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Understanding the role of specific molecules can help reduce the risk of developing SAP. Claudin 11 (CLDN11), a member of the Claudin family, regulates the permeability of various internal barriers. However, the role and mechanism of CLDN11 in the intestinal permeability of obesity-related SAP remain unclear.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We evaluated intestinal permeability and the expression of CLDN11 in experimental obesity-related SAP. A recombinant adeno-associated virus carrying CLDN11 was used to treat experimental obesity-related SAP. The interaction between CLDN11 mRNA and insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) protein was predicted through bioinformatics analysis and validated by RNA immunoprecipitation and RNA pull-down assay. Additionally, tumor necrosis factor-\u03b1 (TNF-\u03b1) treatment in Caco-2 cells was conducted, and the IGF2BP3\/CLDN11 axis was detected. Moreover, we conducted anti-TNF\u03b1 therapy and evaluated intestinal permeability and pancreatic inflammation in experimental obesity-related SAP.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Downregulation of CLDN11 was observed in the intestinal epithelial cells of experimental obesity-related SAP. When the expression of CLDN11 in intestinal epithelial cells of experimental obesity-related SAP was increased exogenously, intestinal epithelial permeability and pancreatic inflammation were relieved. Overexpression of CLDN11 reduced the paracellular permeability of Caco-2 monolayer cells, while knockdown of CLDN11 increased it. IGF2BP3 bound to and regulated the stability of CLDN11 mRNA. TNF-\u03b1 treatment downregulated IGF2BP3 and CLDN11 in vitro. Anti-TNF\u03b1 therapy reduced intestinal permeability, alleviated pancreatitis, and improved the expression of IGF2BP3 and CLDN11 in intestinal epithelial cells in experimental obesity-related SAP.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>CLDN11 regulates intestinal permeability in obesity-related SAP. Mechanistically, an increase in TNF-\u03b1 impaired the stability of IGF2BP3-dependent CLDN11 mRNA in obesity-related SAP.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/s10020-025-01078-9","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T13:59:45Z","timestamp":1737727185000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Disrupting of IGF2BP3-stabilized CLDN11 mRNA by TNF-\u03b1 increases intestinal permeability in obesity-related severe acute pancreatitis"],"prefix":"10.1186","volume":"31","author":[{"given":"Lihui","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yansong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianwen","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zewen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,24]]},"reference":[{"key":"1078_CR1","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1186\/s12885-016-2371-5","volume":"16","author":"M Abe","year":"2016","unstructured":"Abe M, Yamashita S, Mori Y, Abe T, Saijo H, Hoshi K, et al. 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