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Previous literature has found fluctuations of alpha oscillation (8-14\u2009Hz) over the visual cortex to be associated with the gating of the visual stream. In the current study, we examined whether alpha activity was differentially modulated in migraineurs in anticipation of an upcoming stimulus as well as post-stimulus periods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used EEG to examine the brain activity in a group of 28 migraineurs (17 with aura\u00a0\/11 without) and 29 non-migraineurs and compared their alpha power in the pre\/post-stimulus period relative to the onset of stripped gratings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, we found that migraineurs had significantly less alpha power prior to the onset of the stimulus relative to controls. Moreover, migraineurs had significantly greater post-stimulus alpha suppression (i.e event-related desynchronization) induced by the grating in 3\u2009cycles per degree at the 2nd half of the experiment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings, taken together, provide strong support for the presence of the hyperresponsiveness of the visual cortex of migraine sufferers. We speculate that it could be the consequence of impaired perceptual learning driven by the dysfunction of GABAergic inhibitory mechanism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s10194-022-01410-2","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T07:09:36Z","timestamp":1649142576000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Attenuated alpha oscillation and hyperresponsiveness reveals impaired perceptual learning in migraineurs"],"prefix":"10.1186","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6265-1499","authenticated-orcid":false,"given":"Chun Yuen","family":"Fong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai Him Crystal","family":"Law","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes Jacobus","family":"Fahrenfort","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason J.","family":"Braithwaite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Mazaheri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,4,5]]},"reference":[{"key":"1410_CR1","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1136\/jnnp.2009.190223","volume":"81","author":"N Boulloche","year":"2010","unstructured":"Boulloche N, Denuelle M, Payoux P et al (2010) Photophobia in migraine: an interictal PET study of cortical hyperexcitability and its modulation by pain. 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