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In this article, we assessed the effect of ghrelin on preventing oxidative stress induced by hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>) in ARPE-19 cells and its mechanism. We observed that pretreatment with ghrelin protected ARPE-19 cells from H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>-induced cell oxidative injuries and apoptosis responses. Furthermore, an oxidative stress-induced mouse model of AMD was established via injection of sodium iodate (NaIO<jats:sub>3<\/jats:sub>) to tail veins, and treatment with ghrelin preserved retinal function, and protected photoreceptors.<\/jats:p>","DOI":"10.1186\/s10020-024-00920-w","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T19:02:20Z","timestamp":1725908540000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Protective effect of ghrelin in oxidative stress-induced age-related macular degeneration in vitro and in vivo"],"prefix":"10.1186","volume":"30","author":[{"given":"Jie","family":"Bai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanze","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1921-1644","authenticated-orcid":false,"given":"Shan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,9]]},"reference":[{"key":"920_CR9","doi-asserted-by":"publisher","first-page":"1910450","DOI":"10.1155\/2017\/1910450","volume":"2017","author":"J Bai","year":"2017","unstructured":"Bai J, Yang F. Ghrelin protects human lens epithelial cells against oxidative stress-induced damage. Oxid Med Cell Longev. 2017;2017:1910450.","journal-title":"Oxid Med Cell Longev"},{"key":"920_CR22","doi-asserted-by":"crossref","unstructured":"Bai J, Yang F, Wang R et al. Ghrelin ameliorates diabetic retinal injury: potential therapeutic avenues for diabetic retinopathy. Oxid Med Cell Longev. 2021; 2021:8043299.","DOI":"10.1155\/2021\/8043299"},{"key":"920_CR23","first-page":"2819","volume":"9","author":"N Can","year":"2015","unstructured":"Can N, Catak O, Turgut B, et al. Neuroprotective and antioxidant effects of ghrelin in an experimental glaucoma model. Drug Des Devel Ther. 2015;9:2819\u201329.","journal-title":"Drug Des Devel Ther"},{"issue":"1","key":"920_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13578-021-00736-9","volume":"12","author":"KC Chang","year":"2022","unstructured":"Chang KC, Liu PF, Chang CH, et al. The interplay of autophagy and oxidative stress in the pathogenesis and therapy of retinal degenerative diseases. Cell Biosci. 2022;12(1):1.","journal-title":"Cell Biosci"},{"issue":"1","key":"920_CR8","doi-asserted-by":"publisher","first-page":"2179","DOI":"10.1080\/21691401.2019.1620253","volume":"47","author":"Y Chen","year":"2019","unstructured":"Chen Y, Wang H, Zhang Y, et al. Pretreatment of ghrelin protects H9c2 cells against hypoxia\/reoxygenation induced cell death via PI3K\/AKT and AMPK pathways. Artif Cells Nanomed Biotechnol. 2019;47(1):2179\u201387.","journal-title":"Artif Cells Nanomed Biotechnol"},{"issue":"1","key":"920_CR16","doi-asserted-by":"publisher","first-page":"12694","DOI":"10.1038\/s41598-022-16701-6","volume":"12","author":"L Chen","year":"2022","unstructured":"Chen L, Perera ND, Karoukis AJ, et al. Oxidative stress differentially impacts apical and basolateral secretion of angiogenic factors from human iPSC-derived retinal pigment epithelium cells. 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