{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:55:57Z","timestamp":1787237757278,"version":"build-2736575974"},"reference-count":91,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["P01AI102852"],"award-info":[{"award-number":["P01AI102852"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI135063"],"award-info":[{"award-number":["R01AI135063"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002570","name":"American Association of Immunologists","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002570","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005865","name":"Mochida Memorial Foundation for Medical and Pharmaceutical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005865","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Japan Rheumatism Foundation"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Med"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Sepsis survivors exhibit immune dysregulation that contributes to poor long-term outcomes. Phenotypic and functional alterations within the myeloid compartment are believed to be a contributing factor. Here we dissect the cellular and transcriptional heterogeneity of splenic CD11b\n                      <jats:sup>+<\/jats:sup>\n                      Ly6C\n                      <jats:sup>high<\/jats:sup>\n                      myeloid cells that are expanded in mice that survive the cecal ligation and puncture (CLP) murine model of polymicrobial sepsis to better understand the basis of immune dysregulation in sepsis survivors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Sham or CLP surgeries were performed on C57BL\/6J and BALB\/c mice. Four weeks later splenic CD11b\n                      <jats:sup>+<\/jats:sup>\n                      Ly6C\n                      <jats:sup>high<\/jats:sup>\n                      cells from both groups were isolated for phenotypic (flow cytometry) and functional (phagocytosis and glycolysis) characterization and RNA was obtained for single-cell RNA-seq (scRNA-seq) and subsequent analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CD11b\n                      <jats:sup>+<\/jats:sup>\n                      Ly6C\n                      <jats:sup>high<\/jats:sup>\n                      cells from sham and CLP surviving mice exhibit phenotypic and functional differences that relate to immune function, some of which are observed in both C57BL\/6J and BALB\/c strains and others that are not. To dissect disease-specific and strain-specific distinctions within the myeloid compartment, scRNA-seq analysis was performed on CD11b\n                      <jats:sup>+<\/jats:sup>\n                      Ly6C\n                      <jats:sup>high<\/jats:sup>\n                      cells from C57BL\/6J and BALB\/c sham and CLP mice. Uniform Manifold Approximation and Projection from both strains identified 13 distinct clusters of sorted CD11b\n                      <jats:sup>+<\/jats:sup>\n                      Ly6C\n                      <jats:sup>high<\/jats:sup>\n                      cells demonstrating significant transcriptional heterogeneity and expressing gene signatures corresponding to classical-monocytes, non-classical monocytes, M1- or M2-like macrophages, dendritic-like cells, monocyte-derived dendritic-like cells, and proliferating monocytic myeloid-derived suppressor cells (M-MDSCs). Frequency plots showed that the percentages of proliferating M-MDSCs (clusters 8, 11 and 12) were increased in CLP mice compared to sham mice in both strains. Pathway and UCell score analysis in CLP mice revealed that cell cycle and glycolytic pathways were upregulated in proliferating M-MDSCs in both strains. Notably, granule protease genes were upregulated in M-MDSCs from CLP mice. ScRNA-seq analyses also showed that phagocytic pathways were upregulated in multiple clusters including the classical monocyte cluster, confirming the increased phagocytic capacity in CD11b\n                      <jats:sup>+<\/jats:sup>\n                      Ly6C\n                      <jats:sup>high<\/jats:sup>\n                      cells from CLP mice observed in ex vivo functional assays in C57BL\/6J mice.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The splenic CD11b\n                      <jats:sup>+<\/jats:sup>\n                      Ly6C\n                      <jats:sup>high<\/jats:sup>\n                      myeloid populations expanded in survivors of CLP sepsis correspond to proliferating cells that have an increased metabolic demand and gene signatures consistent with M-MDSCs, a population known to have immunosuppressive capacity.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s10020-024-00970-0","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T05:03:59Z","timestamp":1730869439000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Single cell RNA-seq reveals cellular and transcriptional heterogeneity in the splenic CD11b+Ly6Chigh monocyte population expanded in sepsis-surviving mice"],"prefix":"10.1186","volume":"30","author":[{"given":"Haruki","family":"Watanabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minakshi","family":"Rana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myoungsun","family":"Son","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pui Yan","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurong","family":"Fei-Bloom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwangmin","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty","family":"Diamond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3119-1463","authenticated-orcid":false,"given":"Barbara","family":"Sherry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,6]]},"reference":[{"key":"970_CR1","first-page":"325","volume-title":"Cellular and molecular immunology","author":"AK Abbas","year":"2018","unstructured":"Abbas AK, Lichtman AH, Pillai S, Baker DL, Baker A. Cellular and molecular immunology. 9th ed. Philadelphia: Elsevier; 2018. p. 325\u201348.","edition":"9"},{"issue":"1","key":"970_CR2","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1038\/s41467-022-28372-y","volume":"13","author":"N Abdelfattah","year":"2022","unstructured":"Abdelfattah N, Kumar P, Wang C, Leu JS, Flynn WF, Gao R, et al. Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target. Nat Commun. 2022;13(1):767.","journal-title":"Nat Commun"},{"issue":"6774","key":"970_CR3","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1038\/35004599","volume":"404","author":"K Akashi","year":"2000","unstructured":"Akashi K, Traver D, Miyamoto T, Weissman IL. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature. 2000;404(6774):193\u20137.","journal-title":"Nature"},{"issue":"8","key":"970_CR4","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1002\/eji.201747050","volume":"47","author":"DA Anderson 3rd","year":"2017","unstructured":"Anderson DA 3rd, Grajales-Reyes GE, Satpathy AT, Vasquez Hueichucura CE, Murphy TL, Murphy KM. Revisiting the specificity of the MHC class II transactivator CIITA in classical murine dendritic cells in vivo. Eur J Immunol. 2017;47(8):1317\u201323.","journal-title":"Eur J Immunol"},{"issue":"5","key":"970_CR5","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.smim.2016.09.002","volume":"28","author":"RJ Arts","year":"2016","unstructured":"Arts RJ, Joosten LA, Netea MG. Immunometabolic circuits in trained immunity. Semin Immunol. 2016;28(5):425\u201330.","journal-title":"Semin Immunol"},{"key":"970_CR6","doi-asserted-by":"publisher","first-page":"675","DOI":"10.3389\/fimmu.2020.00675","volume":"11","author":"C Baudesson de Chanville","year":"2020","unstructured":"Baudesson de Chanville C, Chousterman BG, Hamon P, Laviron M, Guillou N, Loyher PL, et al. Sepsis triggers a late expansion of functionally impaired tissue-vascular inflammatory monocytes during clinical recovery. Front Immunol. 2020;11:675.","journal-title":"Front Immunol"},{"key":"970_CR7","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.MCHD-0045-2016","author":"S Bournazos","year":"2016","unstructured":"Bournazos S, Wang TT, Ravetch JV. The role and function of Fcgamma receptors on myeloid cells. Microbiol Spectr. 2016. https:\/\/doi.org\/10.1128\/microbiolspec.MCHD-0045-2016.","journal-title":"Microbiol Spectr"},{"key":"970_CR8","doi-asserted-by":"publisher","first-page":"12150","DOI":"10.1038\/ncomms12150","volume":"7","author":"V Bronte","year":"2016","unstructured":"Bronte V, Brandau S, Chen SH, Colombo MP, Frey AB, Greten TF, et al. Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards. Nat Commun. 2016;7:12150.","journal-title":"Nat Commun"},{"issue":"6","key":"970_CR9","doi-asserted-by":"publisher","first-page":"2026","DOI":"10.1128\/IAI.00239-12","volume":"80","author":"L Brudecki","year":"2012","unstructured":"Brudecki L, Ferguson DA, McCall CE, El Gazzar M. Myeloid-derived suppressor cells evolve during sepsis and can enhance or attenuate the systemic inflammatory response. Infect Immun. 2012;80(6):2026\u201334.","journal-title":"Infect Immun"},{"issue":"23","key":"970_CR10","doi-asserted-by":"publisher","first-page":"6526","DOI":"10.1073\/pnas.1524292113","volume":"113","author":"B Cai","year":"2016","unstructured":"Cai B, Thorp EB, Doran AC, Subramanian M, Sansbury BE, Lin CS, et al. MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation. Proc Natl Acad Sci U S A. 2016;113(23):6526\u201331.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"970_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10245831","author":"D Cenariu","year":"2021","unstructured":"Cenariu D, Iluta S, Zimta AA, Petrushev B, Qian L, Dirzu N, et al. Extramedullary hematopoiesis of the liver and spleen. J Clin Med. 2021. https:\/\/doi.org\/10.3390\/jcm10245831.","journal-title":"J Clin Med"},{"issue":"5","key":"970_CR12","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1097\/00024382-200116050-00004","volume":"16","author":"M Chiamolera","year":"2001","unstructured":"Chiamolera M, Launay P, Montenegro V, Rivero MC, Velasco IT, Monteiro RC. Enhanced expression of Fc alpha receptor I on blood phagocytes of patients with gram-negative bacteremia is associated with tyrosine phosphorylation of the FcR-gamma subunit. Shock. 2001;16(5):344\u20138.","journal-title":"Shock"},{"key":"970_CR13","doi-asserted-by":"publisher","DOI":"10.1002\/0471142735.im1913s91","author":"AG Cuenca","year":"2010","unstructured":"Cuenca AG, Delano MJ, Kelly-Scumpia KM, Moldawer LL, Efron PA. Cecal ligation and puncture. Curr Protoc Immunol. 2010. https:\/\/doi.org\/10.1002\/0471142735.im1913s91.","journal-title":"Curr Protoc Immunol"},{"issue":"3\u20134","key":"970_CR14","doi-asserted-by":"publisher","first-page":"281","DOI":"10.2119\/molmed.2010.00178","volume":"17","author":"AG Cuenca","year":"2011","unstructured":"Cuenca AG, Delano MJ, Kelly-Scumpia KM, Moreno C, Scumpia PO, Laface DM, et al. A paradoxical role for myeloid-derived suppressor cells in sepsis and trauma. Mol Med. 2011;17(3\u20134):281\u201392.","journal-title":"Mol Med"},{"issue":"1","key":"970_CR15","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1111\/j.1365-2249.2008.03737.x","volume":"154","author":"DD Danikas","year":"2008","unstructured":"Danikas DD, Karakantza M, Theodorou GL, Sakellaropoulos GC, Gogos CA. Prognostic value of phagocytic activity of neutrophils and monocytes in sepsis. Correlation to CD64 and CD14 antigen expression. Clin Exp Immunol. 2008;154(1):87\u201397.","journal-title":"Clin Exp Immunol"},{"issue":"5","key":"970_CR16","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1097\/SHK.0000000000001671","volume":"55","author":"DB Darden","year":"2021","unstructured":"Darden DB, Bacher R, Brusko MA, Knight P, Hawkins RB, Cox MC, et al. Single-cell RNA-seq of human myeloid-derived suppressor cells in late sepsis reveals multiple subsets with unique transcriptional responses: a pilot study. Shock. 2021;55(5):587\u201395.","journal-title":"Shock"},{"issue":"1","key":"970_CR17","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1038\/s41420-021-00621-x","volume":"7","author":"NA DaSilva","year":"2021","unstructured":"DaSilva NA, Barlock BJ, Guha P, Ghosh CC, Trebino CE, Camberg JL, et al. Proteomic signatures of myeloid derived suppressor cells from liver and lung metastases reveal functional divergence and potential therapeutic targets. Cell Death Discov. 2021;7(1):232.","journal-title":"Cell Death Discov"},{"issue":"3","key":"970_CR18","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/j.celrep.2019.03.062","volume":"27","author":"C De Tymowski","year":"2019","unstructured":"De Tymowski C, Heming N, Correia MDT, Abbad L, Chavarot N, Le Stang MB, et al. CD89 is a potent innate receptor for bacteria and mediates host protection from sepsis. Cell Rep. 2019;27(3):762-75 e5.","journal-title":"Cell Rep"},{"issue":"1","key":"970_CR19","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1111\/imr.12499","volume":"274","author":"MJ Delano","year":"2016","unstructured":"Delano MJ, Ward PA. The immune system\u2019s role in sepsis progression, resolution, and long-term outcome. Immunol Rev. 2016a;274(1):330\u201353.","journal-title":"Immunol Rev"},{"issue":"1","key":"970_CR20","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1172\/JCI82224","volume":"126","author":"MJ Delano","year":"2016","unstructured":"Delano MJ, Ward PA. Sepsis-induced immune dysfunction: can immune therapies reduce mortality? J Clin Invest. 2016b;126(1):23\u201331.","journal-title":"J Clin Invest"},{"issue":"3","key":"970_CR21","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1159\/000519306","volume":"14","author":"O Dietrich","year":"2022","unstructured":"Dietrich O, Heinz A, Goldmann O, Geffers R, Beineke A, Hiller K, et al. Dysregulated immunometabolism is associated with the generation of myeloid-derived suppressor cells in staphylococcus aureus chronic infection. J Innate Immun. 2022;14(3):257\u201374.","journal-title":"J Innate Immun"},{"issue":"12","key":"970_CR22","doi-asserted-by":"publisher","first-page":"2040","DOI":"10.1086\/324502","volume":"33","author":"G Engelich","year":"2001","unstructured":"Engelich G, Wright DG, Hartshorn KL. Acquired disorders of phagocyte function complicating medical and surgical illnesses. Clin Infect Dis. 2001;33(12):2040\u20138.","journal-title":"Clin Infect Dis"},{"issue":"5757","key":"970_CR23","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1126\/science.1117729","volume":"311","author":"DK Fogg","year":"2006","unstructured":"Fogg DK, Sibon C, Miled C, Jung S, Aucouturier P, Littman DR, et al. A clonogenic bone marrow progenitor specific for macrophages and dendritic cells. Science. 2006;311(5757):83\u20137.","journal-title":"Science"},{"key":"970_CR500","doi-asserted-by":"crossref","unstructured":"Ge SX, Jung D, Yao R. ShinyGO: a graphical gene-set enrichment tool for animals and plants. Bioinformatics (Oxford, England). 2020;36(8):2628-9.","DOI":"10.1093\/bioinformatics\/btz931"},{"issue":"12","key":"970_CR24","first-page":"5696","volume":"8","author":"XY Ge","year":"2016","unstructured":"Ge XY, Fang SP, Zhou M, Luo J, Wei J, Wen XP, et al. TLR4-dependent internalization of CX3CR1 aggravates sepsis-induced immunoparalysis. Am J Transl Res. 2016;8(12):5696\u2013705.","journal-title":"Am J Transl Res"},{"issue":"1","key":"970_CR25","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S1074-7613(03)00174-2","volume":"19","author":"F Geissmann","year":"2003","unstructured":"Geissmann F, Jung S, Littman DR. Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity. 2003;19(1):71\u201382.","journal-title":"Immunity"},{"issue":"5966","key":"970_CR26","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1126\/science.1178331","volume":"327","author":"F Geissmann","year":"2010","unstructured":"Geissmann F, Manz MG, Jung S, Sieweke MH, Merad M, Ley K. Development of monocytes, macrophages, and dendritic cells. Science. 2010;327(5966):656\u201361.","journal-title":"Science"},{"issue":"6","key":"970_CR27","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1038\/nri3671","volume":"14","author":"F Ginhoux","year":"2014","unstructured":"Ginhoux F, Jung S. Monocytes and macrophages: developmental pathways and tissue homeostasis. Nat Rev Immunol. 2014;14(6):392\u2013404.","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"970_CR28","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s12974-024-03032-8","volume":"21","author":"EK Gudenschwager Basso","year":"2024","unstructured":"Gudenschwager Basso EK, Ju J, Soliman E, de Jager C, Wei X, Pridham KJ, et al. Immunoregulatory and neutrophil-like monocyte subsets with distinct single-cell transcriptomic signatures emerge following brain injury. J Neuroinflammation. 2024;21(1):41.","journal-title":"J Neuroinflammation"},{"issue":"4","key":"970_CR29","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.immuni.2018.10.005","volume":"49","author":"M Guilliams","year":"2018","unstructured":"Guilliams M, Mildner A, Yona S. Developmental and functional heterogeneity of monocytes. Immunity. 2018;49(4):595\u2013613.","journal-title":"Immunity"},{"key":"970_CR30","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00684-18","author":"CE Heim","year":"2018","unstructured":"Heim CE, West SC, Ali H, Kielian T. Heterogeneity of Ly6G(+) Ly6C(+) myeloid-derived suppressor cell infiltrates during staphylococcus aureus biofilm infection. Infect Immun. 2018. https:\/\/doi.org\/10.1128\/IAI.00684-18.","journal-title":"Infect Immun"},{"issue":"8","key":"970_CR31","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1038\/ni.2638","volume":"14","author":"J Hettinger","year":"2013","unstructured":"Hettinger J, Richards DM, Hansson J, Barra MM, Joschko AC, Krijgsveld J, Feuerer M. Origin of monocytes and macrophages in a committed progenitor. Nat Immunol. 2013;14(8):821\u201330.","journal-title":"Nat Immunol"},{"issue":"8","key":"970_CR32","doi-asserted-by":"publisher","first-page":"5128","DOI":"10.1111\/jcmm.14382","volume":"23","author":"YY Hey","year":"2019","unstructured":"Hey YY, O\u2019Neill TJ, O\u2019Neill HC. A novel myeloid cell in murine spleen defined through gene profiling. J Cell Mol Med. 2019;23(8):5128\u201343.","journal-title":"J Cell Mol Med"},{"issue":"5","key":"970_CR33","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1097\/SHK.0000000000001541","volume":"54","author":"M Hortova-Kohoutkova","year":"2020","unstructured":"Hortova-Kohoutkova M, Tidu F, De Zuani M, Sramek V, Helan M, Fric J. Phagocytosis-inflammation crosstalk in sepsis: new avenues for therapeutic intervention. Shock. 2020;54(5):606\u201314.","journal-title":"Shock"},{"issue":"3","key":"970_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112165","volume":"42","author":"N Ikeda","year":"2023","unstructured":"Ikeda N, Kubota H, Suzuki R, Morita M, Yoshimura A, Osada Y, et al. The early neutrophil-committed progenitors aberrantly differentiate into immunoregulatory monocytes during emergency myelopoiesis. Cell Rep. 2023;42(3): 112165.","journal-title":"Cell Rep"},{"issue":"2","key":"970_CR35","doi-asserted-by":"publisher","first-page":"421","DOI":"10.4049\/jimmunol.2000498","volume":"207","author":"M Lancien","year":"2021","unstructured":"Lancien M, Bienvenu G, Salle S, Gueno L, Feyeux M, Merieau E, et al. Dendritic cells require TMEM176A\/B ion channels for optimal MHC class II antigen presentation to naive CD4(+) T cells. J Immunol. 2021;207(2):421\u201335.","journal-title":"J Immunol"},{"issue":"12","key":"970_CR36","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1038\/ki.2008.500","volume":"74","author":"L Li","year":"2008","unstructured":"Li L, Huang L, Sung SS, Vergis AL, Rosin DL, Rose CE Jr, et al. The chemokine receptors CCR2 and CX3CR1 mediate monocyte\/macrophage trafficking in kidney ischemia-reperfusion injury. Kidney Int. 2008;74(12):1526\u201337.","journal-title":"Kidney Int"},{"issue":"9","key":"970_CR37","doi-asserted-by":"publisher","first-page":"2503","DOI":"10.1002\/eji.201141743","volume":"41","author":"K Liddiard","year":"2011","unstructured":"Liddiard K, Rosas M, Davies LC, Jones SA, Taylor PR. Macrophage heterogeneity and acute inflammation. Eur J Immunol. 2011;41(9):2503\u20138.","journal-title":"Eur J Immunol"},{"issue":"6","key":"970_CR38","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1016\/j.cell.2019.08.009","volume":"178","author":"Z Liu","year":"2019","unstructured":"Liu Z, Gu Y, Chakarov S, Bleriot C, Kwok I, Chen X, et al. Fate mapping via Ms4a3-expression history traces monocyte-derived cells. Cell. 2019;178(6):1509-25 e19.","journal-title":"Cell"},{"issue":"1","key":"970_CR39","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1189\/jlb.3MA0915-433RR","volume":"100","author":"D Loukov","year":"2016","unstructured":"Loukov D, Naidoo A, Puchta A, Marin JL, Bowdish DM. Tumor necrosis factor drives increased splenic monopoiesis in old mice. J Leukoc Biol. 2016;100(1):121\u20139.","journal-title":"J Leukoc Biol"},{"issue":"6","key":"970_CR40","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1189\/jlb.3A0415-158R","volume":"99","author":"H Ma","year":"2016","unstructured":"Ma H, Wan S, Xia CQ. Immunosuppressive CD11b+Ly6Chi monocytes in pristane-induced lupus mouse model. J Leukoc Biol. 2016;99(6):1121\u20139.","journal-title":"J Leukoc Biol"},{"issue":"5","key":"970_CR41","first-page":"4313","volume":"18","author":"B Ma","year":"2018","unstructured":"Ma B, Yang Y, Li Z, Zhao D, Zhang W, Jiang Y, Xue D. Modular bioinformatics analysis demonstrates that a Toll-like receptor signaling pathway is involved in the regulation of macrophage polarization. Mol Med Rep. 2018;18(5):4313\u201320.","journal-title":"Mol Med Rep"},{"key":"970_CR42","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.3389\/fimmu.2020.01043","volume":"11","author":"MA McBride","year":"2020","unstructured":"McBride MA, Owen AM, Stothers CL, Hernandez A, Luan L, Burelbach KR, et al. The metabolic basis of immune dysfunction following sepsis and trauma. Front Immunol. 2020;11:1043.","journal-title":"Front Immunol"},{"issue":"12","key":"970_CR43","first-page":"5574","volume":"8","author":"CS McGinnis","year":"2023","unstructured":"McGinnis CS, Miao Z, Reticker-Flynn NE, Winker J, Satpathy AT. The temporal progression of immune remodeling during metastasis. bioRxiv. 2023;8(12):5574.","journal-title":"bioRxiv"},{"key":"970_CR44","volume-title":"Biochemistry, anaerobic glycolysis","author":"EA Melkonian","year":"2024","unstructured":"Melkonian EA, Schury MP. Biochemistry, anaerobic glycolysis. Treasure Island (FL): StatPearls; 2024."},{"issue":"6","key":"970_CR45","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1016\/j.immuni.2016.12.001","volume":"45","author":"S Menezes","year":"2016","unstructured":"Menezes S, Melandri D, Anselmi G, Perchet T, Loschko J, Dubrot J, et al. The heterogeneity of Ly6C (hi) monocytes controls their differentiation into iNOS (+) macrophages or monocyte-derived dendritic cells. Immunity. 2016;45(6):1205\u201318.","journal-title":"Immunity"},{"issue":"5","key":"970_CR46","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/j.immuni.2017.04.018","volume":"46","author":"A Mildner","year":"2017","unstructured":"Mildner A, Schonheit J, Giladi A, David E, Lara-Astiaso D, Lorenzo-Vivas E, et al. Genomic characterization of murine monocytes reveals C\/EBPbeta transcription factor dependence of Ly6C(\u2013) cells. Immunity. 2017;46(5):849-62 e7.","journal-title":"Immunity"},{"issue":"2","key":"970_CR47","doi-asserted-by":"publisher","first-page":"3649","DOI":"10.18632\/oncotarget.12278","volume":"8","author":"CR Millrud","year":"2017","unstructured":"Millrud CR, Bergenfelz C, Leandersson K. On the origin of myeloid-derived suppressor cells. Oncotarget. 2017;8(2):3649\u201365.","journal-title":"Oncotarget"},{"key":"970_CR48","doi-asserted-by":"publisher","DOI":"10.1002\/0471142735.im1427s95","author":"DM Mosser","year":"2011","unstructured":"Mosser DM, Zhang X. Measuring opsonic phagocytosis via Fcgamma receptors and complement receptors on macrophages. Curr Protoc Immunol. 2011. https:\/\/doi.org\/10.1002\/0471142735.im1427s95.","journal-title":"Curr Protoc Immunol"},{"issue":"2","key":"970_CR49","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1097\/SHK.0000000000000958","volume":"49","author":"B Nolt","year":"2018","unstructured":"Nolt B, Tu F, Wang X, Ha T, Winter R, Williams DL, Li C. Lactate and Immunosuppression in sepsis. Shock. 2018;49(2):120\u20135.","journal-title":"Shock"},{"issue":"3","key":"970_CR50","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1189\/jlb.0810479","volume":"89","author":"LM Ocuin","year":"2011","unstructured":"Ocuin LM, Bamboat ZM, Balachandran VP, Cavnar MJ, Obaid H, Plitas G, DeMatteo RP. Neutrophil IL-10 suppresses peritoneal inflammatory monocytes during polymicrobial sepsis. J Leukoc Biol. 2011;89(3):423\u201332.","journal-title":"J Leukoc Biol"},{"issue":"14","key":"970_CR51","doi-asserted-by":"publisher","first-page":"3932","DOI":"10.1111\/febs.15803","volume":"289","author":"A Othman","year":"2022","unstructured":"Othman A, Sekheri M, Filep JG. Roles of neutrophil granule proteins in orchestrating inflammation and immunity. FEBS J. 2022;289(14):3932\u201353.","journal-title":"FEBS J"},{"issue":"1","key":"970_CR52","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s13613-021-00893-7","volume":"11","author":"S Preau","year":"2021","unstructured":"Preau S, Vodovar D, Jung B, Lancel S, Zafrani L, Flatres A, et al. Energetic dysfunction in sepsis: a narrative review. Ann Intensive Care. 2021;11(1):104.","journal-title":"Ann Intensive Care"},{"key":"970_CR53","first-page":"4575","volume":"10","author":"GSD Purvis","year":"2021","unstructured":"Purvis GSD, McNeill E, Wright B, Revale S, Lockstone H, Channon KM, Greaves DR. Ly6C<sup>hi<\/sup> monocytes are metabolically reprogrammed in the blood during inflammatory stimulation allowing for macrophage lineage commitment. bioRxiv. 2021;10:4575.","journal-title":"bioRxiv"},{"issue":"1","key":"970_CR54","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1186\/s13075-017-1447-1","volume":"19","author":"L Quero","year":"2017","unstructured":"Quero L, Hanser E, Manigold T, Tiaden AN, Kyburz D. TLR2 stimulation impairs anti-inflammatory activity of M2-like macrophages, generating a chimeric M1\/M2 phenotype. Arthritis Res Ther. 2017;19(1):245.","journal-title":"Arthritis Res Ther"},{"key":"970_CR55","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.3389\/fimmu.2018.02032","volume":"9","author":"M Rana","year":"2018","unstructured":"Rana M, Fei-Bloom Y, Son M, La Bella A, Ochani M, Levine YA, et al. Constitutive vagus nerve activation modulates immune suppression in sepsis survivors. Front Immunol. 2018;9:2032.","journal-title":"Front Immunol"},{"key":"970_CR56","doi-asserted-by":"publisher","DOI":"10.1172\/JCI146776","author":"M Rana","year":"2021","unstructured":"Rana M, La Bella A, Lederman R, Volpe BT, Sherry B, Diamond B. Follicular dendritic cell dysfunction contributes to impaired antigen-specific humoral responses in sepsis-surviving mice. J Clin Invest. 2021. https:\/\/doi.org\/10.1172\/JCI146776.","journal-title":"J Clin Invest"},{"issue":"1","key":"970_CR57","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/nprot.2008.214","volume":"4","author":"D Rittirsch","year":"2009","unstructured":"Rittirsch D, Huber-Lang MS, Flierl MA, Ward PA. Immunodesign of experimental sepsis by cecal ligation and puncture. Nat Protoc. 2009;4(1):31\u20136.","journal-title":"Nat Protoc"},{"key":"970_CR58","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2021.104302","volume":"362","author":"MD Sanchez-Pino","year":"2021","unstructured":"Sanchez-Pino MD, Dean MJ, Ochoa AC. Myeloid-derived suppressor cells (MDSC): when good intentions go awry. Cell Immunol. 2021;362: 104302.","journal-title":"Cell Immunol"},{"key":"970_CR59","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.semcdb.2015.03.011","volume":"41","author":"A Schlitzer","year":"2015","unstructured":"Schlitzer A, McGovern N, Ginhoux F. Dendritic cells and monocyte-derived cells: two complementary and integrated functional systems. Semin Cell Dev Biol. 2015;41:9\u201322.","journal-title":"Semin Cell Dev Biol"},{"key":"970_CR60","doi-asserted-by":"publisher","first-page":"327","DOI":"10.3389\/fimmu.2019.00327","volume":"10","author":"IT Schrijver","year":"2019","unstructured":"Schrijver IT, Theroude C, Roger T. Myeloid-derived suppressor cells in sepsis. Front Immunol. 2019;10:327.","journal-title":"Front Immunol"},{"key":"970_CR61","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.660760","volume":"12","author":"M Sekheri","year":"2021","unstructured":"Sekheri M, Othman A, Filep JG. \u03b22 integrin regulation of neutrophil functional plasticity and fate in the resolution of inflammation. Front Immunol. 2021;12: 660760.","journal-title":"Front Immunol"},{"issue":"3","key":"970_CR62","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1038\/ni1309","volume":"7","author":"NV Serbina","year":"2006","unstructured":"Serbina NV, Pamer EG. Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2. Nat Immunol. 2006;7(3):311\u20137.","journal-title":"Nat Immunol"},{"key":"970_CR63","doi-asserted-by":"publisher","first-page":"448","DOI":"10.3389\/fimmu.2014.00448","volume":"5","author":"A Sheshachalam","year":"2014","unstructured":"Sheshachalam A, Srivastava N, Mitchell T, Lacy P, Eitzen G. Granule protein processing and regulated secretion in neutrophils. Front Immunol. 2014;5:448.","journal-title":"Front Immunol"},{"issue":"8","key":"970_CR64","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","volume":"315","author":"M Singer","year":"2016","unstructured":"Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA. 2016;315(8):801\u201310.","journal-title":"JAMA"},{"issue":"1","key":"970_CR65","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s11060-017-2508-7","volume":"134","author":"DC Soler","year":"2017","unstructured":"Soler DC, Young AB, Cooper KD, Kerstetter-Fogle A, Barnholtz-Sloan JS, Gittleman H, et al. The ratio of HLA-DR and VNN2. J Neurooncol. 2017;134(1):189\u201396.","journal-title":"J Neurooncol"},{"issue":"18","key":"970_CR66","doi-asserted-by":"publisher","first-page":"2218","DOI":"10.1182\/blood-2016-05-719757","volume":"128","author":"M Son","year":"2016","unstructured":"Son M, Porat A, He M, Suurmond J, Santiago-Schwarz F, Andersson U, et al. C1q and HMGB1 reciprocally regulate human macrophage polarization. Blood. 2016;128(18):2218\u201328.","journal-title":"Blood"},{"issue":"10","key":"970_CR67","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1007\/s00011-014-0762-0","volume":"63","author":"W Spivia","year":"2014","unstructured":"Spivia W, Magno PS, Le P, Fraser DA. Complement protein C1q promotes macrophage anti-inflammatory M2-like polarization during the clearance of atherogenic lipoproteins. Inflamm Res. 2014;63(10):885\u201393.","journal-title":"Inflamm Res"},{"issue":"1","key":"970_CR68","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1186\/s13059-018-1603-1","volume":"19","author":"M Stoeckius","year":"2018","unstructured":"Stoeckius M, Zheng S, Houck-Loomis B, Hao S, Yeung BZ, Mauck WM 3rd, et al. Cell Hashing with barcoded antibodies enables multiplexing and doublet detection for single cell genomics. Genome Biol. 2018;19(1):224.","journal-title":"Genome Biol"},{"key":"970_CR69","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.260529","author":"A Subramani","year":"2023","unstructured":"Subramani A, Hite MEL, Garcia S, Maxwell J, Kondee H, Millican GE, et al. Regulation of macrophage IFNgamma-stimulated gene expression by the transcriptional coregulator CITED1. J Cell Sci. 2023. https:\/\/doi.org\/10.1242\/jcs.260529.","journal-title":"J Cell Sci"},{"issue":"2","key":"970_CR70","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.surg.2007.04.005","volume":"142","author":"R Swan","year":"2007","unstructured":"Swan R, Chung CS, Albina J, Cioffi W, Perl M, Ayala A. Polymicrobial sepsis enhances clearance of apoptotic immune cells by splenic macrophages. Surgery. 2007;142(2):253\u201361.","journal-title":"Surgery"},{"issue":"5940","key":"970_CR71","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1126\/science.1175202","volume":"325","author":"FK Swirski","year":"2009","unstructured":"Swirski FK, Nahrendorf M, Etzrodt M, Wildgruber M, Cortez-Retamozo V, Panizzi P, et al. Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science. 2009;325(5940):612\u20136.","journal-title":"Science"},{"issue":"1","key":"970_CR72","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1172\/JCI28549","volume":"117","author":"F Tacke","year":"2007","unstructured":"Tacke F, Alvarez D, Kaplan TJ, Jakubzick C, Spanbroek R, Llodra J, et al. Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques. J Clin Invest. 2007;117(1):185\u201394.","journal-title":"J Clin Invest"},{"issue":"4","key":"970_CR73","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1172\/JCI29919","volume":"117","author":"CL Tsou","year":"2007","unstructured":"Tsou CL, Peters W, Si Y, Slaymaker S, Aslanian AM, Weisberg SP, et al. Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites. J Clin Invest. 2007;117(4):902\u20139.","journal-title":"J Clin Invest"},{"key":"970_CR74","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.3389\/fimmu.2020.01066","volume":"11","author":"E Uribe-Querol","year":"2020","unstructured":"Uribe-Querol E, Rosales C. Phagocytosis: our current understanding of a universal biological process. Front Immunol. 2020;11:1066.","journal-title":"Front Immunol"},{"issue":"4","key":"970_CR75","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1111\/joim.12104","volume":"274","author":"SI Valdes-Ferrer","year":"2013","unstructured":"Valdes-Ferrer SI, Rosas-Ballina M, Olofsson PS, Lu B, Dancho ME, Ochani M, et al. HMGB1 mediates splenomegaly and expansion of splenic CD11b+ Ly-6C(high) inflammatory monocytes in murine sepsis survivors. J Intern Med. 2013;274(4):381\u201390.","journal-title":"J Intern Med"},{"key":"970_CR76","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232416136","author":"F Van Laethem","year":"2022","unstructured":"Van Laethem F, Donaty L, Tchernonog E, Lacheretz-Szablewski V, Russello J, Buthiau D, et al. LAIR1, an ITIM-containing receptor involved in immune disorders and in hematological neoplasms. Int J Mol Sci. 2022. https:\/\/doi.org\/10.3390\/ijms232416136.","journal-title":"Int J Mol Sci"},{"key":"970_CR77","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201708712","author":"L Van Wyngene","year":"2018","unstructured":"Van Wyngene L, Vandewalle J, Libert C. Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last? EMBO Mol Med. 2018. https:\/\/doi.org\/10.15252\/emmm.201708712.","journal-title":"EMBO Mol Med"},{"key":"970_CR78","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah4573","author":"AC Villani","year":"2017","unstructured":"Villani AC, Satija R, Reynolds G, Sarkizova S, Shekhar K, Fletcher J, et al. Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors. Science. 2017. https:\/\/doi.org\/10.1126\/science.aah4573.","journal-title":"Science"},{"issue":"5","key":"970_CR79","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1097\/01.shk.0000142249.08135.e9","volume":"22","author":"H Watanabe","year":"2004","unstructured":"Watanabe H, Numata K, Ito T, Takagi K, Matsukawa A. Innate immune response in Th1- and Th2-dominant mouse strains. Shock. 2004;22(5):460\u20136.","journal-title":"Shock"},{"key":"970_CR80","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw3381","author":"C Weinreb","year":"2020","unstructured":"Weinreb C, Rodriguez-Fraticelli A, Camargo FD, Klein AM. Lineage tracing on transcriptional landscapes links state to fate during differentiation. Science. 2020. https:\/\/doi.org\/10.1126\/science.aaw3381.","journal-title":"Science"},{"key":"970_CR81","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-3793353\/v1","volume-title":"Enrichment of a neutrophil-like monocyte transcriptional state in glioblastoma myeloid suppressor cells","author":"JK Wiencke","year":"2023","unstructured":"Wiencke JK, Nissen E, Koestler DC, Tamaki SJ, Tamaki CM, Hansen HM, et al. Enrichment of a neutrophil-like monocyte transcriptional state in glioblastoma myeloid suppressor cells. Durham: American Journal Experts; 2023."},{"issue":"1\u20133","key":"970_CR82","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s12026-012-8297-3","volume":"53","author":"KL Wong","year":"2012","unstructured":"Wong KL, Yeap WH, Tai JJ, Ong SM, Dang TM, Wong SC. The three human monocyte subsets: implications for health and disease. Immunol Res. 2012;53(1\u20133):41\u201357.","journal-title":"Immunol Res"},{"issue":"5","key":"970_CR83","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.jinf.2012.08.001","volume":"65","author":"PB Xu","year":"2012","unstructured":"Xu PB, Lou JS, Ren Y, Miao CH, Deng XM. Gene expression profiling reveals the defining features of monocytes from septic patients with compensatory anti-inflammatory response syndrome. J Infect. 2012;65(5):380\u201391.","journal-title":"J Infect"},{"issue":"5","key":"970_CR84","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1016\/j.immuni.2017.10.021","volume":"47","author":"A Yanez","year":"2017","unstructured":"Yanez A, Coetzee SG, Olsson A, Muench DE, Berman BP, Hazelett DJ, et al. Granulocyte-monocyte progenitors and monocyte-dendritic cell progenitors independently produce functionally distinct monocytes. Immunity. 2017;47(5):890-902 e4.","journal-title":"Immunity"},{"issue":"1","key":"970_CR85","first-page":"27","volume":"10","author":"RQ Yao","year":"2023","unstructured":"Yao RQ, Zhao PY, Li ZX, Liu YY, Zheng LY, Duan Y, et al. Single-cell transcriptome profiling of sepsis identifies HLA-DR (low) S100A (high) monocytes with immunosuppressive function. Mil Med Res. 2023;10(1):27.","journal-title":"Mil Med Res"},{"issue":"2","key":"970_CR86","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1097\/00024382-199408000-00009","volume":"2","author":"P Zhang","year":"1994","unstructured":"Zhang P, Xie M, Spitzer JA. Hepatic neutrophil sequestration in early sepsis: enhanced expression of adhesion molecules and phagocytic activity. Shock. 1994;2(2):133\u201340.","journal-title":"Shock"},{"key":"970_CR87","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.cytogfr.2022.07.007","volume":"69","author":"W Zhang","year":"2023","unstructured":"Zhang W, Fang X, Gao C, Song C, He Y, Zhou T, et al. MDSCs in sepsis-induced immunosuppression and its potential therapeutic targets. Cytokine Growth Fact Rev. 2023;69:90\u2013103.","journal-title":"Cytokine Growth Fact Rev"},{"issue":"1","key":"970_CR88","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1038\/s41420-024-02012-4","volume":"10","author":"T Zhang","year":"2024","unstructured":"Zhang T, Fu JN, Chen GB, Zhang X. Plac8-ERK pathway modulation of monocyte function in sepsis. Cell Death Discov. 2024;10(1):308.","journal-title":"Cell Death Discov"},{"issue":"8","key":"970_CR89","doi-asserted-by":"publisher","first-page":"5228","DOI":"10.4049\/jimmunol.179.8.5228","volume":"179","author":"B Zhu","year":"2007","unstructured":"Zhu B, Bando Y, Xiao S, Yang K, Anderson AC, Kuchroo VK, Khoury SJ. CD11b+Ly-6C(hi) suppressive monocytes in experimental autoimmune encephalomyelitis. J Immunol. 2007;179(8):5228\u201337.","journal-title":"J Immunol"},{"issue":"5","key":"970_CR90","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1016\/j.immuni.2019.03.009","volume":"50","author":"R Zilionis","year":"2019","unstructured":"Zilionis R, Engblom C, Pfirschke C, Savova V, Zemmour D, Saatcioglu HD, et al. Single-cell transcriptomics of human and mouse lung cancers reveals conserved myeloid populations across individuals and species. Immunity. 2019;50(5):1317-34.e10.","journal-title":"Immunity"}],"container-title":["Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s10020-024-00970-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s10020-024-00970-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s10020-024-00970-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T06:09:38Z","timestamp":1730873378000},"score":1,"resource":{"primary":{"URL":"https:\/\/molmed.biomedcentral.com\/articles\/10.1186\/s10020-024-00970-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,6]]},"references-count":91,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["970"],"URL":"https:\/\/doi.org\/10.1186\/s10020-024-00970-0","relation":{},"ISSN":["1528-3658"],"issn-type":[{"value":"1528-3658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,6]]},"assertion":[{"value":"1 May 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study involves the use of experimental animals. Animal studies were conducted in strict accordance with recommendations in the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health. The protocols were approved by the Institutional Animal Care and Use Committee and the Institutional Biosafety Committee of the Feinstein Institutes for Medical Research (Protocol number: 2009\u2013048).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All authors are current or former staff members of The Feinstein Institutes for Medical Research. BD is on the board of Molecular Medicine and MR and MS are Associate Editors of Molecular Medicine. The authors declare that they have no other competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"202"}}