{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:47:04Z","timestamp":1793148424310,"version":"4.5.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T00:00:00Z","timestamp":1742774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 82360208"],"award-info":[{"award-number":["No. 82360208"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81300791"],"award-info":[{"award-number":["No. 81300791"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Tianjin Natural Science Foundation","doi-asserted-by":"crossref","award":["No. 18JCYBJC26500"],"award-info":[{"award-number":["No. 18JCYBJC26500"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Tianjin Science and Technology support key Project","award":["No.19YFZCSY00990"],"award-info":[{"award-number":["No.19YFZCSY00990"]}]},{"name":"Tianjin Health Research Project","award":["No. TJWJ2021MS042"],"award-info":[{"award-number":["No. TJWJ2021MS042"]}]},{"name":"Tianjin Health Research Project","award":["No. TJWJ2022XK037"],"award-info":[{"award-number":["No. TJWJ2022XK037"]}]},{"name":"Key project of Tianjin Eye Hospital","award":["No. YKZD2004"],"award-info":[{"award-number":["No. YKZD2004"]}]},{"name":"Nankai University Eye Institute","award":["No.NKYKK202203"],"award-info":[{"award-number":["No.NKYKK202203"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Med"],"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>Retinopathy of prematurity (ROP) is a disorder that causes blindness in children at a high incidence. Retinal endothelial cells are damaged by variations in oxygen partial pressure, which leads to vascular obstruction and, eventually, ischemia and hypoxia, which cause the formation of new blood vessels. However, little is known about the molecular mechanism of hyperoxic vascular occlusion. High oxygen levels are thought to cause ferroptosis. In this study, experiments with both animal and in vitro models demonstrated that elevated expression of C-X-C motif chemokine ligand 10 (CXCL10)\/C-X-C motif chemokine receptor 3 (CXCR3) in retinal vascular endothelial cells induced ferroptosis. Curcumin decreased ferroptosis by inhibiting the production of CXCL10\/CXCR3. Curcumin also preserved distal sprouts and filopodia, increasing tip cell and astrocyte counts. As a result, we hypothesize that curcumin reduces ferroptosis and preserves retinal blood vessels under hyperoxic conditions by suppressing the CXCL10\/CXCR3 axis. Coimmunoprecipitation (COIP) data were used to determine which proteins interact with CXCR3 during ferroptosis. For the first time, our study applied curcumin to treat eye diseases in oxygen-induced retinopathy (OIR) mice and explored the underlying mechanism in cell experiments, laying the foundation for clinical patients to use this drug. Exploring the interaction between CXCL10\/CXCR3 and ferroptosis provides an experimental basis for using the CXCL10\/CXCR3 axis as a therapeutic target for the treatment of ROP ophthalmopathy.<\/jats:p>\n          <jats:p>\n            <jats:bold>Graphical Abstract<\/jats:bold>\n          <\/jats:p>","DOI":"10.1186\/s10020-025-01161-1","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:03:47Z","timestamp":1742861027000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Curcumin inhibits ferroptosis-mediated vascular occlusion by regulating the CXCL10\/CXCR3 axis in retinopathy of prematurity"],"prefix":"10.1186","volume":"31","author":[{"given":"Rui","family":"Niu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Ran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7486-0044","authenticated-orcid":false,"given":"Yatu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,24]]},"reference":[{"issue":"1","key":"1161_CR1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.canlet.2008.03.025","volume":"267","author":"P Anand","year":"2008","unstructured":"Anand P, Sundaram C, Jhurani S, et al. Curcumin and cancer: an \u201cold-age\u201d disease with an \u201cage-old\u201d solution. Cancer Lett. 2008;267(1):133\u201364.","journal-title":"Cancer Lett"},{"issue":"2","key":"1161_CR2","first-page":"116","volume":"20","author":"M Ashrafizadeh","year":"2020","unstructured":"Ashrafizadeh M, Ahmadi Z, Mohammadinejad R, et al. Curcumin activates the Nrf2 pathway and induces cellular protection against oxidative injury. Curr Mol Med. 2020;20(2):116\u201333.","journal-title":"Curr Mol Med"},{"issue":"7","key":"1161_CR3","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1007\/s12035-021-02320-1","volume":"58","author":"LP Bai","year":"2021","unstructured":"Bai LP, Yan F, Deng RH, et al. Thioredoxin-1 rescues MPP+\/MPTP-induced ferroptosis by increasing glutathione peroxidase 4. Mol Neurobiol. 2021;58(7):3187\u201397.","journal-title":"Mol Neurobiol"},{"issue":"6","key":"1161_CR4","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1152\/jn.00306.2022","volume":"128","author":"Y Dai","year":"2022","unstructured":"Dai Y, Hu L. HSPB1 overexpression improves hypoxic-ischemic brain damage by attenuating ferroptosis in rats through promoting G6PD expression. J Neurophysiol. 2022;128(6):1507\u201317.","journal-title":"J Neurophysiol"},{"issue":"1","key":"1161_CR5","doi-asserted-by":"crossref","first-page":"10062","DOI":"10.1038\/s41598-017-10672-9","volume":"7","author":"C Dende","year":"2017","unstructured":"Dende C, Meena J, Nagarajan P, et al. Nanocurcumin is superior to native curcumin in preventing degenerative changes in experimental cerebral malaria. Sci Rep. 2017;7(1):10062.","journal-title":"Sci Rep"},{"issue":"7","key":"1161_CR6","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1161\/CIRCRESAHA.116.302855","volume":"116","author":"G Eelen","year":"2015","unstructured":"Eelen G, De Zeeuw P, Simons M, et al. Endothelial cell metabolism in normal and diseased vasculature. Circ Res. 2015;116(7):1231\u201344.","journal-title":"Circ Res"},{"issue":"6","key":"1161_CR7","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1007\/s11010-022-04394-4","volume":"477","author":"M Fevereiro-Martins","year":"2022","unstructured":"Fevereiro-Martins M, Guimaraes H, Marques-Neves C, et al. Retinopathy of prematurity: contribution of inflammatory and genetic factors. Mol Cell Biochem. 2022;477(6):1739\u201363.","journal-title":"Mol Cell Biochem"},{"issue":"2","key":"1161_CR8","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/aps.2008.24","volume":"30","author":"JM Gao","year":"2009","unstructured":"Gao JM, Xiang RL, Jiang L, et al. Sulfated tyrosines 27 and 29 in the N-terminus of human CXCR3 participate in binding native IP-10. Acta Pharmacol Sin. 2009;30(2):193\u2013201.","journal-title":"Acta Pharmacol Sin"},{"key":"1161_CR9","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ajo.2020.05.025","volume":"218","author":"ME Hartnett","year":"2020","unstructured":"Hartnett ME. Retinopathy of prematurity: evolving treatment with anti-vascular endothelial growth factor. Am J Ophthalmol. 2020;218:208\u201313.","journal-title":"Am J Ophthalmol"},{"issue":"9902","key":"1161_CR10","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/S0140-6736(13)60178-6","volume":"382","author":"A Hellstr\u00f6m","year":"2013","unstructured":"Hellstr\u00f6m A, Smith LEH, Dammann O. Retinopathy of prematurity. Lancet. 2013;382(9902):1445\u201357.","journal-title":"Lancet"},{"issue":"2","key":"1161_CR11","doi-asserted-by":"crossref","DOI":"10.1002\/pul2.12091","volume":"12","author":"C Hong","year":"2022","unstructured":"Hong C, Lu J, Chen R, et al. CXCL10 levels in diagnosis and improved hemodynamics in patients with chronic thromboembolic pulmonary hypertension undergoing balloon pulmonary angioplasty. Pulm Circ. 2022;12(2): e12091.","journal-title":"Pulm Circ"},{"key":"1161_CR12","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.neures.2015.01.001","volume":"94","author":"T Imaizumi","year":"2015","unstructured":"Imaizumi T, Sakashita N, Mushiga Y, et al. Desferrioxamine, an iron chelator, inhibits CXCL10 expression induced by polyinosinic-polycytidylic acid in U373MG human astrocytoma cells. Neurosci Res. 2015;94:10\u20136.","journal-title":"Neurosci Res"},{"issue":"3","key":"1161_CR13","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s12264-020-00608-1","volume":"37","author":"YF Kong","year":"2021","unstructured":"Kong YF, Sha WL, Wu XB, et al. CXCL10\/CXCR3 signaling in the DRG exacerbates neuropathic pain in mice. Neurosci Bull. 2021;37(3):339\u201352.","journal-title":"Neurosci Bull"},{"key":"1161_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24162930","author":"RR Kotha","year":"2019","unstructured":"Kotha RR, Luthria DL. Curcumin: biological, pharmaceutical, nutraceutical, and analytical aspects. Molecules. 2019. https:\/\/doi.org\/10.3390\/molecules24162930.","journal-title":"Molecules"},{"key":"1161_CR15","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-021-01866-x","author":"JA Lan","year":"2021","unstructured":"Lan JA, Yang M, Chen X, et al. Haem relieves hyperoxia-mediated inhibition of HMEC-1 cell proliferation, migration and angiogenesis by inhibiting BACH1 expression. BMC Ophthalmol. 2021. https:\/\/doi.org\/10.1186\/s12886-021-01866-x.","journal-title":"BMC Ophthalmol"},{"issue":"5","key":"1161_CR16","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.autrev.2008.12.002","volume":"8","author":"EY Lee","year":"2009","unstructured":"Lee EY, Lee ZH, Song YW. CXCL10 and autoimmune diseases. Autoimmun Rev. 2009;8(5):379\u201383.","journal-title":"Autoimmun Rev"},{"issue":"2","key":"1161_CR17","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","volume":"11","author":"J Li","year":"2020","unstructured":"Li J, Cao F, Yin HL, et al. Ferroptosis: past, present and future. Cell Death Dis. 2020;11(2):88.","journal-title":"Cell Death Dis"},{"issue":"2","key":"1161_CR18","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00011-020-01427-w","volume":"70","author":"J Li","year":"2021","unstructured":"Li J, Yu SS, Lu X, et al. The phase changes of M1\/M2 phenotype of microglia\/macrophage following oxygen-induced retinopathy in mice. Inflamm Res. 2021;70(2):183\u201392.","journal-title":"Inflamm Res"},{"key":"1161_CR19","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27196311","author":"Y Li","year":"2022","unstructured":"Li Y, Zhang E, Yang H, et al. Gastrodin ameliorates cognitive dysfunction in vascular dementia rats by suppressing ferroptosis via the regulation of the Nrf2\/Keap1-GPx4 signaling pathway. Molecules. 2022. https:\/\/doi.org\/10.3390\/molecules27196311.","journal-title":"Molecules"},{"issue":"2","key":"1161_CR20","volume":"433","author":"M Li","year":"2023","unstructured":"Li M, Li L, Cheng X, et al. Hypoxia promotes the growth and metastasis of ovarian cancer cells by suppressing ferroptosis via upregulating SLC2A12. Exp Cell Res. 2023;433(2): 113851.","journal-title":"Exp Cell Res"},{"key":"1161_CR21","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.freeradbiomed.2023.01.002","volume":"195","author":"P Liang","year":"2023","unstructured":"Liang P, Zhang X, Zhang Y, et al. Neurotoxic A1 astrocytes promote neuronal ferroptosis via CXCL10\/CXCR3 axis in epilepsy. Free Radic Biol Med. 2023;195:329\u201342.","journal-title":"Free Radic Biol Med"},{"issue":"6","key":"1161_CR22","doi-asserted-by":"crossref","first-page":"331","DOI":"10.21037\/atm-22-1009","volume":"10","author":"Z Lin","year":"2022","unstructured":"Lin Z, Xu Y, Guan L, et al. Seven ferroptosis-specific expressed genes are considered as potential biomarkers for the diagnosis and treatment of cigarette smoke-induced chronic obstructive pulmonary disease. Ann Transl Med. 2022a;10(6):331.","journal-title":"Ann Transl Med"},{"key":"1161_CR23","volume":"52","author":"Z Lin","year":"2022","unstructured":"Lin Z, Song J, Gao Y, et al. Hypoxia-induced HIF-1\u03b1\/lncRNA-PMAN inhibits ferroptosis by promoting the cytoplasmic translocation of ELAVL1 in peritoneal dissemination from gastric cancer. Redox Biol. 2022b;52: 102312.","journal-title":"Redox Biol"},{"key":"1161_CR24","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.actbio.2023.01.022","volume":"159","author":"Y Lin","year":"2023","unstructured":"Lin Y, Chen XW, Yu CC, et al. Radiotherapy-mediated redox homeostasis-controllable nanomedicine for enhanced ferroptosis sensitivity in tumor therapy. Acta Biomater. 2023;159:300\u201311.","journal-title":"Acta Biomater"},{"key":"1161_CR25","volume":"226","author":"CQ Liu","year":"2023","unstructured":"Liu CQ, Liu XY, Ouyang PW, et al. Ferrostatin-1 attenuates pathological angiogenesis in oxygen-induced retinopathy via inhibition of ferroptosis. Exp Eye Res. 2023a;226: 109347.","journal-title":"Exp Eye Res"},{"key":"1161_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154729","author":"YS Liu","year":"2023","unstructured":"Liu YS, Mi Y, Wang YP, et al. Loureirin C inhibits ferroptosis after cerebral ischemia reperfusion through regulation of the Nrf2 pathway in mice. Phytomedicine. 2023b. https:\/\/doi.org\/10.1016\/j.phymed.2023.154729.","journal-title":"Phytomedicine"},{"issue":"3","key":"1161_CR27","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/SHK.0000000000001751","volume":"56","author":"ZQ Lv","year":"2021","unstructured":"Lv ZQ, Wang FE, Zhang XF, et al. Etomidate attenuates the ferroptosis in myocardial ischemia\/reperfusion rat model via Nrf2\/HO-1 pathway. Shock. 2021;56(3):440\u20139.","journal-title":"Shock"},{"key":"1161_CR28","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01090-z","author":"XH Ma","year":"2022","unstructured":"Ma XH, Liu JHZ, Liu CY, et al. ALOX15-launched PUFA-phospholipids peroxidation increases the susceptibility of ferroptosis in ischemia-induced myocardial damage. Signal Transduct Target Therapy. 2022. https:\/\/doi.org\/10.1038\/s41392-022-01090-z.","journal-title":"Signal Transduct Target Therapy"},{"issue":"6","key":"1161_CR29","first-page":"2007","volume":"43","author":"N Miyamoto","year":"2002","unstructured":"Miyamoto N, Mandai M, Takagi H, et al. Contrasting effect of estrogen on VEGF induction under different oxygen status and its role in murine ROP. Invest Ophthalmol vis Sci. 2002;43(6):2007\u201314.","journal-title":"Invest Ophthalmol vis Sci"},{"key":"1161_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2022.115168","author":"WH Moos","year":"2022","unstructured":"Moos WH, Faller DV, Glavas IP, et al. Treatment and prevention of pathological mitochondrial dysfunction in retinal degeneration and in photoreceptor injury. Biochem Pharmacol. 2022. https:\/\/doi.org\/10.1016\/j.bcp.2022.115168.","journal-title":"Biochem Pharmacol"},{"issue":"8","key":"1161_CR31","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1111\/gtc.12872","volume":"26","author":"P Ogor","year":"2021","unstructured":"Ogor P, Yoshida T, Koike M, et al. VCP relocalization limits mitochondrial activity, GSH depletion and ferroptosis during starvation in PC3 prostate cancer cells. Genes Cells. 2021;26(8):570\u201382.","journal-title":"Genes Cells"},{"key":"1161_CR32","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102317","volume":"52","author":"S Ouyang","year":"2022","unstructured":"Ouyang S, Li H, Lou L, et al. Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer. Redox Biol. 2022;52: 102317.","journal-title":"Redox Biol"},{"issue":"8","key":"1161_CR33","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/ncb3555","volume":"19","author":"ME Pitulescu","year":"2017","unstructured":"Pitulescu ME, Schmidt I, Giaimo BD, et al. Dll4 and Notch signalling couples sprouting angiogenesis and artery formation. Nat Cell Biol. 2017;19(8):915.","journal-title":"Nat Cell Biol"},{"key":"1161_CR34","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-017-0943-1","author":"JC Rivera","year":"2017","unstructured":"Rivera JC, Holm M, Austeng D, et al. Retinopathy of prematurity: inflammation, choroidal degeneration, and novel promising therapeutic strategies. J Neuroinflamm. 2017. https:\/\/doi.org\/10.1186\/s12974-017-0943-1.","journal-title":"J Neuroinflamm"},{"issue":"3","key":"1161_CR35","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1182\/blood.V97.3.601","volume":"97","author":"P Romagnani","year":"2001","unstructured":"Romagnani P, Annunziato F, Lazzeri E, et al. Interferon-inducible protein 10, monokine induced by interferon gamma, and interferon-inducible T-cell alpha chemoattractant are produced by thymic epithelial cells and attract T-cell receptor (TCR) \u03b1\u03b2+ CD8+ single-positive T cells, TCR\u03b3\u03b4+ T cells, and natural killer-type cells in human thymus. Blood. 2001;97(3):601\u20137.","journal-title":"Blood"},{"key":"1161_CR36","doi-asserted-by":"crossref","unstructured":"Sabri K, Ells AL, Lee EY, et al (2022) Retinopathy of prematurity: a global perspective and recent developments. Pediatrics 150(3)","DOI":"10.1542\/peds.2021-053924"},{"issue":"2","key":"1161_CR37","doi-asserted-by":"crossref","first-page":"611","DOI":"10.3892\/etm.2015.2554","volume":"10","author":"WJ Shi","year":"2015","unstructured":"Shi WJ, Zhu L, Wang YH, et al. Estrogen therapy to treat retinopathy in newborn mice. Exp Ther Med. 2015;10(2):611\u20137.","journal-title":"Exp Ther Med"},{"issue":"2","key":"1161_CR38","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.cyto.2012.05.002","volume":"59","author":"AME Sidahmed","year":"2012","unstructured":"Sidahmed AME, Le\u00f3n AJ, Bosinger SE, et al. CXCL10 contributes to p38-mediated apoptosis in primary T lymphocytes in vitro. Cytokine. 2012;59(2):433\u201341.","journal-title":"Cytokine"},{"issue":"6","key":"1161_CR39","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1182\/blood-2002-12-3945","volume":"102","author":"MJ Smit","year":"2003","unstructured":"Smit MJ, Verdijk P, Van Der Raaij-Helmer EMH, et al. CXCR3-mediated chernotaxis of human T cells is regulated by a Gi- and phospholipase C-dependent pathway and not via activation of MEK\/p44\/p42 MAPK nor Akt\/PI-3 kinase. Blood. 2003;102(6):1959\u201365.","journal-title":"Blood"},{"key":"1161_CR40","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ctrv.2017.11.007","volume":"63","author":"R Tokunaga","year":"2018","unstructured":"Tokunaga R, Zhang W, Naseem M, et al. CXCL9, CXCL10, CXCL11\/CXCR3 axis for immune activation\u2014a target for novel cancer therapy. Cancer Treat Rev. 2018;63:40\u20137.","journal-title":"Cancer Treat Rev"},{"issue":"1\u20132","key":"1161_CR41","first-page":"53","volume":"358","author":"CT Tu","year":"2011","unstructured":"Tu CT, Han B, Liu HC, et al. Curcumin protects mice against concanavalin A-induced hepatitis by inhibiting intrahepatic intercellular adhesion molecule-1 (ICAM-1) and CXCL10 expression. Mol Cell Biochem. 2011;358(1\u20132):53\u201360.","journal-title":"Mol Cell Biochem"},{"key":"1161_CR42","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24097914","author":"M V\u00e4h\u00e4tupa","year":"2023","unstructured":"V\u00e4h\u00e4tupa M, N\u00e4ttinen J, Aapola U, et al. Proteomics analysis of R-Ras deficiency in oxygen induced retinopathy. Int J Mol Sci. 2023. https:\/\/doi.org\/10.3390\/ijms24097914.","journal-title":"Int J Mol Sci"},{"issue":"5","key":"1161_CR43","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202101785RRR","volume":"36","author":"J Wang","year":"2022","unstructured":"Wang J, Zhang Q, Chen E, et al. Elabela promotes the retinal angiogenesis by inhibiting ferroptosis during the vaso-obliteration phase in mouse oxygen-induced retinopathy model. Faseb J. 2022a;36(5): e22257.","journal-title":"Faseb J"},{"issue":"12","key":"1161_CR44","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1038\/s41374-022-00826-3","volume":"102","author":"L Wang","year":"2022","unstructured":"Wang L, Wu SQ, He HQ, et al. CircRNA-ST6GALNAC6 increases the sensitivity of bladder cancer cells to erastin-induced ferroptosis by regulating the HSPB1\/P38 axis. Lab Invest. 2022b;102(12):1323\u201334.","journal-title":"Lab Invest"},{"key":"1161_CR45","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cyto.2016.02.007","volume":"81","author":"JB Xia","year":"2016","unstructured":"Xia JB, Liu GH, Chen ZY, et al. Hypoxia\/ischemia promotes CXCL10 expression in cardiac microvascular endothelial cells by NFkB activation. Cytokine. 2016;81:63\u201370.","journal-title":"Cytokine"},{"key":"1161_CR46","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2021.4908","author":"J Yang","year":"2021","unstructured":"Yang J, Miao X, Yang FJ, et al. Therapeutic potential of curcumin in\u00a0diabetic retinopathy (review). Int J Mol Med. 2021. https:\/\/doi.org\/10.3892\/ijmm.2021.4908.","journal-title":"Int J Mol Med"},{"key":"1161_CR47","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.brainres.2016.11.002","volume":"1655","author":"J Yuan","year":"2017","unstructured":"Yuan J, Liu W, Zhu H, et al. Curcumin inhibits glial scar formation by suppressing astrocyte-induced inflammation and fibrosis in vitro and in vivo. Brain Res. 2017;1655:90\u2013103.","journal-title":"Brain Res"},{"key":"1161_CR48","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/3159717","author":"W Zhang","year":"2022","unstructured":"Zhang W, Qian SH, Kang PF, et al. Curcumin attenuates ferroptosis-induced myocardial injury in diabetic cardiomyopathy through the Nrf2 pathway. Cardiovasc Ther. 2022a. https:\/\/doi.org\/10.1155\/2022\/3159717.","journal-title":"Cardiovasc Ther"},{"issue":"7","key":"1161_CR49","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/s41419-022-05082-3","volume":"13","author":"W Zhang","year":"2022","unstructured":"Zhang W, Gong M, Zhang W, et al. Thiostrepton induces ferroptosis in pancreatic cancer cells through STAT3\/GPX4 signalling. Cell Death Dis. 2022b;13(7):630.","journal-title":"Cell Death Dis"},{"issue":"10","key":"1161_CR50","volume":"9","author":"Y Zhou","year":"2023","unstructured":"Zhou Y, Jia Z, Wang J, et al. Curcumin reverses erastin-induced chondrocyte ferroptosis by upregulating Nrf2. Heliyon. 2023;9(10): e20163.","journal-title":"Heliyon"},{"key":"1161_CR51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exer.2017.01.002","volume":"155","author":"S Zhu","year":"2017","unstructured":"Zhu S, Liu H, Sha HB, et al. PERK and XBP1 differentially regulate CXCL10 and CCL2 production. Exp Eye Res. 2017;155:1\u201314.","journal-title":"Exp Eye Res"}],"container-title":["Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s10020-025-01161-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s10020-025-01161-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s10020-025-01161-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:05:13Z","timestamp":1742861113000},"score":1,"resource":{"primary":{"URL":"https:\/\/molmed.biomedcentral.com\/articles\/10.1186\/s10020-025-01161-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,24]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1161"],"URL":"https:\/\/doi.org\/10.1186\/s10020-025-01161-1","relation":{},"ISSN":["1528-3658"],"issn-type":[{"value":"1528-3658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,24]]},"assertion":[{"value":"23 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 March 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Beijing Huafukang Company (Beijing, China) provided the C57BL6\/J mice. All animal experiments adhere to the guiding principles of the Tianjin Medical Experimental Animal Protection Center, and the animal experiment design has been authorized by the Yishengyuan Gene Technology Co., Ltd. Animal Ethics Committee (YSY-DWLL-2023121).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare there is no commercial or financial relationships that could be construed as a potential conflict of interest regarding this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"113"}}