{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:42:09Z","timestamp":1790880129088,"version":"4.1.0"},"reference-count":69,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,10,2]],"date-time":"2021-10-02T00:00:00Z","timestamp":1633132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,10,2]],"date-time":"2021-10-02T00:00:00Z","timestamp":1633132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Headache Pain"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Monoclonal antibodies (mABs) targeting the calcitonin gene-related peptide (CGRP) pathway represent the first disease-specific preventive migraine therapy. Growing evidence suggests that they are effective in the preventive treatment of difficult-to-treat patients. In this study, we evaluated the psychological predictors of the outcome of treatment with the anti-CGRP monoclonal antibody erenumab in patients with chronic migraine (CM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Seventy-five patients with CM who had already failed at least 3 preventive therapies received erenumab every 28\u2009days for a period of 12\u2009months. Before the first administration, patients received a full psychological evaluation using The Structured Clinical Interview for DSM-5 Clinician Version (SCID-5-CV) to assess personality disturbances (primary outcome), mood and anxiety disorders, and as well specific questionnaires to evaluate alexithymia traits, childhood traumas, and current stressors (secondary outcomes).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After 12\u2009months of treatment, 53 patients reported a reduction of at least 50% in headache days\/per month (Responders), whereas 22 did not (Non Responders). When compared to Responders, Non Responders were characterized by a higher prevalence of personality disorders belonging to Cluster C (avoidant, dependent, and obsessive-compulsive) (77% vs 37%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.001). Non Responders were also characterized by a higher prevalence of anxiety disorders (90% vs 60%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007), showed more alexithymic traits (51.7\u2009\u00b1\u200913.7 vs 42.9\u2009\u00b1\u200914.3,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017), and reported a higher number of 'at least serious' current stressors (3.2\u2009\u00b1\u20094.0 vs 0.8\u2009\u00b1\u20091.4,\n                      <jats:italic>p\u2009&lt;<\/jats:italic>\n                      \u00a0.0001) than Responders. At the multivariate analysis, higher prevalence of Cluster C personality disorders (OR 3.697;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05) and higher number of \u2018at least serious\u2019 life events (OR 1.382;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017) arose as prognostic factors of erenumab failure.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Erenumab confirmed its effectiveness in a population of difficult-to-treat migraine. The presence of \u201canxious-fearful\u201d personality together with current stressors and anxiety represent negative predictors of treatment outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>\n                      The study protocol was registered at clinicaltrials.gov (\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04361721\">NCT04361721<\/jats:ext-link>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s10194-021-01333-4","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T10:45:42Z","timestamp":1633344342000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Psychological predictors of negative treatment outcome with Erenumab in chronic migraine: data from an open label long-term prospective study"],"prefix":"10.1186","volume":"22","author":[{"given":"Sara","family":"Bottiroli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"De Icco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Vaghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Pazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Guaschino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Allena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natascia","family":"Ghiotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Martinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Tassorelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazia","family":"Sances","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,2]]},"reference":[{"key":"1333_CR1","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1177\/0333102418761047","volume":"38","author":"M Viana","year":"2018","unstructured":"Viana M, Bottiroli S, Sances G et al (2018) Factors associated to chronic migraine with medication overuse: a cross-sectional study. 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Authors obtained local ethics committee (San Matteo Hospital, Pavia, Italy) approval of the protocol, which was registered at ClinicalTrials.gov (NCT04361721). All patients provided written informed consent in advance of study participation.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declared the following potential conflicts of interest with respect to the research, authorship, and\/or publication of this article: CT received honoraria for the participation in advisory boards or for lecturing from: Allergan, Eli-Lilly, Novartis, and Teva. CT and GS has no ownership interest and does not own stocks of any pharmaceutical company. CT is on the editorial board of The Journal of Headache and Pain. GS received honoraria for the participation in advisory boards or for lecturing from: Eli-Lilly, Novartis, and Teva. The remaining authors have no conflicts of interest.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"114"}}