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This study aims to unravel the role of the RPS27A-mediated PSMD12\/NF-\u03baB axis in controlling immune cell infiltration in the context of cerebral I\/R injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To identify genes associated with cerebral I\/R injury, high-throughput sequencing was employed. The potential downstream genes were further analyzed using Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Protein-Protein Interaction (PPI) analyses. For experimental models, primary microglia and neurons were extracted from the cortical tissues of mouse brains. An in vitro cerebral I\/R injury model was established in microglia using the oxygen-glucose deprivation\/reoxygenation (OGD\/R) technique. In vivo models involved inducing cerebral I\/R injury in mice through the middle cerebral artery occlusion (MCAO) method. These models were used to assess neurological function, immune cell infiltration, and inflammatory factor release.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study identified RPS27A as a key player in cerebral I\/R injury, with PSMD12 likely acting as its downstream regulator. Silencing RPS27A in OGD\/R-induced microglia decreased the release of inflammatory factors and reduced neuron apoptosis. Additionally, RPS27A silencing in cerebral cortex tissues mediated the PSMD12\/NF-\u03baB axis, resulting in decreased inflammatory factor release, reduced neutrophil infiltration, and improved cerebral injury outcomes in I\/R-injured mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>RPS27A regulates the expression of the PSMD12\/NF-\u03baB signaling axis, leading to the induction of inflammatory factors in microglial cells, promoting immune cell infiltration in brain tissue, and exacerbating brain damage in I\/R mice. This study introduces novel insights and theoretical foundations for the treatment of nerve damage caused by I\/R, suggesting that targeting the RPS27A and downstream PSMD12\/NF-\u03baB signaling axis for drug development could represent a new direction in I\/R therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s10020-024-00870-3","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T05:02:32Z","timestamp":1721624552000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Modulating the RPS27A\/PSMD12\/NF-\u03baB pathway to control immune response in mouse brain ischemia-reperfusion injury"],"prefix":"10.1186","volume":"30","author":[{"given":"Xiaocheng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenchen","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4546-926X","authenticated-orcid":false,"given":"Yamei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,22]]},"reference":[{"issue":"25","key":"870_CR1","doi-asserted-by":"publisher","first-page":"3791","DOI":"10.1182\/blood-2014-06-584656","volume":"124","author":"E Bibikova","year":"2014","unstructured":"Bibikova E, Youn MY, Danilova N, et al. 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