{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:50:13Z","timestamp":1790707813070,"version":"4.1.0"},"reference-count":97,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T00:00:00Z","timestamp":1520553600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Swedish Reseach Council","award":["5958"],"award-info":[{"award-number":["5958"]}]},{"name":"EuroheadpainFP-7-health","award":["602632"],"award-info":[{"award-number":["602632"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Headache Pain"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s10194-018-0852-4","type":"journal-article","created":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T07:43:39Z","timestamp":1520581419000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":114,"title":["PACAP and its role in primary headaches"],"prefix":"10.1186","volume":"19","author":[{"given":"Lars","family":"Edvinsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e1nos","family":"Tajti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Levente","family":"Szal\u00e1rdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"V\u00e9csei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,3,9]]},"reference":[{"key":"852_CR1","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1093\/brain\/aww097","volume":"139","author":"LH Schulte","year":"2016","unstructured":"Schulte LH, May A (2016) The migraine generator revisited: continuous scanning of the migraine cycle over 30 days and three spontaneous attacks. Brain 139:1987\u20131993","journal-title":"Brain"},{"key":"852_CR2","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1016\/j.peptides.2007.06.006","volume":"28","author":"A Arimura","year":"2007","unstructured":"Arimura A (2007) PACAP: the road to discovery. Peptides 28:1617\u20131619","journal-title":"Peptides"},{"key":"852_CR3","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1124\/pr.109.001370","volume":"61","author":"D Vaudry","year":"2009","unstructured":"Vaudry D, Falluel-Morel A, Bourgault S, Basille M, Burel D, Wurtz O, Fournier A, Chow BK, Hashimoto H, Galas L, Vaudry H (2009) Pituitary adenylate cyclase-activating polypeptide and its receptors: 20 years after the discovery. Pharmacol Rev 61:283\u2013357","journal-title":"Pharmacol Rev"},{"key":"852_CR4","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1210\/endo.140.3.6576","volume":"140","author":"D Alexandre","year":"1999","unstructured":"Alexandre D, Anouar Y, Jegou S, Fournier A, Vaudry H (1999) A cloned frog vasoactive intestinal polypeptide\/pituitary adenylate cyclase-activating polypeptide receptor exhibits pharmacological and tissue distribution characteristics of both VPAC1 and VPAC2 receptors in mammals. Endocrinology 140:1285\u20131293","journal-title":"Endocrinology"},{"key":"852_CR5","doi-asserted-by":"publisher","first-page":"3465","DOI":"10.1210\/endo.139.8.6145","volume":"139","author":"AO Wong","year":"1998","unstructured":"Wong AO, Leung MY, Shea WL, Tse LY, Chang JP, Chow BK (1998) Hypophysiotropic action of pituitary adenylate cyclase-activating polypeptide (PACAP) in the goldfish: immunohistochemical demonstration of PACAP in the pituitary, PACAP stimulation of growth hormone release from pituitary cells, and molecular cloning of pituitary type I PACAP receptor. Endocrinology 139:3465\u20133479","journal-title":"Endocrinology"},{"key":"852_CR6","doi-asserted-by":"publisher","first-page":"467","DOI":"10.2174\/1381612033391586","volume":"9","author":"JZ Nowak","year":"2003","unstructured":"Nowak JZ, Zawilska JB (2003) PACAP in avians: origin, occurrence, and receptors--pharmacological and functional considerations. Curr Pharm Des 9:467\u2013481","journal-title":"Curr Pharm Des"},{"key":"852_CR7","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1111\/j.1432-1033.1974.tb03373.x","volume":"42","author":"V Mutt","year":"1974","unstructured":"Mutt V, Said SI (1974) Structure of the porcine vasoactive intestinal octacosapeptide. The amino-acid sequence. Use of kallikrein in its determination. Eur J Biochem 42:581\u2013589","journal-title":"Eur J Biochem"},{"key":"852_CR8","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/0014-5793(80)81124-0","volume":"114","author":"D Bataille","year":"1980","unstructured":"Bataille D, Gespach C, Laburthe M, Amiranoff B, Tatemoto K, Vauclin N, Mutt V, Rosselin G (1980) Porcine peptide having N-terminal histidine and C-terminal isoleucine amide (PHI): vasoactive intestinal peptide (VIP) and secretin-like effects in different tissues from the rat. FEBS Lett 114:240\u2013242","journal-title":"FEBS Lett"},{"key":"852_CR9","first-page":"G283","volume":"256","author":"ZC Zhou","year":"1989","unstructured":"Zhou ZC, Gardner JD, Jensen RT (1989) Interaction of peptides related to VIP and secretin with Guinea pig pancreatic acini. Am J Phys 256:G283\u2013G290","journal-title":"Am J Phys"},{"key":"852_CR10","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1016\/0006-291X(89)91757-9","volume":"164","author":"A Miyata","year":"1989","unstructured":"Miyata A, Arimura A, Dahl RR, Minamino N, Uehara A, Jiang L, Culler MD, Coy DH (1989) Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells. Biochem Biophys Res Commun 164:567\u2013574","journal-title":"Biochem Biophys Res Commun"},{"key":"852_CR11","doi-asserted-by":"publisher","first-page":"152","DOI":"10.3109\/00016488009127121","volume":"89","author":"R Uddman","year":"1980","unstructured":"Uddman R, Malm L, Sundler F (1980) The origin of vasoactive intestinal polypeptide (VIP) nerves in the feline nasal mucosa. Acta Otolaryngol 89:152\u2013156","journal-title":"Acta Otolaryngol"},{"key":"852_CR12","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1210\/endo-118-2-783","volume":"118","author":"T Grunditz","year":"1986","unstructured":"Grunditz T, Hakanson R, Hedge G, Rerup C, Sundler F, Uddman R (1986) Peptide histidine isoleucine amide stimulates thyroid hormone secretion and coexists with vasoactive intestinal polypeptide in intrathyroid nerve fibers from laryngeal ganglia. Endocrinology 118:783\u2013790","journal-title":"Endocrinology"},{"key":"852_CR13","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1016\/j.peptides.2007.04.026","volume":"28","author":"M Laburthe","year":"2007","unstructured":"Laburthe M, Couvineau A, Tan V (2007) Class II G protein-coupled receptors for VIP and PACAP: structure, models of activation and pharmacology. Peptides 28:1631\u20131639","journal-title":"Peptides"},{"key":"852_CR14","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.nurt.2010.02.003","volume":"7","author":"HW Schytz","year":"2010","unstructured":"Schytz HW, Olesen J, Ashina M (2010) The PACAP receptor: a novel target for migraine treatment. Neurotherapeutics 7:191\u2013196","journal-title":"Neurotherapeutics"},{"key":"852_CR15","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.npep.2014.01.004","volume":"48","author":"I Jansen-Olesen","year":"2014","unstructured":"Jansen-Olesen I, Baun M, Amrutkar DV, Ramachandran R, Christophersen DV, Olesen J (2014) PACAP-38 but not VIP induces release of CGRP from trigeminal nucleus caudalis via a receptor distinct from the PAC1 receptor. Neuropeptides 48:53\u201364","journal-title":"Neuropeptides"},{"key":"852_CR16","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/0006-8993(95)00869-R","volume":"699","author":"M Palkovits","year":"1995","unstructured":"Palkovits M, Somogyvari-Vigh A, Arimura A (1995) Concentrations of pituitary adenylate cyclase activating polypeptide (PACAP) in human brain nuclei. Brain Res 699:116\u2013120","journal-title":"Brain Res"},{"key":"852_CR17","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/0006-8993(92)90430-H","volume":"575","author":"Y Masuo","year":"1992","unstructured":"Masuo Y, Ohtaki T, Masuda Y, Tsuda M, Fujino M (1992) Binding sites for pituitary adenylate cyclase activating polypeptide (PACAP): comparison with vasoactive intestinal polypeptide (VIP) binding site localization in rat brain sections. Brain Res 575:113\u2013123","journal-title":"Brain Res"},{"key":"852_CR18","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.ygcen.2010.11.026","volume":"171","author":"J Fahrenkrug","year":"2011","unstructured":"Fahrenkrug J, Hannibal J (2011) Localisation of the neuropeptide PACAP and its receptors in the rat parathyroid and thyroid glands. Gen Comp Endocrinol 171:105\u2013113","journal-title":"Gen Comp Endocrinol"},{"key":"852_CR19","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1016\/S0196-9781(98)00049-7","volume":"19","author":"K Koves","year":"1998","unstructured":"Koves K, Kantor O, Scammell JG, Arimura A (1998) PACAP colocalizes with luteinizing and follicle-stimulating hormone immunoreactivities in the anterior lobe of the pituitary gland. Peptides 19:1069\u20131072","journal-title":"Peptides"},{"key":"852_CR20","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1530\/EJE-08-0911","volume":"160","author":"R Borzsei","year":"2009","unstructured":"Borzsei R, Mark L, Tamas A, Bagoly T, Bay C, Csanaky K, Banki E, Kiss P, Vaczy A, Horvath G, Nemeth J, Szauer E, Helyes Z, Reglodi D (2009) Presence of pituitary adenylate cyclase activating polypeptide-38 in human plasma and milk. Eur J Endocrinol 160:561\u2013565","journal-title":"Eur J Endocrinol"},{"key":"852_CR21","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1097\/MED.0b013e328342568a","volume":"18","author":"TW Moody","year":"2011","unstructured":"Moody TW, Ito T, Osefo N, Jensen RT (2011) VIP and PACAP: recent insights into their functions\/roles in physiology and disease from molecular and genetic studies. Curr Opin Endocrinol Diabetes Obes 18:61\u201367","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"852_CR22","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1530\/REP-07-0051","volume":"134","author":"M Barberi","year":"2007","unstructured":"Barberi M, Muciaccia B, Morelli MB, Stefanini M, Cecconi S, Canipari R (2007) Expression localisation and functional activity of pituitary adenylate cyclase-activating polypeptide, vasoactive intestinal polypeptide and their receptors in mouse ovary. Reproduction 134:281\u2013292","journal-title":"Reproduction"},{"key":"852_CR23","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/0304-3940(94)90234-8","volume":"170","author":"Y Masuo","year":"1994","unstructured":"Masuo Y, Tokito F, Matsumoto Y, Shimamoto N, Fujino M (1994) Ontogeny of pituitary adenylate cyclase-activating polypeptide (PACAP) and its binding sites in the rat brain. Neurosci Lett 170:43\u201346","journal-title":"Neurosci Lett"},{"key":"852_CR24","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1210\/endo-127-1-264","volume":"127","author":"K Koves","year":"1990","unstructured":"Koves K, Arimura A, Somogyvari-Vigh A, Vigh S, Miller J (1990) Immunohistochemical demonstration of a novel hypothalamic peptide, pituitary adenylate cyclase-activating polypeptide, in the ovine hypothalamus. Endocrinology 127:264\u2013271","journal-title":"Endocrinology"},{"key":"852_CR25","doi-asserted-by":"publisher","first-page":"985","DOI":"10.2174\/138161211795589382","volume":"17","author":"H Hashimoto","year":"2011","unstructured":"Hashimoto H, Shintani N, Tanida M, Hayata A, Hashimoto R, Baba A (2011) PACAP is implicated in the stress axes. Curr Pharm Des 17:985\u2013989","journal-title":"Curr Pharm Des"},{"key":"852_CR26","doi-asserted-by":"publisher","first-page":"962","DOI":"10.2174\/138161211795589355","volume":"17","author":"D Reglodi","year":"2011","unstructured":"Reglodi D, Kiss P, Lubics A, Tamas A (2011) Review on the protective effects of PACAP in models of neurodegenerative diseases in vitro and in vivo. Curr Pharm Des 17:962\u2013972","journal-title":"Curr Pharm Des"},{"key":"852_CR27","doi-asserted-by":"publisher","first-page":"204","DOI":"10.2174\/138161211795049679","volume":"17","author":"T Seaborn","year":"2011","unstructured":"Seaborn T, Masmoudi-Kouli O, Fournier A, Vaudry H, Vaudry D (2011) Protective effects of pituitary adenylate cyclase-activating polypeptide (PACAP) against apoptosis. Curr Pharm Des 17:204\u2013214","journal-title":"Curr Pharm Des"},{"key":"852_CR28","doi-asserted-by":"publisher","first-page":"1144","DOI":"10.1016\/j.bbrc.2008.03.028","volume":"369","author":"M Ohtsuka","year":"2008","unstructured":"Ohtsuka M, Fukumitsu H, Furukawa S (2008) PACAP decides neuronal laminar fate via PKA signaling in the developing cerebral cortex. Biochem Biophys Res Commun 369:1144\u20131149","journal-title":"Biochem Biophys Res Commun"},{"key":"852_CR29","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1016\/j.peptides.2007.06.029","volume":"28","author":"J Watanabe","year":"2007","unstructured":"Watanabe J, Nakamachi T, Matsuno R, Hayashi D, Nakamura M, Kikuyama S, Nakajo S, Shioda S (2007) Localization, characterization and function of pituitary adenylate cyclase-activating polypeptide during brain development. Peptides 28:1713\u20131719","journal-title":"Peptides"},{"key":"852_CR30","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.npep.2011.05.001","volume":"46","author":"D Reglodi","year":"2012","unstructured":"Reglodi D, Kiss P, Horvath G, Lubics A, Laszlo E, Tamas A, Racz B, Szakaly P (2012) Effects of pituitary adenylate cyclase activating polypeptide in the urinary system, with special emphasis on its protective effects in the kidney. Neuropeptides 46:61\u201370","journal-title":"Neuropeptides"},{"key":"852_CR31","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1007\/s12031-010-9352-y","volume":"42","author":"A Ferencz","year":"2010","unstructured":"Ferencz A, Weber G, Helyes Z, Hashimoto H, Baba A, Reglodi D (2010) Presence of endogenous PACAP-38 ameliorated intestinal cold preservation tissue injury. J Mol Neurosci 42:428\u2013434","journal-title":"J Mol Neurosci"},{"key":"852_CR32","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1007\/s12031-010-9349-6","volume":"42","author":"B Racz","year":"2010","unstructured":"Racz B, Reglodi D, Horvath G, Szigeti A, Balatonyi B, Roth E, Weber G, Alotti N, Toth G, Gasz B (2010) Protective effect of PACAP against doxorubicin-induced cell death in cardiomyocyte culture. J Mol Neurosci 42:419\u2013427","journal-title":"J Mol Neurosci"},{"key":"852_CR33","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1016\/j.peptides.2011.05.008","volume":"32","author":"K Elekes","year":"2011","unstructured":"Elekes K, Sandor K, Moricz A, Kereskai L, Kemeny A, Szoke E, Perkecz A, Reglodi D, Hashimoto H, Pinter E, Szolcsanyi J, Helyes Z (2011) Pituitary adenylate cyclase-activating polypeptide plays an anti-inflammatory role in endotoxin-induced airway inflammation: in vivo study with gene-deleted mice. Peptides 32:1439\u20131446","journal-title":"Peptides"},{"key":"852_CR34","doi-asserted-by":"publisher","first-page":"423","DOI":"10.2174\/1389203023380576","volume":"3","author":"CJ Zhou","year":"2002","unstructured":"Zhou CJ, Shioda S, Yada T, Inagaki N, Pleasure SJ, Kikuyama S (2002) PACAP and its receptors exert pleiotropic effects in the nervous system by activating multiple signaling pathways. Curr Protein Pept Sci 3:423\u2013439","journal-title":"Curr Protein Pept Sci"},{"key":"852_CR35","first-page":"83","volume":"20","author":"JB Warren","year":"1992","unstructured":"Warren JB, Cockcroft JR, Larkin SW, Kajekar R, Macrae A, Ghatei MA, Bloom SR (1992) Pituitary adenylate cyclase activating polypeptide is a potent vasodilator in humans. J Cardiovasc Pharmacol 20:83\u201387","journal-title":"J Cardiovasc Pharmacol"},{"key":"852_CR36","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/0167-0115(92)90081-5","volume":"40","author":"Y Ishizuka","year":"1992","unstructured":"Ishizuka Y, Kashimoto K, Mochizuki T, Sato K, Ohshima K, Yanaihara N (1992) Cardiovascular and respiratory actions of pituitary adenylate cyclase-activating polypeptides. Regul Pept 40:29\u201339","journal-title":"Regul Pept"},{"key":"852_CR37","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/0196-9781(93)90139-8","volume":"14","author":"S Naruse","year":"1993","unstructured":"Naruse S, Suzuki T, Ozaki T, Nokihara K (1993) Vasodilator effect of pituitary adenylate cyclase activating polypeptide (PACAP) on femoral blood flow in dogs. Peptides 14:505\u2013510","journal-title":"Peptides"},{"key":"852_CR38","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1016\/j.jpain.2013.03.010","volume":"14","author":"S Eftekhari","year":"2013","unstructured":"Eftekhari S, Warfvinge K, Blixt FW, Edvinsson L (2013) Differentiation of nerve fibers storing CGRP and CGRP receptors in the peripheral trigeminovascular system. J Pain 14:1289\u20131303","journal-title":"J Pain"},{"key":"852_CR39","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1016\/0306-4522(93)90018-B","volume":"57","author":"K Moller","year":"1993","unstructured":"Moller K, Zhang YZ, Hakanson R, Luts A, Sjolund B, Uddman R, Sundler F (1993) Pituitary adenylate cyclase activating peptide is a sensory neuropeptide: immunocytochemical and immunochemical evidence. Neuroscience 57:725\u2013732","journal-title":"Neuroscience"},{"key":"852_CR40","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1097\/01.WCB.0000121234.42748.F6","volume":"24","author":"FM Baeres","year":"2004","unstructured":"Baeres FM, Moller M (2004) Origin of PACAP-immunoreactive nerve fibers innervating the subarachnoidal blood vessels of the rat brain. J Cereb Blood Flow Metab 24:628\u2013635","journal-title":"J Cereb Blood Flow Metab"},{"key":"852_CR41","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1002\/(SICI)1096-9861(19980518)394:4<403::AID-CNE1>3.0.CO;2-5","volume":"394","author":"HS Nielsen","year":"1998","unstructured":"Nielsen HS, Hannibal J, Fahrenkrug J (1998) Embryonic expression of pituitary adenylate cyclase-activating polypeptide in sensory and autonomic ganglia and in spinal cord of the rat. J Comp Neurol 394:403\u2013415","journal-title":"J Comp Neurol"},{"key":"852_CR42","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/S0165-1838(99)00024-7","volume":"76","author":"J Tajti","year":"1999","unstructured":"Tajti J, Uddman R, Moller S, Sundler F, Edvinsson L (1999) Messenger molecules and receptor mRNA in the human trigeminal ganglion. J Auton Nerv Syst 76:176\u2013183","journal-title":"J Auton Nerv Syst"},{"key":"852_CR43","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/S0006-8993(02)03927-6","volume":"964","author":"M Hou","year":"2003","unstructured":"Hou M, Uddman R, Tajti J, Edvinsson L (2003) Nociceptin immunoreactivity and receptor mRNA in the human trigeminal ganglion. Brain Res 964:179\u2013186","journal-title":"Brain Res"},{"key":"852_CR44","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.brainres.2014.11.031","volume":"1600","author":"S Eftekhari","year":"2015","unstructured":"Eftekhari S, Salvatore CA, Johansson S, Chen TB, Zeng Z, Edvinsson L (2015) Localization of CGRP, CGRP receptor, PACAP and glutamate in trigeminal ganglion. Relation to the blood-brain barrier. Brain Res 1600:93\u2013109","journal-title":"Brain Res"},{"key":"852_CR45","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1046\/j.1468-2982.2002.00324.x","volume":"22","author":"R Uddman","year":"2002","unstructured":"Uddman R, Tajti J, Hou M, Sundler F, Edvinsson L (2002) Neuropeptide expression in the human trigeminal nucleus caudalis and in the cervical spinal cord C1 and C2. Cephalalgia 22:112\u2013116","journal-title":"Cephalalgia"},{"key":"852_CR46","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1046\/j.1468-2982.2001.00140.x","volume":"21","author":"J Tajti","year":"2001","unstructured":"Tajti J, Uddman R, Edvinsson L (2001) Neuropeptide localization in the \"migraine generator\" region of the human brainstem. Cephalalgia 21:96\u2013101","journal-title":"Cephalalgia"},{"key":"852_CR47","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/0304-3940(94)90080-9","volume":"176","author":"G Legradi","year":"1994","unstructured":"Legradi G, Shioda S, Arimura A (1994) Pituitary adenylate cyclase-activating polypeptide-like immunoreactivity in autonomic regulatory areas of the rat medulla oblongata. Neurosci Lett 176:193\u2013196","journal-title":"Neurosci Lett"},{"key":"852_CR48","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/S0006-8993(99)01260-3","volume":"826","author":"R Uddman","year":"1999","unstructured":"Uddman R, Tajti J, Moller S, Sundler F, Edvinsson L (1999) Neuronal messengers and peptide receptors in the human sphenopalatine and otic ganglia. Brain Res 826:193\u2013199","journal-title":"Brain Res"},{"key":"852_CR49","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.neuroscience.2011.10.055","volume":"202","author":"A Csati","year":"2012","unstructured":"Csati A, Tajti J, Kuris A, Tuka B, Edvinsson L, Warfvinge K (2012) Distribution of vasoactive intestinal peptide, pituitary adenylate cyclase-activating peptide, nitric oxide synthase, and their receptors in human and rat sphenopalatine ganglion. Neuroscience 202:158\u2013168","journal-title":"Neuroscience"},{"key":"852_CR50","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s10194-016-0664-3","volume":"17","author":"A Steinberg","year":"2016","unstructured":"Steinberg A, Frederiksen SD, Blixt FW, Warfvinge K, Edvinsson L (2016) Expression of messenger molecules and receptors in rat and human sphenopalatine ganglion indicating therapeutic targets. J Headache Pain 17:78","journal-title":"J Headache Pain"},{"key":"852_CR51","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/0306-4522(94)90025-6","volume":"63","author":"H Mulder","year":"1994","unstructured":"Mulder H, Uddman R, Moller K, Zhang YZ, Ekblad E, Alumets J, Sundler F (1994) Pituitary adenylate cyclase activating polypeptide expression in sensory neurons. Neuroscience 63:307\u2013312","journal-title":"Neuroscience"},{"key":"852_CR52","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.brainresrev.2004.09.007","volume":"48","author":"L Edvinsson","year":"2005","unstructured":"Edvinsson L, Uddman R (2005) Neurobiology in primary headaches. Brain Res Brain Res Rev 48:438\u2013456","journal-title":"Brain Res Brain Res Rev"},{"key":"852_CR53","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/0167-0115(91)90478-Y","volume":"35","author":"A Cauvin","year":"1991","unstructured":"Cauvin A, Robberecht P, De Neef P, Gourlet P, Vandermeers A, Vandermeers-Piret MC, Christophe J (1991) Properties and distribution of receptors for pituitary adenylate cyclase activating peptide (PACAP) in rat brain and spinal cord. Regul Pept 35:161\u2013173","journal-title":"Regul Pept"},{"key":"852_CR54","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1210\/jcem-72-5-958","volume":"72","author":"K Suda","year":"1991","unstructured":"Suda K, Smith DM, Ghatei MA, Murphy JK, Bloom SR (1991) Investigation and characterization of receptors for pituitary adenylate cyclase-activating polypeptide in human brain by radioligand binding and chemical cross-linking. J Clin Endocrinol Metab 72:958\u2013964","journal-title":"J Clin Endocrinol Metab"},{"key":"852_CR55","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/S0169-328X(02)00329-7","volume":"104","author":"P Chaudhary","year":"2002","unstructured":"Chaudhary P, Baumann TK (2002) Expression of VPAC2 receptor and PAC1 receptor splice variants in the trigeminal ganglion of the adult rat. Brain Res Mol Brain Res 104:137\u2013142","journal-title":"Brain Res Mol Brain Res"},{"key":"852_CR56","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.neuroscience.2015.08.043","volume":"308","author":"E Saghy","year":"2015","unstructured":"Saghy E, Payrits M, Helyes Z, Reglodi D, Banki E, Toth G, Couvineau A, Szoke E (2015) Stimulatory effect of pituitary adenylate cyclase-activating polypeptide 6-38, M65 and vasoactive intestinal polypeptide 6-28 on trigeminal sensory neurons. Neuroscience 308:144\u2013156","journal-title":"Neuroscience"},{"key":"852_CR57","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1097\/00001756-200203250-00030","volume":"13","author":"M Knutsson","year":"2002","unstructured":"Knutsson M, Edvinsson L (2002) Distribution of mRNA for VIP and PACAP receptors in human cerebral arteries and cranial ganglia. Neuroreport 13:507\u2013509","journal-title":"Neuroreport"},{"issue":"Pt 3","key":"852_CR58","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1093\/brain\/117.3.427","volume":"117","author":"PJ Goadsby","year":"1994","unstructured":"Goadsby PJ, Edvinsson L (1994) Human in vivo evidence for trigeminovascular activation in cluster headache. Neuropeptide changes and effects of acute attacks therapies. Brain 117(Pt 3):427\u2013434","journal-title":"Brain"},{"key":"852_CR59","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1111\/j.1526-4610.1994.hed3407394.x","volume":"34","author":"PJ Goadsby","year":"1994","unstructured":"Goadsby PJ, Edvinsson L (1994) Joint 1994 Wolff award presentation. Peripheral and central trigeminovascular activation in cat is blocked by the serotonin (5HT)-1D receptor agonist 311C90. Headache 34:394\u2013399","journal-title":"Headache"},{"key":"852_CR60","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1093\/brain\/awn307","volume":"132","author":"HW Schytz","year":"2009","unstructured":"Schytz HW, Birk S, Wienecke T, Kruuse C, Olesen J, Ashina M (2009) PACAP38 induces migraine-like attacks in patients with migraine without aura. Brain 132:16\u201325","journal-title":"Brain"},{"key":"852_CR61","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1097\/00001756-199308000-00008","volume":"4","author":"J Olesen","year":"1993","unstructured":"Olesen J, Iversen HK, Thomsen LL (1993) Nitric oxide supersensitivity: a possible molecular mechanism of migraine pain. Neuroreport 4:1027\u20131030","journal-title":"Neuroreport"},{"key":"852_CR62","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1111\/j.1526-4610.1987.hed2704180.x","volume":"27","author":"F Sicuteri","year":"1987","unstructured":"Sicuteri F, Del Bene E, Poggioni M, Bonazzi A (1987) Unmasking latent dysnociception in healthy subjects. Headache 27:180\u2013185","journal-title":"Headache"},{"key":"852_CR63","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1046\/j.1468-2982.2002.00310.x","volume":"22","author":"LH Lassen","year":"2002","unstructured":"Lassen LH, Haderslev PA, Jacobsen VB, Iversen HK, Sperling B, Olesen J (2002) CGRP may play a causative role in migraine. Cephalalgia 22:54\u201361","journal-title":"Cephalalgia"},{"key":"852_CR64","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1177\/0333102411431333","volume":"32","author":"FM Amin","year":"2012","unstructured":"Amin FM, Asghar MS, Guo S, Hougaard A, Hansen AE, Schytz HW, van der Geest RJ, de Koning PJ, Larsson HB, Olesen J, Ashina M (2012) Headache and prolonged dilatation of the middle meningeal artery by PACAP38 in healthy volunteers. Cephalalgia 32:140\u2013149","journal-title":"Cephalalgia"},{"key":"852_CR65","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1093\/brain\/awt369","volume":"137","author":"FM Amin","year":"2014","unstructured":"Amin FM, Hougaard A, Schytz HW, Asghar MS, Lundholm E, Parvaiz AI, de Koning PJ, Andersen MR, Larsson HB, Fahrenkrug J, Olesen J, Ashina M (2014) Investigation of the pathophysiological mechanisms of migraine attacks induced by pituitary adenylate cyclase-activating polypeptide-38. Brain 137:779\u2013794","journal-title":"Brain"},{"key":"852_CR66","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1212\/WNL.0000000000002261","volume":"86","author":"FM Amin","year":"2016","unstructured":"Amin FM, Hougaard A, Magon S, Asghar MS, Ahmad NN, Rostrup E, Sprenger T, Ashina M (2016) Change in brain network connectivity during PACAP38-induced migraine attacks: a resting-state functional MRI study. Neurology 86:180\u2013187","journal-title":"Neurology"},{"key":"852_CR67","volume-title":"Part II: biochemical changes after pituitary adenylate cyclase-activating polypeptide-38 infusion in migraine patients","author":"S Guo","year":"2016","unstructured":"Guo S, Vollesen AL, Hansen YB, Frandsen E, Andersen MR, Amin FM, Fahrenkrug J, Olesen J, Ashina M (2016) Part II: biochemical changes after pituitary adenylate cyclase-activating polypeptide-38 infusion in migraine patients. Cephalalgia"},{"key":"852_CR68","volume-title":"Part I: pituitary adenylate cyclase-activating polypeptide-38 induced migraine-like attacks in patients with and without familial aggregation of migraine","author":"S Guo","year":"2016","unstructured":"Guo S, Vollesen AL, Hansen RD, Esserlind AL, Amin FM, Christensen AF, Olesen J, Ashina M (2016) Part I: pituitary adenylate cyclase-activating polypeptide-38 induced migraine-like attacks in patients with and without familial aggregation of migraine. Cephalalgia"},{"key":"852_CR69","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/0306-4522(93)90019-C","volume":"57","author":"YZ Zhang","year":"1993","unstructured":"Zhang YZ, Sjolund B, Moller K, Hakanson R, Sundler F (1993) Pituitary adenylate cyclase activating peptide produces a marked and long-lasting depression of a C-fibre-evoked flexion reflex. Neuroscience 57:733\u2013737","journal-title":"Neuroscience"},{"key":"852_CR70","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/0014-2999(96)00359-7","volume":"311","author":"M Narita","year":"1996","unstructured":"Narita M, Dun SL, Dun NJ, Tseng LF (1996) Hyperalgesia induced by pituitary adenylate cyclase-activating polypeptide in the mouse spinal cord. Eur J Pharmacol 311:121\u2013126","journal-title":"Eur J Pharmacol"},{"key":"852_CR71","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.jpain.2008.01.329","volume":"9","author":"R Davis-Taber","year":"2008","unstructured":"Davis-Taber R, Baker S, Lehto SG, Zhong C, Surowy CS, Faltynek CR, Scott VE, Honore P (2008) Central pituitary adenylate cyclase 1 receptors modulate nociceptive behaviors in both inflammatory and neuropathic pain states. J Pain 9:449\u2013456","journal-title":"J Pain"},{"key":"852_CR72","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1097\/00001756-200107200-00034","volume":"12","author":"H Jongsma","year":"2001","unstructured":"Jongsma H, Pettersson LM, Zhang Y, Reimer MK, Kanje M, Waldenstrom A, Sundler F, Danielsen N (2001) Markedly reduced chronic nociceptive response in mice lacking the PAC1 receptor. Neuroreport 12:2215\u20132219","journal-title":"Neuroreport"},{"key":"852_CR73","doi-asserted-by":"publisher","first-page":"7283","DOI":"10.1523\/JNEUROSCI.0983-04.2004","volume":"24","author":"T Mabuchi","year":"2004","unstructured":"Mabuchi T, Shintani N, Matsumura S, Okuda-Ashitaka E, Hashimoto H, Muratani T, Minami T, Baba A, Ito S (2004) Pituitary adenylate cyclase-activating polypeptide is required for the development of spinal sensitization and induction of neuropathic pain. J Neurosci 24:7283\u20137291","journal-title":"J Neurosci"},{"key":"852_CR74","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.nbd.2011.10.010","volume":"45","author":"A Markovics","year":"2012","unstructured":"Markovics A, Kormos V, Gaszner B, Lashgarara A, Szoke E, Sandor K, Szabadfi K, Tuka B, Tajti J, Szolcsanyi J, Pinter E, Hashimoto H, Kun J, Reglodi D, Helyes Z (2012) Pituitary adenylate cyclase-activating polypeptide plays a key role in nitroglycerol-induced trigeminovascular activation in mice. Neurobiol Dis 45:633\u2013644","journal-title":"Neurobiol Dis"},{"key":"852_CR75","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/S0169-328X(02)00646-0","volume":"110","author":"M Martin","year":"2003","unstructured":"Martin M, Otto C, Santamarta MT, Torrecilla M, Pineda J, Schutz G, Maldonado R (2003) Morphine withdrawal is modified in pituitary adenylate cyclase-activating polypeptide type I-receptor-deficient mice. Brain Res Mol Brain Res 110:109\u2013118","journal-title":"Brain Res Mol Brain Res"},{"key":"852_CR76","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.neuropharm.2014.06.022","volume":"86","author":"G Missig","year":"2014","unstructured":"Missig G, Roman CW, Vizzard MA, Braas KM, Hammack SE, May V (2014) Parabrachial nucleus (PBn) pituitary adenylate cyclase activating polypeptide (PACAP) signaling in the amygdala: implication for the sensory and behavioral effects of pain. Neuropharmacology 86:38\u201348","journal-title":"Neuropharmacology"},{"key":"852_CR77","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa7557","volume":"7","author":"S Akerman","year":"2015","unstructured":"Akerman S, Goadsby PJ (2015) Neuronal PAC1 receptors mediate delayed activation and sensitization of trigeminocervical neurons: relevance to migraine. Sci Transl Med 7:308ra157","journal-title":"Sci Transl Med"},{"key":"852_CR78","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.pain.2008.10.028","volume":"141","author":"K Sandor","year":"2009","unstructured":"Sandor K, Bolcskei K, McDougall JJ, Schuelert N, Reglodi D, Elekes K, Petho G, Pinter E, Szolcsanyi J, Helyes Z (2009) Divergent peripheral effects of pituitary adenylate cyclase-activating polypeptide-38 on nociception in rats and mice. Pain 141:143\u2013150","journal-title":"Pain"},{"key":"852_CR79","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.1016\/j.peptides.2007.07.001","volume":"28","author":"Z Helyes","year":"2007","unstructured":"Helyes Z, Pozsgai G, Borzsei R, Nemeth J, Bagoly T, Mark L, Pinter E, Toth G, Elekes K, Szolcsanyi J, Reglodi D (2007) Inhibitory effect of PACAP-38 on acute neurogenic and non-neurogenic inflammatory processes in the rat. Peptides 28:1847\u20131855","journal-title":"Peptides"},{"key":"852_CR80","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.neuroscience.2006.07.028","volume":"143","author":"J Nemeth","year":"2006","unstructured":"Nemeth J, Reglodi D, Pozsgai G, Szabo A, Elekes K, Pinter E, Szolcsanyi J, Helyes Z (2006) Effect of pituitary adenylate cyclase activating polypeptide-38 on sensory neuropeptide release and neurogenic inflammation in rats and mice. Neuroscience 143:223\u2013230","journal-title":"Neuroscience"},{"key":"852_CR81","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/0304-3940(96)12516-7","volume":"207","author":"Y Zhang","year":"1996","unstructured":"Zhang Y, Malmberg AB, Sjolund B, Yaksh TL (1996) The effect of pituitary adenylate cyclase activating peptide (PACAP) on the nociceptive formalin test. Neurosci Lett 207:187\u2013190","journal-title":"Neurosci Lett"},{"key":"852_CR82","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1177\/0333102412439354","volume":"32","author":"M Baun","year":"2012","unstructured":"Baun M, Pedersen MH, Olesen J, Jansen-Olesen I (2012) Dural mast cell degranulation is a putative mechanism for headache induced by PACAP-38. Cephalalgia 32:337\u2013345","journal-title":"Cephalalgia"},{"key":"852_CR83","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1177\/0333102414523846","volume":"34","author":"DK Bhatt","year":"2014","unstructured":"Bhatt DK, Gupta S, Olesen J, Jansen-Olesen I (2014) PACAP-38 infusion causes sustained vasodilation of the middle meningeal artery in the rat: possible involvement of mast cells. Cephalalgia 34:877\u2013886","journal-title":"Cephalalgia"},{"key":"852_CR84","first-page":"1044","volume":"44","author":"T Mori","year":"1994","unstructured":"Mori T, Kawashima T, Beppu Y, Takagi K (1994) Histamine release induced by pituitary adenylate cyclase activating polypeptide from rat peritoneal mast cells. Arzneimittelforschung 44:1044\u20131046","journal-title":"Arzneimittelforschung"},{"key":"852_CR85","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1007\/s000110050363","volume":"47","author":"L Odum","year":"1998","unstructured":"Odum L, Petersen LJ, Skov PS, Ebskov LB (1998) Pituitary adenylate cyclase activating polypeptide (PACAP) is localized in human dermal neurons and causes histamine release from skin mast cells. Inflamm Res 47:488\u2013492","journal-title":"Inflamm Res"},{"key":"852_CR86","first-page":"B4223","volume":"57","author":"HW Schytz","year":"2010","unstructured":"Schytz HW (2010) Investigation of carbachol and PACAP38 in a human model of migraine. Dan Med Bull 57:B4223","journal-title":"Dan Med Bull"},{"key":"852_CR87","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S0167-0115(97)02133-2","volume":"69","author":"Y Zhang","year":"1997","unstructured":"Zhang Y, Malmberg AB, Yaksh TL, Sjolund B, Sundler F, Hakanson R (1997) Capsaicin-evoked release of pituitary adenylate cyclase activating peptide (PACAP) and calcitonin gene-related peptide (CGRP) from rat spinal cord in vivo. Regul Pept 69:83\u201387","journal-title":"Regul Pept"},{"key":"852_CR88","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.peptides.2011.12.019","volume":"33","author":"B Tuka","year":"2012","unstructured":"Tuka B, Helyes Z, Markovics A, Bagoly T, Nemeth J, Mark L, Brubel R, Reglodi D, Pardutz A, Szolcsanyi J, Vecsei L, Tajti J (2012) Peripheral and central alterations of pituitary adenylate cyclase activating polypeptide-like immunoreactivity in the rat in response to activation of the trigeminovascular system. Peptides 33:307\u2013316","journal-title":"Peptides"},{"key":"852_CR89","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.1002\/acn3.113","volume":"1","author":"AS Zagami","year":"2014","unstructured":"Zagami AS, Edvinsson L, Goadsby PJ (2014) Pituitary adenylate cyclase activating polypeptide and migraine. Ann Clin Transl Neurol 1:1036\u20131040","journal-title":"Ann Clin Transl Neurol"},{"key":"852_CR90","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/0143-4179(90)90114-E","volume":"16","author":"AS Zagami","year":"1990","unstructured":"Zagami AS, Goadsby PJ, Edvinsson L (1990) Stimulation of the superior sagittal sinus in the cat causes release of vasoactive peptides. Neuropeptides 16:69\u201375","journal-title":"Neuropeptides"},{"key":"852_CR91","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1177\/0333102413483931","volume":"33","author":"B Tuka","year":"2013","unstructured":"Tuka B, Helyes Z, Markovics A, Bagoly T, Szolcsanyi J, Szabo N, Toth E, Kincses ZT, Vecsei L, Tajti J (2013) Alterations in PACAP-38-like immunoreactivity in the plasma during ictal and interictal periods of migraine patients. Cephalalgia 33:1085\u20131095","journal-title":"Cephalalgia"},{"key":"852_CR92","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s10194-016-0660-7","volume":"17","author":"B Tuka","year":"2016","unstructured":"Tuka B, Szabo N, Toth E, Kincses ZT, Pardutz A, Szok D, Kortesi T, Bagoly T, Helyes Z, Edvinsson L, Vecsei L, Tajti J (2016) Release of PACAP-38 in episodic cluster headache patients - an exploratory study. J Headache Pain 17:69","journal-title":"J Headache Pain"},{"key":"852_CR93","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.cca.2015.08.017","volume":"450","author":"X Han","year":"2015","unstructured":"Han X, Dong Z, Hou L, Wan D, Chen M, Tang W, Yu S (2015) Interictal plasma pituitary adenylate cyclase-activating polypeptide levels are decreased in migraineurs but remain unchanged in patients with tension-type headache. Clin Chim Acta 450:151\u2013154","journal-title":"Clin Chim Acta"},{"issue":"Suppl 14","key":"852_CR94","first-page":"109","volume":"15","author":"AS Zagami","year":"1995","unstructured":"Zagami AS, Edvinsson L, Hoskin KL, Goadsby PJ (1995) Stimulation of the superior sagittal sinus causes extracranial release of PACAP. Cephalalgia 15(Suppl 14):109","journal-title":"Cephalalgia"},{"key":"852_CR95","doi-asserted-by":"crossref","unstructured":"Reglodi D, Tamas A (2016) Pituitary Adenylate Cyclase activating polypeptide \u2014 PACAP. Cham. Springer International Publishing","DOI":"10.1007\/978-3-319-35135-3"},{"key":"852_CR96","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.npep.2012.12.005","volume":"47","author":"A Erdling","year":"2013","unstructured":"Erdling A, Sheykhzade M, Maddahi A, Bari F, Edvinsson L (2013) VIP\/PACAP receptors in cerebral arteries of rat: characterization, localization and relation to intracellular calcium. Neuropeptides 47:85\u201392","journal-title":"Neuropeptides"},{"key":"852_CR97","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1007\/s12031-012-9851-0","volume":"48","author":"AU Syed","year":"2012","unstructured":"Syed AU, Koide M, Braas KM, May V, Wellman GC (2012) Pituitary adenylate cyclase-activating polypeptide (PACAP) potently dilates middle meningeal arteries: implications for migraine. J Mol Neurosci 48:574\u2013583","journal-title":"J Mol Neurosci"}],"container-title":["The Journal of Headache and Pain"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s10194-018-0852-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s10194-018-0852-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s10194-018-0852-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T19:05:22Z","timestamp":1552071922000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejournalofheadacheandpain.biomedcentral.com\/articles\/10.1186\/s10194-018-0852-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,9]]},"references-count":97,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["852"],"URL":"https:\/\/doi.org\/10.1186\/s10194-018-0852-4","relation":{},"ISSN":["1129-2369","1129-2377"],"issn-type":[{"value":"1129-2369","type":"print"},{"value":"1129-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,9]]},"assertion":[{"value":"6 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The author declares no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"21"}}