion B. Ischemic cardiomyopathy and heart failure. Circ Heart Fail. 2019;12(6):e006006.","journal-title":"Circ Heart Fail"},{"key":"569_CR59","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.cytogfr.2017.12.001","volume":"39","author":"M Skoda","year":"2018","unstructured":"Skoda M, Stangret A, Szukiewicz D. Fractalkine and placental growth factor: a duet of inflammation and angiogenesis in cardiovascular disorders. Cytokine Growth Factor Rev. 2018;39:116\u201323.","journal-title":"Cytokine Growth Factor Rev"},{"issue":"1","key":"569_CR60","doi-asserted-by":"publisher","first-page":"8705","DOI":"10.1038\/s41598-020-65633-6","volume":"10","author":"M Sumathipala","year":"2020","unstructured":"Sumathipala M, Weiss ST. Predicting miRNA-based disease\u2013disease relationships through network diffusion on multi-omics biological data. Sci Rep. 2020;10(1):8705.","journal-title":"Sci Rep"},{"key":"569_CR61","doi-asserted-by":"publisher","first-page":"175","DOI":"10.4137\/BBI.S35237","volume":"9","author":"A Suratanee","year":"2015","unstructured":"Suratanee A, Plaimas K. DDA: a novel network-based scoring method to identify disease\u2013disease associations. Bioinform Biol Insights. 2015;9:175\u201386.","journal-title":"Bioinform Biol Insights"},{"key":"569_CR62","doi-asserted-by":"publisher","first-page":"6473745","DOI":"10.1155\/2020\/6473745","volume":"2020","author":"YG Tao","year":"2020","unstructured":"Tao YG, Huang XF, Wang JY, Kang MR, Wang LJ, Xian SX. Exploring molecular mechanism of Huangqi in treating heart failure using network pharmacology. Evid Based Complement Alternat Med. 2020;2020:6473745.","journal-title":"Evid Based Complement Alternat Med"},{"issue":"9","key":"569_CR63","first-page":"1593","volume":"19","author":"D Tousoulis","year":"2013","unstructured":"Tousoulis D, Androulakis E, Kontogeorgou A, Papageorgiou N, Charakida M, et al. Insight to the pathophysiology of stable angina pectoris. Curr Pharm Des. 2013;19(9):1593\u2013600.","journal-title":"Curr Pharm Des"},{"issue":"20","key":"569_CR64","doi-asserted-by":"publisher","first-page":"10955","DOI":"10.3390\/ijerph182010955","volume":"18","author":"W Wang","year":"2021","unstructured":"Wang W, Zhang C, Guo Y, Xu D. Impact of environmental and health risks on rural households\u2019 sustainable livelihoods: evidence from China. Int J Environ Res Public Health. 2021a;18(20):10955 (Published 2021 Oct 18).","journal-title":"Int J Environ Res Public Health"},{"issue":"6","key":"569_CR65","doi-asserted-by":"publisher","first-page":"2836","DOI":"10.3390\/ijerph18062836","volume":"18","author":"F Wang","year":"2021","unstructured":"Wang F, Lu Y, Li J, Ni J. Evaluating environmentally sustainable development based on the PSR framework and variable weigh analytic hierarchy process. Int J Environ Res Public Health. 2021b;18(6):2836 (Published 2021 Mar 10).","journal-title":"Int J Environ Res Public Health"},{"issue":"14","key":"569_CR66","doi-asserted-by":"publisher","first-page":"E841","DOI":"10.1073\/pnas.1202081109","volume":"109","author":"H Wei","year":"2012","unstructured":"Wei H, Bedja D, Koitabashi N, Xing D, et al. Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-\u03b2 signaling. Proc Natl Acad Sci USA. 2012;109(14):E841\u201350.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"23","key":"569_CR67","doi-asserted-by":"publisher","first-page":"1910","DOI":"10.1136\/heartjnl-2018-313397","volume":"104","author":"AM Wolfson","year":"2018","unstructured":"Wolfson AM, Fong M, Grazette L, Rahman JE, Shavelle DM. Chronic heart failure management and remote haemodynamic monitoring. Heart. 2018;104(23):1910\u20139.","journal-title":"Heart"},{"issue":"1","key":"569_CR68","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1038\/s41467-018-03024-2","volume":"9","author":"B Yang","year":"2018","unstructured":"Yang B, Li M, Tang W, Liu W, Zhang S, Chen L, Xia J. Dynamic network biomarker indicates pulmonary metastasis at the tipping point of hepatocellular carcinoma. Nat Commun. 2018;9(1):678.","journal-title":"Nat Commun"},{"issue":"4","key":"569_CR69","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1615\/CritRevEukaryotGeneExpr.2016016649","volume":"26","author":"Y Yu","year":"2016","unstructured":"Yu Y, Wang Z, Wang Y. Decoding the polyphyletic flexibility of allosteric modular networks: progress and perspectives. Crit Rev Eukaryot Gene Expr. 2016;26(4):279\u2013301.","journal-title":"Crit Rev Eukaryot Gene Expr"},{"issue":"2","key":"569_CR70","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s00395-005-0511-6","volume":"100","author":"A Zernecke","year":"2005","unstructured":"Zernecke A, Weber C. Inflammatory mediators in atherosclerotic vascular disease. Basic Res Cardiol. 2005;100(2):93\u2013101.","journal-title":"Basic Res Cardiol"},{"issue":"4","key":"569_CR71","first-page":"3547","volume":"18","author":"Z Zhang","year":"2018","unstructured":"Zhang Z, Yao L, Yang J, Wang Z, Du G. PI3K\/Akt and HIF-1 signaling pathway in hypoxia-ischemia (Review). Mol Med Rep. 2018;18(4):3547\u201354.","journal-title":"Mol Med Rep"},{"issue":"1","key":"569_CR72","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s11306-020-1637-8","volume":"16","author":"G Zhang","year":"2020","unstructured":"Zhang G, Zhang J, DeHoog RJ, et al. DESI-MSI and METASPACE indicates lipid abnormalities and altered mitochondrial membrane components in diabetic renal proximal tubules. Metabolomics. 2020;16(1):11.","journal-title":"Metabolomics"}],"container-title":["Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s10020-022-00569-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s10020-022-00569-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s10020-022-00569-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,27]],"date-time":"2022-11-27T11:21:10Z","timestamp":1669548070000},"score":1,"resource":{"primary":{"URL":"https:\/\/molmed.biomedcentral.com\/articles\/10.1186\/s10020-022-00569-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,26]]},"references-count":72,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["569"],"URL":"https:\/\/doi.org\/10.1186\/s10020-022-00569-3","relation":{},"ISSN":["1076-1551","1528-3658"],"issn-type":[{"value":"1076-1551","type":"print"},{"value":"1528-3658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,26]]},"assertion":[{"value":"31 March 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 November 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no conflict of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"140"}}