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Studies suggested that the abnormal\n                      <jats:italic>N<\/jats:italic>\n                      <jats:sup>6<\/jats:sup>\n                      -methyladenosine (m\n                      <jats:sup>6<\/jats:sup>\n                      A) modification induced by fat mass and obesity protein (FTO) is vital in MI. However, the effects of FTO on post-infarction cardiac fibrosis have not been detected.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Western blot and quantitative real-time PCR were performed to detect the expression of FTO in the fibrotic tissue of rats. The functions of FTO on collagen biosynthesis were analyzed in vitro and in vivo. The underlying targets of FTO were selected through RNA-seq with m\n                      <jats:sup>6<\/jats:sup>\n                      A-seq.\u00a0The following dual luciferase reporter assay and RNA stability assay were conducted to investigate the mechanisms of FTO-mediated m\n                      <jats:sup>6<\/jats:sup>\n                      A regulation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The expression of FTO was decreased in the fibrotic tissue of post-infarction rats. The HIF-1 signal pathway was enriched after MI. HIF-1\u03b1 could bind to the promoter of FTO and inhibit its expression. Functionally, FTO inhibited collagen synthesis after MI in vitro and in vivo. Mechanistically, EPRS was selected as the underlying target of FTO-induced m\n                      <jats:sup>6<\/jats:sup>\n                      A regulation. IGF2BP3 recognized and bound to the m\n                      <jats:sup>6<\/jats:sup>\n                      A sites of EPRS mRNA, which improved its stability. EPRS was required for cardiac fibrosis induced by FTO silencing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      FTO, identified as a cardioprotective factor, suppressed collagen synthesis in post-infarction cardiac fibrosis via m\n                      <jats:sup>6<\/jats:sup>\n                      A modification, which provided a new therapeutic strategy for cardiac fibrosis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s10020-024-00985-7","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T16:42:38Z","timestamp":1731516158000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["FTO suppresses cardiac fibrosis after myocardial infarction via m6A-mediated epigenetic modification of EPRS"],"prefix":"10.1186","volume":"30","author":[{"given":"Jian","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijie","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafang","family":"Zha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,13]]},"reference":[{"key":"985_CR3","doi-asserted-by":"crossref","unstructured":"Arif A, Yao P, Terenzi F, Jia J, Ray PS, Fox PL. 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