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Platelet-rich plasma (PRP) is an autologous product rich in growth factors, with tissue regenerative potential. PRP has shown promise in multiple I\/R-induced tissue injuries, but its effects on skin flap injury remain unexplored.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We evaluated the effects of PRP on I\/R-injured skin flaps, optimal timing of PRP administration, and the involved mechanisms.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>PRP protected against I\/R-induced skin flap injury by improving flap survival, promoting blood perfusion and angiogenesis, suppressing oxidative stress and inflammatory response, and reducing apoptosis, at least partly via deactivating Janus kinase (JAK)-signal transducers and activators of transcription (STAT) signalling pathway. PRP given before ischemia displayed overall advantages over that given before reperfusion or during reperfusion. In addition, PRP pretreatment had a stronger ability to reverse I\/R-induced JAK\/STAT activation and apoptosis than AG490, a specific inhibitor of JAK\/STAT signalling.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This study firstly demonstrates the protective role of PRP against I\/R-injured skin flaps through negative regulation of JAK\/STAT activation, with PRP pretreatment showing optimal therapeutic effects.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s10020-024-00781-3","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T17:02:37Z","timestamp":1706806957000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Pretreatment with platelet-rich plasma protects against ischemia\u2013reperfusion induced flap injury by deactivating the JAK\/STAT pathway in mice"],"prefix":"10.1186","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9381-1114","authenticated-orcid":false,"given":"Linlin","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songtao","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhui","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunchuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,1]]},"reference":[{"issue":"3","key":"781_CR1","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1007\/s00383-004-1317-1","volume":"21","author":"PK Adivarekar","year":"2005","unstructured":"Adivarekar PK, Bhagwat SS, Raghavan V, Bandivdekar AH. 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