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On the same day, a sequential interictal scan was performed with <jats:sup>18<\/jats:sup>FDG-PET and MRI. 3D T1-weighted images were segmented with FreeSurfer, normalized to a reference atlas and the mean values of metabolism, cortical thickness (CTh) and local gyrification index (IGI) were determined. Groups were compared using age-adjusted linear models, corrected for multiple comparisons. <jats:sup>18<\/jats:sup>FDG-PET measurements between groups were also analysed adjusting by patient\u2019s age, CTh and lGI. The variables independently associated with diagnosis were obtained using a logistic regression analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Fifteen patients (8 EM, 7 CM) and 11 HC were included. Morphometric data showed an increased CTh in 6 frontal areas (L\/R-Caudal Middle Frontal, L\/R-Rostral Middle Frontal, L-Medial Orbitofrontal and L-Superior Frontal) in CM patients compared to HC without differences for IGI. The structural adjusted analysis in CM showed a statistically significantly hypometabolism in 9 frontal areas (L-Lateral Orbitofrontal, L\/R-Medial Orbitofrontal, L-Frontal Superior, R-Frontal pole, R-Parts Triangularis, L\/R-Paracentral and R-Precentral) and 7 temporal areas (L\/R-Insula, L\/R-Inferior temporal, L\/R-Temporal pole and R-Banks superior temporal sulcus) compared to HC. EM patients presented intermediate metabolic values \u200b\u200bbetween EM and HC (non-significant).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>CM patients showed frontotemporal hypometabolism and increased frontal cortical thickness when compared to HC that may explain some cognitive and behavioural pain-processing and sensory integration alterations in CM patients. Combined information from sequential or simultaneous PET and MRI could optimize the study of complex functional neurological disorders such as migraine.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s10194-021-01289-5","type":"journal-article","created":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T09:03:03Z","timestamp":1626512583000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Cortical metabolic and structural differences in patients with chronic migraine. 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Pareto D has received speaking honoraria from Novartis and Sanofi-Genzyme. Alpuente A has received honoraria as a consultant or speaker for Allergan-Abbvie, Chiesi and Novartis. Rovira A serves on scientific advisory boards for Novartis, Sanofi-Genzyme, SyntheticMR, Bayer, Roche, Biogen, and OLEA Medical, and has received speaker honoraria from Sanofi-Genzyme, Bracco, Merck-Serono, Teva Pharmaceutical Industries Ltd, Novartis, Roche and Biogen. Lorenzo-Bosquet C has received honoraria as speaker for GE Healthcare. Pozo-Rosich P has received honoraria as a consultant and speaker for: Allergan-Abbvie, Almirall, Amgen, Biohaven, Chiesi, Eli Lilly, Medscape, Neurodiem, Novartis and Teva. Her research group has received research grants from Allergan, and has received funding for clinical trials from Alder, Allergan-Abbvie, Electrocore, Eli Lilly, Novartis and Teva. She is a trustee member of the board of the International Headache Society, member of the Council of the European Headache Society. She is in the editorial board of Revista de Neurologia, associate editor for Cephalalgia, Headache, Neurologia, Frontiers of Neurology and The Journal of Headache and Pain. She is a member of the Clinical Trials Guidelines Committee of the International Headache Society. She has edited the Guidelines for the Diagnosis and Treatment of Headache of the Spanish Neurological Society. She is the founder of . Pozo-Rosich P does not own stocks from any pharmaceutical company. Cubera-Borr\u00f3s G, Gallardo VJ and Vil\u00e0-Ball\u00f3 A report no disclosures.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"75"}}