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Little is known regarding the repercussions of neurological symptoms for patients and how these symptoms are related to one another.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>To determine whether there is an association between the neurological symptoms in patients with COVID-19, and to characterize the headache.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Method<\/jats:title>\n                <jats:p>This was a cross-sectional study. All hospital inpatients and health workers at the Hospital Universitario Oswaldo Cruz with a PCR-confirmed COVID-19 infection between March and June 2020 were considered for the study and were interviewed by telephone at least 2-months after the acute phase of the disease. These patients were identified by the hospital epidemiological surveillance department. A semi-structured questionnaire was used containing sociodemographic and clinical data and the ID-Migraine.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 288 patients was interviewed; 53.1% were male; with a median age of 49.9 (41.5\u201360.5) years; 91.7% presented some neurological symptom; 22.2% reported some neurological symptom as the symptom that troubled them most during COVID-19. Neurological symptoms were: ageusia (69.8%), headache (69.1%), anosmia (67%), myalgia (44.4%), drowsiness (37.2%), agitation (20.8%); mental confusion (14.9%), syncope (4.9%) and epileptic seizures (2.8%). Females, those who presented with fever, sore throat, anosmia\/ageusia and myalgia also presented significantly more with headache (logistic regression). The most frequent headache phenotype was a non-migraine phenotype, was of severe intensity and differed from previous headaches. This persisted for more than 30\u2009days in 18% and for more than 90\u2009days in 10% of patients. Thirteen percent of those with anosmia and 11% with ageusia continued with these complaints after more than 90\u2009days of the acute phase of the disease. Aged over 50\u2009years, agitation and epileptic seizures were significantly associated with mental confusion (logistic regression).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Headache is frequent in COVID-19, is associated with other symptoms such as fever, sore throat, anosmia, ageusia, and myalgia, and may persist beyond the acute phase of the disease.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s10194-021-01367-8","type":"journal-article","created":{"date-parts":[[2022,1,3]],"date-time":"2022-01-03T11:03:43Z","timestamp":1641207823000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Headache, anosmia, ageusia and other neurological symptoms in COVID-19: a cross-sectional study"],"prefix":"10.1186","volume":"23","author":[{"given":"Pedro Augusto","family":"Sampaio Rocha-Filho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Mota","family":"Albuquerque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa Clementino Leite S\u00e1","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mylana","family":"Dandara Pereira Gama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Eudes","family":"Magalh\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,3]]},"reference":[{"issue":"9","key":"1367_CR1","doi-asserted-by":"publisher","first-page":"3086","DOI":"10.1007\/s00415-020-10380-x","volume":"268","author":"V Nersesjan","year":"2021","unstructured":"Nersesjan V, Amiri M, Lebech AM, Roed C, Mens H, Russell L, Fonsmark L, Berntsen M, Sigurdsson ST, Carlsen J, Langkilde AR, Martens P, Lund EL, Hansen K, Jespersen B, Folke MN, Meden P, Hejl AM, Wamberg C, Benros ME, Kondziella D (2021) Central and peripheral nervous system complications of COVID-19: a prospective tertiary center cohort with 3-month follow-up. 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