{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:46:15Z","timestamp":1781106375284,"version":"3.54.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T00:00:00Z","timestamp":1595980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T00:00:00Z","timestamp":1595980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Headache Pain"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Headache is one of the most frequent neurologic manifestations in COVID-19. We aimed to analyze which symptoms and laboratory abnormalities were associated with the presence of headache and to evaluate if patients with headache had a higher adjusted in-hospital risk of mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective cohort study. We included all consecutive patients admitted to the Hospital with confirmed SARS-CoV-2 infection between March 8th and April 11th, 2020. We collected demographic data, clinical variables and laboratory abnormalities. We used multivariate regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the study period, 576 patients were included, aged 67.2 (SD: 14.7), and 250\/576 (43.3%) being female. Presence of headache was described by 137 (23.7%) patients. The all-cause in-hospital mortality rate was 127\/576 (20.0%). In the multivariate analysis, patients with headache had a lower risk of mortality (OR: 0.39, 95% CI: 0.17\u20130.88,<jats:italic>p<\/jats:italic>\u2009=\u20090.007). After adjusting for multiple comparisons in a multivariate analysis, variables that were independently associated with a higher odds of having headache in COVID-19 patients were anosmia, myalgia, female sex and fever; variables that were associated with a lower odds of having headache were younger age, lower score on modified Rankin scale, and, regarding laboratory variables on admission, increased C-reactive protein, abnormal platelet values, lymphopenia and increased D-dimer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Headache is a frequent symptom in COVID-19 patients and its presence is an independent predictor of lower risk of mortality in COVID-19 hospitalized patients.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s10194-020-01165-8","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T13:05:10Z","timestamp":1596027910000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":109,"title":["Factors associated with the presence of headache in hospitalized COVID-19 patients and impact on prognosis: a retrospective cohort study"],"prefix":"10.1186","volume":"21","author":[{"given":"Javier","family":"Trigo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3132-1064","authenticated-orcid":false,"given":"David","family":"Garc\u00eda-Azor\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro","family":"Planchuelo-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Mart\u00ednez-P\u00edas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"Talavera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Hern\u00e1ndez-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Valle-Pe\u00f1acoba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Sim\u00f3n-Campo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"de Lera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Chavarr\u00eda-Miranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"L\u00f3pez-Sanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Guti\u00e9rrez-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Mart\u00ednez-Velasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Pedraza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro","family":"Sierra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"G\u00f3mez-Vicente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Francisco","family":"Arenillas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel L.","family":"Guerrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,29]]},"reference":[{"key":"1165_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11684-019-0733-5","volume":"2","author":"M Zhou","year":"2020","unstructured":"Zhou M, Zhang X, Qu J (2020) Coronavirus disease 2019 (COVID-19): a clinical update. Front Med 2:1\u201310","journal-title":"Front Med"},{"key":"1165_CR2","volume-title":"Covid-19 report number 33","author":"National Epidemiologic Surveillance Network","year":"2020","unstructured":"National Epidemiologic Surveillance Network. Covid-19 report number 33. 2020. Available on: https:\/\/www.isciii.es\/QueHacemos\/Servicios\/VigilanciaSaludPublicaRENAVE\/EnfermedadesTransmisibles\/Documents\/INFORMES\/Informes%20COVID-19\/COVID-19%20en%20personal%20sanitario%2029%20de%20mayo%20de%202020.pdf. Accessed 3 July 2020"},{"key":"1165_CR3","first-page":"S0163","volume":"23","author":"Z Zheng","year":"2020","unstructured":"Zheng Z, Peng F, Xu B, Zhao J, Liu H, Peng J et al (2020) Risk factors of critical & mortal COVID-19 cases: a systematic literature review and meta-analysis. J Infect 23:S0163\u20134453(20)30234-6","journal-title":"J Infect"},{"key":"1165_CR4","doi-asserted-by":"publisher","unstructured":"Garc\u00eda-Azorin D, Mart\u00ednez-P\u00edas D, Trigo J, Hern\u00e1ndez-P\u00e9rez I, Valle-Pe\u00f1acoba G, Talavera B et al (2020) Neurological comorbidity is a predictor of death in Covid-19 disease: a cohort study on 576 patients. Front Neurol. https:\/\/doi.org\/10.3389\/fneur.2020.00781","DOI":"10.3389\/fneur.2020.00781"},{"key":"1165_CR5","doi-asserted-by":"publisher","first-page":"941","DOI":"10.3390\/jcm9040941","volume":"9","author":"IJ Borges do Nascimento","year":"2020","unstructured":"Borges do Nascimento IJ, Cacic N, Abdulazeem HM, Von Groote TC, Jayarajah U, Weerasekara I et al (2020) Novel Coronavirus Infection (COVID-19) in humans: a scoping review and meta-analysis. J Clin Med 9:941","journal-title":"J Clin Med"},{"key":"1165_CR6","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.jinf.2020.02.018","volume":"80","author":"S Tian","year":"2020","unstructured":"Tian S, Hu N, Lou J, Chen K, Kang X, Xiang Z et al (2020) Characteristics of COVID-19 infection in Beijing. J Infect 80:401\u2013406","journal-title":"J Infect"},{"key":"1165_CR7","doi-asserted-by":"publisher","unstructured":"Lechien JR, Chiesa-Estomba CM, Place S, Van Laethem Y, Cabaraux P, Mat Q et al (2020) Clinical and epidemiological characteristics of 1420 European patients with mild-to-moderate coronavirus disease 2019. J Int Med. https:\/\/doi.org\/10.1111\/joim.13089","DOI":"10.1111\/joim.13089"},{"issue":"6","key":"1165_CR8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1001\/jamaneurol.2020.1127","volume":"77","author":"L Mao","year":"2020","unstructured":"Mao L, Jin H, Wang M, Hu Y, Chen S, He Q et al (2020) Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol 77(6):1\u20139","journal-title":"JAMA Neurol"},{"key":"1165_CR9","doi-asserted-by":"publisher","unstructured":"Li LQ, Huang T, Wang YQ, Wang ZP, Liang Y, LIang Y et al (2020) COVID-19 patients\u2019 clinical characteristics, discharge rate, and fatality rate of meta-analysis. J Med Virol:1\u20137. https:\/\/doi.org\/10.1002\/jmv.25757","DOI":"10.1002\/jmv.25757"},{"key":"1165_CR10","doi-asserted-by":"publisher","unstructured":"Masieri S, Trabattoni D, Incorvaia C, De Luca MC, Dell'Allbani I, Leo G, et al. A role for Waldeyer's ring in immunological response to alergens. Curr Med Res Opin. 2014;30(2):203\u20135. https:\/\/doi.org\/10.1185\/03007995.2013.855185.","DOI":"10.1185\/03007995.2013.855185"},{"key":"1165_CR11","doi-asserted-by":"publisher","unstructured":"El-Anwar MW, Elzayat S, Fouad YA. ENT manifestation in COVID-19 patients. Auris Nasus Larynx. 2020;15:S0385-8146(20):30146\u20132. https:\/\/doi.org\/10.1016\/j.anl.2020.06.003.","DOI":"10.1016\/j.anl.2020.06.003"},{"key":"1165_CR12","doi-asserted-by":"publisher","first-page":"e296","DOI":"10.1371\/journal.pmed.0040296","volume":"4","author":"E Von Elm","year":"2007","unstructured":"Von Elm E, Altman DG, Egger M et al (2007) The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. PLoS Med 4:e296","journal-title":"PLoS Med"},{"key":"1165_CR13","unstructured":"World Health Organization. Coronavirus disease (COVID-19) technical guidance: laboratory testing for 2019-nCoV in humans (https:\/\/www.who.int\/emergencies\/diseases\/novel-coronavirus-2019\/technical-guidance\/laboratory-guidance). Accessed 19 May 2020."},{"key":"1165_CR14","volume-title":"Technical documents. Hospital management of COVID-19","author":"Ministry of Health","year":"2020","unstructured":"Ministry of Health. Technical documents. Hospital management of COVID-19. 2020. https:\/\/www.mscbs.gob.es\/profesionales\/saludPublica\/ccayes\/alertasActual\/nCo v-China\/documentos\/Protocolo_manejo_clinico_ah_COVID-19.pdf. Accessed 19 May 2020"},{"key":"1165_CR15","volume-title":"Clinical management of severe acute respiratory infection when novel coronavirus (2019- nCoV) infection is suspected: interim guidance","author":"World Health Organization","year":"2020","unstructured":"World Health Organization. Clinical management of severe acute respiratory infection when novel coronavirus (2019- nCoV) infection is suspected: interim guidance. 2020. https:\/\/www.who.int\/docs\/default- source\/coronaviruse\/ clinical-management-of-novel-cov.pdf. Accessed 19 May 2020"},{"key":"1165_CR16","doi-asserted-by":"publisher","first-page":"3393","DOI":"10.1161\/STROKEAHA.109.557256","volume":"40","author":"TJ Quinn","year":"2009","unstructured":"Quinn TJ, Dawson J, Walters MR, Lees KR (2009) Reliability of the modified Rankin scale: a systematic review. Stroke 40:3393\u20133395","journal-title":"Stroke"},{"key":"1165_CR17","volume-title":"Proceedings of the International conference on harmonisation of technical requirements for registrations of pharmaceuticals for human use","author":"International Conference on Harmonisation","year":"1996","unstructured":"International Conference on Harmonisation (1996) Good clinical practice: consolidate guideline. In: Proceedings of the International conference on harmonisation of technical requirements for registrations of pharmaceuticals for human use. International Conference on Harmonisation, Geneva"},{"issue":"1","key":"1165_CR18","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","author":"Y Benjamini","year":"1995","unstructured":"Benjamini Y, Hochberg Y (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser B 57(1):289\u2013230","journal-title":"J R Stat Soc Ser B"},{"key":"1165_CR19","doi-asserted-by":"publisher","unstructured":"Kaur N, Gupta I, Singh H, Karia R, Ashraf A, Habib A et al (2020) Epidemiological and clinical characteristics of 6635 COVID-19 patients: a pooled analysis. SN Compr Clin Med:1\u20135. https:\/\/doi.org\/10.1007\/s42399-020-00393-y PMC7343407","DOI":"10.1007\/s42399-020-00393-y"},{"key":"1165_CR20","doi-asserted-by":"publisher","unstructured":"Sanyaolu A, Okorie C, Marinkovic A, Patidar R, Younis K, Desai P et al (2020) Comorbidity and its impact on patients with COVID-19. SN Compr Clin Med:1\u20138. https:\/\/doi.org\/10.1007\/s42399-020-00363-4 PMCID: PMC7314621","DOI":"10.1007\/s42399-020-00363-4"},{"key":"1165_CR21","doi-asserted-by":"publisher","unstructured":"Bwire GM (2020) Coronavirus: Why men are more vulnerable to Covid-19 than women? SN Compr Clin Med:1\u20133. https:\/\/doi.org\/10.1007\/s42399-020-00341-w PMCID: PMC7271824","DOI":"10.1007\/s42399-020-00341-w"},{"key":"1165_CR22","doi-asserted-by":"publisher","unstructured":"Pennica A, Conforti G, Falangone F, Martocchia A, Tafaro L, Sentimentale A, Marini V et al (2020) Clinical management of adult coronavirus infection disease 2019 (COVID-19) positive in the setting of low and medium intensity of care: a short practical review. SN Compr Clin Med:1\u20136. https:\/\/doi.org\/10.1007\/s42399-020-00333-w PMCID: PMC7258606","DOI":"10.1007\/s42399-020-00333-w"},{"key":"1165_CR23","doi-asserted-by":"publisher","unstructured":"Shen B, Chen L, Zhang L, Zhang M, Li J, Wu J et al (2020) Wuchang Fangcang Shelter Hospital: Practices, experiences, and lessons learned in controlling COVID-19. SN Compr Clin Med:1\u20136. https:\/\/doi.org\/10.1007\/s42399-020-00382-1 PMCID: PMC7334130","DOI":"10.1007\/s42399-020-00382-1"},{"key":"1165_CR24","doi-asserted-by":"publisher","unstructured":"O\u2019Reilly GM, Mitchell RD, Rajiv P, Wu J, Brennecke H, Brichko L, Noonan MP et al (2020) Epidemiology and clinical features of emergency department patients with suspected COVID-19: initial results from the COVID 19 emergency department quality improvement project (COVED-1). Emerg Med Australas. https:\/\/doi.org\/10.1111\/1742-6723.13540","DOI":"10.1111\/1742-6723.13540"},{"key":"1165_CR25","doi-asserted-by":"publisher","first-page":"e00512","DOI":"10.1128\/JCM.00512-20","volume":"58","author":"YW Tang","year":"2020","unstructured":"Tang YW, Schmitz JE, Persing DH, Stratton CW (2020) Laboratory diagnosis of COVID-19: current issues and challenges. J Clin Microbiol 58:e00512\u2013e00520","journal-title":"J Clin Microbiol"},{"key":"1165_CR26","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1016\/S0140-6736(20)30566-3","volume":"395","author":"F Zhou","year":"2020","unstructured":"Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z et al (2020) Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 395:1054\u20131062","journal-title":"Lancet"},{"key":"1165_CR27","doi-asserted-by":"publisher","unstructured":"Vacchiano V, Riguzzi P, Volpi L, Tappat\u00e0 M, Avoni P, Rizzo G et al (2020) Early neurological manifestations of hospitalized COVID-19 patients. Neurol Sci:1\u20133. https:\/\/doi.org\/10.1007\/S10072-020-04525-z","DOI":"10.1007\/S10072-020-04525-z"},{"key":"1165_CR28","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1046\/j.1526-4637.2003.03019.x","volume":"4","author":"R Eccles","year":"2003","unstructured":"Eccles R, Loose I, Jawad M, Nyman L (2003) Effects of acetylsalicylic acid on sore throat pain and other pain symptoms associated with acute upper respiratory tract infection. Pain Med 4:118\u2013124","journal-title":"Pain Med"},{"key":"1165_CR29","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1086\/650458","volume":"50","author":"S Ng","year":"2010","unstructured":"Ng S, Cowling BJ, Fang VJ, Chang KH, Ip DKM, Cheng CKY et al (2010) Effects of Oseltamivir treatment on duration of clinical illness and viral shedding and household transmission of influenza virus. Clin Infect Dis 50:707\u2013714","journal-title":"Clin Infect Dis"},{"key":"1165_CR30","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.jiac.2019.01.012","volume":"25","author":"T Ishii","year":"2019","unstructured":"Ishii T, Sasaki Y, Maeda T, Komatsu F, Suzuki T, Urita Y (2019) Clinical differentiation of infectious mononucleosis that is caused by Epstein-Barr virus or cytomegalovirus: a single-center case-control study in Japan. J Infect Chemother 25:431\u2013436","journal-title":"J Infect Chemother"},{"key":"1165_CR31","doi-asserted-by":"publisher","unstructured":"Guo L, Ren L, Yang S, Xiao M, Chang D, Yang F, et al. Profiling early humoral response to diagnose novel coronavirus disease (COVID-19). Clin Infect Dis. 2020;ciaa310. https:\/\/doi.org\/10.1093\/cid\/ciaa310.","DOI":"10.1093\/cid\/ciaa310"},{"issue":"6","key":"1165_CR32","first-page":"607","volume":"80","author":"Q Ye","year":"2020","unstructured":"Ye Q, Wang B, Mao J (2020) The pathogenesis and treatment of the `cytokine Storm' in COVID-19. J Inf Secur 80(6):607\u2013613","journal-title":"J Inf Secur"},{"issue":"6","key":"1165_CR33","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1038\/s41577-020-0311-8","volume":"20","author":"MZ Tay","year":"2020","unstructured":"Tay MZ, Poh CM, R\u00e9nia L, MacAry PA, Ng LFP (2020) The trinity of COVID-19: immunity, inflammation and intervention. Nat Rev Immunol 20(6):363\u2013374","journal-title":"Nat Rev Immunol"},{"key":"1165_CR34","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1111\/jth.14859","volume":"18","author":"L Zhang","year":"2020","unstructured":"Zhang L, Yan X, Fan Q, Liu H, Liu X, Liu Z et al (2020) D-dimer levels on admission to predict in-hospital mortality in patients with Covid-19. J Thromb Haemost 18:1324\u20131329","journal-title":"J Thromb Haemost"},{"issue":"20","key":"1165_CR35","doi-asserted-by":"publisher","first-page":"30344","DOI":"10.1016\/jmedcli.2020.05.017","volume":"S0025\u20137753","author":"GV Soraya","year":"2020","unstructured":"Soraya GV, Ulhaq ZS (2020) Crucial laboratory parameters in COVID-19 diagnosis and prognosis: an updated meta-analysis. Med Clin S0025\u20137753(20):30344\u201330344. https:\/\/doi.org\/10.1016\/jmedcli.2020.05.017","journal-title":"Med Clin"},{"key":"1165_CR36","first-page":"1","volume":"11","author":"GH Meftahi","year":"2020","unstructured":"Meftahi GH, Jangravi Z, Sahraei H, Bahari Z (2020) The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of \u201cinflame-aging\u201d. Inflamm Res 11:1\u201315","journal-title":"Inflamm Res"},{"key":"1165_CR37","doi-asserted-by":"publisher","first-page":"2000524","DOI":"10.1183\/13993003.00524-2020","volume":"55","author":"D Rong-Hui","year":"2020","unstructured":"Rong-Hui D, Li-Rong L, Cheng-Qing Y, Wen W, Tan-Ze C, Ming L (2020) Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study. Eur Respir J 55:2000524","journal-title":"Eur Respir J"},{"key":"1165_CR38","doi-asserted-by":"publisher","first-page":"101623","DOI":"10.1016\/j.tmaid.2020.101623","volume":"34","author":"AJ Rodriguez-Morales","year":"2020","unstructured":"Rodriguez-Morales AJ, Cardona-Ospina JA, Guti\u00e9rrez-Ocampo E, Villamizar-Pe\u00f1a R, Holguin-Rivera Y, Escalera-Antezana P et al (2020) Clinical, laboratory and imaging features of COVID-19: a systematic review and meta-analysis. Travel Med Infect Dis 34:101623","journal-title":"Travel Med Infect Dis"},{"key":"1165_CR39","doi-asserted-by":"publisher","unstructured":"Belvis R (2020) Headaches during COVID-19: my clinical case and review of the literature. Headache. https:\/\/doi.org\/10.1111\/head.13841","DOI":"10.1111\/head.13841"},{"key":"1165_CR40","doi-asserted-by":"publisher","unstructured":"Porta-Etessam J, Mat\u00edas-Guiu JA, Gonzalez-Garc\u00eda N, Gomez Iglesias P, Santos-Bueso E, Arriola-Villalobos P et al (2020) Spectrum of headaches associated with SARS-CoV-2 infection: study of healthcare professionals. Headache. https:\/\/doi.org\/10.1111\/head.13902","DOI":"10.1111\/head.13902"},{"key":"1165_CR41","doi-asserted-by":"publisher","unstructured":"Garc\u00eda-Azor\u00edn D, Trigo J, Talavera B, Mart\u00ednez-P\u00edas E, Sierra A, Porta-Etessam J et al (2020) Frequency and type of red flags in patients with Covid-19 and headache: a series of 104 hospitalized patients. Headache. https:\/\/doi.org\/10.1111\/head.13927","DOI":"10.1111\/head.13927"}],"container-title":["The Journal of Headache and Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s10194-020-01165-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s10194-020-01165-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s10194-020-01165-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,11]],"date-time":"2024-08-11T00:06:17Z","timestamp":1723334777000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejournalofheadacheandpain.biomedcentral.com\/articles\/10.1186\/s10194-020-01165-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,29]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["1165"],"URL":"https:\/\/doi.org\/10.1186\/s10194-020-01165-8","relation":{},"ISSN":["1129-2369","1129-2377"],"issn-type":[{"value":"1129-2369","type":"print"},{"value":"1129-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,29]]},"assertion":[{"value":"3 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Clinical Research Ethics Committee of East Valladolid Area approved the study<i>.<\/i>","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"94"}}