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Evolving clinical and mechanistic evidences support the notation that chronic persistent MTBI related headaches (MTBI-HA) carry the hallmark characteristics of neuropathic pain. Thus, in addition to conventional treatment options applicable to non-traumatic primary headache disorders, other available treatment modalities for neuropathic pain should be considered. In this comprehensive review article, the author reveals the prevalence of MTBI-HA and its clinical manifestation, discusses existing clinical and mechanistic evidence supporting the classification of chronic persistent MTBI-HA as a neuropathic pain state, and explores current available treatment options and future directions of therapeutic research related to MTBI-HA.<\/jats:p>","DOI":"10.1186\/s10194-020-01133-2","type":"journal-article","created":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T11:03:52Z","timestamp":1592564632000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Addressing chronic persistent headaches after MTBI as a neuropathic pain state"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1614-5883","authenticated-orcid":false,"given":"Albert","family":"Leung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,19]]},"reference":[{"key":"1133_CR1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/B978-0-444-52892-6.00001-5","volume":"127","author":"M Faul","year":"2015","unstructured":"Faul M, Coronado V (2015) Epidemiology of traumatic brain injury. 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