{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T08:42:00Z","timestamp":1788943320949,"version":"build-2803163510"},"reference-count":6,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T00:00:00Z","timestamp":1591747200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T00:00:00Z","timestamp":1591747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Headache Pain"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>There are no previous controlled studies of sentinel headache in ischemic stroke. The purpose of the present study was to evaluate the presence of such headache, its characteristics and possible risk factors as compared to a simultaneous control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Eligible patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009550) had first-ever acute ischemic stroke with presence of new infarction on\n                      <jats:italic>magnetic resonance<\/jats:italic>\n                      imaging with diffusion-weighted imaging (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009469) or on computed tomography (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200981). As a control group we studied in parallel patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009192) who were admitted to the emergency room without acute neurological deficits or serious neurological or somatic disorders. Consecutive patients with stroke and a simultaneous control group were extensively interviewed soon after admission using validated neurologist conducted semi-structured interview forms. Based on our previous study of sentinel headache in transient ischemic attacks we defined sentinel headache as a new type of headache or a previous kind of headache with altered characteristics (severe intensity, increased frequency, absence of effect of drugs) within seven days before stroke.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 550 patients with stroke 94 patients (17.1%) had headache during seven days before stroke and 12 (6.2%) controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001; OR 3.9; 95% CI 1.7\u20135.8). Totally 81 patients (14.7%) had sentinel headache within the last week before stroke and one control. Attacks of arrythmia during seven days before stroke were significantly associated with sentinel headache (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04, OR 2.3; 95% CI 1.1\u20134.8).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>A new type of headache and a previous kind of headache with altered characteristics during one week before stroke are significantly more prevalent than in controls. These headaches represent sentinel headaches. Sudden onset of such headaches should alarm about stroke.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s10194-020-01140-3","type":"journal-article","created":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T05:03:03Z","timestamp":1591765383000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Sentinel headache as a warning symptom of ischemic stroke"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2463-7113","authenticated-orcid":false,"given":"Elena R.","family":"Lebedeva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton V.","family":"Ushenin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia M.","family":"Gurary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis V.","family":"Gilev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes","family":"Olesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,10]]},"reference":[{"key":"1140_CR1","doi-asserted-by":"publisher","first-page":"162","DOI":"10.4103\/2152-7806.105101","volume":"3","author":"JL Pereira","year":"2012","unstructured":"Pereira JL, de Albuquerque LA, Dellaretti M et al (2012) Importance of recognizing sentinel headache. Surg Neurol Int 3:162","journal-title":"Surg Neurol Int"},{"issue":"1","key":"1140_CR2","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s10194-018-0888-5","volume":"19","author":"ER Lebedeva","year":"2018","unstructured":"Lebedeva ER, Gurary NM, Gilev DV, Olesen J (2018) Headache in transient ischemic attacks. J Headache Pain 19(1):60","journal-title":"J Headache Pain"},{"issue":"11","key":"1140_CR3","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1212\/WNL.36.11.1445","volume":"36","author":"PB Gorelick","year":"1986","unstructured":"Gorelick PB, Hier DB, Caplan LR, Langenberg P (1986) Headache in acute cerebrovascular disease. Neurology. 36(11):1445\u20131450","journal-title":"Neurology."},{"issue":"2","key":"1140_CR4","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.08.033","volume":"24","author":"A Sharma","year":"2015","unstructured":"Sharma A, Prasad K, Padma MV et al (2015) Prevalence of triggering factors in acute stroke: hospital-based observational cross-sectional study. J Stroke Cerebrovasc Dis 24(2):337\u2013347","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"1140_CR5","doi-asserted-by":"crossref","unstructured":"Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018 Jan; 38(1):1\u2013211.","DOI":"10.1177\/0333102417738202"},{"issue":"3","key":"1140_CR6","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1161\/01.STR.12.3.367","volume":"12","author":"SH Auerbach","year":"1981","unstructured":"Auerbach SH, Butler RB, Levine HL (1981) Headache in cerebral embolic disease. Stroke. 12(3):367\u2013369","journal-title":"Stroke."}],"container-title":["The Journal of Headache and Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s10194-020-01140-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s10194-020-01140-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s10194-020-01140-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T19:05:54Z","timestamp":1623265554000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejournalofheadacheandpain.biomedcentral.com\/articles\/10.1186\/s10194-020-01140-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,10]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["1140"],"URL":"https:\/\/doi.org\/10.1186\/s10194-020-01140-3","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-19584\/v1","asserted-by":"object"}]},"ISSN":["1129-2369","1129-2377"],"issn-type":[{"value":"1129-2369","type":"print"},{"value":"1129-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,10]]},"assertion":[{"value":"25 March 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The Medical Ethics Committee of the Ural State Medical University approved this study. All respondents were informed of the purpose of the study. Written informed consent was obtained from all participants.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"N\/A","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"No conflict interest.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"70"}}