{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:10:44Z","timestamp":1792267844316,"version":"4.4.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T00:00:00Z","timestamp":1708300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T00:00:00Z","timestamp":1708300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100003356","name":"Gazi \u00dcniversitesi","doi-asserted-by":"publisher","award":["TGA-2022-7857"],"award-info":[{"award-number":["TGA-2022-7857"]}],"id":[{"id":"10.13039\/501100003356","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Headache Pain"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Medication overuse headache (MOH) was recently shown to be associated with leaky gut in rodents. We aimed to investigate whether chronic migraine (CM) patients with MOH have elevated lipopolysaccharide levels and inflammatory molecules in blood circulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>The study included women participants (40 CM patients with NSAID overuse headache, 35 episodic migraine (EM) patients, and 20 healthy non-headache sufferers). Migraine duration, monthly migraine headache days, MigSCog, HADS-D, HADS-A, and HIT-6 scores were recorded. Serum samples were collected to measure circulating LPS, LPS binding protein (LBP), tight junction protein occludin, adherens junction protein vascular endothelial cadherin (VE-cadherin), CGRP, HMGB1, HIF-1\u03b1, IL-6, and IL-17 levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Serum LPS, VE-Cadherin, CGRP, HIF-1\u03b1, and IL-6 levels were significantly higher in the CM\u2009+\u2009MOH group compared to the EM group and healthy controls while serum LBP and HMGB1 were higher in the CM\u2009+\u2009MOH group compared to healthy controls. IL-17 and occludin levels were comparable between the three groups. Serum HMGB1 levels in EM patients were higher compared to the control group. Mig-SCog and HIT-6 scores were higher in the CM\u2009+\u2009MOH group compared to EM patients. HADS-A and HADS-D scores were significantly higher in the CM\u2009+\u2009MOH group compared to EM patients and healthy controls, and they were also higher in EM patients compared to healthy subjects. LPS levels were correlated with VE-cadherin and occludin levels. The number of monthly migraine headache days was positively correlated with serum LPS, HIF-1\u03b1, VE-cadherin, and IL-6 levels, HADS-A, HADS-D, HIT-6, and MigSCog scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We have evidence for the first time that CM\u2009+\u2009MOH is associated with elevated serum LPS and LBP levels suggestive of LPS leak into the systemic circulation. Higher levels of nociceptive and\/or pro-inflammatory molecules such as HMGB1, HIF-1\u03b1, IL-6, and CGRP may play a role in trigeminal sensitization and neurobiology of MOH. Intestinal hyperpermeability and consequent inflammatory response should be considered as a potential contributory factor in patients with MOH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Graphical Abstract<\/jats:title>\n                  <\/jats:sec>","DOI":"10.1186\/s10194-024-01730-5","type":"journal-article","created":{"date-parts":[[2024,2,18]],"date-time":"2024-02-18T19:05:13Z","timestamp":1708283113000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Lipopolysaccharide, VE-cadherin, HMGB1, and HIF-1\u03b1 levels are elevated in the systemic circulation in chronic migraine patients with medication overuse headache: evidence of leaky gut and inflammation"],"prefix":"10.1186","volume":"25","author":[{"given":"Doga","family":"Vuralli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merve","family":"Ceren Akgor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hale","family":"Gok Dagidir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozlem","family":"Gulbahar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meltem","family":"Yalinay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayrunnisa","family":"Bolay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,19]]},"reference":[{"issue":"20","key":"1730_CR1","doi-asserted-by":"publisher","first-page":"6488","DOI":"10.3390\/jcm12206488","volume":"12","author":"M Ceren Akgor","year":"2023","unstructured":"Ceren Akgor M, Vuralli D, Sucu DH, Gokce S, Tasdelen B, Gultekin F et al (2023) Distinct food triggers for migraine, medication overuse headache and irritable bowel syndrome. J Clin Med 12(20):6488","journal-title":"J Clin Med"},{"issue":"6","key":"1730_CR2","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1038\/ajg.2016.574","volume":"112","author":"GS Sayuk","year":"2017","unstructured":"Sayuk GS, Wolf R, Chang L (2017) Comparison of symptoms, healthcare utilization, and treatment in diagnosed and undiagnosed individuals with diarrhea-predominant irritable bowel syndrome. Am J Gastroenterol 112(6):892\u2013899","journal-title":"Am J Gastroenterol"},{"issue":"14","key":"1730_CR3","doi-asserted-by":"publisher","first-page":"7613","DOI":"10.3390\/ijms22147613","volume":"22","author":"H Usuda","year":"2021","unstructured":"Usuda H, Okamoto T, Wada K (2021) Leaky gut: effect of dietary fiber and fats on microbiome and intestinal barrier. Int J Mol Sci 22(14):7613","journal-title":"Int J Mol Sci"},{"issue":"1","key":"1730_CR4","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/s10194-023-01672-4","volume":"24","author":"HG Da\u011f\u0131d\u0131r","year":"2023","unstructured":"Da\u011f\u0131d\u0131r HG, Topa E, Vuralli D, Bolay H (2023) Medication overuse headache is associated with elevated lipopolysaccharide binding protein and pro-inflammatory molecules in the bloodstream. J Headache Pain 24(1):150","journal-title":"J Headache Pain"},{"issue":"7","key":"1730_CR5","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.3390\/ijms18071431","volume":"18","author":"R Rorato","year":"2017","unstructured":"Rorato R, Borges BC, Uchoa ET, Antunes-Rodrigues J, Elias CF, Elias LLK (2017) LPS-induced low-grade inflammation increases hypothalamic JNK expression and causes central insulin resistance irrespective of body weight changes. Int J Mol Sci 18(7):1431","journal-title":"Int J Mol Sci"},{"issue":"4","key":"1730_CR6","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1136\/gut.43.4.506","volume":"43","author":"G Sigthorsson","year":"1998","unstructured":"Sigthorsson G, Tibble J, Hayllar J, Menzies I, Macpherson A, Moots R et al (1998) Intestinal permeability and inflammation in patients on NSAIDs. Gut 43(4):506\u2013511","journal-title":"Gut"},{"issue":"1","key":"1730_CR7","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1021\/acsinfecdis.7b00139","volume":"4","author":"AP Bhatt","year":"2018","unstructured":"Bhatt AP, Gunasekara DB, Speer J, Reed MI, Pe\u00f1a AN, Midkiff BR et al (2018) Nonsteroidal anti-inflammatory drug-induced leaky gut modeled using polarized monolayers of primary human intestinal epithelial cells. ACS Infect Dis 4(1):46\u201352","journal-title":"ACS Infect Dis"},{"issue":"12","key":"1730_CR8","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1016\/j.tcb.2020.10.001","volume":"30","author":"T Otani","year":"2020","unstructured":"Otani T (2020) Tight Junction Structure and Function Revisited: (Trends in Cell Biology 30, 805\u2013817,. Trends Cell Biol. 30(12):1014","journal-title":"Trends Cell Biol."},{"issue":"2","key":"1730_CR9","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1128\/MCB.06029-11","volume":"32","author":"PM Cummins","year":"2012","unstructured":"Cummins PM (2012) Occludin: one protein, many forms. Mol Cell Biol 32(2):242\u2013250","journal-title":"Mol Cell Biol"},{"issue":"5","key":"1730_CR10","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1007\/s10620-019-05777-2","volume":"65","author":"D Hollander","year":"2020","unstructured":"Hollander D, Kaunitz JD (2020) The leaky gut: tight junctions but Loose associations? Dig Dis Sci 65(5):1277\u20131287","journal-title":"Dig Dis Sci"},{"key":"1730_CR11","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.jad.2022.11.058","volume":"323","author":"H Wu","year":"2023","unstructured":"Wu H, Wang J, Teng T, Yin B, He Y, Jiang Y et al (2023) Biomarkers of intestinal permeability and blood-brain barrier permeability in adolescents with major depressive disorder. J Affect Disord 323:659\u2013666","journal-title":"J Affect Disord"},{"key":"1730_CR12","doi-asserted-by":"crossref","unstructured":"Vuralli D, G\u00f6k Da\u011f\u0131d\u0131r H, Abbaso\u011flu Topa E, Bolay H (2024) Leaky gut and inflammatory biomarkers in a medication overuse headache model in male rats. Turkish J Med Sci. doi:\/sag-2308-172. (in press)","DOI":"10.55730\/1300-0144.5763"},{"issue":"5","key":"1730_CR13","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1111\/head.13529","volume":"59","author":"S Iyengar","year":"2019","unstructured":"Iyengar S, Johnson KW, Ossipov MH, Aurora SK (2019) CGRP and the Trigeminal System in Migraine. Headache 59(5):659\u2013681","journal-title":"Headache"},{"issue":"9","key":"1730_CR14","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.5455\/annalsmedres.2023.08.226","volume":"30","author":"D Vuralli","year":"2023","unstructured":"Vuralli D, Bolay H (2023) Migraine chronification is associated with higher body mass index and elevated serum interleukin-6 levels. Annals Med Res 30(9):1149\u20131152","journal-title":"Annals Med Res"},{"issue":"Pt 12","key":"1730_CR15","doi-asserted-by":"publisher","first-page":"2490","DOI":"10.1093\/brain\/124.12.2490","volume":"124","author":"U Reuter","year":"2001","unstructured":"Reuter U, Bolay H, Jansen-Olesen I, Chiarugi A, Sanchez del Rio M, Letourneau R et al (2001) Delayed inflammation in rat meninges: implications for migraine pathophysiology. Brain 124(Pt 12):2490\u20132502","journal-title":"Brain"},{"issue":"1","key":"1730_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s10194-021-01374-9","volume":"23","author":"H Chen","year":"2022","unstructured":"Chen H, Tang X, Li J, Hu B, Yang W, Zhan M et al (2022) IL-17 crosses the blood-brain barrier to trigger neuroinflammation: a novel mechanism in nitroglycerin-induced chronic migraine. J Headache Pain 23(1):1","journal-title":"J Headache Pain"},{"issue":"1","key":"1730_CR17","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/s10194-021-01306-7","volume":"22","author":"H Bolay","year":"2021","unstructured":"Bolay H, Karadas \u00d6, Ozt\u00fcrk B, Sonkaya R, Tasdelen B, Bulut TDS et al (2021) HMGB1, NLRP3, IL-6 and ACE2 levels are elevated in COVID-19 with headache: a window to the infection-related headache mechanism. J Headache Pain 22(1):94","journal-title":"J Headache Pain"},{"issue":"13","key":"1730_CR18","doi-asserted-by":"publisher","first-page":"3800","DOI":"10.1182\/blood.V98.13.3800","volume":"98","author":"J Zweigner","year":"2001","unstructured":"Zweigner J, Gramm HJ, Singer OC, Wegscheider K, Schumann RR (2001) High concentrations of lipopolysaccharide-binding protein in serum of patients with severe sepsis or septic shock inhibit the lipopolysaccharide response in human monocytes. Blood 98(13):3800\u20133808","journal-title":"Blood"},{"issue":"4","key":"1730_CR19","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1042\/BST0390989","volume":"39","author":"RR Schumann","year":"2011","unstructured":"Schumann RR (2011) Old and new findings on lipopolysaccharide-binding protein: a soluble pattern-recognition molecule. Biochem Soc Trans 39(4):989\u2013993","journal-title":"Biochem Soc Trans"},{"issue":"3","key":"1730_CR20","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1158\/1055-9965.EPI-18-0641","volume":"28","author":"JN Kuzma","year":"2019","unstructured":"Kuzma JN, Hagman DK, Cromer G, Breymeyer KL, Roth CL, Foster-Schubert KE et al (2019) Intraindividual variation in markers of intestinal permeability and adipose tissue inflammation in healthy normal-weight to obese adults. Cancer Epidemiol Biomarkers Prev 28(3):610\u2013615","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"2","key":"1730_CR21","doi-asserted-by":"publisher","first-page":"151","DOI":"10.5056\/jnm16214","volume":"23","author":"MJ Schmulson","year":"2017","unstructured":"Schmulson MJ, Drossman DA (2017) What is New in Rome IV. J Neurogastroenterol Motil 23(2):151\u2013163","journal-title":"J Neurogastroenterol Motil"},{"issue":"1","key":"1730_CR22","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s10194-023-01572-7","volume":"24","author":"AK Musubire","year":"2023","unstructured":"Musubire AK, Cheema S, Ray JC, Hutton EJ, Matharu M (2023) Cytokines in primary headache disorders: a systematic review and meta-analysis. J Headache Pain 24(1):36","journal-title":"J Headache Pain"},{"issue":"1","key":"1730_CR23","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s10194-020-1078-9","volume":"21","author":"M Arzani","year":"2020","unstructured":"Arzani M, Jahromi SR, Ghorbani Z, Vahabizad F, Martelletti P, Ghaemi A et al (2020) Gut-brain Axis and migraine headache: a comprehensive review. J Headache Pain 21(1):15","journal-title":"J Headache Pain"},{"issue":"1","key":"1730_CR24","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1038\/s41598-023-27586-4","volume":"13","author":"D Yong","year":"2023","unstructured":"Yong D, Lee H, Min H-G, Kim K, Oh H-S, Chu MK (2023) Altered gut microbiota in individuals with episodic and chronic migraine. Sci Rep 13(1):626","journal-title":"Sci Rep"},{"issue":"504","key":"1730_CR25","first-page":"495","volume":"54","author":"S Wilson","year":"2004","unstructured":"Wilson S, Roberts L, Roalfe A, Bridge P, Singh S (2004) Prevalence of irritable bowel syndrome: a community survey. Br J Gen Pract 54(504):495\u2013502","journal-title":"Br J Gen Pract"},{"key":"1730_CR26","first-page":"71","volume":"6","author":"C Canavan","year":"2014","unstructured":"Canavan C, West J, Card T (2014) The epidemiology of irritable bowel syndrome. Clin Epidemiol 6:71\u201380","journal-title":"Clin Epidemiol"},{"key":"1730_CR27","doi-asserted-by":"crossref","first-page":"175628482199358","DOI":"10.1177\/1756284821993586","volume":"14","author":"N Hanning","year":"2021","unstructured":"Hanning N, Edwinson AL, Ceuleers H, Peters SA, De Man JG, Hassett LC et al (2021) Intestinal barrier dysfunction in irritable bowel syndrome: a systematic review. Th Adv Gastroenterol 14:1756284821993586","journal-title":"Th Adv Gastroenterol"},{"issue":"11","key":"1730_CR28","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1111\/j.1365-2036.2005.02463.x","volume":"21","author":"AP Hungin","year":"2005","unstructured":"Hungin AP, Chang L, Locke GR, Dennis EH, Barghout V (2005) Irritable bowel syndrome in the United States: prevalence, symptom patterns and impact. Aliment Pharmacol Ther 21(11):1365\u20131375","journal-title":"Aliment Pharmacol Ther"},{"issue":"14","key":"1730_CR29","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1177\/03331024221118924","volume":"42","author":"J Thuraiaiyah","year":"2022","unstructured":"Thuraiaiyah J, Erritz\u00f8e-Jervild M, Al-Khazali HM, Schytz HW, Younis S (2022) The role of cytokines in migraine: a systematic review. Cephalalgia 42(14):1565\u20131588","journal-title":"Cephalalgia"},{"issue":"14","key":"1730_CR30","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1212\/WNL.0b013e3182a6cb72","volume":"81","author":"E Cernuda-Moroll\u00f3n","year":"2013","unstructured":"Cernuda-Moroll\u00f3n E, Larrosa D, Ram\u00f3n C, Vega J, Mart\u00ednez-Camblor P, Pascual J (2013) Interictal increase of CGRP levels in peripheral blood as a biomarker for chronic migraine. Neurology 81(14):1191\u20131196","journal-title":"Neurology"},{"issue":"3","key":"1730_CR31","doi-asserted-by":"publisher","first-page":"277","DOI":"10.4103\/aian.AIAN_371_18","volume":"22","author":"D Han","year":"2019","unstructured":"Han D (2019) Association of Serum Levels of Calcitonin gene-related peptide and cytokines during migraine attacks. Ann Indian Acad Neurol 22(3):277\u2013281","journal-title":"Ann Indian Acad Neurol"},{"issue":"1","key":"1730_CR32","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.ajpath.2012.03.039","volume":"181","author":"Y Nadatani","year":"2012","unstructured":"Nadatani Y, Watanabe T, Tanigawa T, Machida H, Okazaki H, Yamagami H et al (2012) High mobility Group Box 1 promotes small intestinal damage Induced by Nonsteroidal anti-inflammatory drugs through toll-like receptor 4. Am J Pathol 181(1):98\u2013110","journal-title":"Am J Pathol"},{"issue":"5","key":"1730_CR33","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/s41590-019-0368-3","volume":"20","author":"VAK Rathinam","year":"2019","unstructured":"Rathinam VAK, Zhao Y, Shao F (2019) Innate immunity to intracellular LPS. Nat Immunol 20(5):527\u2013533","journal-title":"Nat Immunol"},{"issue":"7","key":"1730_CR34","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.3390\/molecules26072035","volume":"26","author":"T Kochi","year":"2021","unstructured":"Kochi T, Nakamura Y, Ma S, Hisaoka-Nakashima K, Wang D, Liu K et al (2021) Pretreatment with high mobility Group Box-1 monoclonal antibody prevents the Onset of Trigeminal Neuropathy in mice with a distal infraorbital nerve chronic constriction Injury. Molecules 26(7):2035","journal-title":"Molecules"},{"issue":"1","key":"1730_CR35","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.bbi.2009.09.001","volume":"24","author":"WA Banks","year":"2010","unstructured":"Banks WA, Robinson SM (2010) Minimal penetration of lipopolysaccharide across the murine blood-brain barrier. Brain Behav Immun 24(1):102\u2013109","journal-title":"Brain Behav Immun"},{"issue":"1","key":"1730_CR36","doi-asserted-by":"publisher","first-page":"13113","DOI":"10.1038\/s41598-017-13302-6","volume":"7","author":"A Vargas-Caraveo","year":"2017","unstructured":"Vargas-Caraveo A, Sayd A, Maus SR, Caso JR, Madrigal JLM, Garc\u00eda-Bueno B et al (2017) Lipopolysaccharide enters the rat brain by a lipoprotein-mediated transport mechanism in physiological conditions. Sci Rep 7(1):13113","journal-title":"Sci Rep"},{"key":"1730_CR37","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.bbi.2023.04.018","volume":"111","author":"WA Banks","year":"2023","unstructured":"Banks WA, Hansen KM, Erickson MA, Crews FT (2023) High-mobility group box 1 (HMGB1) crosses the BBB bidirectionally. Brain Behav Immun 111:386\u2013394","journal-title":"Brain Behav Immun"},{"issue":"8","key":"1730_CR38","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1111\/head.14618","volume":"63","author":"YB Kilinc","year":"2023","unstructured":"Kilinc YB, Kilinc E, Danis A, Hanci F, Turay S, Ozge A et al (2023) Mitochondrial metabolism related markers GDF-15, FGF-21, and HIF-1\u03b1 are elevated in pediatric migraine attacks. Headache 63(8):1076\u20131086","journal-title":"Headache"},{"key":"1730_CR39","doi-asserted-by":"crossref","unstructured":"Aral LA, Erg\u00dcn MA, Bolay H (2021) Cellular iron storage and trafficking are affected by GTN stimulation in primary glial and meningeal cell culture. Turk J Biol 45(1):46\u201355","DOI":"10.3906\/biy-2009-1"},{"issue":"3","key":"1730_CR40","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1111\/j.1468-2982.2008.01723.x","volume":"29","author":"MC Kruit","year":"2009","unstructured":"Kruit MC, Launer LJ, Overbosch J, van Buchem MA, Ferrari MD (2009) Iron accumulation in deep brain nuclei in migraine: a population-based magnetic resonance imaging study. Cephalalgia 29(3):351\u2013359","journal-title":"Cephalalgia"},{"issue":"7","key":"1730_CR41","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1046\/j.1526-4610.2001.041007629.x","volume":"41","author":"KM Welch","year":"2001","unstructured":"Welch KM, Nagesh V, Aurora SK, Gelman N (2001) Periaqueductal gray matter dysfunction in migraine: cause or the burden of illness? Headache 41(7):629\u2013637","journal-title":"Headache"},{"issue":"22","key":"1730_CR42","doi-asserted-by":"publisher","first-page":"4190","DOI":"10.1016\/j.cell.2022.09.024","volume":"185","author":"D Yang","year":"2022","unstructured":"Yang D, Jacobson A, Meerschaert KA, Sifakis JJ, Wu M, Chen X et al (2022) Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection. Cell 185(22):4190-205e25","journal-title":"Cell"},{"issue":"1","key":"1730_CR43","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/s10194-018-0933-4","volume":"19","author":"D Vuralli","year":"2018","unstructured":"Vuralli D, Ayata C, Bolay H (2018) Cognitive dysfunction and migraine. J Headache Pain 19(1):109","journal-title":"J Headache Pain"}],"container-title":["The Journal of Headache and Pain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s10194-024-01730-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s10194-024-01730-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s10194-024-01730-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T14:47:35Z","timestamp":1731336455000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejournalofheadacheandpain.biomedcentral.com\/articles\/10.1186\/s10194-024-01730-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,19]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1730"],"URL":"https:\/\/doi.org\/10.1186\/s10194-024-01730-5","relation":{},"ISSN":["1129-2377"],"issn-type":[{"value":"1129-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,19]]},"assertion":[{"value":"5 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Clinical Research Ethics Committee of Gazi University Faculty of Medicine (EK-22-396). Written informed consent was obtained from all participants.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"23"}}